1,25-Dihydroxyvitamin D3 impairs the differentiation of effector memory T cells in vitro in multiple sclerosis patients and healthy controls
Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studied the effects of 1,25-dihydroxyvitamin D3 (1,25(O...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Bhargava, Pavan [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015transfer abstract |
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| Umfang: |
5 |
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| Übergeordnetes Werk: |
Enthalten in: Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process - Li, Kuo ELSEVIER, 2020, official journal of the International Society for Neuroimmunology, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:279 ; year:2015 ; day:15 ; month:02 ; pages:20-24 ; extent:5 |
| Links: |
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| DOI / URN: |
10.1016/j.jneuroim.2014.12.018 |
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| 520 | |a Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studied the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on T cell memory in MS patients (n=10) and healthy controls (n=10). In vitro treatment of PBMC cultures with 1,25(OH)2D3, led to a decrease in the proportion of effector memory T cells with an increase in naïve T cells, compared to vehicle in both groups. Further studies to unravel the mechanism of this effect and to understand its long-term implications are required. | ||
| 520 | |a Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studied the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on T cell memory in MS patients (n=10) and healthy controls (n=10). In vitro treatment of PBMC cultures with 1,25(OH)2D3, led to a decrease in the proportion of effector memory T cells with an increase in naïve T cells, compared to vehicle in both groups. Further studies to unravel the mechanism of this effect and to understand its long-term implications are required. | ||
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10.1016/j.jneuroim.2014.12.018 doi GBVA2015005000017.pica (DE-627)ELV023331933 (ELSEVIER)S0165-5728(15)00002-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Bhargava, Pavan verfasserin aut 1,25-Dihydroxyvitamin D3 impairs the differentiation of effector memory T cells in vitro in multiple sclerosis patients and healthy controls 2015transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studied the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on T cell memory in MS patients (n=10) and healthy controls (n=10). In vitro treatment of PBMC cultures with 1,25(OH)2D3, led to a decrease in the proportion of effector memory T cells with an increase in naïve T cells, compared to vehicle in both groups. Further studies to unravel the mechanism of this effect and to understand its long-term implications are required. Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studied the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on T cell memory in MS patients (n=10) and healthy controls (n=10). In vitro treatment of PBMC cultures with 1,25(OH)2D3, led to a decrease in the proportion of effector memory T cells with an increase in naïve T cells, compared to vehicle in both groups. Further studies to unravel the mechanism of this effect and to understand its long-term implications are required. Gocke, Anne oth Calabresi, Peter A. oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:279 year:2015 day:15 month:02 pages:20-24 extent:5 https://doi.org/10.1016/j.jneuroim.2014.12.018 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 279 2015 15 0215 20-24 5 045F 610 |
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10.1016/j.jneuroim.2014.12.018 doi GBVA2015005000017.pica (DE-627)ELV023331933 (ELSEVIER)S0165-5728(15)00002-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Bhargava, Pavan verfasserin aut 1,25-Dihydroxyvitamin D3 impairs the differentiation of effector memory T cells in vitro in multiple sclerosis patients and healthy controls 2015transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studied the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on T cell memory in MS patients (n=10) and healthy controls (n=10). In vitro treatment of PBMC cultures with 1,25(OH)2D3, led to a decrease in the proportion of effector memory T cells with an increase in naïve T cells, compared to vehicle in both groups. Further studies to unravel the mechanism of this effect and to understand its long-term implications are required. Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studied the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on T cell memory in MS patients (n=10) and healthy controls (n=10). In vitro treatment of PBMC cultures with 1,25(OH)2D3, led to a decrease in the proportion of effector memory T cells with an increase in naïve T cells, compared to vehicle in both groups. Further studies to unravel the mechanism of this effect and to understand its long-term implications are required. Gocke, Anne oth Calabresi, Peter A. oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:279 year:2015 day:15 month:02 pages:20-24 extent:5 https://doi.org/10.1016/j.jneuroim.2014.12.018 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 279 2015 15 0215 20-24 5 045F 610 |
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10.1016/j.jneuroim.2014.12.018 doi GBVA2015005000017.pica (DE-627)ELV023331933 (ELSEVIER)S0165-5728(15)00002-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Bhargava, Pavan verfasserin aut 1,25-Dihydroxyvitamin D3 impairs the differentiation of effector memory T cells in vitro in multiple sclerosis patients and healthy controls 2015transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studied the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on T cell memory in MS patients (n=10) and healthy controls (n=10). In vitro treatment of PBMC cultures with 1,25(OH)2D3, led to a decrease in the proportion of effector memory T cells with an increase in naïve T cells, compared to vehicle in both groups. Further studies to unravel the mechanism of this effect and to understand its long-term implications are required. Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studied the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on T cell memory in MS patients (n=10) and healthy controls (n=10). In vitro treatment of PBMC cultures with 1,25(OH)2D3, led to a decrease in the proportion of effector memory T cells with an increase in naïve T cells, compared to vehicle in both groups. Further studies to unravel the mechanism of this effect and to understand its long-term implications are required. Gocke, Anne oth Calabresi, Peter A. oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:279 year:2015 day:15 month:02 pages:20-24 extent:5 https://doi.org/10.1016/j.jneuroim.2014.12.018 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 279 2015 15 0215 20-24 5 045F 610 |
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10.1016/j.jneuroim.2014.12.018 doi GBVA2015005000017.pica (DE-627)ELV023331933 (ELSEVIER)S0165-5728(15)00002-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Bhargava, Pavan verfasserin aut 1,25-Dihydroxyvitamin D3 impairs the differentiation of effector memory T cells in vitro in multiple sclerosis patients and healthy controls 2015transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studied the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on T cell memory in MS patients (n=10) and healthy controls (n=10). In vitro treatment of PBMC cultures with 1,25(OH)2D3, led to a decrease in the proportion of effector memory T cells with an increase in naïve T cells, compared to vehicle in both groups. Further studies to unravel the mechanism of this effect and to understand its long-term implications are required. Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studied the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on T cell memory in MS patients (n=10) and healthy controls (n=10). In vitro treatment of PBMC cultures with 1,25(OH)2D3, led to a decrease in the proportion of effector memory T cells with an increase in naïve T cells, compared to vehicle in both groups. Further studies to unravel the mechanism of this effect and to understand its long-term implications are required. Gocke, Anne oth Calabresi, Peter A. oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:279 year:2015 day:15 month:02 pages:20-24 extent:5 https://doi.org/10.1016/j.jneuroim.2014.12.018 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 279 2015 15 0215 20-24 5 045F 610 |
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10.1016/j.jneuroim.2014.12.018 doi GBVA2015005000017.pica (DE-627)ELV023331933 (ELSEVIER)S0165-5728(15)00002-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Bhargava, Pavan verfasserin aut 1,25-Dihydroxyvitamin D3 impairs the differentiation of effector memory T cells in vitro in multiple sclerosis patients and healthy controls 2015transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studied the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on T cell memory in MS patients (n=10) and healthy controls (n=10). In vitro treatment of PBMC cultures with 1,25(OH)2D3, led to a decrease in the proportion of effector memory T cells with an increase in naïve T cells, compared to vehicle in both groups. Further studies to unravel the mechanism of this effect and to understand its long-term implications are required. Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studied the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on T cell memory in MS patients (n=10) and healthy controls (n=10). In vitro treatment of PBMC cultures with 1,25(OH)2D3, led to a decrease in the proportion of effector memory T cells with an increase in naïve T cells, compared to vehicle in both groups. Further studies to unravel the mechanism of this effect and to understand its long-term implications are required. Gocke, Anne oth Calabresi, Peter A. oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:279 year:2015 day:15 month:02 pages:20-24 extent:5 https://doi.org/10.1016/j.jneuroim.2014.12.018 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 279 2015 15 0215 20-24 5 045F 610 |
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Enthalten in Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process Amsterdam [u.a.] volume:279 year:2015 day:15 month:02 pages:20-24 extent:5 |
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Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process |
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Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process |
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Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process |
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1,25-Dihydroxyvitamin D3 impairs the differentiation of effector memory T cells in vitro in multiple sclerosis patients and healthy controls |
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1,25-Dihydroxyvitamin D3 impairs the differentiation of effector memory T cells in vitro in multiple sclerosis patients and healthy controls |
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Bhargava, Pavan |
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Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process |
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Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process |
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10.1016/j.jneuroim.2014.12.018 |
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1,25-dihydroxyvitamin d3 impairs the differentiation of effector memory t cells in vitro in multiple sclerosis patients and healthy controls |
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1,25-Dihydroxyvitamin D3 impairs the differentiation of effector memory T cells in vitro in multiple sclerosis patients and healthy controls |
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Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studied the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on T cell memory in MS patients (n=10) and healthy controls (n=10). In vitro treatment of PBMC cultures with 1,25(OH)2D3, led to a decrease in the proportion of effector memory T cells with an increase in naïve T cells, compared to vehicle in both groups. Further studies to unravel the mechanism of this effect and to understand its long-term implications are required. |
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Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studied the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on T cell memory in MS patients (n=10) and healthy controls (n=10). In vitro treatment of PBMC cultures with 1,25(OH)2D3, led to a decrease in the proportion of effector memory T cells with an increase in naïve T cells, compared to vehicle in both groups. Further studies to unravel the mechanism of this effect and to understand its long-term implications are required. |
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Vitamin D deficiency is associated with increased susceptibility to multiple sclerosis (MS) and increased disease activity. Vitamin D is a potent immunomodulator but the effects of vitamin D treatment on T cell memory have not been explored. We studied the effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on T cell memory in MS patients (n=10) and healthy controls (n=10). In vitro treatment of PBMC cultures with 1,25(OH)2D3, led to a decrease in the proportion of effector memory T cells with an increase in naïve T cells, compared to vehicle in both groups. Further studies to unravel the mechanism of this effect and to understand its long-term implications are required. |
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1,25-Dihydroxyvitamin D3 impairs the differentiation of effector memory T cells in vitro in multiple sclerosis patients and healthy controls |
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