Modulation of GABAA receptors by neurosteroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy
Model proposed to explain (A) how increased GABAergic tone leads to reduced function of the glutamate-NO-cGMP pathway and formation of cGMP in cerebellum, and (B) how GABAA receptor-directed therapeutics would restore the glutamate-NO-cGMP pathway and formation of cGMP. (A) Increased GABAergic tone...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Agusti, Ana [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2016transfer abstract |
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| Schlagwörter: |
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| Umfang: |
6 |
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| Übergeordnetes Werk: |
Enthalten in: Goethite modified biochar simultaneously mitigates the arsenic and cadmium accumulation in paddy rice ( - Irshad, Muhammad Kashif ELSEVIER, 2021, New York, NY [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:160 ; year:2016 ; pages:88-93 ; extent:6 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.jsbmb.2015.08.020 |
|---|
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ELV024678031 |
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| 520 | |a Model proposed to explain (A) how increased GABAergic tone leads to reduced function of the glutamate-NO-cGMP pathway and formation of cGMP in cerebellum, and (B) how GABAA receptor-directed therapeutics would restore the glutamate-NO-cGMP pathway and formation of cGMP. (A) Increased GABAergic tone would induce a mild hyperpolarization, increasing the voltage-dependent block of the NMDA receptor by Mg2+, which would contribute to reducing the activation of the pathway and cGMP formation. (B) Reducing activation of GABAA receptors by any means would reduce hyperpolarization and voltage-dependent block of NMDA receptor, contributing to restore the pathway and cGMP levels. | ||
| 520 | |a Model proposed to explain (A) how increased GABAergic tone leads to reduced function of the glutamate-NO-cGMP pathway and formation of cGMP in cerebellum, and (B) how GABAA receptor-directed therapeutics would restore the glutamate-NO-cGMP pathway and formation of cGMP. (A) Increased GABAergic tone would induce a mild hyperpolarization, increasing the voltage-dependent block of the NMDA receptor by Mg2+, which would contribute to reducing the activation of the pathway and cGMP formation. (B) Reducing activation of GABAA receptors by any means would reduce hyperpolarization and voltage-dependent block of NMDA receptor, contributing to restore the pathway and cGMP levels. | ||
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10.1016/j.jsbmb.2015.08.020 doi GBVA2016017000003.pica (DE-627)ELV024678031 (ELSEVIER)S0960-0760(15)30052-2 DE-627 ger DE-627 rakwb eng 570 540 570 DE-600 540 DE-600 333.7 610 VZ 44.13 bkl Agusti, Ana verfasserin aut Modulation of GABAA receptors by neurosteroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy 2016transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Model proposed to explain (A) how increased GABAergic tone leads to reduced function of the glutamate-NO-cGMP pathway and formation of cGMP in cerebellum, and (B) how GABAA receptor-directed therapeutics would restore the glutamate-NO-cGMP pathway and formation of cGMP. (A) Increased GABAergic tone would induce a mild hyperpolarization, increasing the voltage-dependent block of the NMDA receptor by Mg2+, which would contribute to reducing the activation of the pathway and cGMP formation. (B) Reducing activation of GABAA receptors by any means would reduce hyperpolarization and voltage-dependent block of NMDA receptor, contributing to restore the pathway and cGMP levels. Model proposed to explain (A) how increased GABAergic tone leads to reduced function of the glutamate-NO-cGMP pathway and formation of cGMP in cerebellum, and (B) how GABAA receptor-directed therapeutics would restore the glutamate-NO-cGMP pathway and formation of cGMP. (A) Increased GABAergic tone would induce a mild hyperpolarization, increasing the voltage-dependent block of the NMDA receptor by Mg2+, which would contribute to reducing the activation of the pathway and cGMP formation. (B) Reducing activation of GABAA receptors by any means would reduce hyperpolarization and voltage-dependent block of NMDA receptor, contributing to restore the pathway and cGMP levels. PCS Elsevier MHE Elsevier HE Elsevier Llansola, Marta oth Hernández-Rabaza, Vicente oth Cabrera-Pastor, Andrea oth Montoliu, Carmina oth Felipo, Vicente oth Enthalten in Elsevier Irshad, Muhammad Kashif ELSEVIER Goethite modified biochar simultaneously mitigates the arsenic and cadmium accumulation in paddy rice ( 2021 New York, NY [u.a.] (DE-627)ELV00731535X volume:160 year:2016 pages:88-93 extent:6 https://doi.org/10.1016/j.jsbmb.2015.08.020 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.13 Medizinische Ökologie VZ AR 160 2016 88-93 6 045F 570 |
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10.1016/j.jsbmb.2015.08.020 doi GBVA2016017000003.pica (DE-627)ELV024678031 (ELSEVIER)S0960-0760(15)30052-2 DE-627 ger DE-627 rakwb eng 570 540 570 DE-600 540 DE-600 333.7 610 VZ 44.13 bkl Agusti, Ana verfasserin aut Modulation of GABAA receptors by neurosteroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy 2016transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Model proposed to explain (A) how increased GABAergic tone leads to reduced function of the glutamate-NO-cGMP pathway and formation of cGMP in cerebellum, and (B) how GABAA receptor-directed therapeutics would restore the glutamate-NO-cGMP pathway and formation of cGMP. (A) Increased GABAergic tone would induce a mild hyperpolarization, increasing the voltage-dependent block of the NMDA receptor by Mg2+, which would contribute to reducing the activation of the pathway and cGMP formation. (B) Reducing activation of GABAA receptors by any means would reduce hyperpolarization and voltage-dependent block of NMDA receptor, contributing to restore the pathway and cGMP levels. Model proposed to explain (A) how increased GABAergic tone leads to reduced function of the glutamate-NO-cGMP pathway and formation of cGMP in cerebellum, and (B) how GABAA receptor-directed therapeutics would restore the glutamate-NO-cGMP pathway and formation of cGMP. (A) Increased GABAergic tone would induce a mild hyperpolarization, increasing the voltage-dependent block of the NMDA receptor by Mg2+, which would contribute to reducing the activation of the pathway and cGMP formation. (B) Reducing activation of GABAA receptors by any means would reduce hyperpolarization and voltage-dependent block of NMDA receptor, contributing to restore the pathway and cGMP levels. PCS Elsevier MHE Elsevier HE Elsevier Llansola, Marta oth Hernández-Rabaza, Vicente oth Cabrera-Pastor, Andrea oth Montoliu, Carmina oth Felipo, Vicente oth Enthalten in Elsevier Irshad, Muhammad Kashif ELSEVIER Goethite modified biochar simultaneously mitigates the arsenic and cadmium accumulation in paddy rice ( 2021 New York, NY [u.a.] (DE-627)ELV00731535X volume:160 year:2016 pages:88-93 extent:6 https://doi.org/10.1016/j.jsbmb.2015.08.020 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.13 Medizinische Ökologie VZ AR 160 2016 88-93 6 045F 570 |
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10.1016/j.jsbmb.2015.08.020 doi GBVA2016017000003.pica (DE-627)ELV024678031 (ELSEVIER)S0960-0760(15)30052-2 DE-627 ger DE-627 rakwb eng 570 540 570 DE-600 540 DE-600 333.7 610 VZ 44.13 bkl Agusti, Ana verfasserin aut Modulation of GABAA receptors by neurosteroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy 2016transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Model proposed to explain (A) how increased GABAergic tone leads to reduced function of the glutamate-NO-cGMP pathway and formation of cGMP in cerebellum, and (B) how GABAA receptor-directed therapeutics would restore the glutamate-NO-cGMP pathway and formation of cGMP. (A) Increased GABAergic tone would induce a mild hyperpolarization, increasing the voltage-dependent block of the NMDA receptor by Mg2+, which would contribute to reducing the activation of the pathway and cGMP formation. (B) Reducing activation of GABAA receptors by any means would reduce hyperpolarization and voltage-dependent block of NMDA receptor, contributing to restore the pathway and cGMP levels. Model proposed to explain (A) how increased GABAergic tone leads to reduced function of the glutamate-NO-cGMP pathway and formation of cGMP in cerebellum, and (B) how GABAA receptor-directed therapeutics would restore the glutamate-NO-cGMP pathway and formation of cGMP. (A) Increased GABAergic tone would induce a mild hyperpolarization, increasing the voltage-dependent block of the NMDA receptor by Mg2+, which would contribute to reducing the activation of the pathway and cGMP formation. (B) Reducing activation of GABAA receptors by any means would reduce hyperpolarization and voltage-dependent block of NMDA receptor, contributing to restore the pathway and cGMP levels. PCS Elsevier MHE Elsevier HE Elsevier Llansola, Marta oth Hernández-Rabaza, Vicente oth Cabrera-Pastor, Andrea oth Montoliu, Carmina oth Felipo, Vicente oth Enthalten in Elsevier Irshad, Muhammad Kashif ELSEVIER Goethite modified biochar simultaneously mitigates the arsenic and cadmium accumulation in paddy rice ( 2021 New York, NY [u.a.] (DE-627)ELV00731535X volume:160 year:2016 pages:88-93 extent:6 https://doi.org/10.1016/j.jsbmb.2015.08.020 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.13 Medizinische Ökologie VZ AR 160 2016 88-93 6 045F 570 |
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10.1016/j.jsbmb.2015.08.020 doi GBVA2016017000003.pica (DE-627)ELV024678031 (ELSEVIER)S0960-0760(15)30052-2 DE-627 ger DE-627 rakwb eng 570 540 570 DE-600 540 DE-600 333.7 610 VZ 44.13 bkl Agusti, Ana verfasserin aut Modulation of GABAA receptors by neurosteroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy 2016transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Model proposed to explain (A) how increased GABAergic tone leads to reduced function of the glutamate-NO-cGMP pathway and formation of cGMP in cerebellum, and (B) how GABAA receptor-directed therapeutics would restore the glutamate-NO-cGMP pathway and formation of cGMP. (A) Increased GABAergic tone would induce a mild hyperpolarization, increasing the voltage-dependent block of the NMDA receptor by Mg2+, which would contribute to reducing the activation of the pathway and cGMP formation. (B) Reducing activation of GABAA receptors by any means would reduce hyperpolarization and voltage-dependent block of NMDA receptor, contributing to restore the pathway and cGMP levels. Model proposed to explain (A) how increased GABAergic tone leads to reduced function of the glutamate-NO-cGMP pathway and formation of cGMP in cerebellum, and (B) how GABAA receptor-directed therapeutics would restore the glutamate-NO-cGMP pathway and formation of cGMP. (A) Increased GABAergic tone would induce a mild hyperpolarization, increasing the voltage-dependent block of the NMDA receptor by Mg2+, which would contribute to reducing the activation of the pathway and cGMP formation. (B) Reducing activation of GABAA receptors by any means would reduce hyperpolarization and voltage-dependent block of NMDA receptor, contributing to restore the pathway and cGMP levels. PCS Elsevier MHE Elsevier HE Elsevier Llansola, Marta oth Hernández-Rabaza, Vicente oth Cabrera-Pastor, Andrea oth Montoliu, Carmina oth Felipo, Vicente oth Enthalten in Elsevier Irshad, Muhammad Kashif ELSEVIER Goethite modified biochar simultaneously mitigates the arsenic and cadmium accumulation in paddy rice ( 2021 New York, NY [u.a.] (DE-627)ELV00731535X volume:160 year:2016 pages:88-93 extent:6 https://doi.org/10.1016/j.jsbmb.2015.08.020 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.13 Medizinische Ökologie VZ AR 160 2016 88-93 6 045F 570 |
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10.1016/j.jsbmb.2015.08.020 doi GBVA2016017000003.pica (DE-627)ELV024678031 (ELSEVIER)S0960-0760(15)30052-2 DE-627 ger DE-627 rakwb eng 570 540 570 DE-600 540 DE-600 333.7 610 VZ 44.13 bkl Agusti, Ana verfasserin aut Modulation of GABAA receptors by neurosteroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy 2016transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Model proposed to explain (A) how increased GABAergic tone leads to reduced function of the glutamate-NO-cGMP pathway and formation of cGMP in cerebellum, and (B) how GABAA receptor-directed therapeutics would restore the glutamate-NO-cGMP pathway and formation of cGMP. (A) Increased GABAergic tone would induce a mild hyperpolarization, increasing the voltage-dependent block of the NMDA receptor by Mg2+, which would contribute to reducing the activation of the pathway and cGMP formation. (B) Reducing activation of GABAA receptors by any means would reduce hyperpolarization and voltage-dependent block of NMDA receptor, contributing to restore the pathway and cGMP levels. Model proposed to explain (A) how increased GABAergic tone leads to reduced function of the glutamate-NO-cGMP pathway and formation of cGMP in cerebellum, and (B) how GABAA receptor-directed therapeutics would restore the glutamate-NO-cGMP pathway and formation of cGMP. (A) Increased GABAergic tone would induce a mild hyperpolarization, increasing the voltage-dependent block of the NMDA receptor by Mg2+, which would contribute to reducing the activation of the pathway and cGMP formation. (B) Reducing activation of GABAA receptors by any means would reduce hyperpolarization and voltage-dependent block of NMDA receptor, contributing to restore the pathway and cGMP levels. PCS Elsevier MHE Elsevier HE Elsevier Llansola, Marta oth Hernández-Rabaza, Vicente oth Cabrera-Pastor, Andrea oth Montoliu, Carmina oth Felipo, Vicente oth Enthalten in Elsevier Irshad, Muhammad Kashif ELSEVIER Goethite modified biochar simultaneously mitigates the arsenic and cadmium accumulation in paddy rice ( 2021 New York, NY [u.a.] (DE-627)ELV00731535X volume:160 year:2016 pages:88-93 extent:6 https://doi.org/10.1016/j.jsbmb.2015.08.020 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.13 Medizinische Ökologie VZ AR 160 2016 88-93 6 045F 570 |
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Goethite modified biochar simultaneously mitigates the arsenic and cadmium accumulation in paddy rice ( |
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Modulation of GABAA receptors by neurosteroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy |
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Modulation of GABAA receptors by neurosteroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy |
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Goethite modified biochar simultaneously mitigates the arsenic and cadmium accumulation in paddy rice ( |
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modulation of gabaa receptors by neurosteroids. a new concept to improve cognitive and motor alterations in hepatic encephalopathy |
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Modulation of GABAA receptors by neurosteroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy |
| abstract |
Model proposed to explain (A) how increased GABAergic tone leads to reduced function of the glutamate-NO-cGMP pathway and formation of cGMP in cerebellum, and (B) how GABAA receptor-directed therapeutics would restore the glutamate-NO-cGMP pathway and formation of cGMP. (A) Increased GABAergic tone would induce a mild hyperpolarization, increasing the voltage-dependent block of the NMDA receptor by Mg2+, which would contribute to reducing the activation of the pathway and cGMP formation. (B) Reducing activation of GABAA receptors by any means would reduce hyperpolarization and voltage-dependent block of NMDA receptor, contributing to restore the pathway and cGMP levels. |
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Model proposed to explain (A) how increased GABAergic tone leads to reduced function of the glutamate-NO-cGMP pathway and formation of cGMP in cerebellum, and (B) how GABAA receptor-directed therapeutics would restore the glutamate-NO-cGMP pathway and formation of cGMP. (A) Increased GABAergic tone would induce a mild hyperpolarization, increasing the voltage-dependent block of the NMDA receptor by Mg2+, which would contribute to reducing the activation of the pathway and cGMP formation. (B) Reducing activation of GABAA receptors by any means would reduce hyperpolarization and voltage-dependent block of NMDA receptor, contributing to restore the pathway and cGMP levels. |
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Model proposed to explain (A) how increased GABAergic tone leads to reduced function of the glutamate-NO-cGMP pathway and formation of cGMP in cerebellum, and (B) how GABAA receptor-directed therapeutics would restore the glutamate-NO-cGMP pathway and formation of cGMP. (A) Increased GABAergic tone would induce a mild hyperpolarization, increasing the voltage-dependent block of the NMDA receptor by Mg2+, which would contribute to reducing the activation of the pathway and cGMP formation. (B) Reducing activation of GABAA receptors by any means would reduce hyperpolarization and voltage-dependent block of NMDA receptor, contributing to restore the pathway and cGMP levels. |
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Modulation of GABAA receptors by neurosteroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy |
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Llansola, Marta Hernández-Rabaza, Vicente Cabrera-Pastor, Andrea Montoliu, Carmina Felipo, Vicente |
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