Selective targeting of FAK–Pyk2 axis by alpha-naphthoflavone abrogates doxorubicin resistance in breast cancer cells
• Defined a new role for ANF in abrogating Dox resistance in breast cancer cells. • ANF decreases survival via inhibition of FAK–Pyk2 axis in Dox resistant cells. • ANF increases Dox retention through inhibition of P-gp pumps Dox resistant cells. • ANF has broad safety profile and inhibits growth of...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Datta, Amrita [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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11 |
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| Übergeordnetes Werk: |
Enthalten in: GW26-e0273 Relationship between thrombelastography test and routine platelet parameters in patients with acute coronary syndrome - Hao, Lijun ELSEVIER, 2015, an international journal providing a forum for original and pertinent contributions in cancer research, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:362 ; year:2015 ; number:1 ; day:28 ; month:06 ; pages:25-35 ; extent:11 |
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10.1016/j.canlet.2015.03.009 |
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| dewey-full |
570 610 600 690 |
| title_sort |
selective targeting of fak–pyk2 axis by alpha-naphthoflavone abrogates doxorubicin resistance in breast cancer cells |
| title_auth |
Selective targeting of FAK–Pyk2 axis by alpha-naphthoflavone abrogates doxorubicin resistance in breast cancer cells |
| abstract |
• Defined a new role for ANF in abrogating Dox resistance in breast cancer cells. • ANF decreases survival via inhibition of FAK–Pyk2 axis in Dox resistant cells. • ANF increases Dox retention through inhibition of P-gp pumps Dox resistant cells. • ANF has broad safety profile and inhibits growth of Dox-resistant cells in vivo. • ANF is an attractive anti-cancer drug in patients presenting with Dox resistance. |
| abstractGer |
• Defined a new role for ANF in abrogating Dox resistance in breast cancer cells. • ANF decreases survival via inhibition of FAK–Pyk2 axis in Dox resistant cells. • ANF increases Dox retention through inhibition of P-gp pumps Dox resistant cells. • ANF has broad safety profile and inhibits growth of Dox-resistant cells in vivo. • ANF is an attractive anti-cancer drug in patients presenting with Dox resistance. |
| abstract_unstemmed |
• Defined a new role for ANF in abrogating Dox resistance in breast cancer cells. • ANF decreases survival via inhibition of FAK–Pyk2 axis in Dox resistant cells. • ANF increases Dox retention through inhibition of P-gp pumps Dox resistant cells. • ANF has broad safety profile and inhibits growth of Dox-resistant cells in vivo. • ANF is an attractive anti-cancer drug in patients presenting with Dox resistance. |
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| title_short |
Selective targeting of FAK–Pyk2 axis by alpha-naphthoflavone abrogates doxorubicin resistance in breast cancer cells |
| url |
https://doi.org/10.1016/j.canlet.2015.03.009 |
| remote_bool |
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Bhasin, Nobel Kim, Hogyoung Ranjan, Manish Rider, Barbara Abd Elmageed, Zakaria Y. Mondal, Debasis Agrawal, Krishna C. Abdel-Mageed, Asim B. |
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Bhasin, Nobel Kim, Hogyoung Ranjan, Manish Rider, Barbara Abd Elmageed, Zakaria Y. Mondal, Debasis Agrawal, Krishna C. Abdel-Mageed, Asim B. |
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| doi_str |
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| up_date |
2024-07-06T19:03:43.515Z |
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