Different mechanisms are involved in oxidative DNA damage and genotoxicity induction by ZnO and TiO2 nanoparticles in human colon carcinoma cells
• We compared ZnO and TiO2 nanoparticle genotoxic potential in relation to oxidative stress. • Multiple endpoints for genotoxic detection were analyzed on Caco-2 cells. • Both nanoparticles were able to induce ROS and 8-oxodG. • Oxidative DNA damage was efficiently repaired only after treatment with...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zijno, Andrea [verfasserIn] |
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Englisch |
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2015 |
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10 |
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Enthalten in: Prenatal diagnostic testing decisions in twin pregnancies in the era of cell-free DNA screening - Janssen, Matthew ELSEVIER, 2022, official journal of the European Society of Toxicology in Vitro, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:29 ; year:2015 ; number:7 ; pages:1503-1512 ; extent:10 |
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10.1016/j.tiv.2015.06.009 |
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| 520 | |a • We compared ZnO and TiO2 nanoparticle genotoxic potential in relation to oxidative stress. • Multiple endpoints for genotoxic detection were analyzed on Caco-2 cells. • Both nanoparticles were able to induce ROS and 8-oxodG. • Oxidative DNA damage was efficiently repaired only after treatment with TiO2 nanoparticles. • Only ZnO nanoparticles induced micronuclei. | ||
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Different mechanisms are involved in oxidative DNA damage and genotoxicity induction by ZnO and TiO2 nanoparticles in human colon carcinoma cells |
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• We compared ZnO and TiO2 nanoparticle genotoxic potential in relation to oxidative stress. • Multiple endpoints for genotoxic detection were analyzed on Caco-2 cells. • Both nanoparticles were able to induce ROS and 8-oxodG. • Oxidative DNA damage was efficiently repaired only after treatment with TiO2 nanoparticles. • Only ZnO nanoparticles induced micronuclei. |
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• We compared ZnO and TiO2 nanoparticle genotoxic potential in relation to oxidative stress. • Multiple endpoints for genotoxic detection were analyzed on Caco-2 cells. • Both nanoparticles were able to induce ROS and 8-oxodG. • Oxidative DNA damage was efficiently repaired only after treatment with TiO2 nanoparticles. • Only ZnO nanoparticles induced micronuclei. |
| abstract_unstemmed |
• We compared ZnO and TiO2 nanoparticle genotoxic potential in relation to oxidative stress. • Multiple endpoints for genotoxic detection were analyzed on Caco-2 cells. • Both nanoparticles were able to induce ROS and 8-oxodG. • Oxidative DNA damage was efficiently repaired only after treatment with TiO2 nanoparticles. • Only ZnO nanoparticles induced micronuclei. |
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| title_short |
Different mechanisms are involved in oxidative DNA damage and genotoxicity induction by ZnO and TiO2 nanoparticles in human colon carcinoma cells |
| url |
https://doi.org/10.1016/j.tiv.2015.06.009 |
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| author2 |
De Angelis, Isabella De Berardis, Barbara Andreoli, Cristina Russo, Maria Teresa Pietraforte, Donatella Scorza, Giuseppe Degan, Paolo Ponti, Jessica Rossi, Francois Barone, Flavia |
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De Angelis, Isabella De Berardis, Barbara Andreoli, Cristina Russo, Maria Teresa Pietraforte, Donatella Scorza, Giuseppe Degan, Paolo Ponti, Jessica Rossi, Francois Barone, Flavia |
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| doi_str |
10.1016/j.tiv.2015.06.009 |
| up_date |
2024-07-06T19:39:40.810Z |
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