Roles of LIM kinases in central nervous system function and dysfunction
LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) regulate actin dynamics by phosphorylating cofilin. In this review, we outline studies that have shown an involvement of LIMKs in neuronal function and we detail some of the pathways and molecular mechanisms involving LIMKs in neurodevelopment and synapt...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Cuberos, H. [verfasserIn] |
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E-Artikel |
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Englisch |
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2015 |
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12 |
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| Übergeordnetes Werk: |
Enthalten in: Mitigating the environmental impacts of milk production via anaerobic digestion of manure: Case study of a dairy farm in the Po Valley - Battini, F. ELSEVIER, 2014, for the rapid publication of short reports in biochemistry, biophysics, and molecular biology, Chichester |
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| Übergeordnetes Werk: |
volume:589 ; year:2015 ; number:24 ; day:21 ; month:12 ; pages:3795-3806 ; extent:12 |
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| DOI / URN: |
10.1016/j.febslet.2015.10.032 |
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LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) regulate actin dynamics by phosphorylating cofilin. In this review, we outline studies that have shown an involvement of LIMKs in neuronal function and we detail some of the pathways and molecular mechanisms involving LIMKs in neurodevelopment and synaptic plasticity. We also review the involvement of LIMKs in neuronal diseases and emphasize the differences in the regulation of LIMKs expression and mode of action. |
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LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) regulate actin dynamics by phosphorylating cofilin. In this review, we outline studies that have shown an involvement of LIMKs in neuronal function and we detail some of the pathways and molecular mechanisms involving LIMKs in neurodevelopment and synaptic plasticity. We also review the involvement of LIMKs in neuronal diseases and emphasize the differences in the regulation of LIMKs expression and mode of action. |
| abstract_unstemmed |
LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) regulate actin dynamics by phosphorylating cofilin. In this review, we outline studies that have shown an involvement of LIMKs in neuronal function and we detail some of the pathways and molecular mechanisms involving LIMKs in neurodevelopment and synaptic plasticity. We also review the involvement of LIMKs in neuronal diseases and emphasize the differences in the regulation of LIMKs expression and mode of action. |
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Roles of LIM kinases in central nervous system function and dysfunction |
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https://doi.org/10.1016/j.febslet.2015.10.032 |
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Vallée, B. Vourc’h, P. Tastet, J. Andres, C.R. Bénédetti, H. |
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Vallée, B. Vourc’h, P. Tastet, J. Andres, C.R. Bénédetti, H. |
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10.1016/j.febslet.2015.10.032 |
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