Naloxone exacerbates memory impairments and depressive-like behavior after mild traumatic brain injury (mTBI) in mice with upregulated opioid system activity
• Severity of post-mTBI deficits correlates with endogenous opioid system activity. • Increased opioid tone protects against mTBI-induced memory deficits. • Naloxone impairs memory and exacerbates depressive-like behavior only in HA mice. • mTBI strongly induces depressive-like behavior in LA mice...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Lesniak, Anna [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: Combined use of cisplatin plus natural killer cells overcomes immunoresistance of cisplatin resistant ovarian cancer - Choi, Seung Hee ELSEVIER, 2021, an international journal, Amsterdam |
|---|---|
| Übergeordnetes Werk: |
volume:326 ; year:2017 ; day:30 ; month:05 ; pages:209-216 ; extent:8 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.bbr.2017.03.015 |
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Naloxone exacerbates memory impairments and depressive-like behavior after mild traumatic brain injury (mTBI) in mice with upregulated opioid system activity |
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• Severity of post-mTBI deficits correlates with endogenous opioid system activity. • Increased opioid tone protects against mTBI-induced memory deficits. • Naloxone impairs memory and exacerbates depressive-like behavior only in HA mice. • mTBI strongly induces depressive-like behavior in LA mice |
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• Severity of post-mTBI deficits correlates with endogenous opioid system activity. • Increased opioid tone protects against mTBI-induced memory deficits. • Naloxone impairs memory and exacerbates depressive-like behavior only in HA mice. • mTBI strongly induces depressive-like behavior in LA mice |
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• Severity of post-mTBI deficits correlates with endogenous opioid system activity. • Increased opioid tone protects against mTBI-induced memory deficits. • Naloxone impairs memory and exacerbates depressive-like behavior only in HA mice. • mTBI strongly induces depressive-like behavior in LA mice |
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Naloxone exacerbates memory impairments and depressive-like behavior after mild traumatic brain injury (mTBI) in mice with upregulated opioid system activity |
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https://doi.org/10.1016/j.bbr.2017.03.015 |
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Leszczynski, Pawel Bujalska-Zadrozny, Magdalena Pick, Chaim G. Sacharczuk, Mariusz |
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Leszczynski, Pawel Bujalska-Zadrozny, Magdalena Pick, Chaim G. Sacharczuk, Mariusz |
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10.1016/j.bbr.2017.03.015 |
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2024-07-06T16:39:09.384Z |
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