A branched polymer as a pH responsive nanocarrier: Synthesis, characterization and targeted delivery
A series of branched and folic acid (FA) conjugated amphiphilic block copolymers were synthesized by sequential steps of ring opening and atom transfer radical polymerizations. The chemical structure of the FA conjugated block copolymer was established by spectroscopic method. The FA conjugated copo...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Panja, S. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
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2015transfer abstract |
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12 |
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| Übergeordnetes Werk: |
Enthalten in: Functional outcomes at 12 months for patients with traumatic brain injury, intracerebral haemorrhage and subarachnoid haemorrhage treated in an Australian neurocritical care unit: A prospective cohort study - Fitzgerald, Emily ELSEVIER, 2020, the international journal for the science and technology of polymers, Oxford |
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| Übergeordnetes Werk: |
volume:61 ; year:2015 ; day:20 ; month:03 ; pages:75-86 ; extent:12 |
| Links: |
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| DOI / URN: |
10.1016/j.polymer.2015.01.075 |
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| 520 | |a A series of branched and folic acid (FA) conjugated amphiphilic block copolymers were synthesized by sequential steps of ring opening and atom transfer radical polymerizations. The chemical structure of the FA conjugated block copolymer was established by spectroscopic method. The FA conjugated copolymers give rise to nearly spherical polymeric micelles (PMs) in water (40–60 nm). The polymers are showing low range of CMC (0.63 × 10−2 to 2.01 × 10−2 mg/mL) with a negative zeta potential (−44.4 mV). The branched structure supports a very high loading (∼25%) of DOX molecules compare to the literature reported nanocarriers prepared from analogous linear block copolymers. The cell viability and cell uptake study of PMs were conducted on both normal and cancerous cell lines. The pH sensitive decrease of miceller size affords sparkling in vitro release of DOX molecule (67–88%) at physiological pH (5.0) of the cancer cells. | ||
| 520 | |a A series of branched and folic acid (FA) conjugated amphiphilic block copolymers were synthesized by sequential steps of ring opening and atom transfer radical polymerizations. The chemical structure of the FA conjugated block copolymer was established by spectroscopic method. The FA conjugated copolymers give rise to nearly spherical polymeric micelles (PMs) in water (40–60 nm). The polymers are showing low range of CMC (0.63 × 10−2 to 2.01 × 10−2 mg/mL) with a negative zeta potential (−44.4 mV). The branched structure supports a very high loading (∼25%) of DOX molecules compare to the literature reported nanocarriers prepared from analogous linear block copolymers. The cell viability and cell uptake study of PMs were conducted on both normal and cancerous cell lines. The pH sensitive decrease of miceller size affords sparkling in vitro release of DOX molecule (67–88%) at physiological pH (5.0) of the cancer cells. | ||
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10.1016/j.polymer.2015.01.075 doi GBVA2015023000022.pica (DE-627)ELV024086185 (ELSEVIER)S0032-3861(15)00134-2 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.63 bkl 44.69 bkl Panja, S. verfasserin aut A branched polymer as a pH responsive nanocarrier: Synthesis, characterization and targeted delivery 2015transfer abstract 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A series of branched and folic acid (FA) conjugated amphiphilic block copolymers were synthesized by sequential steps of ring opening and atom transfer radical polymerizations. The chemical structure of the FA conjugated block copolymer was established by spectroscopic method. The FA conjugated copolymers give rise to nearly spherical polymeric micelles (PMs) in water (40–60 nm). The polymers are showing low range of CMC (0.63 × 10−2 to 2.01 × 10−2 mg/mL) with a negative zeta potential (−44.4 mV). The branched structure supports a very high loading (∼25%) of DOX molecules compare to the literature reported nanocarriers prepared from analogous linear block copolymers. The cell viability and cell uptake study of PMs were conducted on both normal and cancerous cell lines. The pH sensitive decrease of miceller size affords sparkling in vitro release of DOX molecule (67–88%) at physiological pH (5.0) of the cancer cells. A series of branched and folic acid (FA) conjugated amphiphilic block copolymers were synthesized by sequential steps of ring opening and atom transfer radical polymerizations. The chemical structure of the FA conjugated block copolymer was established by spectroscopic method. The FA conjugated copolymers give rise to nearly spherical polymeric micelles (PMs) in water (40–60 nm). The polymers are showing low range of CMC (0.63 × 10−2 to 2.01 × 10−2 mg/mL) with a negative zeta potential (−44.4 mV). The branched structure supports a very high loading (∼25%) of DOX molecules compare to the literature reported nanocarriers prepared from analogous linear block copolymers. The cell viability and cell uptake study of PMs were conducted on both normal and cancerous cell lines. The pH sensitive decrease of miceller size affords sparkling in vitro release of DOX molecule (67–88%) at physiological pH (5.0) of the cancer cells. Branch polymer Elsevier Drug delivery Elsevier Polymeric micelle Elsevier Maji, S. oth Maiti, T.K. oth Chattopadhyay, S. oth Enthalten in Elsevier Science Fitzgerald, Emily ELSEVIER Functional outcomes at 12 months for patients with traumatic brain injury, intracerebral haemorrhage and subarachnoid haemorrhage treated in an Australian neurocritical care unit: A prospective cohort study 2020 the international journal for the science and technology of polymers Oxford (DE-627)ELV005093368 volume:61 year:2015 day:20 month:03 pages:75-86 extent:12 https://doi.org/10.1016/j.polymer.2015.01.075 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.63 Krankenpflege VZ 44.69 Intensivmedizin VZ AR 61 2015 20 0320 75-86 12 045F 540 |
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10.1016/j.polymer.2015.01.075 doi GBVA2015023000022.pica (DE-627)ELV024086185 (ELSEVIER)S0032-3861(15)00134-2 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.63 bkl 44.69 bkl Panja, S. verfasserin aut A branched polymer as a pH responsive nanocarrier: Synthesis, characterization and targeted delivery 2015transfer abstract 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A series of branched and folic acid (FA) conjugated amphiphilic block copolymers were synthesized by sequential steps of ring opening and atom transfer radical polymerizations. The chemical structure of the FA conjugated block copolymer was established by spectroscopic method. The FA conjugated copolymers give rise to nearly spherical polymeric micelles (PMs) in water (40–60 nm). The polymers are showing low range of CMC (0.63 × 10−2 to 2.01 × 10−2 mg/mL) with a negative zeta potential (−44.4 mV). The branched structure supports a very high loading (∼25%) of DOX molecules compare to the literature reported nanocarriers prepared from analogous linear block copolymers. The cell viability and cell uptake study of PMs were conducted on both normal and cancerous cell lines. The pH sensitive decrease of miceller size affords sparkling in vitro release of DOX molecule (67–88%) at physiological pH (5.0) of the cancer cells. A series of branched and folic acid (FA) conjugated amphiphilic block copolymers were synthesized by sequential steps of ring opening and atom transfer radical polymerizations. The chemical structure of the FA conjugated block copolymer was established by spectroscopic method. The FA conjugated copolymers give rise to nearly spherical polymeric micelles (PMs) in water (40–60 nm). The polymers are showing low range of CMC (0.63 × 10−2 to 2.01 × 10−2 mg/mL) with a negative zeta potential (−44.4 mV). The branched structure supports a very high loading (∼25%) of DOX molecules compare to the literature reported nanocarriers prepared from analogous linear block copolymers. The cell viability and cell uptake study of PMs were conducted on both normal and cancerous cell lines. The pH sensitive decrease of miceller size affords sparkling in vitro release of DOX molecule (67–88%) at physiological pH (5.0) of the cancer cells. Branch polymer Elsevier Drug delivery Elsevier Polymeric micelle Elsevier Maji, S. oth Maiti, T.K. oth Chattopadhyay, S. oth Enthalten in Elsevier Science Fitzgerald, Emily ELSEVIER Functional outcomes at 12 months for patients with traumatic brain injury, intracerebral haemorrhage and subarachnoid haemorrhage treated in an Australian neurocritical care unit: A prospective cohort study 2020 the international journal for the science and technology of polymers Oxford (DE-627)ELV005093368 volume:61 year:2015 day:20 month:03 pages:75-86 extent:12 https://doi.org/10.1016/j.polymer.2015.01.075 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.63 Krankenpflege VZ 44.69 Intensivmedizin VZ AR 61 2015 20 0320 75-86 12 045F 540 |
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10.1016/j.polymer.2015.01.075 doi GBVA2015023000022.pica (DE-627)ELV024086185 (ELSEVIER)S0032-3861(15)00134-2 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.63 bkl 44.69 bkl Panja, S. verfasserin aut A branched polymer as a pH responsive nanocarrier: Synthesis, characterization and targeted delivery 2015transfer abstract 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A series of branched and folic acid (FA) conjugated amphiphilic block copolymers were synthesized by sequential steps of ring opening and atom transfer radical polymerizations. The chemical structure of the FA conjugated block copolymer was established by spectroscopic method. The FA conjugated copolymers give rise to nearly spherical polymeric micelles (PMs) in water (40–60 nm). The polymers are showing low range of CMC (0.63 × 10−2 to 2.01 × 10−2 mg/mL) with a negative zeta potential (−44.4 mV). The branched structure supports a very high loading (∼25%) of DOX molecules compare to the literature reported nanocarriers prepared from analogous linear block copolymers. The cell viability and cell uptake study of PMs were conducted on both normal and cancerous cell lines. The pH sensitive decrease of miceller size affords sparkling in vitro release of DOX molecule (67–88%) at physiological pH (5.0) of the cancer cells. A series of branched and folic acid (FA) conjugated amphiphilic block copolymers were synthesized by sequential steps of ring opening and atom transfer radical polymerizations. The chemical structure of the FA conjugated block copolymer was established by spectroscopic method. The FA conjugated copolymers give rise to nearly spherical polymeric micelles (PMs) in water (40–60 nm). The polymers are showing low range of CMC (0.63 × 10−2 to 2.01 × 10−2 mg/mL) with a negative zeta potential (−44.4 mV). The branched structure supports a very high loading (∼25%) of DOX molecules compare to the literature reported nanocarriers prepared from analogous linear block copolymers. The cell viability and cell uptake study of PMs were conducted on both normal and cancerous cell lines. The pH sensitive decrease of miceller size affords sparkling in vitro release of DOX molecule (67–88%) at physiological pH (5.0) of the cancer cells. Branch polymer Elsevier Drug delivery Elsevier Polymeric micelle Elsevier Maji, S. oth Maiti, T.K. oth Chattopadhyay, S. oth Enthalten in Elsevier Science Fitzgerald, Emily ELSEVIER Functional outcomes at 12 months for patients with traumatic brain injury, intracerebral haemorrhage and subarachnoid haemorrhage treated in an Australian neurocritical care unit: A prospective cohort study 2020 the international journal for the science and technology of polymers Oxford (DE-627)ELV005093368 volume:61 year:2015 day:20 month:03 pages:75-86 extent:12 https://doi.org/10.1016/j.polymer.2015.01.075 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.63 Krankenpflege VZ 44.69 Intensivmedizin VZ AR 61 2015 20 0320 75-86 12 045F 540 |
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10.1016/j.polymer.2015.01.075 doi GBVA2015023000022.pica (DE-627)ELV024086185 (ELSEVIER)S0032-3861(15)00134-2 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.63 bkl 44.69 bkl Panja, S. verfasserin aut A branched polymer as a pH responsive nanocarrier: Synthesis, characterization and targeted delivery 2015transfer abstract 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A series of branched and folic acid (FA) conjugated amphiphilic block copolymers were synthesized by sequential steps of ring opening and atom transfer radical polymerizations. The chemical structure of the FA conjugated block copolymer was established by spectroscopic method. The FA conjugated copolymers give rise to nearly spherical polymeric micelles (PMs) in water (40–60 nm). The polymers are showing low range of CMC (0.63 × 10−2 to 2.01 × 10−2 mg/mL) with a negative zeta potential (−44.4 mV). The branched structure supports a very high loading (∼25%) of DOX molecules compare to the literature reported nanocarriers prepared from analogous linear block copolymers. The cell viability and cell uptake study of PMs were conducted on both normal and cancerous cell lines. The pH sensitive decrease of miceller size affords sparkling in vitro release of DOX molecule (67–88%) at physiological pH (5.0) of the cancer cells. A series of branched and folic acid (FA) conjugated amphiphilic block copolymers were synthesized by sequential steps of ring opening and atom transfer radical polymerizations. The chemical structure of the FA conjugated block copolymer was established by spectroscopic method. The FA conjugated copolymers give rise to nearly spherical polymeric micelles (PMs) in water (40–60 nm). The polymers are showing low range of CMC (0.63 × 10−2 to 2.01 × 10−2 mg/mL) with a negative zeta potential (−44.4 mV). The branched structure supports a very high loading (∼25%) of DOX molecules compare to the literature reported nanocarriers prepared from analogous linear block copolymers. The cell viability and cell uptake study of PMs were conducted on both normal and cancerous cell lines. The pH sensitive decrease of miceller size affords sparkling in vitro release of DOX molecule (67–88%) at physiological pH (5.0) of the cancer cells. Branch polymer Elsevier Drug delivery Elsevier Polymeric micelle Elsevier Maji, S. oth Maiti, T.K. oth Chattopadhyay, S. oth Enthalten in Elsevier Science Fitzgerald, Emily ELSEVIER Functional outcomes at 12 months for patients with traumatic brain injury, intracerebral haemorrhage and subarachnoid haemorrhage treated in an Australian neurocritical care unit: A prospective cohort study 2020 the international journal for the science and technology of polymers Oxford (DE-627)ELV005093368 volume:61 year:2015 day:20 month:03 pages:75-86 extent:12 https://doi.org/10.1016/j.polymer.2015.01.075 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.63 Krankenpflege VZ 44.69 Intensivmedizin VZ AR 61 2015 20 0320 75-86 12 045F 540 |
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10.1016/j.polymer.2015.01.075 doi GBVA2015023000022.pica (DE-627)ELV024086185 (ELSEVIER)S0032-3861(15)00134-2 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.63 bkl 44.69 bkl Panja, S. verfasserin aut A branched polymer as a pH responsive nanocarrier: Synthesis, characterization and targeted delivery 2015transfer abstract 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier A series of branched and folic acid (FA) conjugated amphiphilic block copolymers were synthesized by sequential steps of ring opening and atom transfer radical polymerizations. The chemical structure of the FA conjugated block copolymer was established by spectroscopic method. The FA conjugated copolymers give rise to nearly spherical polymeric micelles (PMs) in water (40–60 nm). The polymers are showing low range of CMC (0.63 × 10−2 to 2.01 × 10−2 mg/mL) with a negative zeta potential (−44.4 mV). The branched structure supports a very high loading (∼25%) of DOX molecules compare to the literature reported nanocarriers prepared from analogous linear block copolymers. The cell viability and cell uptake study of PMs were conducted on both normal and cancerous cell lines. The pH sensitive decrease of miceller size affords sparkling in vitro release of DOX molecule (67–88%) at physiological pH (5.0) of the cancer cells. A series of branched and folic acid (FA) conjugated amphiphilic block copolymers were synthesized by sequential steps of ring opening and atom transfer radical polymerizations. The chemical structure of the FA conjugated block copolymer was established by spectroscopic method. The FA conjugated copolymers give rise to nearly spherical polymeric micelles (PMs) in water (40–60 nm). The polymers are showing low range of CMC (0.63 × 10−2 to 2.01 × 10−2 mg/mL) with a negative zeta potential (−44.4 mV). The branched structure supports a very high loading (∼25%) of DOX molecules compare to the literature reported nanocarriers prepared from analogous linear block copolymers. The cell viability and cell uptake study of PMs were conducted on both normal and cancerous cell lines. The pH sensitive decrease of miceller size affords sparkling in vitro release of DOX molecule (67–88%) at physiological pH (5.0) of the cancer cells. Branch polymer Elsevier Drug delivery Elsevier Polymeric micelle Elsevier Maji, S. oth Maiti, T.K. oth Chattopadhyay, S. oth Enthalten in Elsevier Science Fitzgerald, Emily ELSEVIER Functional outcomes at 12 months for patients with traumatic brain injury, intracerebral haemorrhage and subarachnoid haemorrhage treated in an Australian neurocritical care unit: A prospective cohort study 2020 the international journal for the science and technology of polymers Oxford (DE-627)ELV005093368 volume:61 year:2015 day:20 month:03 pages:75-86 extent:12 https://doi.org/10.1016/j.polymer.2015.01.075 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.63 Krankenpflege VZ 44.69 Intensivmedizin VZ AR 61 2015 20 0320 75-86 12 045F 540 |
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Enthalten in Functional outcomes at 12 months for patients with traumatic brain injury, intracerebral haemorrhage and subarachnoid haemorrhage treated in an Australian neurocritical care unit: A prospective cohort study Oxford volume:61 year:2015 day:20 month:03 pages:75-86 extent:12 |
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A branched polymer as a pH responsive nanocarrier: Synthesis, characterization and targeted delivery |
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A series of branched and folic acid (FA) conjugated amphiphilic block copolymers were synthesized by sequential steps of ring opening and atom transfer radical polymerizations. The chemical structure of the FA conjugated block copolymer was established by spectroscopic method. The FA conjugated copolymers give rise to nearly spherical polymeric micelles (PMs) in water (40–60 nm). The polymers are showing low range of CMC (0.63 × 10−2 to 2.01 × 10−2 mg/mL) with a negative zeta potential (−44.4 mV). The branched structure supports a very high loading (∼25%) of DOX molecules compare to the literature reported nanocarriers prepared from analogous linear block copolymers. The cell viability and cell uptake study of PMs were conducted on both normal and cancerous cell lines. The pH sensitive decrease of miceller size affords sparkling in vitro release of DOX molecule (67–88%) at physiological pH (5.0) of the cancer cells. |
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A series of branched and folic acid (FA) conjugated amphiphilic block copolymers were synthesized by sequential steps of ring opening and atom transfer radical polymerizations. The chemical structure of the FA conjugated block copolymer was established by spectroscopic method. The FA conjugated copolymers give rise to nearly spherical polymeric micelles (PMs) in water (40–60 nm). The polymers are showing low range of CMC (0.63 × 10−2 to 2.01 × 10−2 mg/mL) with a negative zeta potential (−44.4 mV). The branched structure supports a very high loading (∼25%) of DOX molecules compare to the literature reported nanocarriers prepared from analogous linear block copolymers. The cell viability and cell uptake study of PMs were conducted on both normal and cancerous cell lines. The pH sensitive decrease of miceller size affords sparkling in vitro release of DOX molecule (67–88%) at physiological pH (5.0) of the cancer cells. |
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A series of branched and folic acid (FA) conjugated amphiphilic block copolymers were synthesized by sequential steps of ring opening and atom transfer radical polymerizations. The chemical structure of the FA conjugated block copolymer was established by spectroscopic method. The FA conjugated copolymers give rise to nearly spherical polymeric micelles (PMs) in water (40–60 nm). The polymers are showing low range of CMC (0.63 × 10−2 to 2.01 × 10−2 mg/mL) with a negative zeta potential (−44.4 mV). The branched structure supports a very high loading (∼25%) of DOX molecules compare to the literature reported nanocarriers prepared from analogous linear block copolymers. The cell viability and cell uptake study of PMs were conducted on both normal and cancerous cell lines. The pH sensitive decrease of miceller size affords sparkling in vitro release of DOX molecule (67–88%) at physiological pH (5.0) of the cancer cells. |
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