Antagonizing cytokine-mediated JAK-STAT signaling by porcine reproductive and respiratory syndrome virus
• PRRSV inhibits the interferon-activated JAK-STAT1/STAT2 signaling. • PRRSV nsp1β induces degradation of KPNA1 to block the STAT1 nuclear translocation. • PRRSV nsp5 reduces STAT3 to inhibit the JAK-STAT3 signaling. • PRRSV may interfere with other STAT signaling and antagonizes ISGs.
Gespeichert in:
| Autor*in: |
Yang, Liping [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Umfang: |
9 |
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| Übergeordnetes Werk: |
Enthalten in: Grain refinement and hardness distribution in cryogenically cooled ferritic stainless steel welds - 2013, an international journal concerned with microbiological diseases of all animals that are useful to man, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:209 ; year:2017 ; pages:57-65 ; extent:9 |
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| DOI / URN: |
10.1016/j.vetmic.2016.12.036 |
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Antagonizing cytokine-mediated JAK-STAT signaling by porcine reproductive and respiratory syndrome virus |
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• PRRSV inhibits the interferon-activated JAK-STAT1/STAT2 signaling. • PRRSV nsp1β induces degradation of KPNA1 to block the STAT1 nuclear translocation. • PRRSV nsp5 reduces STAT3 to inhibit the JAK-STAT3 signaling. • PRRSV may interfere with other STAT signaling and antagonizes ISGs. |
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• PRRSV inhibits the interferon-activated JAK-STAT1/STAT2 signaling. • PRRSV nsp1β induces degradation of KPNA1 to block the STAT1 nuclear translocation. • PRRSV nsp5 reduces STAT3 to inhibit the JAK-STAT3 signaling. • PRRSV may interfere with other STAT signaling and antagonizes ISGs. |
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• PRRSV inhibits the interferon-activated JAK-STAT1/STAT2 signaling. • PRRSV nsp1β induces degradation of KPNA1 to block the STAT1 nuclear translocation. • PRRSV nsp5 reduces STAT3 to inhibit the JAK-STAT3 signaling. • PRRSV may interfere with other STAT signaling and antagonizes ISGs. |
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Antagonizing cytokine-mediated JAK-STAT signaling by porcine reproductive and respiratory syndrome virus |
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