Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis
• Intracellular aggregation of mutant SOD1 is a major pathological change in ALS. • In vitro SOD1 fibrillar aggregates seed aggregation of endogenous SOD1 in cells. • Seeded aggregation of mutant SOD1 may describe propagation of SOD1 pathology in ALS.
Gespeichert in:
| Autor*in: |
Furukawa, Yoshiaki [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Umfang: |
6 |
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| Übergeordnetes Werk: |
Enthalten in: Mitigating the environmental impacts of milk production via anaerobic digestion of manure: Case study of a dairy farm in the Po Valley - Battini, F. ELSEVIER, 2014, for the rapid publication of short reports in biochemistry, biophysics, and molecular biology, Chichester |
|---|---|
| Übergeordnetes Werk: |
volume:587 ; year:2013 ; number:16 ; day:19 ; month:08 ; pages:2500-2505 ; extent:6 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.febslet.2013.06.046 |
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• Intracellular aggregation of mutant SOD1 is a major pathological change in ALS. • In vitro SOD1 fibrillar aggregates seed aggregation of endogenous SOD1 in cells. • Seeded aggregation of mutant SOD1 may describe propagation of SOD1 pathology in ALS. |
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