c-Met targeting in advanced gastric cancer: An open challenge
• Different compounds targeting c-Met have been developed and tested in gastric cancer. • Discouraging outcomes of anti-c-Met monoclonal antibodies has been recently underlined. • No clear anti-tumor activity was identified in small molecule c-Met inhibitors except for high c-Met-positive tumors. •...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Marano, Luigi [verfasserIn] |
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E-Artikel |
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Englisch |
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2015 |
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7 |
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Enthalten in: GW26-e0273 Relationship between thrombelastography test and routine platelet parameters in patients with acute coronary syndrome - Hao, Lijun ELSEVIER, 2015, an international journal providing a forum for original and pertinent contributions in cancer research, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:365 ; year:2015 ; number:1 ; day:28 ; month:08 ; pages:30-36 ; extent:7 |
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10.1016/j.canlet.2015.05.028 |
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c-Met targeting in advanced gastric cancer: An open challenge |
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• Different compounds targeting c-Met have been developed and tested in gastric cancer. • Discouraging outcomes of anti-c-Met monoclonal antibodies has been recently underlined. • No clear anti-tumor activity was identified in small molecule c-Met inhibitors except for high c-Met-positive tumors. • Several biomarkers are being explored in order to clarify the question of potential treatment benefits in selected patients. |
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• Different compounds targeting c-Met have been developed and tested in gastric cancer. • Discouraging outcomes of anti-c-Met monoclonal antibodies has been recently underlined. • No clear anti-tumor activity was identified in small molecule c-Met inhibitors except for high c-Met-positive tumors. • Several biomarkers are being explored in order to clarify the question of potential treatment benefits in selected patients. |
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• Different compounds targeting c-Met have been developed and tested in gastric cancer. • Discouraging outcomes of anti-c-Met monoclonal antibodies has been recently underlined. • No clear anti-tumor activity was identified in small molecule c-Met inhibitors except for high c-Met-positive tumors. • Several biomarkers are being explored in order to clarify the question of potential treatment benefits in selected patients. |
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c-Met targeting in advanced gastric cancer: An open challenge |
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Chiari, Rita Fabozzi, Alessio De Vita, Ferdinando Boccardi, Virginia Roviello, Giandomenico Petrioli, Roberto Marrelli, Daniele Roviello, Franco Patriti, Alberto |
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Chiari, Rita Fabozzi, Alessio De Vita, Ferdinando Boccardi, Virginia Roviello, Giandomenico Petrioli, Roberto Marrelli, Daniele Roviello, Franco Patriti, Alberto |
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10.1016/j.canlet.2015.05.028 |
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2024-07-06T19:03:51.399Z |
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