Delayed malignant transformation of petroclival meningioma to chondrosarcoma after stereotactic radiosurgery
Stereotactic radiosurgery (SRS) is often used as adjuvant treatment for residual or recurrent tumor following microsurgical resection of posterior fossa meningiomas. SRS is associated with excellent rates of local control, however long-term complications remain unclear. Secondary malignancy is an of...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Lall, Rohan R. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014transfer abstract |
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| Schlagwörter: |
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| Umfang: |
4 |
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| Übergeordnetes Werk: |
Enthalten in: New trends of new psychoactive substances (NPS)-infused chocolate: Identification and quantification of trace level of NPS in complex matrix by GC-MS and NMR - Song, Chun-hui ELSEVIER, 2023, Burlington, Mass |
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| Übergeordnetes Werk: |
volume:21 ; year:2014 ; number:7 ; pages:1225-1228 ; extent:4 |
| Links: |
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| DOI / URN: |
10.1016/j.jocn.2013.11.015 |
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ELV022877657 |
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| 520 | |a Stereotactic radiosurgery (SRS) is often used as adjuvant treatment for residual or recurrent tumor following microsurgical resection of posterior fossa meningiomas. SRS is associated with excellent rates of local control, however long-term complications remain unclear. Secondary malignancy is an often discussed but rarely described complication of SRS. We present a 56-year-old woman who underwent near total resection of a petroclival meningioma, followed by two episodes of SRS over the ensuing 8years for local recurrence. She returned 14years after initial diagnosis with neurologic deterioration and was found to have massive recurrence. Pathology was consistent with high-grade chondrosarcoma. The tumor continued to progress despite debulking and proton-beam therapy and the patient died of medical complications. To our knowledge this is the first report of malignant transformation of a meningioma to high-grade chondrosarcoma, further notable due to the remarkable clinical course and delayed presentation after initial surgery and radiosurgery. Though this may have been a de novo tumor, it is also possible that this represents a case of radiation-induced neoplasm. Although SRS continues to gain favor as a treatment modality, delayed malignant degeneration is a potential complication and physicians should counsel patients of this risk. | ||
| 520 | |a Stereotactic radiosurgery (SRS) is often used as adjuvant treatment for residual or recurrent tumor following microsurgical resection of posterior fossa meningiomas. SRS is associated with excellent rates of local control, however long-term complications remain unclear. Secondary malignancy is an often discussed but rarely described complication of SRS. We present a 56-year-old woman who underwent near total resection of a petroclival meningioma, followed by two episodes of SRS over the ensuing 8years for local recurrence. She returned 14years after initial diagnosis with neurologic deterioration and was found to have massive recurrence. Pathology was consistent with high-grade chondrosarcoma. The tumor continued to progress despite debulking and proton-beam therapy and the patient died of medical complications. To our knowledge this is the first report of malignant transformation of a meningioma to high-grade chondrosarcoma, further notable due to the remarkable clinical course and delayed presentation after initial surgery and radiosurgery. Though this may have been a de novo tumor, it is also possible that this represents a case of radiation-induced neoplasm. Although SRS continues to gain favor as a treatment modality, delayed malignant degeneration is a potential complication and physicians should counsel patients of this risk. | ||
| 650 | 7 | |a Malignant degeneration |2 Elsevier | |
| 650 | 7 | |a Stereotactic radiosurgery |2 Elsevier | |
| 650 | 7 | |a Chondrosarcoma |2 Elsevier | |
| 650 | 7 | |a Neuropathology |2 Elsevier | |
| 650 | 7 | |a SRS |2 Elsevier | |
| 650 | 7 | |a Radiosurgery |2 Elsevier | |
| 650 | 7 | |a Meningioma |2 Elsevier | |
| 700 | 1 | |a Lall, Rishi R. |4 oth | |
| 700 | 1 | |a Smith, Timothy R. |4 oth | |
| 700 | 1 | |a Lee, Kyung-Hwa |4 oth | |
| 700 | 1 | |a Mao, Qinwen |4 oth | |
| 700 | 1 | |a Kalapurakal, John A. |4 oth | |
| 700 | 1 | |a Marymont, Maryanne H. |4 oth | |
| 700 | 1 | |a Chandler, James P. |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Harcourt |a Song, Chun-hui ELSEVIER |t New trends of new psychoactive substances (NPS)-infused chocolate: Identification and quantification of trace level of NPS in complex matrix by GC-MS and NMR |d 2023 |g Burlington, Mass |w (DE-627)ELV009125612 |
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10.1016/j.jocn.2013.11.015 doi GBVA2014015000029.pica (DE-627)ELV022877657 (ELSEVIER)S0967-5868(13)00654-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 540 VZ 35.00 bkl Lall, Rohan R. verfasserin aut Delayed malignant transformation of petroclival meningioma to chondrosarcoma after stereotactic radiosurgery 2014transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Stereotactic radiosurgery (SRS) is often used as adjuvant treatment for residual or recurrent tumor following microsurgical resection of posterior fossa meningiomas. SRS is associated with excellent rates of local control, however long-term complications remain unclear. Secondary malignancy is an often discussed but rarely described complication of SRS. We present a 56-year-old woman who underwent near total resection of a petroclival meningioma, followed by two episodes of SRS over the ensuing 8years for local recurrence. She returned 14years after initial diagnosis with neurologic deterioration and was found to have massive recurrence. Pathology was consistent with high-grade chondrosarcoma. The tumor continued to progress despite debulking and proton-beam therapy and the patient died of medical complications. To our knowledge this is the first report of malignant transformation of a meningioma to high-grade chondrosarcoma, further notable due to the remarkable clinical course and delayed presentation after initial surgery and radiosurgery. Though this may have been a de novo tumor, it is also possible that this represents a case of radiation-induced neoplasm. Although SRS continues to gain favor as a treatment modality, delayed malignant degeneration is a potential complication and physicians should counsel patients of this risk. Stereotactic radiosurgery (SRS) is often used as adjuvant treatment for residual or recurrent tumor following microsurgical resection of posterior fossa meningiomas. SRS is associated with excellent rates of local control, however long-term complications remain unclear. Secondary malignancy is an often discussed but rarely described complication of SRS. We present a 56-year-old woman who underwent near total resection of a petroclival meningioma, followed by two episodes of SRS over the ensuing 8years for local recurrence. She returned 14years after initial diagnosis with neurologic deterioration and was found to have massive recurrence. Pathology was consistent with high-grade chondrosarcoma. The tumor continued to progress despite debulking and proton-beam therapy and the patient died of medical complications. To our knowledge this is the first report of malignant transformation of a meningioma to high-grade chondrosarcoma, further notable due to the remarkable clinical course and delayed presentation after initial surgery and radiosurgery. Though this may have been a de novo tumor, it is also possible that this represents a case of radiation-induced neoplasm. Although SRS continues to gain favor as a treatment modality, delayed malignant degeneration is a potential complication and physicians should counsel patients of this risk. Malignant degeneration Elsevier Stereotactic radiosurgery Elsevier Chondrosarcoma Elsevier Neuropathology Elsevier SRS Elsevier Radiosurgery Elsevier Meningioma Elsevier Lall, Rishi R. oth Smith, Timothy R. oth Lee, Kyung-Hwa oth Mao, Qinwen oth Kalapurakal, John A. oth Marymont, Maryanne H. oth Chandler, James P. oth Enthalten in Harcourt Song, Chun-hui ELSEVIER New trends of new psychoactive substances (NPS)-infused chocolate: Identification and quantification of trace level of NPS in complex matrix by GC-MS and NMR 2023 Burlington, Mass (DE-627)ELV009125612 volume:21 year:2014 number:7 pages:1225-1228 extent:4 https://doi.org/10.1016/j.jocn.2013.11.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 21 2014 7 1225-1228 4 045F 610 |
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10.1016/j.jocn.2013.11.015 doi GBVA2014015000029.pica (DE-627)ELV022877657 (ELSEVIER)S0967-5868(13)00654-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 540 VZ 35.00 bkl Lall, Rohan R. verfasserin aut Delayed malignant transformation of petroclival meningioma to chondrosarcoma after stereotactic radiosurgery 2014transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Stereotactic radiosurgery (SRS) is often used as adjuvant treatment for residual or recurrent tumor following microsurgical resection of posterior fossa meningiomas. SRS is associated with excellent rates of local control, however long-term complications remain unclear. Secondary malignancy is an often discussed but rarely described complication of SRS. We present a 56-year-old woman who underwent near total resection of a petroclival meningioma, followed by two episodes of SRS over the ensuing 8years for local recurrence. She returned 14years after initial diagnosis with neurologic deterioration and was found to have massive recurrence. Pathology was consistent with high-grade chondrosarcoma. The tumor continued to progress despite debulking and proton-beam therapy and the patient died of medical complications. To our knowledge this is the first report of malignant transformation of a meningioma to high-grade chondrosarcoma, further notable due to the remarkable clinical course and delayed presentation after initial surgery and radiosurgery. Though this may have been a de novo tumor, it is also possible that this represents a case of radiation-induced neoplasm. Although SRS continues to gain favor as a treatment modality, delayed malignant degeneration is a potential complication and physicians should counsel patients of this risk. Stereotactic radiosurgery (SRS) is often used as adjuvant treatment for residual or recurrent tumor following microsurgical resection of posterior fossa meningiomas. SRS is associated with excellent rates of local control, however long-term complications remain unclear. Secondary malignancy is an often discussed but rarely described complication of SRS. We present a 56-year-old woman who underwent near total resection of a petroclival meningioma, followed by two episodes of SRS over the ensuing 8years for local recurrence. She returned 14years after initial diagnosis with neurologic deterioration and was found to have massive recurrence. Pathology was consistent with high-grade chondrosarcoma. The tumor continued to progress despite debulking and proton-beam therapy and the patient died of medical complications. To our knowledge this is the first report of malignant transformation of a meningioma to high-grade chondrosarcoma, further notable due to the remarkable clinical course and delayed presentation after initial surgery and radiosurgery. Though this may have been a de novo tumor, it is also possible that this represents a case of radiation-induced neoplasm. Although SRS continues to gain favor as a treatment modality, delayed malignant degeneration is a potential complication and physicians should counsel patients of this risk. Malignant degeneration Elsevier Stereotactic radiosurgery Elsevier Chondrosarcoma Elsevier Neuropathology Elsevier SRS Elsevier Radiosurgery Elsevier Meningioma Elsevier Lall, Rishi R. oth Smith, Timothy R. oth Lee, Kyung-Hwa oth Mao, Qinwen oth Kalapurakal, John A. oth Marymont, Maryanne H. oth Chandler, James P. oth Enthalten in Harcourt Song, Chun-hui ELSEVIER New trends of new psychoactive substances (NPS)-infused chocolate: Identification and quantification of trace level of NPS in complex matrix by GC-MS and NMR 2023 Burlington, Mass (DE-627)ELV009125612 volume:21 year:2014 number:7 pages:1225-1228 extent:4 https://doi.org/10.1016/j.jocn.2013.11.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 21 2014 7 1225-1228 4 045F 610 |
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10.1016/j.jocn.2013.11.015 doi GBVA2014015000029.pica (DE-627)ELV022877657 (ELSEVIER)S0967-5868(13)00654-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 540 VZ 35.00 bkl Lall, Rohan R. verfasserin aut Delayed malignant transformation of petroclival meningioma to chondrosarcoma after stereotactic radiosurgery 2014transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Stereotactic radiosurgery (SRS) is often used as adjuvant treatment for residual or recurrent tumor following microsurgical resection of posterior fossa meningiomas. SRS is associated with excellent rates of local control, however long-term complications remain unclear. Secondary malignancy is an often discussed but rarely described complication of SRS. We present a 56-year-old woman who underwent near total resection of a petroclival meningioma, followed by two episodes of SRS over the ensuing 8years for local recurrence. She returned 14years after initial diagnosis with neurologic deterioration and was found to have massive recurrence. Pathology was consistent with high-grade chondrosarcoma. The tumor continued to progress despite debulking and proton-beam therapy and the patient died of medical complications. To our knowledge this is the first report of malignant transformation of a meningioma to high-grade chondrosarcoma, further notable due to the remarkable clinical course and delayed presentation after initial surgery and radiosurgery. Though this may have been a de novo tumor, it is also possible that this represents a case of radiation-induced neoplasm. Although SRS continues to gain favor as a treatment modality, delayed malignant degeneration is a potential complication and physicians should counsel patients of this risk. Stereotactic radiosurgery (SRS) is often used as adjuvant treatment for residual or recurrent tumor following microsurgical resection of posterior fossa meningiomas. SRS is associated with excellent rates of local control, however long-term complications remain unclear. Secondary malignancy is an often discussed but rarely described complication of SRS. We present a 56-year-old woman who underwent near total resection of a petroclival meningioma, followed by two episodes of SRS over the ensuing 8years for local recurrence. She returned 14years after initial diagnosis with neurologic deterioration and was found to have massive recurrence. Pathology was consistent with high-grade chondrosarcoma. The tumor continued to progress despite debulking and proton-beam therapy and the patient died of medical complications. To our knowledge this is the first report of malignant transformation of a meningioma to high-grade chondrosarcoma, further notable due to the remarkable clinical course and delayed presentation after initial surgery and radiosurgery. Though this may have been a de novo tumor, it is also possible that this represents a case of radiation-induced neoplasm. Although SRS continues to gain favor as a treatment modality, delayed malignant degeneration is a potential complication and physicians should counsel patients of this risk. Malignant degeneration Elsevier Stereotactic radiosurgery Elsevier Chondrosarcoma Elsevier Neuropathology Elsevier SRS Elsevier Radiosurgery Elsevier Meningioma Elsevier Lall, Rishi R. oth Smith, Timothy R. oth Lee, Kyung-Hwa oth Mao, Qinwen oth Kalapurakal, John A. oth Marymont, Maryanne H. oth Chandler, James P. oth Enthalten in Harcourt Song, Chun-hui ELSEVIER New trends of new psychoactive substances (NPS)-infused chocolate: Identification and quantification of trace level of NPS in complex matrix by GC-MS and NMR 2023 Burlington, Mass (DE-627)ELV009125612 volume:21 year:2014 number:7 pages:1225-1228 extent:4 https://doi.org/10.1016/j.jocn.2013.11.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 21 2014 7 1225-1228 4 045F 610 |
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10.1016/j.jocn.2013.11.015 doi GBVA2014015000029.pica (DE-627)ELV022877657 (ELSEVIER)S0967-5868(13)00654-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 540 VZ 35.00 bkl Lall, Rohan R. verfasserin aut Delayed malignant transformation of petroclival meningioma to chondrosarcoma after stereotactic radiosurgery 2014transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Stereotactic radiosurgery (SRS) is often used as adjuvant treatment for residual or recurrent tumor following microsurgical resection of posterior fossa meningiomas. SRS is associated with excellent rates of local control, however long-term complications remain unclear. Secondary malignancy is an often discussed but rarely described complication of SRS. We present a 56-year-old woman who underwent near total resection of a petroclival meningioma, followed by two episodes of SRS over the ensuing 8years for local recurrence. She returned 14years after initial diagnosis with neurologic deterioration and was found to have massive recurrence. Pathology was consistent with high-grade chondrosarcoma. The tumor continued to progress despite debulking and proton-beam therapy and the patient died of medical complications. To our knowledge this is the first report of malignant transformation of a meningioma to high-grade chondrosarcoma, further notable due to the remarkable clinical course and delayed presentation after initial surgery and radiosurgery. Though this may have been a de novo tumor, it is also possible that this represents a case of radiation-induced neoplasm. Although SRS continues to gain favor as a treatment modality, delayed malignant degeneration is a potential complication and physicians should counsel patients of this risk. Stereotactic radiosurgery (SRS) is often used as adjuvant treatment for residual or recurrent tumor following microsurgical resection of posterior fossa meningiomas. SRS is associated with excellent rates of local control, however long-term complications remain unclear. Secondary malignancy is an often discussed but rarely described complication of SRS. We present a 56-year-old woman who underwent near total resection of a petroclival meningioma, followed by two episodes of SRS over the ensuing 8years for local recurrence. She returned 14years after initial diagnosis with neurologic deterioration and was found to have massive recurrence. Pathology was consistent with high-grade chondrosarcoma. The tumor continued to progress despite debulking and proton-beam therapy and the patient died of medical complications. To our knowledge this is the first report of malignant transformation of a meningioma to high-grade chondrosarcoma, further notable due to the remarkable clinical course and delayed presentation after initial surgery and radiosurgery. Though this may have been a de novo tumor, it is also possible that this represents a case of radiation-induced neoplasm. Although SRS continues to gain favor as a treatment modality, delayed malignant degeneration is a potential complication and physicians should counsel patients of this risk. Malignant degeneration Elsevier Stereotactic radiosurgery Elsevier Chondrosarcoma Elsevier Neuropathology Elsevier SRS Elsevier Radiosurgery Elsevier Meningioma Elsevier Lall, Rishi R. oth Smith, Timothy R. oth Lee, Kyung-Hwa oth Mao, Qinwen oth Kalapurakal, John A. oth Marymont, Maryanne H. oth Chandler, James P. oth Enthalten in Harcourt Song, Chun-hui ELSEVIER New trends of new psychoactive substances (NPS)-infused chocolate: Identification and quantification of trace level of NPS in complex matrix by GC-MS and NMR 2023 Burlington, Mass (DE-627)ELV009125612 volume:21 year:2014 number:7 pages:1225-1228 extent:4 https://doi.org/10.1016/j.jocn.2013.11.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 21 2014 7 1225-1228 4 045F 610 |
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10.1016/j.jocn.2013.11.015 doi GBVA2014015000029.pica (DE-627)ELV022877657 (ELSEVIER)S0967-5868(13)00654-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 540 VZ 35.00 bkl Lall, Rohan R. verfasserin aut Delayed malignant transformation of petroclival meningioma to chondrosarcoma after stereotactic radiosurgery 2014transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Stereotactic radiosurgery (SRS) is often used as adjuvant treatment for residual or recurrent tumor following microsurgical resection of posterior fossa meningiomas. SRS is associated with excellent rates of local control, however long-term complications remain unclear. Secondary malignancy is an often discussed but rarely described complication of SRS. We present a 56-year-old woman who underwent near total resection of a petroclival meningioma, followed by two episodes of SRS over the ensuing 8years for local recurrence. She returned 14years after initial diagnosis with neurologic deterioration and was found to have massive recurrence. Pathology was consistent with high-grade chondrosarcoma. The tumor continued to progress despite debulking and proton-beam therapy and the patient died of medical complications. To our knowledge this is the first report of malignant transformation of a meningioma to high-grade chondrosarcoma, further notable due to the remarkable clinical course and delayed presentation after initial surgery and radiosurgery. Though this may have been a de novo tumor, it is also possible that this represents a case of radiation-induced neoplasm. Although SRS continues to gain favor as a treatment modality, delayed malignant degeneration is a potential complication and physicians should counsel patients of this risk. Stereotactic radiosurgery (SRS) is often used as adjuvant treatment for residual or recurrent tumor following microsurgical resection of posterior fossa meningiomas. SRS is associated with excellent rates of local control, however long-term complications remain unclear. Secondary malignancy is an often discussed but rarely described complication of SRS. We present a 56-year-old woman who underwent near total resection of a petroclival meningioma, followed by two episodes of SRS over the ensuing 8years for local recurrence. She returned 14years after initial diagnosis with neurologic deterioration and was found to have massive recurrence. Pathology was consistent with high-grade chondrosarcoma. The tumor continued to progress despite debulking and proton-beam therapy and the patient died of medical complications. To our knowledge this is the first report of malignant transformation of a meningioma to high-grade chondrosarcoma, further notable due to the remarkable clinical course and delayed presentation after initial surgery and radiosurgery. Though this may have been a de novo tumor, it is also possible that this represents a case of radiation-induced neoplasm. Although SRS continues to gain favor as a treatment modality, delayed malignant degeneration is a potential complication and physicians should counsel patients of this risk. Malignant degeneration Elsevier Stereotactic radiosurgery Elsevier Chondrosarcoma Elsevier Neuropathology Elsevier SRS Elsevier Radiosurgery Elsevier Meningioma Elsevier Lall, Rishi R. oth Smith, Timothy R. oth Lee, Kyung-Hwa oth Mao, Qinwen oth Kalapurakal, John A. oth Marymont, Maryanne H. oth Chandler, James P. oth Enthalten in Harcourt Song, Chun-hui ELSEVIER New trends of new psychoactive substances (NPS)-infused chocolate: Identification and quantification of trace level of NPS in complex matrix by GC-MS and NMR 2023 Burlington, Mass (DE-627)ELV009125612 volume:21 year:2014 number:7 pages:1225-1228 extent:4 https://doi.org/10.1016/j.jocn.2013.11.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 21 2014 7 1225-1228 4 045F 610 |
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Enthalten in New trends of new psychoactive substances (NPS)-infused chocolate: Identification and quantification of trace level of NPS in complex matrix by GC-MS and NMR Burlington, Mass volume:21 year:2014 number:7 pages:1225-1228 extent:4 |
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delayed malignant transformation of petroclival meningioma to chondrosarcoma after stereotactic radiosurgery |
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Delayed malignant transformation of petroclival meningioma to chondrosarcoma after stereotactic radiosurgery |
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Stereotactic radiosurgery (SRS) is often used as adjuvant treatment for residual or recurrent tumor following microsurgical resection of posterior fossa meningiomas. SRS is associated with excellent rates of local control, however long-term complications remain unclear. Secondary malignancy is an often discussed but rarely described complication of SRS. We present a 56-year-old woman who underwent near total resection of a petroclival meningioma, followed by two episodes of SRS over the ensuing 8years for local recurrence. She returned 14years after initial diagnosis with neurologic deterioration and was found to have massive recurrence. Pathology was consistent with high-grade chondrosarcoma. The tumor continued to progress despite debulking and proton-beam therapy and the patient died of medical complications. To our knowledge this is the first report of malignant transformation of a meningioma to high-grade chondrosarcoma, further notable due to the remarkable clinical course and delayed presentation after initial surgery and radiosurgery. Though this may have been a de novo tumor, it is also possible that this represents a case of radiation-induced neoplasm. Although SRS continues to gain favor as a treatment modality, delayed malignant degeneration is a potential complication and physicians should counsel patients of this risk. |
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Stereotactic radiosurgery (SRS) is often used as adjuvant treatment for residual or recurrent tumor following microsurgical resection of posterior fossa meningiomas. SRS is associated with excellent rates of local control, however long-term complications remain unclear. Secondary malignancy is an often discussed but rarely described complication of SRS. We present a 56-year-old woman who underwent near total resection of a petroclival meningioma, followed by two episodes of SRS over the ensuing 8years for local recurrence. She returned 14years after initial diagnosis with neurologic deterioration and was found to have massive recurrence. Pathology was consistent with high-grade chondrosarcoma. The tumor continued to progress despite debulking and proton-beam therapy and the patient died of medical complications. To our knowledge this is the first report of malignant transformation of a meningioma to high-grade chondrosarcoma, further notable due to the remarkable clinical course and delayed presentation after initial surgery and radiosurgery. Though this may have been a de novo tumor, it is also possible that this represents a case of radiation-induced neoplasm. Although SRS continues to gain favor as a treatment modality, delayed malignant degeneration is a potential complication and physicians should counsel patients of this risk. |
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Stereotactic radiosurgery (SRS) is often used as adjuvant treatment for residual or recurrent tumor following microsurgical resection of posterior fossa meningiomas. SRS is associated with excellent rates of local control, however long-term complications remain unclear. Secondary malignancy is an often discussed but rarely described complication of SRS. We present a 56-year-old woman who underwent near total resection of a petroclival meningioma, followed by two episodes of SRS over the ensuing 8years for local recurrence. She returned 14years after initial diagnosis with neurologic deterioration and was found to have massive recurrence. Pathology was consistent with high-grade chondrosarcoma. The tumor continued to progress despite debulking and proton-beam therapy and the patient died of medical complications. To our knowledge this is the first report of malignant transformation of a meningioma to high-grade chondrosarcoma, further notable due to the remarkable clinical course and delayed presentation after initial surgery and radiosurgery. Though this may have been a de novo tumor, it is also possible that this represents a case of radiation-induced neoplasm. Although SRS continues to gain favor as a treatment modality, delayed malignant degeneration is a potential complication and physicians should counsel patients of this risk. |
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