Cinnamon intake alleviates the combined effects of dietary-induced insulin resistance and acute stress on brain mitochondria
Insulin resistance (IR), which is a leading cause of the metabolic syndrome, results in early brain function alterations which may alter brain mitochondrial functioning. Previously, we demonstrated that rats fed a control diet and submitted to an acute restraint stress exhibited a delayed mitochondr...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Couturier, Karine [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2016transfer abstract |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: Distribution of critical metals in evolving pyrite from massive sulfide ores of the Iberian Pyrite Belt - Yesares, Lola ELSEVIER, 2022, New York, NY [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:28 ; year:2016 ; pages:183-190 ; extent:8 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.jnutbio.2015.10.016 |
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| 520 | |a Insulin resistance (IR), which is a leading cause of the metabolic syndrome, results in early brain function alterations which may alter brain mitochondrial functioning. Previously, we demonstrated that rats fed a control diet and submitted to an acute restraint stress exhibited a delayed mitochondrial permeability transition pore (mPTP) opening. In this study, we evaluated the combined effects of dietary and emotional stressors as found in western way of life. We studied, in rats submitted or not to an acute stress, the effects of diet-induced IR on brain mitochondria, using a high fat/high fructose diet (HF2), as an IR inducer, with addition or not of cinnamon as an insulin sensitizer. We measured Ca2+ retention capacity, respiration, ROS production, enzymatic activities and cell signaling activation. Under stress, HF2 diet dramatically decreased the amount of Ca2+ required to open the mPTP (13%) suggesting an adverse effect on mitochondrial survival. Cinnamon added to the diet corrected this negative effect and resulted in a partial recovery (30%). The effects related to cinnamon addition to the diet could be due to its antioxidant properties or to the observed modulation of PI3K-AKT-GSK3β and MAPK-P38 pathways or to a combination of both. These data suggest a protective effect of cinnamon on brain mitochondria against the negative impact of an HF2 diet. Cinnamon could be beneficial to counteract deleterious dietary effects in stressed conditions. | ||
| 520 | |a Insulin resistance (IR), which is a leading cause of the metabolic syndrome, results in early brain function alterations which may alter brain mitochondrial functioning. Previously, we demonstrated that rats fed a control diet and submitted to an acute restraint stress exhibited a delayed mitochondrial permeability transition pore (mPTP) opening. In this study, we evaluated the combined effects of dietary and emotional stressors as found in western way of life. We studied, in rats submitted or not to an acute stress, the effects of diet-induced IR on brain mitochondria, using a high fat/high fructose diet (HF2), as an IR inducer, with addition or not of cinnamon as an insulin sensitizer. We measured Ca2+ retention capacity, respiration, ROS production, enzymatic activities and cell signaling activation. Under stress, HF2 diet dramatically decreased the amount of Ca2+ required to open the mPTP (13%) suggesting an adverse effect on mitochondrial survival. Cinnamon added to the diet corrected this negative effect and resulted in a partial recovery (30%). The effects related to cinnamon addition to the diet could be due to its antioxidant properties or to the observed modulation of PI3K-AKT-GSK3β and MAPK-P38 pathways or to a combination of both. These data suggest a protective effect of cinnamon on brain mitochondria against the negative impact of an HF2 diet. Cinnamon could be beneficial to counteract deleterious dietary effects in stressed conditions. | ||
| 700 | 1 | |a Hininger, Isabelle |4 oth | |
| 700 | 1 | |a Poulet, Laurent |4 oth | |
| 700 | 1 | |a Anderson, Richard A. |4 oth | |
| 700 | 1 | |a Roussel, Anne-Marie |4 oth | |
| 700 | 1 | |a Canini, Frédéric |4 oth | |
| 700 | 1 | |a Batandier, Cécile |4 oth | |
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10.1016/j.jnutbio.2015.10.016 doi GBVA2016016000021.pica (DE-627)ELV024662127 (ELSEVIER)S0955-2863(15)00330-7 DE-627 ger DE-627 rakwb eng 540 630 640 540 DE-600 630 DE-600 640 DE-600 550 VZ 38.52 bkl 57.20 bkl Couturier, Karine verfasserin aut Cinnamon intake alleviates the combined effects of dietary-induced insulin resistance and acute stress on brain mitochondria 2016transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Insulin resistance (IR), which is a leading cause of the metabolic syndrome, results in early brain function alterations which may alter brain mitochondrial functioning. Previously, we demonstrated that rats fed a control diet and submitted to an acute restraint stress exhibited a delayed mitochondrial permeability transition pore (mPTP) opening. In this study, we evaluated the combined effects of dietary and emotional stressors as found in western way of life. We studied, in rats submitted or not to an acute stress, the effects of diet-induced IR on brain mitochondria, using a high fat/high fructose diet (HF2), as an IR inducer, with addition or not of cinnamon as an insulin sensitizer. We measured Ca2+ retention capacity, respiration, ROS production, enzymatic activities and cell signaling activation. Under stress, HF2 diet dramatically decreased the amount of Ca2+ required to open the mPTP (13%) suggesting an adverse effect on mitochondrial survival. Cinnamon added to the diet corrected this negative effect and resulted in a partial recovery (30%). The effects related to cinnamon addition to the diet could be due to its antioxidant properties or to the observed modulation of PI3K-AKT-GSK3β and MAPK-P38 pathways or to a combination of both. These data suggest a protective effect of cinnamon on brain mitochondria against the negative impact of an HF2 diet. Cinnamon could be beneficial to counteract deleterious dietary effects in stressed conditions. Insulin resistance (IR), which is a leading cause of the metabolic syndrome, results in early brain function alterations which may alter brain mitochondrial functioning. Previously, we demonstrated that rats fed a control diet and submitted to an acute restraint stress exhibited a delayed mitochondrial permeability transition pore (mPTP) opening. In this study, we evaluated the combined effects of dietary and emotional stressors as found in western way of life. We studied, in rats submitted or not to an acute stress, the effects of diet-induced IR on brain mitochondria, using a high fat/high fructose diet (HF2), as an IR inducer, with addition or not of cinnamon as an insulin sensitizer. We measured Ca2+ retention capacity, respiration, ROS production, enzymatic activities and cell signaling activation. Under stress, HF2 diet dramatically decreased the amount of Ca2+ required to open the mPTP (13%) suggesting an adverse effect on mitochondrial survival. Cinnamon added to the diet corrected this negative effect and resulted in a partial recovery (30%). The effects related to cinnamon addition to the diet could be due to its antioxidant properties or to the observed modulation of PI3K-AKT-GSK3β and MAPK-P38 pathways or to a combination of both. These data suggest a protective effect of cinnamon on brain mitochondria against the negative impact of an HF2 diet. Cinnamon could be beneficial to counteract deleterious dietary effects in stressed conditions. Hininger, Isabelle oth Poulet, Laurent oth Anderson, Richard A. oth Roussel, Anne-Marie oth Canini, Frédéric oth Batandier, Cécile oth Enthalten in Elsevier Yesares, Lola ELSEVIER Distribution of critical metals in evolving pyrite from massive sulfide ores of the Iberian Pyrite Belt 2022 New York, NY [u.a.] (DE-627)ELV009132147 volume:28 year:2016 pages:183-190 extent:8 https://doi.org/10.1016/j.jnutbio.2015.10.016 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO 38.52 Geologie der Erze VZ 57.20 Exploration und Prospektion von Bodenschätzen VZ AR 28 2016 183-190 8 045F 540 |
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10.1016/j.jnutbio.2015.10.016 doi GBVA2016016000021.pica (DE-627)ELV024662127 (ELSEVIER)S0955-2863(15)00330-7 DE-627 ger DE-627 rakwb eng 540 630 640 540 DE-600 630 DE-600 640 DE-600 550 VZ 38.52 bkl 57.20 bkl Couturier, Karine verfasserin aut Cinnamon intake alleviates the combined effects of dietary-induced insulin resistance and acute stress on brain mitochondria 2016transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Insulin resistance (IR), which is a leading cause of the metabolic syndrome, results in early brain function alterations which may alter brain mitochondrial functioning. Previously, we demonstrated that rats fed a control diet and submitted to an acute restraint stress exhibited a delayed mitochondrial permeability transition pore (mPTP) opening. In this study, we evaluated the combined effects of dietary and emotional stressors as found in western way of life. We studied, in rats submitted or not to an acute stress, the effects of diet-induced IR on brain mitochondria, using a high fat/high fructose diet (HF2), as an IR inducer, with addition or not of cinnamon as an insulin sensitizer. We measured Ca2+ retention capacity, respiration, ROS production, enzymatic activities and cell signaling activation. Under stress, HF2 diet dramatically decreased the amount of Ca2+ required to open the mPTP (13%) suggesting an adverse effect on mitochondrial survival. Cinnamon added to the diet corrected this negative effect and resulted in a partial recovery (30%). The effects related to cinnamon addition to the diet could be due to its antioxidant properties or to the observed modulation of PI3K-AKT-GSK3β and MAPK-P38 pathways or to a combination of both. These data suggest a protective effect of cinnamon on brain mitochondria against the negative impact of an HF2 diet. Cinnamon could be beneficial to counteract deleterious dietary effects in stressed conditions. Insulin resistance (IR), which is a leading cause of the metabolic syndrome, results in early brain function alterations which may alter brain mitochondrial functioning. Previously, we demonstrated that rats fed a control diet and submitted to an acute restraint stress exhibited a delayed mitochondrial permeability transition pore (mPTP) opening. In this study, we evaluated the combined effects of dietary and emotional stressors as found in western way of life. We studied, in rats submitted or not to an acute stress, the effects of diet-induced IR on brain mitochondria, using a high fat/high fructose diet (HF2), as an IR inducer, with addition or not of cinnamon as an insulin sensitizer. We measured Ca2+ retention capacity, respiration, ROS production, enzymatic activities and cell signaling activation. Under stress, HF2 diet dramatically decreased the amount of Ca2+ required to open the mPTP (13%) suggesting an adverse effect on mitochondrial survival. Cinnamon added to the diet corrected this negative effect and resulted in a partial recovery (30%). The effects related to cinnamon addition to the diet could be due to its antioxidant properties or to the observed modulation of PI3K-AKT-GSK3β and MAPK-P38 pathways or to a combination of both. These data suggest a protective effect of cinnamon on brain mitochondria against the negative impact of an HF2 diet. Cinnamon could be beneficial to counteract deleterious dietary effects in stressed conditions. Hininger, Isabelle oth Poulet, Laurent oth Anderson, Richard A. oth Roussel, Anne-Marie oth Canini, Frédéric oth Batandier, Cécile oth Enthalten in Elsevier Yesares, Lola ELSEVIER Distribution of critical metals in evolving pyrite from massive sulfide ores of the Iberian Pyrite Belt 2022 New York, NY [u.a.] (DE-627)ELV009132147 volume:28 year:2016 pages:183-190 extent:8 https://doi.org/10.1016/j.jnutbio.2015.10.016 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO 38.52 Geologie der Erze VZ 57.20 Exploration und Prospektion von Bodenschätzen VZ AR 28 2016 183-190 8 045F 540 |
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10.1016/j.jnutbio.2015.10.016 doi GBVA2016016000021.pica (DE-627)ELV024662127 (ELSEVIER)S0955-2863(15)00330-7 DE-627 ger DE-627 rakwb eng 540 630 640 540 DE-600 630 DE-600 640 DE-600 550 VZ 38.52 bkl 57.20 bkl Couturier, Karine verfasserin aut Cinnamon intake alleviates the combined effects of dietary-induced insulin resistance and acute stress on brain mitochondria 2016transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Insulin resistance (IR), which is a leading cause of the metabolic syndrome, results in early brain function alterations which may alter brain mitochondrial functioning. Previously, we demonstrated that rats fed a control diet and submitted to an acute restraint stress exhibited a delayed mitochondrial permeability transition pore (mPTP) opening. In this study, we evaluated the combined effects of dietary and emotional stressors as found in western way of life. We studied, in rats submitted or not to an acute stress, the effects of diet-induced IR on brain mitochondria, using a high fat/high fructose diet (HF2), as an IR inducer, with addition or not of cinnamon as an insulin sensitizer. We measured Ca2+ retention capacity, respiration, ROS production, enzymatic activities and cell signaling activation. Under stress, HF2 diet dramatically decreased the amount of Ca2+ required to open the mPTP (13%) suggesting an adverse effect on mitochondrial survival. Cinnamon added to the diet corrected this negative effect and resulted in a partial recovery (30%). The effects related to cinnamon addition to the diet could be due to its antioxidant properties or to the observed modulation of PI3K-AKT-GSK3β and MAPK-P38 pathways or to a combination of both. These data suggest a protective effect of cinnamon on brain mitochondria against the negative impact of an HF2 diet. Cinnamon could be beneficial to counteract deleterious dietary effects in stressed conditions. Insulin resistance (IR), which is a leading cause of the metabolic syndrome, results in early brain function alterations which may alter brain mitochondrial functioning. Previously, we demonstrated that rats fed a control diet and submitted to an acute restraint stress exhibited a delayed mitochondrial permeability transition pore (mPTP) opening. In this study, we evaluated the combined effects of dietary and emotional stressors as found in western way of life. We studied, in rats submitted or not to an acute stress, the effects of diet-induced IR on brain mitochondria, using a high fat/high fructose diet (HF2), as an IR inducer, with addition or not of cinnamon as an insulin sensitizer. We measured Ca2+ retention capacity, respiration, ROS production, enzymatic activities and cell signaling activation. Under stress, HF2 diet dramatically decreased the amount of Ca2+ required to open the mPTP (13%) suggesting an adverse effect on mitochondrial survival. Cinnamon added to the diet corrected this negative effect and resulted in a partial recovery (30%). The effects related to cinnamon addition to the diet could be due to its antioxidant properties or to the observed modulation of PI3K-AKT-GSK3β and MAPK-P38 pathways or to a combination of both. These data suggest a protective effect of cinnamon on brain mitochondria against the negative impact of an HF2 diet. Cinnamon could be beneficial to counteract deleterious dietary effects in stressed conditions. Hininger, Isabelle oth Poulet, Laurent oth Anderson, Richard A. oth Roussel, Anne-Marie oth Canini, Frédéric oth Batandier, Cécile oth Enthalten in Elsevier Yesares, Lola ELSEVIER Distribution of critical metals in evolving pyrite from massive sulfide ores of the Iberian Pyrite Belt 2022 New York, NY [u.a.] (DE-627)ELV009132147 volume:28 year:2016 pages:183-190 extent:8 https://doi.org/10.1016/j.jnutbio.2015.10.016 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO 38.52 Geologie der Erze VZ 57.20 Exploration und Prospektion von Bodenschätzen VZ AR 28 2016 183-190 8 045F 540 |
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10.1016/j.jnutbio.2015.10.016 doi GBVA2016016000021.pica (DE-627)ELV024662127 (ELSEVIER)S0955-2863(15)00330-7 DE-627 ger DE-627 rakwb eng 540 630 640 540 DE-600 630 DE-600 640 DE-600 550 VZ 38.52 bkl 57.20 bkl Couturier, Karine verfasserin aut Cinnamon intake alleviates the combined effects of dietary-induced insulin resistance and acute stress on brain mitochondria 2016transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Insulin resistance (IR), which is a leading cause of the metabolic syndrome, results in early brain function alterations which may alter brain mitochondrial functioning. Previously, we demonstrated that rats fed a control diet and submitted to an acute restraint stress exhibited a delayed mitochondrial permeability transition pore (mPTP) opening. In this study, we evaluated the combined effects of dietary and emotional stressors as found in western way of life. We studied, in rats submitted or not to an acute stress, the effects of diet-induced IR on brain mitochondria, using a high fat/high fructose diet (HF2), as an IR inducer, with addition or not of cinnamon as an insulin sensitizer. We measured Ca2+ retention capacity, respiration, ROS production, enzymatic activities and cell signaling activation. Under stress, HF2 diet dramatically decreased the amount of Ca2+ required to open the mPTP (13%) suggesting an adverse effect on mitochondrial survival. Cinnamon added to the diet corrected this negative effect and resulted in a partial recovery (30%). The effects related to cinnamon addition to the diet could be due to its antioxidant properties or to the observed modulation of PI3K-AKT-GSK3β and MAPK-P38 pathways or to a combination of both. These data suggest a protective effect of cinnamon on brain mitochondria against the negative impact of an HF2 diet. Cinnamon could be beneficial to counteract deleterious dietary effects in stressed conditions. Insulin resistance (IR), which is a leading cause of the metabolic syndrome, results in early brain function alterations which may alter brain mitochondrial functioning. Previously, we demonstrated that rats fed a control diet and submitted to an acute restraint stress exhibited a delayed mitochondrial permeability transition pore (mPTP) opening. In this study, we evaluated the combined effects of dietary and emotional stressors as found in western way of life. We studied, in rats submitted or not to an acute stress, the effects of diet-induced IR on brain mitochondria, using a high fat/high fructose diet (HF2), as an IR inducer, with addition or not of cinnamon as an insulin sensitizer. We measured Ca2+ retention capacity, respiration, ROS production, enzymatic activities and cell signaling activation. Under stress, HF2 diet dramatically decreased the amount of Ca2+ required to open the mPTP (13%) suggesting an adverse effect on mitochondrial survival. Cinnamon added to the diet corrected this negative effect and resulted in a partial recovery (30%). The effects related to cinnamon addition to the diet could be due to its antioxidant properties or to the observed modulation of PI3K-AKT-GSK3β and MAPK-P38 pathways or to a combination of both. These data suggest a protective effect of cinnamon on brain mitochondria against the negative impact of an HF2 diet. Cinnamon could be beneficial to counteract deleterious dietary effects in stressed conditions. Hininger, Isabelle oth Poulet, Laurent oth Anderson, Richard A. oth Roussel, Anne-Marie oth Canini, Frédéric oth Batandier, Cécile oth Enthalten in Elsevier Yesares, Lola ELSEVIER Distribution of critical metals in evolving pyrite from massive sulfide ores of the Iberian Pyrite Belt 2022 New York, NY [u.a.] (DE-627)ELV009132147 volume:28 year:2016 pages:183-190 extent:8 https://doi.org/10.1016/j.jnutbio.2015.10.016 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO 38.52 Geologie der Erze VZ 57.20 Exploration und Prospektion von Bodenschätzen VZ AR 28 2016 183-190 8 045F 540 |
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10.1016/j.jnutbio.2015.10.016 doi GBVA2016016000021.pica (DE-627)ELV024662127 (ELSEVIER)S0955-2863(15)00330-7 DE-627 ger DE-627 rakwb eng 540 630 640 540 DE-600 630 DE-600 640 DE-600 550 VZ 38.52 bkl 57.20 bkl Couturier, Karine verfasserin aut Cinnamon intake alleviates the combined effects of dietary-induced insulin resistance and acute stress on brain mitochondria 2016transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Insulin resistance (IR), which is a leading cause of the metabolic syndrome, results in early brain function alterations which may alter brain mitochondrial functioning. Previously, we demonstrated that rats fed a control diet and submitted to an acute restraint stress exhibited a delayed mitochondrial permeability transition pore (mPTP) opening. In this study, we evaluated the combined effects of dietary and emotional stressors as found in western way of life. We studied, in rats submitted or not to an acute stress, the effects of diet-induced IR on brain mitochondria, using a high fat/high fructose diet (HF2), as an IR inducer, with addition or not of cinnamon as an insulin sensitizer. We measured Ca2+ retention capacity, respiration, ROS production, enzymatic activities and cell signaling activation. Under stress, HF2 diet dramatically decreased the amount of Ca2+ required to open the mPTP (13%) suggesting an adverse effect on mitochondrial survival. Cinnamon added to the diet corrected this negative effect and resulted in a partial recovery (30%). The effects related to cinnamon addition to the diet could be due to its antioxidant properties or to the observed modulation of PI3K-AKT-GSK3β and MAPK-P38 pathways or to a combination of both. These data suggest a protective effect of cinnamon on brain mitochondria against the negative impact of an HF2 diet. Cinnamon could be beneficial to counteract deleterious dietary effects in stressed conditions. Insulin resistance (IR), which is a leading cause of the metabolic syndrome, results in early brain function alterations which may alter brain mitochondrial functioning. Previously, we demonstrated that rats fed a control diet and submitted to an acute restraint stress exhibited a delayed mitochondrial permeability transition pore (mPTP) opening. In this study, we evaluated the combined effects of dietary and emotional stressors as found in western way of life. We studied, in rats submitted or not to an acute stress, the effects of diet-induced IR on brain mitochondria, using a high fat/high fructose diet (HF2), as an IR inducer, with addition or not of cinnamon as an insulin sensitizer. We measured Ca2+ retention capacity, respiration, ROS production, enzymatic activities and cell signaling activation. Under stress, HF2 diet dramatically decreased the amount of Ca2+ required to open the mPTP (13%) suggesting an adverse effect on mitochondrial survival. Cinnamon added to the diet corrected this negative effect and resulted in a partial recovery (30%). The effects related to cinnamon addition to the diet could be due to its antioxidant properties or to the observed modulation of PI3K-AKT-GSK3β and MAPK-P38 pathways or to a combination of both. These data suggest a protective effect of cinnamon on brain mitochondria against the negative impact of an HF2 diet. Cinnamon could be beneficial to counteract deleterious dietary effects in stressed conditions. Hininger, Isabelle oth Poulet, Laurent oth Anderson, Richard A. oth Roussel, Anne-Marie oth Canini, Frédéric oth Batandier, Cécile oth Enthalten in Elsevier Yesares, Lola ELSEVIER Distribution of critical metals in evolving pyrite from massive sulfide ores of the Iberian Pyrite Belt 2022 New York, NY [u.a.] (DE-627)ELV009132147 volume:28 year:2016 pages:183-190 extent:8 https://doi.org/10.1016/j.jnutbio.2015.10.016 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO 38.52 Geologie der Erze VZ 57.20 Exploration und Prospektion von Bodenschätzen VZ AR 28 2016 183-190 8 045F 540 |
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Cinnamon intake alleviates the combined effects of dietary-induced insulin resistance and acute stress on brain mitochondria |
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Insulin resistance (IR), which is a leading cause of the metabolic syndrome, results in early brain function alterations which may alter brain mitochondrial functioning. Previously, we demonstrated that rats fed a control diet and submitted to an acute restraint stress exhibited a delayed mitochondrial permeability transition pore (mPTP) opening. In this study, we evaluated the combined effects of dietary and emotional stressors as found in western way of life. We studied, in rats submitted or not to an acute stress, the effects of diet-induced IR on brain mitochondria, using a high fat/high fructose diet (HF2), as an IR inducer, with addition or not of cinnamon as an insulin sensitizer. We measured Ca2+ retention capacity, respiration, ROS production, enzymatic activities and cell signaling activation. Under stress, HF2 diet dramatically decreased the amount of Ca2+ required to open the mPTP (13%) suggesting an adverse effect on mitochondrial survival. Cinnamon added to the diet corrected this negative effect and resulted in a partial recovery (30%). The effects related to cinnamon addition to the diet could be due to its antioxidant properties or to the observed modulation of PI3K-AKT-GSK3β and MAPK-P38 pathways or to a combination of both. These data suggest a protective effect of cinnamon on brain mitochondria against the negative impact of an HF2 diet. Cinnamon could be beneficial to counteract deleterious dietary effects in stressed conditions. |
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Insulin resistance (IR), which is a leading cause of the metabolic syndrome, results in early brain function alterations which may alter brain mitochondrial functioning. Previously, we demonstrated that rats fed a control diet and submitted to an acute restraint stress exhibited a delayed mitochondrial permeability transition pore (mPTP) opening. In this study, we evaluated the combined effects of dietary and emotional stressors as found in western way of life. We studied, in rats submitted or not to an acute stress, the effects of diet-induced IR on brain mitochondria, using a high fat/high fructose diet (HF2), as an IR inducer, with addition or not of cinnamon as an insulin sensitizer. We measured Ca2+ retention capacity, respiration, ROS production, enzymatic activities and cell signaling activation. Under stress, HF2 diet dramatically decreased the amount of Ca2+ required to open the mPTP (13%) suggesting an adverse effect on mitochondrial survival. Cinnamon added to the diet corrected this negative effect and resulted in a partial recovery (30%). The effects related to cinnamon addition to the diet could be due to its antioxidant properties or to the observed modulation of PI3K-AKT-GSK3β and MAPK-P38 pathways or to a combination of both. These data suggest a protective effect of cinnamon on brain mitochondria against the negative impact of an HF2 diet. Cinnamon could be beneficial to counteract deleterious dietary effects in stressed conditions. |
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Insulin resistance (IR), which is a leading cause of the metabolic syndrome, results in early brain function alterations which may alter brain mitochondrial functioning. Previously, we demonstrated that rats fed a control diet and submitted to an acute restraint stress exhibited a delayed mitochondrial permeability transition pore (mPTP) opening. In this study, we evaluated the combined effects of dietary and emotional stressors as found in western way of life. We studied, in rats submitted or not to an acute stress, the effects of diet-induced IR on brain mitochondria, using a high fat/high fructose diet (HF2), as an IR inducer, with addition or not of cinnamon as an insulin sensitizer. We measured Ca2+ retention capacity, respiration, ROS production, enzymatic activities and cell signaling activation. Under stress, HF2 diet dramatically decreased the amount of Ca2+ required to open the mPTP (13%) suggesting an adverse effect on mitochondrial survival. Cinnamon added to the diet corrected this negative effect and resulted in a partial recovery (30%). The effects related to cinnamon addition to the diet could be due to its antioxidant properties or to the observed modulation of PI3K-AKT-GSK3β and MAPK-P38 pathways or to a combination of both. These data suggest a protective effect of cinnamon on brain mitochondria against the negative impact of an HF2 diet. Cinnamon could be beneficial to counteract deleterious dietary effects in stressed conditions. |
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