Antiviral strategies to eliminate hepatitis B virus covalently closed circular DNA (cccDNA)
It has been over 50 years since the discovery of hepatitis B virus (HBV), yet 240 million people worldwide live with chronic HBV, resulting in up to 800000 deaths per year. A cure is yet to be achieved, due largely to a viral nuclear reservoir of transcriptionally active covalently closed circular D...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Revill, Peter [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2016transfer abstract |
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| Umfang: |
7 |
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| Übergeordnetes Werk: |
Enthalten in: Biodeterioration potential of algae on building materials - Model study - Komar, Michał ELSEVIER, 2023, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:30 ; year:2016 ; pages:144-150 ; extent:7 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.coph.2016.08.015 |
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| 520 | |a It has been over 50 years since the discovery of hepatitis B virus (HBV), yet 240 million people worldwide live with chronic HBV, resulting in up to 800000 deaths per year. A cure is yet to be achieved, due largely to a viral nuclear reservoir of transcriptionally active covalently closed circular DNA (cccDNA). While current antiviral therapies are effective at reducing viral replication, they have no impact on the existing cccDNA reservoir. Identifying mechanisms to either eliminate (complete cure) or inactivate (functional cure) HBV cccDNA are a major focus of HBV research worldwide. This review discusses recent advances in efforts to eliminate and/or regulate cccDNA, as well as future directions that may be considered in efforts to cure chronic HBV. | ||
| 520 | |a It has been over 50 years since the discovery of hepatitis B virus (HBV), yet 240 million people worldwide live with chronic HBV, resulting in up to 800000 deaths per year. A cure is yet to be achieved, due largely to a viral nuclear reservoir of transcriptionally active covalently closed circular DNA (cccDNA). While current antiviral therapies are effective at reducing viral replication, they have no impact on the existing cccDNA reservoir. Identifying mechanisms to either eliminate (complete cure) or inactivate (functional cure) HBV cccDNA are a major focus of HBV research worldwide. This review discusses recent advances in efforts to eliminate and/or regulate cccDNA, as well as future directions that may be considered in efforts to cure chronic HBV. | ||
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10.1016/j.coph.2016.08.015 doi GBVA2016004000006.pica (DE-627)ELV024211818 (ELSEVIER)S1471-4892(16)30104-7 DE-627 ger DE-627 rakwb eng 340 340 DE-600 570 VZ BIODIV DE-30 fid 51.24 bkl 58.30 bkl 58.53 bkl Revill, Peter verfasserin aut Antiviral strategies to eliminate hepatitis B virus covalently closed circular DNA (cccDNA) 2016transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier It has been over 50 years since the discovery of hepatitis B virus (HBV), yet 240 million people worldwide live with chronic HBV, resulting in up to 800000 deaths per year. A cure is yet to be achieved, due largely to a viral nuclear reservoir of transcriptionally active covalently closed circular DNA (cccDNA). While current antiviral therapies are effective at reducing viral replication, they have no impact on the existing cccDNA reservoir. Identifying mechanisms to either eliminate (complete cure) or inactivate (functional cure) HBV cccDNA are a major focus of HBV research worldwide. This review discusses recent advances in efforts to eliminate and/or regulate cccDNA, as well as future directions that may be considered in efforts to cure chronic HBV. It has been over 50 years since the discovery of hepatitis B virus (HBV), yet 240 million people worldwide live with chronic HBV, resulting in up to 800000 deaths per year. A cure is yet to be achieved, due largely to a viral nuclear reservoir of transcriptionally active covalently closed circular DNA (cccDNA). While current antiviral therapies are effective at reducing viral replication, they have no impact on the existing cccDNA reservoir. Identifying mechanisms to either eliminate (complete cure) or inactivate (functional cure) HBV cccDNA are a major focus of HBV research worldwide. This review discusses recent advances in efforts to eliminate and/or regulate cccDNA, as well as future directions that may be considered in efforts to cure chronic HBV. Locarnini, Stephen oth Enthalten in Elsevier Science Komar, Michał ELSEVIER Biodeterioration potential of algae on building materials - Model study 2023 Amsterdam [u.a.] (DE-627)ELV009586474 volume:30 year:2016 pages:144-150 extent:7 https://doi.org/10.1016/j.coph.2016.08.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-GGO 51.24 Korrosion VZ 58.30 Biotechnologie VZ 58.53 Abfallwirtschaft VZ AR 30 2016 144-150 7 045F 340 |
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10.1016/j.coph.2016.08.015 doi GBVA2016004000006.pica (DE-627)ELV024211818 (ELSEVIER)S1471-4892(16)30104-7 DE-627 ger DE-627 rakwb eng 340 340 DE-600 570 VZ BIODIV DE-30 fid 51.24 bkl 58.30 bkl 58.53 bkl Revill, Peter verfasserin aut Antiviral strategies to eliminate hepatitis B virus covalently closed circular DNA (cccDNA) 2016transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier It has been over 50 years since the discovery of hepatitis B virus (HBV), yet 240 million people worldwide live with chronic HBV, resulting in up to 800000 deaths per year. A cure is yet to be achieved, due largely to a viral nuclear reservoir of transcriptionally active covalently closed circular DNA (cccDNA). While current antiviral therapies are effective at reducing viral replication, they have no impact on the existing cccDNA reservoir. Identifying mechanisms to either eliminate (complete cure) or inactivate (functional cure) HBV cccDNA are a major focus of HBV research worldwide. This review discusses recent advances in efforts to eliminate and/or regulate cccDNA, as well as future directions that may be considered in efforts to cure chronic HBV. It has been over 50 years since the discovery of hepatitis B virus (HBV), yet 240 million people worldwide live with chronic HBV, resulting in up to 800000 deaths per year. A cure is yet to be achieved, due largely to a viral nuclear reservoir of transcriptionally active covalently closed circular DNA (cccDNA). While current antiviral therapies are effective at reducing viral replication, they have no impact on the existing cccDNA reservoir. Identifying mechanisms to either eliminate (complete cure) or inactivate (functional cure) HBV cccDNA are a major focus of HBV research worldwide. This review discusses recent advances in efforts to eliminate and/or regulate cccDNA, as well as future directions that may be considered in efforts to cure chronic HBV. Locarnini, Stephen oth Enthalten in Elsevier Science Komar, Michał ELSEVIER Biodeterioration potential of algae on building materials - Model study 2023 Amsterdam [u.a.] (DE-627)ELV009586474 volume:30 year:2016 pages:144-150 extent:7 https://doi.org/10.1016/j.coph.2016.08.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-GGO 51.24 Korrosion VZ 58.30 Biotechnologie VZ 58.53 Abfallwirtschaft VZ AR 30 2016 144-150 7 045F 340 |
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10.1016/j.coph.2016.08.015 doi GBVA2016004000006.pica (DE-627)ELV024211818 (ELSEVIER)S1471-4892(16)30104-7 DE-627 ger DE-627 rakwb eng 340 340 DE-600 570 VZ BIODIV DE-30 fid 51.24 bkl 58.30 bkl 58.53 bkl Revill, Peter verfasserin aut Antiviral strategies to eliminate hepatitis B virus covalently closed circular DNA (cccDNA) 2016transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier It has been over 50 years since the discovery of hepatitis B virus (HBV), yet 240 million people worldwide live with chronic HBV, resulting in up to 800000 deaths per year. A cure is yet to be achieved, due largely to a viral nuclear reservoir of transcriptionally active covalently closed circular DNA (cccDNA). While current antiviral therapies are effective at reducing viral replication, they have no impact on the existing cccDNA reservoir. Identifying mechanisms to either eliminate (complete cure) or inactivate (functional cure) HBV cccDNA are a major focus of HBV research worldwide. This review discusses recent advances in efforts to eliminate and/or regulate cccDNA, as well as future directions that may be considered in efforts to cure chronic HBV. It has been over 50 years since the discovery of hepatitis B virus (HBV), yet 240 million people worldwide live with chronic HBV, resulting in up to 800000 deaths per year. A cure is yet to be achieved, due largely to a viral nuclear reservoir of transcriptionally active covalently closed circular DNA (cccDNA). While current antiviral therapies are effective at reducing viral replication, they have no impact on the existing cccDNA reservoir. Identifying mechanisms to either eliminate (complete cure) or inactivate (functional cure) HBV cccDNA are a major focus of HBV research worldwide. This review discusses recent advances in efforts to eliminate and/or regulate cccDNA, as well as future directions that may be considered in efforts to cure chronic HBV. Locarnini, Stephen oth Enthalten in Elsevier Science Komar, Michał ELSEVIER Biodeterioration potential of algae on building materials - Model study 2023 Amsterdam [u.a.] (DE-627)ELV009586474 volume:30 year:2016 pages:144-150 extent:7 https://doi.org/10.1016/j.coph.2016.08.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-GGO 51.24 Korrosion VZ 58.30 Biotechnologie VZ 58.53 Abfallwirtschaft VZ AR 30 2016 144-150 7 045F 340 |
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10.1016/j.coph.2016.08.015 doi GBVA2016004000006.pica (DE-627)ELV024211818 (ELSEVIER)S1471-4892(16)30104-7 DE-627 ger DE-627 rakwb eng 340 340 DE-600 570 VZ BIODIV DE-30 fid 51.24 bkl 58.30 bkl 58.53 bkl Revill, Peter verfasserin aut Antiviral strategies to eliminate hepatitis B virus covalently closed circular DNA (cccDNA) 2016transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier It has been over 50 years since the discovery of hepatitis B virus (HBV), yet 240 million people worldwide live with chronic HBV, resulting in up to 800000 deaths per year. A cure is yet to be achieved, due largely to a viral nuclear reservoir of transcriptionally active covalently closed circular DNA (cccDNA). While current antiviral therapies are effective at reducing viral replication, they have no impact on the existing cccDNA reservoir. Identifying mechanisms to either eliminate (complete cure) or inactivate (functional cure) HBV cccDNA are a major focus of HBV research worldwide. This review discusses recent advances in efforts to eliminate and/or regulate cccDNA, as well as future directions that may be considered in efforts to cure chronic HBV. It has been over 50 years since the discovery of hepatitis B virus (HBV), yet 240 million people worldwide live with chronic HBV, resulting in up to 800000 deaths per year. A cure is yet to be achieved, due largely to a viral nuclear reservoir of transcriptionally active covalently closed circular DNA (cccDNA). While current antiviral therapies are effective at reducing viral replication, they have no impact on the existing cccDNA reservoir. Identifying mechanisms to either eliminate (complete cure) or inactivate (functional cure) HBV cccDNA are a major focus of HBV research worldwide. This review discusses recent advances in efforts to eliminate and/or regulate cccDNA, as well as future directions that may be considered in efforts to cure chronic HBV. Locarnini, Stephen oth Enthalten in Elsevier Science Komar, Michał ELSEVIER Biodeterioration potential of algae on building materials - Model study 2023 Amsterdam [u.a.] (DE-627)ELV009586474 volume:30 year:2016 pages:144-150 extent:7 https://doi.org/10.1016/j.coph.2016.08.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-GGO 51.24 Korrosion VZ 58.30 Biotechnologie VZ 58.53 Abfallwirtschaft VZ AR 30 2016 144-150 7 045F 340 |
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10.1016/j.coph.2016.08.015 doi GBVA2016004000006.pica (DE-627)ELV024211818 (ELSEVIER)S1471-4892(16)30104-7 DE-627 ger DE-627 rakwb eng 340 340 DE-600 570 VZ BIODIV DE-30 fid 51.24 bkl 58.30 bkl 58.53 bkl Revill, Peter verfasserin aut Antiviral strategies to eliminate hepatitis B virus covalently closed circular DNA (cccDNA) 2016transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier It has been over 50 years since the discovery of hepatitis B virus (HBV), yet 240 million people worldwide live with chronic HBV, resulting in up to 800000 deaths per year. A cure is yet to be achieved, due largely to a viral nuclear reservoir of transcriptionally active covalently closed circular DNA (cccDNA). While current antiviral therapies are effective at reducing viral replication, they have no impact on the existing cccDNA reservoir. Identifying mechanisms to either eliminate (complete cure) or inactivate (functional cure) HBV cccDNA are a major focus of HBV research worldwide. This review discusses recent advances in efforts to eliminate and/or regulate cccDNA, as well as future directions that may be considered in efforts to cure chronic HBV. It has been over 50 years since the discovery of hepatitis B virus (HBV), yet 240 million people worldwide live with chronic HBV, resulting in up to 800000 deaths per year. A cure is yet to be achieved, due largely to a viral nuclear reservoir of transcriptionally active covalently closed circular DNA (cccDNA). While current antiviral therapies are effective at reducing viral replication, they have no impact on the existing cccDNA reservoir. Identifying mechanisms to either eliminate (complete cure) or inactivate (functional cure) HBV cccDNA are a major focus of HBV research worldwide. This review discusses recent advances in efforts to eliminate and/or regulate cccDNA, as well as future directions that may be considered in efforts to cure chronic HBV. Locarnini, Stephen oth Enthalten in Elsevier Science Komar, Michał ELSEVIER Biodeterioration potential of algae on building materials - Model study 2023 Amsterdam [u.a.] (DE-627)ELV009586474 volume:30 year:2016 pages:144-150 extent:7 https://doi.org/10.1016/j.coph.2016.08.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA SSG-OPC-GGO 51.24 Korrosion VZ 58.30 Biotechnologie VZ 58.53 Abfallwirtschaft VZ AR 30 2016 144-150 7 045F 340 |
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Biodeterioration potential of algae on building materials - Model study |
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Biodeterioration potential of algae on building materials - Model study |
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Revill, Peter |
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Elektronische Aufsätze |
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Revill, Peter |
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10.1016/j.coph.2016.08.015 |
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340 570 |
| title_sort |
antiviral strategies to eliminate hepatitis b virus covalently closed circular dna (cccdna) |
| title_auth |
Antiviral strategies to eliminate hepatitis B virus covalently closed circular DNA (cccDNA) |
| abstract |
It has been over 50 years since the discovery of hepatitis B virus (HBV), yet 240 million people worldwide live with chronic HBV, resulting in up to 800000 deaths per year. A cure is yet to be achieved, due largely to a viral nuclear reservoir of transcriptionally active covalently closed circular DNA (cccDNA). While current antiviral therapies are effective at reducing viral replication, they have no impact on the existing cccDNA reservoir. Identifying mechanisms to either eliminate (complete cure) or inactivate (functional cure) HBV cccDNA are a major focus of HBV research worldwide. This review discusses recent advances in efforts to eliminate and/or regulate cccDNA, as well as future directions that may be considered in efforts to cure chronic HBV. |
| abstractGer |
It has been over 50 years since the discovery of hepatitis B virus (HBV), yet 240 million people worldwide live with chronic HBV, resulting in up to 800000 deaths per year. A cure is yet to be achieved, due largely to a viral nuclear reservoir of transcriptionally active covalently closed circular DNA (cccDNA). While current antiviral therapies are effective at reducing viral replication, they have no impact on the existing cccDNA reservoir. Identifying mechanisms to either eliminate (complete cure) or inactivate (functional cure) HBV cccDNA are a major focus of HBV research worldwide. This review discusses recent advances in efforts to eliminate and/or regulate cccDNA, as well as future directions that may be considered in efforts to cure chronic HBV. |
| abstract_unstemmed |
It has been over 50 years since the discovery of hepatitis B virus (HBV), yet 240 million people worldwide live with chronic HBV, resulting in up to 800000 deaths per year. A cure is yet to be achieved, due largely to a viral nuclear reservoir of transcriptionally active covalently closed circular DNA (cccDNA). While current antiviral therapies are effective at reducing viral replication, they have no impact on the existing cccDNA reservoir. Identifying mechanisms to either eliminate (complete cure) or inactivate (functional cure) HBV cccDNA are a major focus of HBV research worldwide. This review discusses recent advances in efforts to eliminate and/or regulate cccDNA, as well as future directions that may be considered in efforts to cure chronic HBV. |
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| title_short |
Antiviral strategies to eliminate hepatitis B virus covalently closed circular DNA (cccDNA) |
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https://doi.org/10.1016/j.coph.2016.08.015 |
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Locarnini, Stephen |
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