Efficient generation of targeted and controlled mutational events in porcine cells using nuclease-directed homologous recombination
Nuclease-based genome editing has rapidly sped the creation of new models of human disease. These techniques also hold great promise for the future of clinical xenotransplantation and cell-based therapies for cancer or immunodeficient pathology. However, to fully realize the potential of nuclease ed...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Butler, James R. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: Iatrogenic pneumothorax during hypoglossal nerve stimulator implantation - Arteaga, Alberto A. ELSEVIER, 2018, JSR : clinical and laboratory investigation : official publication of the Association for Academic Surgery : official publication of the Association of Veterans Administration Surgeons, Orlando, Fla |
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| Übergeordnetes Werk: |
volume:212 ; year:2017 ; day:15 ; month:05 ; pages:238-245 ; extent:8 |
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| DOI / URN: |
10.1016/j.jss.2017.01.025 |
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efficient generation of targeted and controlled mutational events in porcine cells using nuclease-directed homologous recombination |
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Efficient generation of targeted and controlled mutational events in porcine cells using nuclease-directed homologous recombination |
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Nuclease-based genome editing has rapidly sped the creation of new models of human disease. These techniques also hold great promise for the future of clinical xenotransplantation and cell-based therapies for cancer or immunodeficient pathology. However, to fully realize the potential of nuclease editing tools, the efficiency and precision of their application must be optimized. The object of this study was to use nonintegrating selection and nuclease-directed homologous recombination to efficiently control the genetic modification of the porcine genome. |
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Nuclease-based genome editing has rapidly sped the creation of new models of human disease. These techniques also hold great promise for the future of clinical xenotransplantation and cell-based therapies for cancer or immunodeficient pathology. However, to fully realize the potential of nuclease editing tools, the efficiency and precision of their application must be optimized. The object of this study was to use nonintegrating selection and nuclease-directed homologous recombination to efficiently control the genetic modification of the porcine genome. |
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Nuclease-based genome editing has rapidly sped the creation of new models of human disease. These techniques also hold great promise for the future of clinical xenotransplantation and cell-based therapies for cancer or immunodeficient pathology. However, to fully realize the potential of nuclease editing tools, the efficiency and precision of their application must be optimized. The object of this study was to use nonintegrating selection and nuclease-directed homologous recombination to efficiently control the genetic modification of the porcine genome. |
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