The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated With Panic Disorder and Amygdala Structure and Function
Individuals with panic disorder (PD) exhibit a hypersensitivity to inhaled carbon dioxide, possibly reflecting a lowered threshold for sensing signals of suffocation. Animal studies have shown that carbon dioxide–mediated fear behavior depends on chemosensing of acidosis in the amygdala via the acid...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Smoller, Jordan W. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Umfang: |
9 |
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| Übergeordnetes Werk: |
Enthalten in: Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells - Xu, Qi ELSEVIER, 2016, a journal of psychiatric neuroscience : a publication of the Society of Biological Psychiatry, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:76 ; year:2014 ; number:11 ; day:1 ; month:12 ; pages:902-910 ; extent:9 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.biopsych.2013.12.018 |
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ELV022982183 |
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| 520 | |a Individuals with panic disorder (PD) exhibit a hypersensitivity to inhaled carbon dioxide, possibly reflecting a lowered threshold for sensing signals of suffocation. Animal studies have shown that carbon dioxide–mediated fear behavior depends on chemosensing of acidosis in the amygdala via the acid-sensing ion channel ASIC1a. We examined whether the human ortholog of the ASIC1a gene, ACCN2, is associated with the presence of PD and with amygdala structure and function. | ||
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10.1016/j.biopsych.2013.12.018 doi GBVA2014019000003.pica (DE-627)ELV022982183 (ELSEVIER)S0006-3223(14)00017-1 DE-627 ger DE-627 rakwb eng 570 610 570 DE-600 610 DE-600 610 VZ 44.40 bkl Smoller, Jordan W. verfasserin aut The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated With Panic Disorder and Amygdala Structure and Function 2014 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Individuals with panic disorder (PD) exhibit a hypersensitivity to inhaled carbon dioxide, possibly reflecting a lowered threshold for sensing signals of suffocation. Animal studies have shown that carbon dioxide–mediated fear behavior depends on chemosensing of acidosis in the amygdala via the acid-sensing ion channel ASIC1a. We examined whether the human ortholog of the ASIC1a gene, ACCN2, is associated with the presence of PD and with amygdala structure and function. genetic Elsevier amygdala Elsevier ASIC1a Elsevier ACCN2 Elsevier association Elsevier panic disorder Elsevier Gallagher, Patience J. oth Duncan, Laramie E. oth McGrath, Lauren M. oth Haddad, Stephen A. oth Holmes, Avram J. oth Wolf, Aaron B. oth Hilker, Sidney oth Block, Stefanie R. oth Weill, Sydney oth Young, Sarah oth Choi, Eun Young oth Rosenbaum, Jerrold F. oth Biederman, Joseph oth Faraone, Stephen V. oth Roffman, Joshua L. oth Manfro, Gisele G. oth Blaya, Carolina oth Hirshfeld-Becker, Dina R. oth Stein, Murray B. oth Van Ameringen, Michael oth Tolin, David F. oth Otto, Michael W. oth Pollack, Mark H. oth Simon, Naomi M. oth Buckner, Randy L. oth Öngür, Dost oth Cohen, Bruce M. oth Enthalten in Elsevier Science Xu, Qi ELSEVIER Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells 2016 a journal of psychiatric neuroscience : a publication of the Society of Biological Psychiatry Amsterdam [u.a.] (DE-627)ELV01006897X volume:76 year:2014 number:11 day:1 month:12 pages:902-910 extent:9 https://doi.org/10.1016/j.biopsych.2013.12.018 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 76 2014 11 1 1201 902-910 9 045F 570 |
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10.1016/j.biopsych.2013.12.018 doi GBVA2014019000003.pica (DE-627)ELV022982183 (ELSEVIER)S0006-3223(14)00017-1 DE-627 ger DE-627 rakwb eng 570 610 570 DE-600 610 DE-600 610 VZ 44.40 bkl Smoller, Jordan W. verfasserin aut The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated With Panic Disorder and Amygdala Structure and Function 2014 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Individuals with panic disorder (PD) exhibit a hypersensitivity to inhaled carbon dioxide, possibly reflecting a lowered threshold for sensing signals of suffocation. Animal studies have shown that carbon dioxide–mediated fear behavior depends on chemosensing of acidosis in the amygdala via the acid-sensing ion channel ASIC1a. We examined whether the human ortholog of the ASIC1a gene, ACCN2, is associated with the presence of PD and with amygdala structure and function. genetic Elsevier amygdala Elsevier ASIC1a Elsevier ACCN2 Elsevier association Elsevier panic disorder Elsevier Gallagher, Patience J. oth Duncan, Laramie E. oth McGrath, Lauren M. oth Haddad, Stephen A. oth Holmes, Avram J. oth Wolf, Aaron B. oth Hilker, Sidney oth Block, Stefanie R. oth Weill, Sydney oth Young, Sarah oth Choi, Eun Young oth Rosenbaum, Jerrold F. oth Biederman, Joseph oth Faraone, Stephen V. oth Roffman, Joshua L. oth Manfro, Gisele G. oth Blaya, Carolina oth Hirshfeld-Becker, Dina R. oth Stein, Murray B. oth Van Ameringen, Michael oth Tolin, David F. oth Otto, Michael W. oth Pollack, Mark H. oth Simon, Naomi M. oth Buckner, Randy L. oth Öngür, Dost oth Cohen, Bruce M. oth Enthalten in Elsevier Science Xu, Qi ELSEVIER Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells 2016 a journal of psychiatric neuroscience : a publication of the Society of Biological Psychiatry Amsterdam [u.a.] (DE-627)ELV01006897X volume:76 year:2014 number:11 day:1 month:12 pages:902-910 extent:9 https://doi.org/10.1016/j.biopsych.2013.12.018 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 76 2014 11 1 1201 902-910 9 045F 570 |
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10.1016/j.biopsych.2013.12.018 doi GBVA2014019000003.pica (DE-627)ELV022982183 (ELSEVIER)S0006-3223(14)00017-1 DE-627 ger DE-627 rakwb eng 570 610 570 DE-600 610 DE-600 610 VZ 44.40 bkl Smoller, Jordan W. verfasserin aut The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated With Panic Disorder and Amygdala Structure and Function 2014 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Individuals with panic disorder (PD) exhibit a hypersensitivity to inhaled carbon dioxide, possibly reflecting a lowered threshold for sensing signals of suffocation. Animal studies have shown that carbon dioxide–mediated fear behavior depends on chemosensing of acidosis in the amygdala via the acid-sensing ion channel ASIC1a. We examined whether the human ortholog of the ASIC1a gene, ACCN2, is associated with the presence of PD and with amygdala structure and function. genetic Elsevier amygdala Elsevier ASIC1a Elsevier ACCN2 Elsevier association Elsevier panic disorder Elsevier Gallagher, Patience J. oth Duncan, Laramie E. oth McGrath, Lauren M. oth Haddad, Stephen A. oth Holmes, Avram J. oth Wolf, Aaron B. oth Hilker, Sidney oth Block, Stefanie R. oth Weill, Sydney oth Young, Sarah oth Choi, Eun Young oth Rosenbaum, Jerrold F. oth Biederman, Joseph oth Faraone, Stephen V. oth Roffman, Joshua L. oth Manfro, Gisele G. oth Blaya, Carolina oth Hirshfeld-Becker, Dina R. oth Stein, Murray B. oth Van Ameringen, Michael oth Tolin, David F. oth Otto, Michael W. oth Pollack, Mark H. oth Simon, Naomi M. oth Buckner, Randy L. oth Öngür, Dost oth Cohen, Bruce M. oth Enthalten in Elsevier Science Xu, Qi ELSEVIER Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells 2016 a journal of psychiatric neuroscience : a publication of the Society of Biological Psychiatry Amsterdam [u.a.] (DE-627)ELV01006897X volume:76 year:2014 number:11 day:1 month:12 pages:902-910 extent:9 https://doi.org/10.1016/j.biopsych.2013.12.018 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 76 2014 11 1 1201 902-910 9 045F 570 |
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10.1016/j.biopsych.2013.12.018 doi GBVA2014019000003.pica (DE-627)ELV022982183 (ELSEVIER)S0006-3223(14)00017-1 DE-627 ger DE-627 rakwb eng 570 610 570 DE-600 610 DE-600 610 VZ 44.40 bkl Smoller, Jordan W. verfasserin aut The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated With Panic Disorder and Amygdala Structure and Function 2014 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Individuals with panic disorder (PD) exhibit a hypersensitivity to inhaled carbon dioxide, possibly reflecting a lowered threshold for sensing signals of suffocation. Animal studies have shown that carbon dioxide–mediated fear behavior depends on chemosensing of acidosis in the amygdala via the acid-sensing ion channel ASIC1a. We examined whether the human ortholog of the ASIC1a gene, ACCN2, is associated with the presence of PD and with amygdala structure and function. genetic Elsevier amygdala Elsevier ASIC1a Elsevier ACCN2 Elsevier association Elsevier panic disorder Elsevier Gallagher, Patience J. oth Duncan, Laramie E. oth McGrath, Lauren M. oth Haddad, Stephen A. oth Holmes, Avram J. oth Wolf, Aaron B. oth Hilker, Sidney oth Block, Stefanie R. oth Weill, Sydney oth Young, Sarah oth Choi, Eun Young oth Rosenbaum, Jerrold F. oth Biederman, Joseph oth Faraone, Stephen V. oth Roffman, Joshua L. oth Manfro, Gisele G. oth Blaya, Carolina oth Hirshfeld-Becker, Dina R. oth Stein, Murray B. oth Van Ameringen, Michael oth Tolin, David F. oth Otto, Michael W. oth Pollack, Mark H. oth Simon, Naomi M. oth Buckner, Randy L. oth Öngür, Dost oth Cohen, Bruce M. oth Enthalten in Elsevier Science Xu, Qi ELSEVIER Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells 2016 a journal of psychiatric neuroscience : a publication of the Society of Biological Psychiatry Amsterdam [u.a.] (DE-627)ELV01006897X volume:76 year:2014 number:11 day:1 month:12 pages:902-910 extent:9 https://doi.org/10.1016/j.biopsych.2013.12.018 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 76 2014 11 1 1201 902-910 9 045F 570 |
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10.1016/j.biopsych.2013.12.018 doi GBVA2014019000003.pica (DE-627)ELV022982183 (ELSEVIER)S0006-3223(14)00017-1 DE-627 ger DE-627 rakwb eng 570 610 570 DE-600 610 DE-600 610 VZ 44.40 bkl Smoller, Jordan W. verfasserin aut The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated With Panic Disorder and Amygdala Structure and Function 2014 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Individuals with panic disorder (PD) exhibit a hypersensitivity to inhaled carbon dioxide, possibly reflecting a lowered threshold for sensing signals of suffocation. Animal studies have shown that carbon dioxide–mediated fear behavior depends on chemosensing of acidosis in the amygdala via the acid-sensing ion channel ASIC1a. We examined whether the human ortholog of the ASIC1a gene, ACCN2, is associated with the presence of PD and with amygdala structure and function. genetic Elsevier amygdala Elsevier ASIC1a Elsevier ACCN2 Elsevier association Elsevier panic disorder Elsevier Gallagher, Patience J. oth Duncan, Laramie E. oth McGrath, Lauren M. oth Haddad, Stephen A. oth Holmes, Avram J. oth Wolf, Aaron B. oth Hilker, Sidney oth Block, Stefanie R. oth Weill, Sydney oth Young, Sarah oth Choi, Eun Young oth Rosenbaum, Jerrold F. oth Biederman, Joseph oth Faraone, Stephen V. oth Roffman, Joshua L. oth Manfro, Gisele G. oth Blaya, Carolina oth Hirshfeld-Becker, Dina R. oth Stein, Murray B. oth Van Ameringen, Michael oth Tolin, David F. oth Otto, Michael W. oth Pollack, Mark H. oth Simon, Naomi M. oth Buckner, Randy L. oth Öngür, Dost oth Cohen, Bruce M. oth Enthalten in Elsevier Science Xu, Qi ELSEVIER Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells 2016 a journal of psychiatric neuroscience : a publication of the Society of Biological Psychiatry Amsterdam [u.a.] (DE-627)ELV01006897X volume:76 year:2014 number:11 day:1 month:12 pages:902-910 extent:9 https://doi.org/10.1016/j.biopsych.2013.12.018 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 76 2014 11 1 1201 902-910 9 045F 570 |
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Enthalten in Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells Amsterdam [u.a.] volume:76 year:2014 number:11 day:1 month:12 pages:902-910 extent:9 |
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Enthalten in Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells Amsterdam [u.a.] volume:76 year:2014 number:11 day:1 month:12 pages:902-910 extent:9 |
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Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells |
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The Human Ortholog of Acid-Sensing Ion Channel Gene ASIC1a Is Associated With Panic Disorder and Amygdala Structure and Function |
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Individuals with panic disorder (PD) exhibit a hypersensitivity to inhaled carbon dioxide, possibly reflecting a lowered threshold for sensing signals of suffocation. Animal studies have shown that carbon dioxide–mediated fear behavior depends on chemosensing of acidosis in the amygdala via the acid-sensing ion channel ASIC1a. We examined whether the human ortholog of the ASIC1a gene, ACCN2, is associated with the presence of PD and with amygdala structure and function. |
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Individuals with panic disorder (PD) exhibit a hypersensitivity to inhaled carbon dioxide, possibly reflecting a lowered threshold for sensing signals of suffocation. Animal studies have shown that carbon dioxide–mediated fear behavior depends on chemosensing of acidosis in the amygdala via the acid-sensing ion channel ASIC1a. We examined whether the human ortholog of the ASIC1a gene, ACCN2, is associated with the presence of PD and with amygdala structure and function. |
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Individuals with panic disorder (PD) exhibit a hypersensitivity to inhaled carbon dioxide, possibly reflecting a lowered threshold for sensing signals of suffocation. Animal studies have shown that carbon dioxide–mediated fear behavior depends on chemosensing of acidosis in the amygdala via the acid-sensing ion channel ASIC1a. We examined whether the human ortholog of the ASIC1a gene, ACCN2, is associated with the presence of PD and with amygdala structure and function. |
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