E-ADA activity in erythrocytes of lambs experimentally infected with Haemonchus contortus and its possible functional correlations with anemia
The aim of this study was to evaluate the ecto-adenosine deaminase (E-ADA) activity in erythrocytes of lambs experimentally infected with Haemonchus contortus, correlating it with the degrees of anemia of the experimental animals. A total of 14 healthy lambs, with negative fecal exam for parasites,...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Da Silva, Aleksandro S. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013transfer abstract |
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| Schlagwörter: |
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| Umfang: |
5 |
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| Übergeordnetes Werk: |
Enthalten in: Physical activity temporal trends among children and adolescents - Booth, Verity M. ELSEVIER, 2015, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:95 ; year:2013 ; number:3 ; pages:1026-1030 ; extent:5 |
| Links: |
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| DOI / URN: |
10.1016/j.rvsc.2013.07.008 |
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ELV027711293 |
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| 245 | 1 | 0 | |a E-ADA activity in erythrocytes of lambs experimentally infected with Haemonchus contortus and its possible functional correlations with anemia |
| 264 | 1 | |c 2013transfer abstract | |
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| 520 | |a The aim of this study was to evaluate the ecto-adenosine deaminase (E-ADA) activity in erythrocytes of lambs experimentally infected with Haemonchus contortus, correlating it with the degrees of anemia of the experimental animals. A total of 14 healthy lambs, with negative fecal exam for parasites, were to carry out the present study. They were divided into two groups, composed by seven animals: Group A represented the healthy animals (uninfected), while in Group B the animals were infected with 15,000 larvae of H. contortus. Blood was drawn on the days 15, 45 and 75 post-infection (PI) in order to perform the hematological analysis, as well as the mensuration of E-ADA activity in erythrocytes. Parasitological stool exam were performed on the same days mentioned above to follow up the evolution of the infection, as well to determine the number of eggs per gram of feces (EPG). On day 15PI, the animals presented negative EPG and there was not significant (P >0.05) difference between groups in relation to E-ADA activity and hematologic parameters. Animals in Group B had positive EPG for helminths on days 45 and 75 PI, accompanied by varying degrees of anemia, when compared to Group A. At the same periods E-ADA activity was significantly (P <0.05) increased in the erythrocytes of animals of Group B when compared with the not-infected ones. Statistically, there was a negative correlation (P <0.01) between activity E-ADA in erythrocytes and hematocrit on days 45 (r =−0.76) and 75 (r =−0.85)PI. Based on these results and in the scientific literature, it is possible to conclude that the E-ADA may participate on mechanisms related with the pathogenesis and host response against anemia caused by H. contortus. | ||
| 520 | |a The aim of this study was to evaluate the ecto-adenosine deaminase (E-ADA) activity in erythrocytes of lambs experimentally infected with Haemonchus contortus, correlating it with the degrees of anemia of the experimental animals. A total of 14 healthy lambs, with negative fecal exam for parasites, were to carry out the present study. They were divided into two groups, composed by seven animals: Group A represented the healthy animals (uninfected), while in Group B the animals were infected with 15,000 larvae of H. contortus. Blood was drawn on the days 15, 45 and 75 post-infection (PI) in order to perform the hematological analysis, as well as the mensuration of E-ADA activity in erythrocytes. Parasitological stool exam were performed on the same days mentioned above to follow up the evolution of the infection, as well to determine the number of eggs per gram of feces (EPG). On day 15PI, the animals presented negative EPG and there was not significant (P >0.05) difference between groups in relation to E-ADA activity and hematologic parameters. Animals in Group B had positive EPG for helminths on days 45 and 75 PI, accompanied by varying degrees of anemia, when compared to Group A. At the same periods E-ADA activity was significantly (P <0.05) increased in the erythrocytes of animals of Group B when compared with the not-infected ones. Statistically, there was a negative correlation (P <0.01) between activity E-ADA in erythrocytes and hematocrit on days 45 (r =−0.76) and 75 (r =−0.85)PI. Based on these results and in the scientific literature, it is possible to conclude that the E-ADA may participate on mechanisms related with the pathogenesis and host response against anemia caused by H. contortus. | ||
| 650 | 7 | |a Haemonchus |2 Elsevier | |
| 650 | 7 | |a Adenosine |2 Elsevier | |
| 650 | 7 | |a Hematology |2 Elsevier | |
| 650 | 7 | |a Trichostrongylus |2 Elsevier | |
| 650 | 7 | |a Sheep |2 Elsevier | |
| 650 | 7 | |a Helminths |2 Elsevier | |
| 700 | 1 | |a Schafer, Andressa S. |4 oth | |
| 700 | 1 | |a Aires, Adelina R. |4 oth | |
| 700 | 1 | |a Tonin, Alexandre A. |4 oth | |
| 700 | 1 | |a Pimentel, Victor C. |4 oth | |
| 700 | 1 | |a Oliveira, Camila B. |4 oth | |
| 700 | 1 | |a Zanini, Daniela |4 oth | |
| 700 | 1 | |a Schetinger, Maria R.C. |4 oth | |
| 700 | 1 | |a Lopes, Sonia T.A. |4 oth | |
| 700 | 1 | |a Leal, Marta L.R. |4 oth | |
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10.1016/j.rvsc.2013.07.008 doi GBVA2013023000004.pica (DE-627)ELV027711293 (ELSEVIER)S0034-5288(13)00233-6 DE-627 ger DE-627 rakwb eng 630 630 DE-600 610 VZ 796 VZ 670 VZ 51.60 bkl 58.45 bkl Da Silva, Aleksandro S. verfasserin aut E-ADA activity in erythrocytes of lambs experimentally infected with Haemonchus contortus and its possible functional correlations with anemia 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The aim of this study was to evaluate the ecto-adenosine deaminase (E-ADA) activity in erythrocytes of lambs experimentally infected with Haemonchus contortus, correlating it with the degrees of anemia of the experimental animals. A total of 14 healthy lambs, with negative fecal exam for parasites, were to carry out the present study. They were divided into two groups, composed by seven animals: Group A represented the healthy animals (uninfected), while in Group B the animals were infected with 15,000 larvae of H. contortus. Blood was drawn on the days 15, 45 and 75 post-infection (PI) in order to perform the hematological analysis, as well as the mensuration of E-ADA activity in erythrocytes. Parasitological stool exam were performed on the same days mentioned above to follow up the evolution of the infection, as well to determine the number of eggs per gram of feces (EPG). On day 15PI, the animals presented negative EPG and there was not significant (P >0.05) difference between groups in relation to E-ADA activity and hematologic parameters. Animals in Group B had positive EPG for helminths on days 45 and 75 PI, accompanied by varying degrees of anemia, when compared to Group A. At the same periods E-ADA activity was significantly (P <0.05) increased in the erythrocytes of animals of Group B when compared with the not-infected ones. Statistically, there was a negative correlation (P <0.01) between activity E-ADA in erythrocytes and hematocrit on days 45 (r =−0.76) and 75 (r =−0.85)PI. Based on these results and in the scientific literature, it is possible to conclude that the E-ADA may participate on mechanisms related with the pathogenesis and host response against anemia caused by H. contortus. The aim of this study was to evaluate the ecto-adenosine deaminase (E-ADA) activity in erythrocytes of lambs experimentally infected with Haemonchus contortus, correlating it with the degrees of anemia of the experimental animals. A total of 14 healthy lambs, with negative fecal exam for parasites, were to carry out the present study. They were divided into two groups, composed by seven animals: Group A represented the healthy animals (uninfected), while in Group B the animals were infected with 15,000 larvae of H. contortus. Blood was drawn on the days 15, 45 and 75 post-infection (PI) in order to perform the hematological analysis, as well as the mensuration of E-ADA activity in erythrocytes. Parasitological stool exam were performed on the same days mentioned above to follow up the evolution of the infection, as well to determine the number of eggs per gram of feces (EPG). On day 15PI, the animals presented negative EPG and there was not significant (P >0.05) difference between groups in relation to E-ADA activity and hematologic parameters. Animals in Group B had positive EPG for helminths on days 45 and 75 PI, accompanied by varying degrees of anemia, when compared to Group A. At the same periods E-ADA activity was significantly (P <0.05) increased in the erythrocytes of animals of Group B when compared with the not-infected ones. Statistically, there was a negative correlation (P <0.01) between activity E-ADA in erythrocytes and hematocrit on days 45 (r =−0.76) and 75 (r =−0.85)PI. Based on these results and in the scientific literature, it is possible to conclude that the E-ADA may participate on mechanisms related with the pathogenesis and host response against anemia caused by H. contortus. Haemonchus Elsevier Adenosine Elsevier Hematology Elsevier Trichostrongylus Elsevier Sheep Elsevier Helminths Elsevier Schafer, Andressa S. oth Aires, Adelina R. oth Tonin, Alexandre A. oth Pimentel, Victor C. oth Oliveira, Camila B. oth Zanini, Daniela oth Schetinger, Maria R.C. oth Lopes, Sonia T.A. oth Leal, Marta L.R. oth Enthalten in Elsevier Booth, Verity M. ELSEVIER Physical activity temporal trends among children and adolescents 2015 Amsterdam [u.a.] (DE-627)ELV012775517 volume:95 year:2013 number:3 pages:1026-1030 extent:5 https://doi.org/10.1016/j.rvsc.2013.07.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_22 GBV_ILN_24 GBV_ILN_60 GBV_ILN_181 GBV_ILN_227 GBV_ILN_352 GBV_ILN_2084 51.60 Keramische Werkstoffe Hartstoffe Werkstoffkunde VZ 58.45 Gesteinshüttenkunde VZ AR 95 2013 3 1026-1030 5 045F 630 |
| spelling |
10.1016/j.rvsc.2013.07.008 doi GBVA2013023000004.pica (DE-627)ELV027711293 (ELSEVIER)S0034-5288(13)00233-6 DE-627 ger DE-627 rakwb eng 630 630 DE-600 610 VZ 796 VZ 670 VZ 51.60 bkl 58.45 bkl Da Silva, Aleksandro S. verfasserin aut E-ADA activity in erythrocytes of lambs experimentally infected with Haemonchus contortus and its possible functional correlations with anemia 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The aim of this study was to evaluate the ecto-adenosine deaminase (E-ADA) activity in erythrocytes of lambs experimentally infected with Haemonchus contortus, correlating it with the degrees of anemia of the experimental animals. A total of 14 healthy lambs, with negative fecal exam for parasites, were to carry out the present study. They were divided into two groups, composed by seven animals: Group A represented the healthy animals (uninfected), while in Group B the animals were infected with 15,000 larvae of H. contortus. Blood was drawn on the days 15, 45 and 75 post-infection (PI) in order to perform the hematological analysis, as well as the mensuration of E-ADA activity in erythrocytes. Parasitological stool exam were performed on the same days mentioned above to follow up the evolution of the infection, as well to determine the number of eggs per gram of feces (EPG). On day 15PI, the animals presented negative EPG and there was not significant (P >0.05) difference between groups in relation to E-ADA activity and hematologic parameters. Animals in Group B had positive EPG for helminths on days 45 and 75 PI, accompanied by varying degrees of anemia, when compared to Group A. At the same periods E-ADA activity was significantly (P <0.05) increased in the erythrocytes of animals of Group B when compared with the not-infected ones. Statistically, there was a negative correlation (P <0.01) between activity E-ADA in erythrocytes and hematocrit on days 45 (r =−0.76) and 75 (r =−0.85)PI. Based on these results and in the scientific literature, it is possible to conclude that the E-ADA may participate on mechanisms related with the pathogenesis and host response against anemia caused by H. contortus. The aim of this study was to evaluate the ecto-adenosine deaminase (E-ADA) activity in erythrocytes of lambs experimentally infected with Haemonchus contortus, correlating it with the degrees of anemia of the experimental animals. A total of 14 healthy lambs, with negative fecal exam for parasites, were to carry out the present study. They were divided into two groups, composed by seven animals: Group A represented the healthy animals (uninfected), while in Group B the animals were infected with 15,000 larvae of H. contortus. Blood was drawn on the days 15, 45 and 75 post-infection (PI) in order to perform the hematological analysis, as well as the mensuration of E-ADA activity in erythrocytes. Parasitological stool exam were performed on the same days mentioned above to follow up the evolution of the infection, as well to determine the number of eggs per gram of feces (EPG). On day 15PI, the animals presented negative EPG and there was not significant (P >0.05) difference between groups in relation to E-ADA activity and hematologic parameters. Animals in Group B had positive EPG for helminths on days 45 and 75 PI, accompanied by varying degrees of anemia, when compared to Group A. At the same periods E-ADA activity was significantly (P <0.05) increased in the erythrocytes of animals of Group B when compared with the not-infected ones. Statistically, there was a negative correlation (P <0.01) between activity E-ADA in erythrocytes and hematocrit on days 45 (r =−0.76) and 75 (r =−0.85)PI. Based on these results and in the scientific literature, it is possible to conclude that the E-ADA may participate on mechanisms related with the pathogenesis and host response against anemia caused by H. contortus. Haemonchus Elsevier Adenosine Elsevier Hematology Elsevier Trichostrongylus Elsevier Sheep Elsevier Helminths Elsevier Schafer, Andressa S. oth Aires, Adelina R. oth Tonin, Alexandre A. oth Pimentel, Victor C. oth Oliveira, Camila B. oth Zanini, Daniela oth Schetinger, Maria R.C. oth Lopes, Sonia T.A. oth Leal, Marta L.R. oth Enthalten in Elsevier Booth, Verity M. ELSEVIER Physical activity temporal trends among children and adolescents 2015 Amsterdam [u.a.] (DE-627)ELV012775517 volume:95 year:2013 number:3 pages:1026-1030 extent:5 https://doi.org/10.1016/j.rvsc.2013.07.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_22 GBV_ILN_24 GBV_ILN_60 GBV_ILN_181 GBV_ILN_227 GBV_ILN_352 GBV_ILN_2084 51.60 Keramische Werkstoffe Hartstoffe Werkstoffkunde VZ 58.45 Gesteinshüttenkunde VZ AR 95 2013 3 1026-1030 5 045F 630 |
| allfields_unstemmed |
10.1016/j.rvsc.2013.07.008 doi GBVA2013023000004.pica (DE-627)ELV027711293 (ELSEVIER)S0034-5288(13)00233-6 DE-627 ger DE-627 rakwb eng 630 630 DE-600 610 VZ 796 VZ 670 VZ 51.60 bkl 58.45 bkl Da Silva, Aleksandro S. verfasserin aut E-ADA activity in erythrocytes of lambs experimentally infected with Haemonchus contortus and its possible functional correlations with anemia 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The aim of this study was to evaluate the ecto-adenosine deaminase (E-ADA) activity in erythrocytes of lambs experimentally infected with Haemonchus contortus, correlating it with the degrees of anemia of the experimental animals. A total of 14 healthy lambs, with negative fecal exam for parasites, were to carry out the present study. They were divided into two groups, composed by seven animals: Group A represented the healthy animals (uninfected), while in Group B the animals were infected with 15,000 larvae of H. contortus. Blood was drawn on the days 15, 45 and 75 post-infection (PI) in order to perform the hematological analysis, as well as the mensuration of E-ADA activity in erythrocytes. Parasitological stool exam were performed on the same days mentioned above to follow up the evolution of the infection, as well to determine the number of eggs per gram of feces (EPG). On day 15PI, the animals presented negative EPG and there was not significant (P >0.05) difference between groups in relation to E-ADA activity and hematologic parameters. Animals in Group B had positive EPG for helminths on days 45 and 75 PI, accompanied by varying degrees of anemia, when compared to Group A. At the same periods E-ADA activity was significantly (P <0.05) increased in the erythrocytes of animals of Group B when compared with the not-infected ones. Statistically, there was a negative correlation (P <0.01) between activity E-ADA in erythrocytes and hematocrit on days 45 (r =−0.76) and 75 (r =−0.85)PI. Based on these results and in the scientific literature, it is possible to conclude that the E-ADA may participate on mechanisms related with the pathogenesis and host response against anemia caused by H. contortus. The aim of this study was to evaluate the ecto-adenosine deaminase (E-ADA) activity in erythrocytes of lambs experimentally infected with Haemonchus contortus, correlating it with the degrees of anemia of the experimental animals. A total of 14 healthy lambs, with negative fecal exam for parasites, were to carry out the present study. They were divided into two groups, composed by seven animals: Group A represented the healthy animals (uninfected), while in Group B the animals were infected with 15,000 larvae of H. contortus. Blood was drawn on the days 15, 45 and 75 post-infection (PI) in order to perform the hematological analysis, as well as the mensuration of E-ADA activity in erythrocytes. Parasitological stool exam were performed on the same days mentioned above to follow up the evolution of the infection, as well to determine the number of eggs per gram of feces (EPG). On day 15PI, the animals presented negative EPG and there was not significant (P >0.05) difference between groups in relation to E-ADA activity and hematologic parameters. Animals in Group B had positive EPG for helminths on days 45 and 75 PI, accompanied by varying degrees of anemia, when compared to Group A. At the same periods E-ADA activity was significantly (P <0.05) increased in the erythrocytes of animals of Group B when compared with the not-infected ones. Statistically, there was a negative correlation (P <0.01) between activity E-ADA in erythrocytes and hematocrit on days 45 (r =−0.76) and 75 (r =−0.85)PI. Based on these results and in the scientific literature, it is possible to conclude that the E-ADA may participate on mechanisms related with the pathogenesis and host response against anemia caused by H. contortus. Haemonchus Elsevier Adenosine Elsevier Hematology Elsevier Trichostrongylus Elsevier Sheep Elsevier Helminths Elsevier Schafer, Andressa S. oth Aires, Adelina R. oth Tonin, Alexandre A. oth Pimentel, Victor C. oth Oliveira, Camila B. oth Zanini, Daniela oth Schetinger, Maria R.C. oth Lopes, Sonia T.A. oth Leal, Marta L.R. oth Enthalten in Elsevier Booth, Verity M. ELSEVIER Physical activity temporal trends among children and adolescents 2015 Amsterdam [u.a.] (DE-627)ELV012775517 volume:95 year:2013 number:3 pages:1026-1030 extent:5 https://doi.org/10.1016/j.rvsc.2013.07.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_22 GBV_ILN_24 GBV_ILN_60 GBV_ILN_181 GBV_ILN_227 GBV_ILN_352 GBV_ILN_2084 51.60 Keramische Werkstoffe Hartstoffe Werkstoffkunde VZ 58.45 Gesteinshüttenkunde VZ AR 95 2013 3 1026-1030 5 045F 630 |
| allfieldsGer |
10.1016/j.rvsc.2013.07.008 doi GBVA2013023000004.pica (DE-627)ELV027711293 (ELSEVIER)S0034-5288(13)00233-6 DE-627 ger DE-627 rakwb eng 630 630 DE-600 610 VZ 796 VZ 670 VZ 51.60 bkl 58.45 bkl Da Silva, Aleksandro S. verfasserin aut E-ADA activity in erythrocytes of lambs experimentally infected with Haemonchus contortus and its possible functional correlations with anemia 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The aim of this study was to evaluate the ecto-adenosine deaminase (E-ADA) activity in erythrocytes of lambs experimentally infected with Haemonchus contortus, correlating it with the degrees of anemia of the experimental animals. A total of 14 healthy lambs, with negative fecal exam for parasites, were to carry out the present study. They were divided into two groups, composed by seven animals: Group A represented the healthy animals (uninfected), while in Group B the animals were infected with 15,000 larvae of H. contortus. Blood was drawn on the days 15, 45 and 75 post-infection (PI) in order to perform the hematological analysis, as well as the mensuration of E-ADA activity in erythrocytes. Parasitological stool exam were performed on the same days mentioned above to follow up the evolution of the infection, as well to determine the number of eggs per gram of feces (EPG). On day 15PI, the animals presented negative EPG and there was not significant (P >0.05) difference between groups in relation to E-ADA activity and hematologic parameters. Animals in Group B had positive EPG for helminths on days 45 and 75 PI, accompanied by varying degrees of anemia, when compared to Group A. At the same periods E-ADA activity was significantly (P <0.05) increased in the erythrocytes of animals of Group B when compared with the not-infected ones. Statistically, there was a negative correlation (P <0.01) between activity E-ADA in erythrocytes and hematocrit on days 45 (r =−0.76) and 75 (r =−0.85)PI. Based on these results and in the scientific literature, it is possible to conclude that the E-ADA may participate on mechanisms related with the pathogenesis and host response against anemia caused by H. contortus. The aim of this study was to evaluate the ecto-adenosine deaminase (E-ADA) activity in erythrocytes of lambs experimentally infected with Haemonchus contortus, correlating it with the degrees of anemia of the experimental animals. A total of 14 healthy lambs, with negative fecal exam for parasites, were to carry out the present study. They were divided into two groups, composed by seven animals: Group A represented the healthy animals (uninfected), while in Group B the animals were infected with 15,000 larvae of H. contortus. Blood was drawn on the days 15, 45 and 75 post-infection (PI) in order to perform the hematological analysis, as well as the mensuration of E-ADA activity in erythrocytes. Parasitological stool exam were performed on the same days mentioned above to follow up the evolution of the infection, as well to determine the number of eggs per gram of feces (EPG). On day 15PI, the animals presented negative EPG and there was not significant (P >0.05) difference between groups in relation to E-ADA activity and hematologic parameters. Animals in Group B had positive EPG for helminths on days 45 and 75 PI, accompanied by varying degrees of anemia, when compared to Group A. At the same periods E-ADA activity was significantly (P <0.05) increased in the erythrocytes of animals of Group B when compared with the not-infected ones. Statistically, there was a negative correlation (P <0.01) between activity E-ADA in erythrocytes and hematocrit on days 45 (r =−0.76) and 75 (r =−0.85)PI. Based on these results and in the scientific literature, it is possible to conclude that the E-ADA may participate on mechanisms related with the pathogenesis and host response against anemia caused by H. contortus. Haemonchus Elsevier Adenosine Elsevier Hematology Elsevier Trichostrongylus Elsevier Sheep Elsevier Helminths Elsevier Schafer, Andressa S. oth Aires, Adelina R. oth Tonin, Alexandre A. oth Pimentel, Victor C. oth Oliveira, Camila B. oth Zanini, Daniela oth Schetinger, Maria R.C. oth Lopes, Sonia T.A. oth Leal, Marta L.R. oth Enthalten in Elsevier Booth, Verity M. ELSEVIER Physical activity temporal trends among children and adolescents 2015 Amsterdam [u.a.] (DE-627)ELV012775517 volume:95 year:2013 number:3 pages:1026-1030 extent:5 https://doi.org/10.1016/j.rvsc.2013.07.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_22 GBV_ILN_24 GBV_ILN_60 GBV_ILN_181 GBV_ILN_227 GBV_ILN_352 GBV_ILN_2084 51.60 Keramische Werkstoffe Hartstoffe Werkstoffkunde VZ 58.45 Gesteinshüttenkunde VZ AR 95 2013 3 1026-1030 5 045F 630 |
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E-ADA activity in erythrocytes of lambs experimentally infected with Haemonchus contortus and its possible functional correlations with anemia |
| abstract |
The aim of this study was to evaluate the ecto-adenosine deaminase (E-ADA) activity in erythrocytes of lambs experimentally infected with Haemonchus contortus, correlating it with the degrees of anemia of the experimental animals. A total of 14 healthy lambs, with negative fecal exam for parasites, were to carry out the present study. They were divided into two groups, composed by seven animals: Group A represented the healthy animals (uninfected), while in Group B the animals were infected with 15,000 larvae of H. contortus. Blood was drawn on the days 15, 45 and 75 post-infection (PI) in order to perform the hematological analysis, as well as the mensuration of E-ADA activity in erythrocytes. Parasitological stool exam were performed on the same days mentioned above to follow up the evolution of the infection, as well to determine the number of eggs per gram of feces (EPG). On day 15PI, the animals presented negative EPG and there was not significant (P >0.05) difference between groups in relation to E-ADA activity and hematologic parameters. Animals in Group B had positive EPG for helminths on days 45 and 75 PI, accompanied by varying degrees of anemia, when compared to Group A. At the same periods E-ADA activity was significantly (P <0.05) increased in the erythrocytes of animals of Group B when compared with the not-infected ones. Statistically, there was a negative correlation (P <0.01) between activity E-ADA in erythrocytes and hematocrit on days 45 (r =−0.76) and 75 (r =−0.85)PI. Based on these results and in the scientific literature, it is possible to conclude that the E-ADA may participate on mechanisms related with the pathogenesis and host response against anemia caused by H. contortus. |
| abstractGer |
The aim of this study was to evaluate the ecto-adenosine deaminase (E-ADA) activity in erythrocytes of lambs experimentally infected with Haemonchus contortus, correlating it with the degrees of anemia of the experimental animals. A total of 14 healthy lambs, with negative fecal exam for parasites, were to carry out the present study. They were divided into two groups, composed by seven animals: Group A represented the healthy animals (uninfected), while in Group B the animals were infected with 15,000 larvae of H. contortus. Blood was drawn on the days 15, 45 and 75 post-infection (PI) in order to perform the hematological analysis, as well as the mensuration of E-ADA activity in erythrocytes. Parasitological stool exam were performed on the same days mentioned above to follow up the evolution of the infection, as well to determine the number of eggs per gram of feces (EPG). On day 15PI, the animals presented negative EPG and there was not significant (P >0.05) difference between groups in relation to E-ADA activity and hematologic parameters. Animals in Group B had positive EPG for helminths on days 45 and 75 PI, accompanied by varying degrees of anemia, when compared to Group A. At the same periods E-ADA activity was significantly (P <0.05) increased in the erythrocytes of animals of Group B when compared with the not-infected ones. Statistically, there was a negative correlation (P <0.01) between activity E-ADA in erythrocytes and hematocrit on days 45 (r =−0.76) and 75 (r =−0.85)PI. Based on these results and in the scientific literature, it is possible to conclude that the E-ADA may participate on mechanisms related with the pathogenesis and host response against anemia caused by H. contortus. |
| abstract_unstemmed |
The aim of this study was to evaluate the ecto-adenosine deaminase (E-ADA) activity in erythrocytes of lambs experimentally infected with Haemonchus contortus, correlating it with the degrees of anemia of the experimental animals. A total of 14 healthy lambs, with negative fecal exam for parasites, were to carry out the present study. They were divided into two groups, composed by seven animals: Group A represented the healthy animals (uninfected), while in Group B the animals were infected with 15,000 larvae of H. contortus. Blood was drawn on the days 15, 45 and 75 post-infection (PI) in order to perform the hematological analysis, as well as the mensuration of E-ADA activity in erythrocytes. Parasitological stool exam were performed on the same days mentioned above to follow up the evolution of the infection, as well to determine the number of eggs per gram of feces (EPG). On day 15PI, the animals presented negative EPG and there was not significant (P >0.05) difference between groups in relation to E-ADA activity and hematologic parameters. Animals in Group B had positive EPG for helminths on days 45 and 75 PI, accompanied by varying degrees of anemia, when compared to Group A. At the same periods E-ADA activity was significantly (P <0.05) increased in the erythrocytes of animals of Group B when compared with the not-infected ones. Statistically, there was a negative correlation (P <0.01) between activity E-ADA in erythrocytes and hematocrit on days 45 (r =−0.76) and 75 (r =−0.85)PI. Based on these results and in the scientific literature, it is possible to conclude that the E-ADA may participate on mechanisms related with the pathogenesis and host response against anemia caused by H. contortus. |
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| title_short |
E-ADA activity in erythrocytes of lambs experimentally infected with Haemonchus contortus and its possible functional correlations with anemia |
| url |
https://doi.org/10.1016/j.rvsc.2013.07.008 |
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| author2 |
Schafer, Andressa S. Aires, Adelina R. Tonin, Alexandre A. Pimentel, Victor C. Oliveira, Camila B. Zanini, Daniela Schetinger, Maria R.C. Lopes, Sonia T.A. Leal, Marta L.R. |
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Schafer, Andressa S. Aires, Adelina R. Tonin, Alexandre A. Pimentel, Victor C. Oliveira, Camila B. Zanini, Daniela Schetinger, Maria R.C. Lopes, Sonia T.A. Leal, Marta L.R. |
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| doi_str |
10.1016/j.rvsc.2013.07.008 |
| up_date |
2024-07-06T16:56:39.205Z |
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