Sickle red cells as danger signals on proinflammatory gene expression, leukotriene B4 and interleukin-1 beta production in peripheral blood mononuclear cell

• SCA patients have inflammatory mediator’s levels higher than in healthy controls. • RBC from SCA patients induce TLR and NLRP3 inflammasome expression. • HU does not prevent NLRP3 inflammasome- and TLR-dependent inflammation. • TLR and NLRP3 pathways may be key inducers for inflammation in SCA....
Ausführliche Beschreibung

Gespeichert in:
Autor*in:

Pitanga, Thassila N. [verfasserIn]

Oliveira, Ricardo R.

Zanette, Dalila L.

Guarda, Caroline C.

Santiago, Rayra P.

Santana, Sanzio S.

Nascimento, Valma M.L.

Lima, Jonilson B.

Carvalho, Graziele Q.

Maffili, Vitor V.

Carvalho, Magda O.S.

Alcântara, Luiz C.J.

Borges, Valéria M.

Goncalves, Marilda S.

Format:

E-Artikel

Sprache:

Englisch

Erschienen:

2016

Schlagwörter:

LT

AA-PBMC

HMGB1

HbF

HU

PBMC

DAMPs

SS-RBC

SCA

ASC

PAMP

AA-RBC

RBC

SS-PBMC

NLR

SCD

LTB4

NLRP3

TLR

Umfang:

10

Übergeordnetes Werk:

Enthalten in: The minimal clinically important differences of the Simple Shoulder Test are different for different arthroplasty types - McLaughlin, Richard J. ELSEVIER, 2022, the official journal of the International Cytokine Society, Oxford [u.a.]

Übergeordnetes Werk:

volume:83 ; year:2016 ; pages:75-84 ; extent:10

Links:

Volltext

DOI / URN:

10.1016/j.cyto.2016.03.016

Katalog-ID:

ELV024729930

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