Combination with γ-secretase inhibitor prolongs treatment efficacy of BRAF inhibitor in BRAF-mutated melanoma cells
• NOTCH activity protects melanocytes from oncogene-induced senescence. • NOTCH pathway inhibitor enhances the efficacy of BRAF-inhibitor treatment in melanoma. • BRAF-inhibitor resistant cells still respond to additional NOTCH inhibitor treatment.
Gespeichert in:
| Autor*in: |
Zhu, Guannan [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Umfang: |
10 |
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| Übergeordnetes Werk: |
Enthalten in: GW26-e0273 Relationship between thrombelastography test and routine platelet parameters in patients with acute coronary syndrome - Hao, Lijun ELSEVIER, 2015, an international journal providing a forum for original and pertinent contributions in cancer research, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:376 ; year:2016 ; number:1 ; day:28 ; month:06 ; pages:43-52 ; extent:10 |
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| DOI / URN: |
10.1016/j.canlet.2016.03.028 |
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Combination with γ-secretase inhibitor prolongs treatment efficacy of BRAF inhibitor in BRAF-mutated melanoma cells |
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• NOTCH activity protects melanocytes from oncogene-induced senescence. • NOTCH pathway inhibitor enhances the efficacy of BRAF-inhibitor treatment in melanoma. • BRAF-inhibitor resistant cells still respond to additional NOTCH inhibitor treatment. |
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