In vivo photoacoustic molecular imaging of the distribution of serum albumin in rat burned skin
Information on the state of edema is important for treating severe burn injuries, but a method for noninvasive real-time quantitative diagnosis of edema is not available. Thus, in vivo spatiotemporal characteristics of serum albumin, which would behave differently from water in burned tissue, are no...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Tsunoi, Yasuyuki [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013transfer abstract |
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| Schlagwörter: |
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| Umfang: |
6 |
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| Übergeordnetes Werk: |
Enthalten in: Health-related quality of life in developmental coordination disorder and typical developing children - Redondo-Tébar, Andrés ELSEVIER, 2021, journal of the International Society for Burn Injuries, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:39 ; year:2013 ; number:7 ; pages:1403-1408 ; extent:6 |
| Links: |
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| DOI / URN: |
10.1016/j.burns.2013.03.007 |
|---|
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ELV027266397 |
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| 245 | 1 | 0 | |a In vivo photoacoustic molecular imaging of the distribution of serum albumin in rat burned skin |
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| 520 | |a Information on the state of edema is important for treating severe burn injuries, but a method for noninvasive real-time quantitative diagnosis of edema is not available. Thus, in vivo spatiotemporal characteristics of serum albumin, which would behave differently from water in burned tissue, are not fully understood. In this study, we used a photoacoustic (PA) imaging method to visualize depth distribution of albumin in a rat deep burn model, for which Evans blue was used as a nontoxic molecular probe. Water content in the tissue and urine volume were also measured for reference. We performed PA imaging of albumin in three regions in the rats, burn and nonburn regions and their boundary, and the imaging showed that albumin started to leak out of the vessels in the boundary and diffused within the burned tissue. Diffusion of albumin into the nonburn region, where water content was increased, was limited. In the burn and boundary regions, albumin-originating PA signal increased in two phases: immediately after making burns and from 24 to 72h after burn. The second increase is attributable to the selective return of water to the vessels, resulting in increased concentration of albumin in extravascular tissue. | ||
| 520 | |a Information on the state of edema is important for treating severe burn injuries, but a method for noninvasive real-time quantitative diagnosis of edema is not available. Thus, in vivo spatiotemporal characteristics of serum albumin, which would behave differently from water in burned tissue, are not fully understood. In this study, we used a photoacoustic (PA) imaging method to visualize depth distribution of albumin in a rat deep burn model, for which Evans blue was used as a nontoxic molecular probe. Water content in the tissue and urine volume were also measured for reference. We performed PA imaging of albumin in three regions in the rats, burn and nonburn regions and their boundary, and the imaging showed that albumin started to leak out of the vessels in the boundary and diffused within the burned tissue. Diffusion of albumin into the nonburn region, where water content was increased, was limited. In the burn and boundary regions, albumin-originating PA signal increased in two phases: immediately after making burns and from 24 to 72h after burn. The second increase is attributable to the selective return of water to the vessels, resulting in increased concentration of albumin in extravascular tissue. | ||
| 650 | 7 | |a Rat skin tissue |2 Elsevier | |
| 650 | 7 | |a Photoacoustic imaging |2 Elsevier | |
| 650 | 7 | |a Serum albumin |2 Elsevier | |
| 650 | 7 | |a Burn edema |2 Elsevier | |
| 650 | 7 | |a Noninvasive |2 Elsevier | |
| 700 | 1 | |a Sato, Shunichi |4 oth | |
| 700 | 1 | |a Kawauchi, Satoko |4 oth | |
| 700 | 1 | |a Ashida, Hiroshi |4 oth | |
| 700 | 1 | |a Saitoh, Daizoh |4 oth | |
| 700 | 1 | |a Terakawa, Mitsuhiro |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Redondo-Tébar, Andrés ELSEVIER |t Health-related quality of life in developmental coordination disorder and typical developing children |d 2021 |d journal of the International Society for Burn Injuries |g Amsterdam [u.a.] |w (DE-627)ELV006988156 |
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10.1016/j.burns.2013.03.007 doi GBVA2013010000024.pica (DE-627)ELV027266397 (ELSEVIER)S0305-4179(13)00081-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.67 bkl Tsunoi, Yasuyuki verfasserin aut In vivo photoacoustic molecular imaging of the distribution of serum albumin in rat burned skin 2013transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Information on the state of edema is important for treating severe burn injuries, but a method for noninvasive real-time quantitative diagnosis of edema is not available. Thus, in vivo spatiotemporal characteristics of serum albumin, which would behave differently from water in burned tissue, are not fully understood. In this study, we used a photoacoustic (PA) imaging method to visualize depth distribution of albumin in a rat deep burn model, for which Evans blue was used as a nontoxic molecular probe. Water content in the tissue and urine volume were also measured for reference. We performed PA imaging of albumin in three regions in the rats, burn and nonburn regions and their boundary, and the imaging showed that albumin started to leak out of the vessels in the boundary and diffused within the burned tissue. Diffusion of albumin into the nonburn region, where water content was increased, was limited. In the burn and boundary regions, albumin-originating PA signal increased in two phases: immediately after making burns and from 24 to 72h after burn. The second increase is attributable to the selective return of water to the vessels, resulting in increased concentration of albumin in extravascular tissue. Information on the state of edema is important for treating severe burn injuries, but a method for noninvasive real-time quantitative diagnosis of edema is not available. Thus, in vivo spatiotemporal characteristics of serum albumin, which would behave differently from water in burned tissue, are not fully understood. In this study, we used a photoacoustic (PA) imaging method to visualize depth distribution of albumin in a rat deep burn model, for which Evans blue was used as a nontoxic molecular probe. Water content in the tissue and urine volume were also measured for reference. We performed PA imaging of albumin in three regions in the rats, burn and nonburn regions and their boundary, and the imaging showed that albumin started to leak out of the vessels in the boundary and diffused within the burned tissue. Diffusion of albumin into the nonburn region, where water content was increased, was limited. In the burn and boundary regions, albumin-originating PA signal increased in two phases: immediately after making burns and from 24 to 72h after burn. The second increase is attributable to the selective return of water to the vessels, resulting in increased concentration of albumin in extravascular tissue. Rat skin tissue Elsevier Photoacoustic imaging Elsevier Serum albumin Elsevier Burn edema Elsevier Noninvasive Elsevier Sato, Shunichi oth Kawauchi, Satoko oth Ashida, Hiroshi oth Saitoh, Daizoh oth Terakawa, Mitsuhiro oth Enthalten in Elsevier Science Redondo-Tébar, Andrés ELSEVIER Health-related quality of life in developmental coordination disorder and typical developing children 2021 journal of the International Society for Burn Injuries Amsterdam [u.a.] (DE-627)ELV006988156 volume:39 year:2013 number:7 pages:1403-1408 extent:6 https://doi.org/10.1016/j.burns.2013.03.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.67 Kinderheilkunde VZ AR 39 2013 7 1403-1408 6 045F 610 |
| spelling |
10.1016/j.burns.2013.03.007 doi GBVA2013010000024.pica (DE-627)ELV027266397 (ELSEVIER)S0305-4179(13)00081-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.67 bkl Tsunoi, Yasuyuki verfasserin aut In vivo photoacoustic molecular imaging of the distribution of serum albumin in rat burned skin 2013transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Information on the state of edema is important for treating severe burn injuries, but a method for noninvasive real-time quantitative diagnosis of edema is not available. Thus, in vivo spatiotemporal characteristics of serum albumin, which would behave differently from water in burned tissue, are not fully understood. In this study, we used a photoacoustic (PA) imaging method to visualize depth distribution of albumin in a rat deep burn model, for which Evans blue was used as a nontoxic molecular probe. Water content in the tissue and urine volume were also measured for reference. We performed PA imaging of albumin in three regions in the rats, burn and nonburn regions and their boundary, and the imaging showed that albumin started to leak out of the vessels in the boundary and diffused within the burned tissue. Diffusion of albumin into the nonburn region, where water content was increased, was limited. In the burn and boundary regions, albumin-originating PA signal increased in two phases: immediately after making burns and from 24 to 72h after burn. The second increase is attributable to the selective return of water to the vessels, resulting in increased concentration of albumin in extravascular tissue. Information on the state of edema is important for treating severe burn injuries, but a method for noninvasive real-time quantitative diagnosis of edema is not available. Thus, in vivo spatiotemporal characteristics of serum albumin, which would behave differently from water in burned tissue, are not fully understood. In this study, we used a photoacoustic (PA) imaging method to visualize depth distribution of albumin in a rat deep burn model, for which Evans blue was used as a nontoxic molecular probe. Water content in the tissue and urine volume were also measured for reference. We performed PA imaging of albumin in three regions in the rats, burn and nonburn regions and their boundary, and the imaging showed that albumin started to leak out of the vessels in the boundary and diffused within the burned tissue. Diffusion of albumin into the nonburn region, where water content was increased, was limited. In the burn and boundary regions, albumin-originating PA signal increased in two phases: immediately after making burns and from 24 to 72h after burn. The second increase is attributable to the selective return of water to the vessels, resulting in increased concentration of albumin in extravascular tissue. Rat skin tissue Elsevier Photoacoustic imaging Elsevier Serum albumin Elsevier Burn edema Elsevier Noninvasive Elsevier Sato, Shunichi oth Kawauchi, Satoko oth Ashida, Hiroshi oth Saitoh, Daizoh oth Terakawa, Mitsuhiro oth Enthalten in Elsevier Science Redondo-Tébar, Andrés ELSEVIER Health-related quality of life in developmental coordination disorder and typical developing children 2021 journal of the International Society for Burn Injuries Amsterdam [u.a.] (DE-627)ELV006988156 volume:39 year:2013 number:7 pages:1403-1408 extent:6 https://doi.org/10.1016/j.burns.2013.03.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.67 Kinderheilkunde VZ AR 39 2013 7 1403-1408 6 045F 610 |
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10.1016/j.burns.2013.03.007 doi GBVA2013010000024.pica (DE-627)ELV027266397 (ELSEVIER)S0305-4179(13)00081-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.67 bkl Tsunoi, Yasuyuki verfasserin aut In vivo photoacoustic molecular imaging of the distribution of serum albumin in rat burned skin 2013transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Information on the state of edema is important for treating severe burn injuries, but a method for noninvasive real-time quantitative diagnosis of edema is not available. Thus, in vivo spatiotemporal characteristics of serum albumin, which would behave differently from water in burned tissue, are not fully understood. In this study, we used a photoacoustic (PA) imaging method to visualize depth distribution of albumin in a rat deep burn model, for which Evans blue was used as a nontoxic molecular probe. Water content in the tissue and urine volume were also measured for reference. We performed PA imaging of albumin in three regions in the rats, burn and nonburn regions and their boundary, and the imaging showed that albumin started to leak out of the vessels in the boundary and diffused within the burned tissue. Diffusion of albumin into the nonburn region, where water content was increased, was limited. In the burn and boundary regions, albumin-originating PA signal increased in two phases: immediately after making burns and from 24 to 72h after burn. The second increase is attributable to the selective return of water to the vessels, resulting in increased concentration of albumin in extravascular tissue. Information on the state of edema is important for treating severe burn injuries, but a method for noninvasive real-time quantitative diagnosis of edema is not available. Thus, in vivo spatiotemporal characteristics of serum albumin, which would behave differently from water in burned tissue, are not fully understood. In this study, we used a photoacoustic (PA) imaging method to visualize depth distribution of albumin in a rat deep burn model, for which Evans blue was used as a nontoxic molecular probe. Water content in the tissue and urine volume were also measured for reference. We performed PA imaging of albumin in three regions in the rats, burn and nonburn regions and their boundary, and the imaging showed that albumin started to leak out of the vessels in the boundary and diffused within the burned tissue. Diffusion of albumin into the nonburn region, where water content was increased, was limited. In the burn and boundary regions, albumin-originating PA signal increased in two phases: immediately after making burns and from 24 to 72h after burn. The second increase is attributable to the selective return of water to the vessels, resulting in increased concentration of albumin in extravascular tissue. Rat skin tissue Elsevier Photoacoustic imaging Elsevier Serum albumin Elsevier Burn edema Elsevier Noninvasive Elsevier Sato, Shunichi oth Kawauchi, Satoko oth Ashida, Hiroshi oth Saitoh, Daizoh oth Terakawa, Mitsuhiro oth Enthalten in Elsevier Science Redondo-Tébar, Andrés ELSEVIER Health-related quality of life in developmental coordination disorder and typical developing children 2021 journal of the International Society for Burn Injuries Amsterdam [u.a.] (DE-627)ELV006988156 volume:39 year:2013 number:7 pages:1403-1408 extent:6 https://doi.org/10.1016/j.burns.2013.03.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.67 Kinderheilkunde VZ AR 39 2013 7 1403-1408 6 045F 610 |
| allfieldsGer |
10.1016/j.burns.2013.03.007 doi GBVA2013010000024.pica (DE-627)ELV027266397 (ELSEVIER)S0305-4179(13)00081-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.67 bkl Tsunoi, Yasuyuki verfasserin aut In vivo photoacoustic molecular imaging of the distribution of serum albumin in rat burned skin 2013transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Information on the state of edema is important for treating severe burn injuries, but a method for noninvasive real-time quantitative diagnosis of edema is not available. Thus, in vivo spatiotemporal characteristics of serum albumin, which would behave differently from water in burned tissue, are not fully understood. In this study, we used a photoacoustic (PA) imaging method to visualize depth distribution of albumin in a rat deep burn model, for which Evans blue was used as a nontoxic molecular probe. Water content in the tissue and urine volume were also measured for reference. We performed PA imaging of albumin in three regions in the rats, burn and nonburn regions and their boundary, and the imaging showed that albumin started to leak out of the vessels in the boundary and diffused within the burned tissue. Diffusion of albumin into the nonburn region, where water content was increased, was limited. In the burn and boundary regions, albumin-originating PA signal increased in two phases: immediately after making burns and from 24 to 72h after burn. The second increase is attributable to the selective return of water to the vessels, resulting in increased concentration of albumin in extravascular tissue. Information on the state of edema is important for treating severe burn injuries, but a method for noninvasive real-time quantitative diagnosis of edema is not available. Thus, in vivo spatiotemporal characteristics of serum albumin, which would behave differently from water in burned tissue, are not fully understood. In this study, we used a photoacoustic (PA) imaging method to visualize depth distribution of albumin in a rat deep burn model, for which Evans blue was used as a nontoxic molecular probe. Water content in the tissue and urine volume were also measured for reference. We performed PA imaging of albumin in three regions in the rats, burn and nonburn regions and their boundary, and the imaging showed that albumin started to leak out of the vessels in the boundary and diffused within the burned tissue. Diffusion of albumin into the nonburn region, where water content was increased, was limited. In the burn and boundary regions, albumin-originating PA signal increased in two phases: immediately after making burns and from 24 to 72h after burn. The second increase is attributable to the selective return of water to the vessels, resulting in increased concentration of albumin in extravascular tissue. Rat skin tissue Elsevier Photoacoustic imaging Elsevier Serum albumin Elsevier Burn edema Elsevier Noninvasive Elsevier Sato, Shunichi oth Kawauchi, Satoko oth Ashida, Hiroshi oth Saitoh, Daizoh oth Terakawa, Mitsuhiro oth Enthalten in Elsevier Science Redondo-Tébar, Andrés ELSEVIER Health-related quality of life in developmental coordination disorder and typical developing children 2021 journal of the International Society for Burn Injuries Amsterdam [u.a.] (DE-627)ELV006988156 volume:39 year:2013 number:7 pages:1403-1408 extent:6 https://doi.org/10.1016/j.burns.2013.03.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.67 Kinderheilkunde VZ AR 39 2013 7 1403-1408 6 045F 610 |
| allfieldsSound |
10.1016/j.burns.2013.03.007 doi GBVA2013010000024.pica (DE-627)ELV027266397 (ELSEVIER)S0305-4179(13)00081-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.67 bkl Tsunoi, Yasuyuki verfasserin aut In vivo photoacoustic molecular imaging of the distribution of serum albumin in rat burned skin 2013transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Information on the state of edema is important for treating severe burn injuries, but a method for noninvasive real-time quantitative diagnosis of edema is not available. Thus, in vivo spatiotemporal characteristics of serum albumin, which would behave differently from water in burned tissue, are not fully understood. In this study, we used a photoacoustic (PA) imaging method to visualize depth distribution of albumin in a rat deep burn model, for which Evans blue was used as a nontoxic molecular probe. Water content in the tissue and urine volume were also measured for reference. We performed PA imaging of albumin in three regions in the rats, burn and nonburn regions and their boundary, and the imaging showed that albumin started to leak out of the vessels in the boundary and diffused within the burned tissue. Diffusion of albumin into the nonburn region, where water content was increased, was limited. In the burn and boundary regions, albumin-originating PA signal increased in two phases: immediately after making burns and from 24 to 72h after burn. The second increase is attributable to the selective return of water to the vessels, resulting in increased concentration of albumin in extravascular tissue. Information on the state of edema is important for treating severe burn injuries, but a method for noninvasive real-time quantitative diagnosis of edema is not available. Thus, in vivo spatiotemporal characteristics of serum albumin, which would behave differently from water in burned tissue, are not fully understood. In this study, we used a photoacoustic (PA) imaging method to visualize depth distribution of albumin in a rat deep burn model, for which Evans blue was used as a nontoxic molecular probe. Water content in the tissue and urine volume were also measured for reference. We performed PA imaging of albumin in three regions in the rats, burn and nonburn regions and their boundary, and the imaging showed that albumin started to leak out of the vessels in the boundary and diffused within the burned tissue. Diffusion of albumin into the nonburn region, where water content was increased, was limited. In the burn and boundary regions, albumin-originating PA signal increased in two phases: immediately after making burns and from 24 to 72h after burn. The second increase is attributable to the selective return of water to the vessels, resulting in increased concentration of albumin in extravascular tissue. Rat skin tissue Elsevier Photoacoustic imaging Elsevier Serum albumin Elsevier Burn edema Elsevier Noninvasive Elsevier Sato, Shunichi oth Kawauchi, Satoko oth Ashida, Hiroshi oth Saitoh, Daizoh oth Terakawa, Mitsuhiro oth Enthalten in Elsevier Science Redondo-Tébar, Andrés ELSEVIER Health-related quality of life in developmental coordination disorder and typical developing children 2021 journal of the International Society for Burn Injuries Amsterdam [u.a.] (DE-627)ELV006988156 volume:39 year:2013 number:7 pages:1403-1408 extent:6 https://doi.org/10.1016/j.burns.2013.03.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.67 Kinderheilkunde VZ AR 39 2013 7 1403-1408 6 045F 610 |
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Enthalten in Health-related quality of life in developmental coordination disorder and typical developing children Amsterdam [u.a.] volume:39 year:2013 number:7 pages:1403-1408 extent:6 |
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In vivo photoacoustic molecular imaging of the distribution of serum albumin in rat burned skin |
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Information on the state of edema is important for treating severe burn injuries, but a method for noninvasive real-time quantitative diagnosis of edema is not available. Thus, in vivo spatiotemporal characteristics of serum albumin, which would behave differently from water in burned tissue, are not fully understood. In this study, we used a photoacoustic (PA) imaging method to visualize depth distribution of albumin in a rat deep burn model, for which Evans blue was used as a nontoxic molecular probe. Water content in the tissue and urine volume were also measured for reference. We performed PA imaging of albumin in three regions in the rats, burn and nonburn regions and their boundary, and the imaging showed that albumin started to leak out of the vessels in the boundary and diffused within the burned tissue. Diffusion of albumin into the nonburn region, where water content was increased, was limited. In the burn and boundary regions, albumin-originating PA signal increased in two phases: immediately after making burns and from 24 to 72h after burn. The second increase is attributable to the selective return of water to the vessels, resulting in increased concentration of albumin in extravascular tissue. |
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Information on the state of edema is important for treating severe burn injuries, but a method for noninvasive real-time quantitative diagnosis of edema is not available. Thus, in vivo spatiotemporal characteristics of serum albumin, which would behave differently from water in burned tissue, are not fully understood. In this study, we used a photoacoustic (PA) imaging method to visualize depth distribution of albumin in a rat deep burn model, for which Evans blue was used as a nontoxic molecular probe. Water content in the tissue and urine volume were also measured for reference. We performed PA imaging of albumin in three regions in the rats, burn and nonburn regions and their boundary, and the imaging showed that albumin started to leak out of the vessels in the boundary and diffused within the burned tissue. Diffusion of albumin into the nonburn region, where water content was increased, was limited. In the burn and boundary regions, albumin-originating PA signal increased in two phases: immediately after making burns and from 24 to 72h after burn. The second increase is attributable to the selective return of water to the vessels, resulting in increased concentration of albumin in extravascular tissue. |
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Information on the state of edema is important for treating severe burn injuries, but a method for noninvasive real-time quantitative diagnosis of edema is not available. Thus, in vivo spatiotemporal characteristics of serum albumin, which would behave differently from water in burned tissue, are not fully understood. In this study, we used a photoacoustic (PA) imaging method to visualize depth distribution of albumin in a rat deep burn model, for which Evans blue was used as a nontoxic molecular probe. Water content in the tissue and urine volume were also measured for reference. We performed PA imaging of albumin in three regions in the rats, burn and nonburn regions and their boundary, and the imaging showed that albumin started to leak out of the vessels in the boundary and diffused within the burned tissue. Diffusion of albumin into the nonburn region, where water content was increased, was limited. In the burn and boundary regions, albumin-originating PA signal increased in two phases: immediately after making burns and from 24 to 72h after burn. The second increase is attributable to the selective return of water to the vessels, resulting in increased concentration of albumin in extravascular tissue. |
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