Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells
• TEMPO induced time- and concentration-dependent intracellular ROS production. • TEMPO increased caspase-3/7 activity and the proportion of annexin V stained cells. • TEMPO decreased expression of anti-apoptotic proteins (Bcl-2, Bcl-xL, and Mcl-1). • TEMPO activated c-Jun N-terminal kinases (JNK) i...
Ausführliche Beschreibung
Gespeichert in:
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Guo, Xiaoqing [verfasserIn] |
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E-Artikel |
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Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Umfang: |
10 |
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| Übergeordnetes Werk: |
Enthalten in: Ambiguous information and dilation: An experiment - Shishkin, Denis ELSEVIER, 2023, a journal of molecular and biochemical toxicology, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:235 ; year:2015 ; day:25 ; month:06 ; pages:27-36 ; extent:10 |
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| DOI / URN: |
10.1016/j.cbi.2015.04.009 |
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Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells |
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• TEMPO induced time- and concentration-dependent intracellular ROS production. • TEMPO increased caspase-3/7 activity and the proportion of annexin V stained cells. • TEMPO decreased expression of anti-apoptotic proteins (Bcl-2, Bcl-xL, and Mcl-1). • TEMPO activated c-Jun N-terminal kinases (JNK) in the MAPK signaling pathway. |
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• TEMPO induced time- and concentration-dependent intracellular ROS production. • TEMPO increased caspase-3/7 activity and the proportion of annexin V stained cells. • TEMPO decreased expression of anti-apoptotic proteins (Bcl-2, Bcl-xL, and Mcl-1). • TEMPO activated c-Jun N-terminal kinases (JNK) in the MAPK signaling pathway. |
| abstract_unstemmed |
• TEMPO induced time- and concentration-dependent intracellular ROS production. • TEMPO increased caspase-3/7 activity and the proportion of annexin V stained cells. • TEMPO decreased expression of anti-apoptotic proteins (Bcl-2, Bcl-xL, and Mcl-1). • TEMPO activated c-Jun N-terminal kinases (JNK) in the MAPK signaling pathway. |
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Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells |
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Chen, Si Zhang, Zhuhong Dobrovolsky, Vasily N. Dial, Stacey L. Guo, Lei Mei, Nan |
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