Benzyl isothiocyanate but not benzyl nitrile from Brassicales plants dually blocks the COX and LOX pathway in primary human immune cells
• Benzyl ITC suppressed LPS-triggered COX pathway activation in human PBMC. • Benzyl nitrile did not influence PGE2 synthesis. • Benzyl ITC blocked leukotriene LTB4 release in human PBMC. • Benzyl ITC mediated inhibition of ERK1/2 and c-Jun preceded COX-2 suppression. • Benzyl ITC reduced the activa...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Herz, Corinna [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2016 |
|---|
| Umfang: |
9 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Group-based trajectories of maternal intake of sugar-sweetened beverage and offspring oral health from a prospective birth cohort study - Ha, Diep H ELSEVIER, 2022, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:23 ; year:2016 ; pages:135-143 ; extent:9 |
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| DOI / URN: |
10.1016/j.jff.2016.02.034 |
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Benzyl isothiocyanate but not benzyl nitrile from Brassicales plants dually blocks the COX and LOX pathway in primary human immune cells |
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• Benzyl ITC suppressed LPS-triggered COX pathway activation in human PBMC. • Benzyl nitrile did not influence PGE2 synthesis. • Benzyl ITC blocked leukotriene LTB4 release in human PBMC. • Benzyl ITC mediated inhibition of ERK1/2 and c-Jun preceded COX-2 suppression. • Benzyl ITC reduced the activation and function of activated T lymphocytes. |
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• Benzyl ITC suppressed LPS-triggered COX pathway activation in human PBMC. • Benzyl nitrile did not influence PGE2 synthesis. • Benzyl ITC blocked leukotriene LTB4 release in human PBMC. • Benzyl ITC mediated inhibition of ERK1/2 and c-Jun preceded COX-2 suppression. • Benzyl ITC reduced the activation and function of activated T lymphocytes. |
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• Benzyl ITC suppressed LPS-triggered COX pathway activation in human PBMC. • Benzyl nitrile did not influence PGE2 synthesis. • Benzyl ITC blocked leukotriene LTB4 release in human PBMC. • Benzyl ITC mediated inhibition of ERK1/2 and c-Jun preceded COX-2 suppression. • Benzyl ITC reduced the activation and function of activated T lymphocytes. |
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Benzyl isothiocyanate but not benzyl nitrile from Brassicales plants dually blocks the COX and LOX pathway in primary human immune cells |
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