IFPA Senior Award Lecture: Making sense of pre-eclampsia – Two placental causes of preeclampsia?
Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal ang...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Redman, C.W. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014transfer abstract |
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| Schlagwörter: |
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| Umfang: |
6 |
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| Übergeordnetes Werk: |
Enthalten in: O045 : Bioactive lipids in the human liver in ‘Common NAFLD’ and ‘PNPLA3 NAFLD’ - Luukkonen, P. ELSEVIER, 2015, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:35 ; year:2014 ; pages:20-25 ; extent:6 |
| Links: |
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| DOI / URN: |
10.1016/j.placenta.2013.12.008 |
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ELV027845753 |
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| 520 | |a Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal angiogenic balance and are considered to be pre-eclampsia biomarkers. We propose that, in addition and more fundamentally, these STB-derived proteins are biomarkers of a cellular (STB) stress response, which typically involves up-regulation of some proteins and down-regulation of others (positive and negative stress proteins respectively). Soluble vascular growth factor receptor-1 (sVEGFR-1) and reduced growth factor (PlGF) then exemplify positive and negative STB stress response proteins in the maternal circulation. | ||
| 520 | |a Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal angiogenic balance and are considered to be pre-eclampsia biomarkers. We propose that, in addition and more fundamentally, these STB-derived proteins are biomarkers of a cellular (STB) stress response, which typically involves up-regulation of some proteins and down-regulation of others (positive and negative stress proteins respectively). Soluble vascular growth factor receptor-1 (sVEGFR-1) and reduced growth factor (PlGF) then exemplify positive and negative STB stress response proteins in the maternal circulation. | ||
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| 650 | 7 | |a Pre-eclampsia biomarkers |2 Elsevier | |
| 650 | 7 | |a Early onset pre-eclampsia |2 Elsevier | |
| 650 | 7 | |a Integrated stress response |2 Elsevier | |
| 650 | 7 | |a Syncytiotrophoblast stress response |2 Elsevier | |
| 650 | 7 | |a Late onset pre-eclampsia |2 Elsevier | |
| 700 | 1 | |a Sargent, I.L. |4 oth | |
| 700 | 1 | |a Staff, A.C. |4 oth | |
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2014 |
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10.1016/j.placenta.2013.12.008 doi GBVA2014003000020.pica (DE-627)ELV027845753 (ELSEVIER)S0143-4004(13)00868-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 610 VZ 44.44 bkl Redman, C.W. verfasserin aut IFPA Senior Award Lecture: Making sense of pre-eclampsia – Two placental causes of preeclampsia? 2014transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal angiogenic balance and are considered to be pre-eclampsia biomarkers. We propose that, in addition and more fundamentally, these STB-derived proteins are biomarkers of a cellular (STB) stress response, which typically involves up-regulation of some proteins and down-regulation of others (positive and negative stress proteins respectively). Soluble vascular growth factor receptor-1 (sVEGFR-1) and reduced growth factor (PlGF) then exemplify positive and negative STB stress response proteins in the maternal circulation. Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal angiogenic balance and are considered to be pre-eclampsia biomarkers. We propose that, in addition and more fundamentally, these STB-derived proteins are biomarkers of a cellular (STB) stress response, which typically involves up-regulation of some proteins and down-regulation of others (positive and negative stress proteins respectively). Soluble vascular growth factor receptor-1 (sVEGFR-1) and reduced growth factor (PlGF) then exemplify positive and negative STB stress response proteins in the maternal circulation. Placental perfusion Elsevier Pre-eclampsia biomarkers Elsevier Early onset pre-eclampsia Elsevier Integrated stress response Elsevier Syncytiotrophoblast stress response Elsevier Late onset pre-eclampsia Elsevier Sargent, I.L. oth Staff, A.C. oth Enthalten in Elsevier Luukkonen, P. ELSEVIER O045 : Bioactive lipids in the human liver in ‘Common NAFLD’ and ‘PNPLA3 NAFLD’ 2015 Amsterdam [u.a.] (DE-627)ELV012874620 volume:35 year:2014 pages:20-25 extent:6 https://doi.org/10.1016/j.placenta.2013.12.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 35 2014 20-25 6 35.2014, S20-, (6 S.) 045F 610 |
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10.1016/j.placenta.2013.12.008 doi GBVA2014003000020.pica (DE-627)ELV027845753 (ELSEVIER)S0143-4004(13)00868-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 610 VZ 44.44 bkl Redman, C.W. verfasserin aut IFPA Senior Award Lecture: Making sense of pre-eclampsia – Two placental causes of preeclampsia? 2014transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal angiogenic balance and are considered to be pre-eclampsia biomarkers. We propose that, in addition and more fundamentally, these STB-derived proteins are biomarkers of a cellular (STB) stress response, which typically involves up-regulation of some proteins and down-regulation of others (positive and negative stress proteins respectively). Soluble vascular growth factor receptor-1 (sVEGFR-1) and reduced growth factor (PlGF) then exemplify positive and negative STB stress response proteins in the maternal circulation. Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal angiogenic balance and are considered to be pre-eclampsia biomarkers. We propose that, in addition and more fundamentally, these STB-derived proteins are biomarkers of a cellular (STB) stress response, which typically involves up-regulation of some proteins and down-regulation of others (positive and negative stress proteins respectively). Soluble vascular growth factor receptor-1 (sVEGFR-1) and reduced growth factor (PlGF) then exemplify positive and negative STB stress response proteins in the maternal circulation. Placental perfusion Elsevier Pre-eclampsia biomarkers Elsevier Early onset pre-eclampsia Elsevier Integrated stress response Elsevier Syncytiotrophoblast stress response Elsevier Late onset pre-eclampsia Elsevier Sargent, I.L. oth Staff, A.C. oth Enthalten in Elsevier Luukkonen, P. ELSEVIER O045 : Bioactive lipids in the human liver in ‘Common NAFLD’ and ‘PNPLA3 NAFLD’ 2015 Amsterdam [u.a.] (DE-627)ELV012874620 volume:35 year:2014 pages:20-25 extent:6 https://doi.org/10.1016/j.placenta.2013.12.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 35 2014 20-25 6 35.2014, S20-, (6 S.) 045F 610 |
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10.1016/j.placenta.2013.12.008 doi GBVA2014003000020.pica (DE-627)ELV027845753 (ELSEVIER)S0143-4004(13)00868-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 610 VZ 44.44 bkl Redman, C.W. verfasserin aut IFPA Senior Award Lecture: Making sense of pre-eclampsia – Two placental causes of preeclampsia? 2014transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal angiogenic balance and are considered to be pre-eclampsia biomarkers. We propose that, in addition and more fundamentally, these STB-derived proteins are biomarkers of a cellular (STB) stress response, which typically involves up-regulation of some proteins and down-regulation of others (positive and negative stress proteins respectively). Soluble vascular growth factor receptor-1 (sVEGFR-1) and reduced growth factor (PlGF) then exemplify positive and negative STB stress response proteins in the maternal circulation. Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal angiogenic balance and are considered to be pre-eclampsia biomarkers. We propose that, in addition and more fundamentally, these STB-derived proteins are biomarkers of a cellular (STB) stress response, which typically involves up-regulation of some proteins and down-regulation of others (positive and negative stress proteins respectively). Soluble vascular growth factor receptor-1 (sVEGFR-1) and reduced growth factor (PlGF) then exemplify positive and negative STB stress response proteins in the maternal circulation. Placental perfusion Elsevier Pre-eclampsia biomarkers Elsevier Early onset pre-eclampsia Elsevier Integrated stress response Elsevier Syncytiotrophoblast stress response Elsevier Late onset pre-eclampsia Elsevier Sargent, I.L. oth Staff, A.C. oth Enthalten in Elsevier Luukkonen, P. ELSEVIER O045 : Bioactive lipids in the human liver in ‘Common NAFLD’ and ‘PNPLA3 NAFLD’ 2015 Amsterdam [u.a.] (DE-627)ELV012874620 volume:35 year:2014 pages:20-25 extent:6 https://doi.org/10.1016/j.placenta.2013.12.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 35 2014 20-25 6 35.2014, S20-, (6 S.) 045F 610 |
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10.1016/j.placenta.2013.12.008 doi GBVA2014003000020.pica (DE-627)ELV027845753 (ELSEVIER)S0143-4004(13)00868-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 610 VZ 44.44 bkl Redman, C.W. verfasserin aut IFPA Senior Award Lecture: Making sense of pre-eclampsia – Two placental causes of preeclampsia? 2014transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal angiogenic balance and are considered to be pre-eclampsia biomarkers. We propose that, in addition and more fundamentally, these STB-derived proteins are biomarkers of a cellular (STB) stress response, which typically involves up-regulation of some proteins and down-regulation of others (positive and negative stress proteins respectively). Soluble vascular growth factor receptor-1 (sVEGFR-1) and reduced growth factor (PlGF) then exemplify positive and negative STB stress response proteins in the maternal circulation. Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal angiogenic balance and are considered to be pre-eclampsia biomarkers. We propose that, in addition and more fundamentally, these STB-derived proteins are biomarkers of a cellular (STB) stress response, which typically involves up-regulation of some proteins and down-regulation of others (positive and negative stress proteins respectively). Soluble vascular growth factor receptor-1 (sVEGFR-1) and reduced growth factor (PlGF) then exemplify positive and negative STB stress response proteins in the maternal circulation. Placental perfusion Elsevier Pre-eclampsia biomarkers Elsevier Early onset pre-eclampsia Elsevier Integrated stress response Elsevier Syncytiotrophoblast stress response Elsevier Late onset pre-eclampsia Elsevier Sargent, I.L. oth Staff, A.C. oth Enthalten in Elsevier Luukkonen, P. ELSEVIER O045 : Bioactive lipids in the human liver in ‘Common NAFLD’ and ‘PNPLA3 NAFLD’ 2015 Amsterdam [u.a.] (DE-627)ELV012874620 volume:35 year:2014 pages:20-25 extent:6 https://doi.org/10.1016/j.placenta.2013.12.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 35 2014 20-25 6 35.2014, S20-, (6 S.) 045F 610 |
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10.1016/j.placenta.2013.12.008 doi GBVA2014003000020.pica (DE-627)ELV027845753 (ELSEVIER)S0143-4004(13)00868-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 610 VZ 44.44 bkl Redman, C.W. verfasserin aut IFPA Senior Award Lecture: Making sense of pre-eclampsia – Two placental causes of preeclampsia? 2014transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal angiogenic balance and are considered to be pre-eclampsia biomarkers. We propose that, in addition and more fundamentally, these STB-derived proteins are biomarkers of a cellular (STB) stress response, which typically involves up-regulation of some proteins and down-regulation of others (positive and negative stress proteins respectively). Soluble vascular growth factor receptor-1 (sVEGFR-1) and reduced growth factor (PlGF) then exemplify positive and negative STB stress response proteins in the maternal circulation. Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal angiogenic balance and are considered to be pre-eclampsia biomarkers. We propose that, in addition and more fundamentally, these STB-derived proteins are biomarkers of a cellular (STB) stress response, which typically involves up-regulation of some proteins and down-regulation of others (positive and negative stress proteins respectively). Soluble vascular growth factor receptor-1 (sVEGFR-1) and reduced growth factor (PlGF) then exemplify positive and negative STB stress response proteins in the maternal circulation. Placental perfusion Elsevier Pre-eclampsia biomarkers Elsevier Early onset pre-eclampsia Elsevier Integrated stress response Elsevier Syncytiotrophoblast stress response Elsevier Late onset pre-eclampsia Elsevier Sargent, I.L. oth Staff, A.C. oth Enthalten in Elsevier Luukkonen, P. ELSEVIER O045 : Bioactive lipids in the human liver in ‘Common NAFLD’ and ‘PNPLA3 NAFLD’ 2015 Amsterdam [u.a.] (DE-627)ELV012874620 volume:35 year:2014 pages:20-25 extent:6 https://doi.org/10.1016/j.placenta.2013.12.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.44 Parasitologie Medizin VZ AR 35 2014 20-25 6 35.2014, S20-, (6 S.) 045F 610 |
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Enthalten in O045 : Bioactive lipids in the human liver in ‘Common NAFLD’ and ‘PNPLA3 NAFLD’ Amsterdam [u.a.] volume:35 year:2014 pages:20-25 extent:6 |
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Redman, C.W. |
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Redman, C.W. ddc 610 bkl 44.44 Elsevier Placental perfusion Elsevier Pre-eclampsia biomarkers Elsevier Early onset pre-eclampsia Elsevier Integrated stress response Elsevier Syncytiotrophoblast stress response Elsevier Late onset pre-eclampsia IFPA Senior Award Lecture: Making sense of pre-eclampsia – Two placental causes of preeclampsia? |
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610 610 DE-600 610 VZ 44.44 bkl IFPA Senior Award Lecture: Making sense of pre-eclampsia – Two placental causes of preeclampsia? Placental perfusion Elsevier Pre-eclampsia biomarkers Elsevier Early onset pre-eclampsia Elsevier Integrated stress response Elsevier Syncytiotrophoblast stress response Elsevier Late onset pre-eclampsia Elsevier |
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ddc 610 bkl 44.44 Elsevier Placental perfusion Elsevier Pre-eclampsia biomarkers Elsevier Early onset pre-eclampsia Elsevier Integrated stress response Elsevier Syncytiotrophoblast stress response Elsevier Late onset pre-eclampsia |
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O045 : Bioactive lipids in the human liver in ‘Common NAFLD’ and ‘PNPLA3 NAFLD’ |
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O045 : Bioactive lipids in the human liver in ‘Common NAFLD’ and ‘PNPLA3 NAFLD’ |
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O045 : Bioactive lipids in the human liver in ‘Common NAFLD’ and ‘PNPLA3 NAFLD’ |
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10.1016/j.placenta.2013.12.008 |
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ifpa senior award lecture: making sense of pre-eclampsia – two placental causes of preeclampsia? |
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IFPA Senior Award Lecture: Making sense of pre-eclampsia – Two placental causes of preeclampsia? |
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Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal angiogenic balance and are considered to be pre-eclampsia biomarkers. We propose that, in addition and more fundamentally, these STB-derived proteins are biomarkers of a cellular (STB) stress response, which typically involves up-regulation of some proteins and down-regulation of others (positive and negative stress proteins respectively). Soluble vascular growth factor receptor-1 (sVEGFR-1) and reduced growth factor (PlGF) then exemplify positive and negative STB stress response proteins in the maternal circulation. |
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Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal angiogenic balance and are considered to be pre-eclampsia biomarkers. We propose that, in addition and more fundamentally, these STB-derived proteins are biomarkers of a cellular (STB) stress response, which typically involves up-regulation of some proteins and down-regulation of others (positive and negative stress proteins respectively). Soluble vascular growth factor receptor-1 (sVEGFR-1) and reduced growth factor (PlGF) then exemplify positive and negative STB stress response proteins in the maternal circulation. |
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Incomplete spiral artery remodelling is the first of two stages of pre-eclampsia, typically of early onset. The second stage comprises dysregulated uteroplacental perfusion and placental oxidative stress. Oxidatively stressed syncytiotrophoblast (STB) over-secretes proteins that perturb maternal angiogenic balance and are considered to be pre-eclampsia biomarkers. We propose that, in addition and more fundamentally, these STB-derived proteins are biomarkers of a cellular (STB) stress response, which typically involves up-regulation of some proteins and down-regulation of others (positive and negative stress proteins respectively). Soluble vascular growth factor receptor-1 (sVEGFR-1) and reduced growth factor (PlGF) then exemplify positive and negative STB stress response proteins in the maternal circulation. |
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