Safety, immunogenicity and dose response of VLA84, a new vaccine candidate against Clostridium difficile, in healthy volunteers
• A new vaccine candidate VLA84 to prevent CDI has been tested in a Phase I trial. • VLA84 was safe and well tolerated in healthy adult and healthy elderly volunteers. • VLA84 was highly immunogenic in adults and elderly. • IgG antibodies persisted at least 6 months after last immunization. • Functi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Bézay, Nicole [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: Quantifying contributions of leaf area and longevity to leaf area duration under increased planting density and nitrogen input regimens during maize yield improvement - Li, Yaoyao ELSEVIER, 2022, Amsterdam |
|---|---|
| Übergeordnetes Werk: |
volume:34 ; year:2016 ; number:23 ; day:17 ; month:05 ; pages:2585-2592 ; extent:8 |
| Links: |
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| DOI / URN: |
10.1016/j.vaccine.2016.03.098 |
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| title_sort |
safety, immunogenicity and dose response of vla84, a new vaccine candidate against clostridium difficile, in healthy volunteers |
| title_auth |
Safety, immunogenicity and dose response of VLA84, a new vaccine candidate against Clostridium difficile, in healthy volunteers |
| abstract |
• A new vaccine candidate VLA84 to prevent CDI has been tested in a Phase I trial. • VLA84 was safe and well tolerated in healthy adult and healthy elderly volunteers. • VLA84 was highly immunogenic in adults and elderly. • IgG antibodies persisted at least 6 months after last immunization. • Functionality of IgG antibodies was shown in a T84 toxin neutralization assay. |
| abstractGer |
• A new vaccine candidate VLA84 to prevent CDI has been tested in a Phase I trial. • VLA84 was safe and well tolerated in healthy adult and healthy elderly volunteers. • VLA84 was highly immunogenic in adults and elderly. • IgG antibodies persisted at least 6 months after last immunization. • Functionality of IgG antibodies was shown in a T84 toxin neutralization assay. |
| abstract_unstemmed |
• A new vaccine candidate VLA84 to prevent CDI has been tested in a Phase I trial. • VLA84 was safe and well tolerated in healthy adult and healthy elderly volunteers. • VLA84 was highly immunogenic in adults and elderly. • IgG antibodies persisted at least 6 months after last immunization. • Functionality of IgG antibodies was shown in a T84 toxin neutralization assay. |
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| title_short |
Safety, immunogenicity and dose response of VLA84, a new vaccine candidate against Clostridium difficile, in healthy volunteers |
| url |
https://doi.org/10.1016/j.vaccine.2016.03.098 |
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Ayad, Andrea Dubischar, Katrin Firbas, Christa Hochreiter, Romana Kiermayr, Sigrid Kiss, István Pinl, Fritz Jilma, Bernd Westritschnig, Kerstin |
| author2Str |
Ayad, Andrea Dubischar, Katrin Firbas, Christa Hochreiter, Romana Kiermayr, Sigrid Kiss, István Pinl, Fritz Jilma, Bernd Westritschnig, Kerstin |
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| doi_str |
10.1016/j.vaccine.2016.03.098 |
| up_date |
2024-07-06T21:14:08.634Z |
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