HLA-A∗02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study charact...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Engdahl, Elin [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2014transfer abstract |
|---|
| Schlagwörter: |
|---|
| Umfang: |
7 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Towards a Dynamic Understanding of Cadherin-Based Mechanobiology - Hoffman, Brenton D. ELSEVIER, 2015, official journal of the American Society for Histocompatibility and Immunogenetics (ASHI), Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:75 ; year:2014 ; number:6 ; pages:524-530 ; extent:7 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.humimm.2014.03.001 |
|---|
| Katalog-ID: |
ELV027985954 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | ELV027985954 | ||
| 003 | DE-627 | ||
| 005 | 20230625152747.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180603s2014 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.humimm.2014.03.001 |2 doi | |
| 028 | 5 | 2 | |a GBVA2014007000028.pica |
| 035 | |a (DE-627)ELV027985954 | ||
| 035 | |a (ELSEVIER)S0198-8859(14)00109-8 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | |a 610 | |
| 082 | 0 | 4 | |a 610 |q DE-600 |
| 082 | 0 | 4 | |a 570 |q VZ |
| 084 | |a BIODIV |q DE-30 |2 fid | ||
| 100 | 1 | |a Engdahl, Elin |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a HLA-A∗02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6 |
| 264 | 1 | |c 2014transfer abstract | |
| 300 | |a 7 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections. | ||
| 520 | |a Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections. | ||
| 650 | 7 | |a Multiple sclerosis |2 Elsevier | |
| 650 | 7 | |a IgG |2 Elsevier | |
| 650 | 7 | |a Human herpesvirus 6 |2 Elsevier | |
| 650 | 7 | |a p41 |2 Elsevier | |
| 650 | 7 | |a HLA-A∗02 |2 Elsevier | |
| 700 | 1 | |a Gustafsson, Rasmus |4 oth | |
| 700 | 1 | |a Ramanujam, Ryan |4 oth | |
| 700 | 1 | |a Sundqvist, Emilie |4 oth | |
| 700 | 1 | |a Olsson, Tomas |4 oth | |
| 700 | 1 | |a Hillert, Jan |4 oth | |
| 700 | 1 | |a Alfredsson, Lars |4 oth | |
| 700 | 1 | |a Kockum, Ingrid |4 oth | |
| 700 | 1 | |a Fogdell-Hahn, Anna |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Hoffman, Brenton D. ELSEVIER |t Towards a Dynamic Understanding of Cadherin-Based Mechanobiology |d 2015 |d official journal of the American Society for Histocompatibility and Immunogenetics (ASHI) |g Amsterdam [u.a.] |w (DE-627)ELV000456578 |
| 773 | 1 | 8 | |g volume:75 |g year:2014 |g number:6 |g pages:524-530 |g extent:7 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.humimm.2014.03.001 |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a GBV_ELV | ||
| 912 | |a SYSFLAG_U | ||
| 912 | |a FID-BIODIV | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |d 75 |j 2014 |e 6 |h 524-530 |g 7 | ||
| 953 | |2 045F |a 610 | ||
| author_variant |
e e ee |
|---|---|
| matchkey_str |
engdahlelingustafssonrasmusramanujamryan:2014----:la2edrntbcomknbtomlilslrssfettegatbdrso |
| hierarchy_sort_str |
2014transfer abstract |
| publishDate |
2014 |
| allfields |
10.1016/j.humimm.2014.03.001 doi GBVA2014007000028.pica (DE-627)ELV027985954 (ELSEVIER)S0198-8859(14)00109-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ BIODIV DE-30 fid Engdahl, Elin verfasserin aut HLA-A∗02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6 2014transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections. Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections. Multiple sclerosis Elsevier IgG Elsevier Human herpesvirus 6 Elsevier p41 Elsevier HLA-A∗02 Elsevier Gustafsson, Rasmus oth Ramanujam, Ryan oth Sundqvist, Emilie oth Olsson, Tomas oth Hillert, Jan oth Alfredsson, Lars oth Kockum, Ingrid oth Fogdell-Hahn, Anna oth Enthalten in Elsevier Science Hoffman, Brenton D. ELSEVIER Towards a Dynamic Understanding of Cadherin-Based Mechanobiology 2015 official journal of the American Society for Histocompatibility and Immunogenetics (ASHI) Amsterdam [u.a.] (DE-627)ELV000456578 volume:75 year:2014 number:6 pages:524-530 extent:7 https://doi.org/10.1016/j.humimm.2014.03.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA AR 75 2014 6 524-530 7 045F 610 |
| spelling |
10.1016/j.humimm.2014.03.001 doi GBVA2014007000028.pica (DE-627)ELV027985954 (ELSEVIER)S0198-8859(14)00109-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ BIODIV DE-30 fid Engdahl, Elin verfasserin aut HLA-A∗02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6 2014transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections. Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections. Multiple sclerosis Elsevier IgG Elsevier Human herpesvirus 6 Elsevier p41 Elsevier HLA-A∗02 Elsevier Gustafsson, Rasmus oth Ramanujam, Ryan oth Sundqvist, Emilie oth Olsson, Tomas oth Hillert, Jan oth Alfredsson, Lars oth Kockum, Ingrid oth Fogdell-Hahn, Anna oth Enthalten in Elsevier Science Hoffman, Brenton D. ELSEVIER Towards a Dynamic Understanding of Cadherin-Based Mechanobiology 2015 official journal of the American Society for Histocompatibility and Immunogenetics (ASHI) Amsterdam [u.a.] (DE-627)ELV000456578 volume:75 year:2014 number:6 pages:524-530 extent:7 https://doi.org/10.1016/j.humimm.2014.03.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA AR 75 2014 6 524-530 7 045F 610 |
| allfields_unstemmed |
10.1016/j.humimm.2014.03.001 doi GBVA2014007000028.pica (DE-627)ELV027985954 (ELSEVIER)S0198-8859(14)00109-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ BIODIV DE-30 fid Engdahl, Elin verfasserin aut HLA-A∗02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6 2014transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections. Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections. Multiple sclerosis Elsevier IgG Elsevier Human herpesvirus 6 Elsevier p41 Elsevier HLA-A∗02 Elsevier Gustafsson, Rasmus oth Ramanujam, Ryan oth Sundqvist, Emilie oth Olsson, Tomas oth Hillert, Jan oth Alfredsson, Lars oth Kockum, Ingrid oth Fogdell-Hahn, Anna oth Enthalten in Elsevier Science Hoffman, Brenton D. ELSEVIER Towards a Dynamic Understanding of Cadherin-Based Mechanobiology 2015 official journal of the American Society for Histocompatibility and Immunogenetics (ASHI) Amsterdam [u.a.] (DE-627)ELV000456578 volume:75 year:2014 number:6 pages:524-530 extent:7 https://doi.org/10.1016/j.humimm.2014.03.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA AR 75 2014 6 524-530 7 045F 610 |
| allfieldsGer |
10.1016/j.humimm.2014.03.001 doi GBVA2014007000028.pica (DE-627)ELV027985954 (ELSEVIER)S0198-8859(14)00109-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ BIODIV DE-30 fid Engdahl, Elin verfasserin aut HLA-A∗02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6 2014transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections. Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections. Multiple sclerosis Elsevier IgG Elsevier Human herpesvirus 6 Elsevier p41 Elsevier HLA-A∗02 Elsevier Gustafsson, Rasmus oth Ramanujam, Ryan oth Sundqvist, Emilie oth Olsson, Tomas oth Hillert, Jan oth Alfredsson, Lars oth Kockum, Ingrid oth Fogdell-Hahn, Anna oth Enthalten in Elsevier Science Hoffman, Brenton D. ELSEVIER Towards a Dynamic Understanding of Cadherin-Based Mechanobiology 2015 official journal of the American Society for Histocompatibility and Immunogenetics (ASHI) Amsterdam [u.a.] (DE-627)ELV000456578 volume:75 year:2014 number:6 pages:524-530 extent:7 https://doi.org/10.1016/j.humimm.2014.03.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA AR 75 2014 6 524-530 7 045F 610 |
| allfieldsSound |
10.1016/j.humimm.2014.03.001 doi GBVA2014007000028.pica (DE-627)ELV027985954 (ELSEVIER)S0198-8859(14)00109-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ BIODIV DE-30 fid Engdahl, Elin verfasserin aut HLA-A∗02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6 2014transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections. Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections. Multiple sclerosis Elsevier IgG Elsevier Human herpesvirus 6 Elsevier p41 Elsevier HLA-A∗02 Elsevier Gustafsson, Rasmus oth Ramanujam, Ryan oth Sundqvist, Emilie oth Olsson, Tomas oth Hillert, Jan oth Alfredsson, Lars oth Kockum, Ingrid oth Fogdell-Hahn, Anna oth Enthalten in Elsevier Science Hoffman, Brenton D. ELSEVIER Towards a Dynamic Understanding of Cadherin-Based Mechanobiology 2015 official journal of the American Society for Histocompatibility and Immunogenetics (ASHI) Amsterdam [u.a.] (DE-627)ELV000456578 volume:75 year:2014 number:6 pages:524-530 extent:7 https://doi.org/10.1016/j.humimm.2014.03.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA AR 75 2014 6 524-530 7 045F 610 |
| language |
English |
| source |
Enthalten in Towards a Dynamic Understanding of Cadherin-Based Mechanobiology Amsterdam [u.a.] volume:75 year:2014 number:6 pages:524-530 extent:7 |
| sourceStr |
Enthalten in Towards a Dynamic Understanding of Cadherin-Based Mechanobiology Amsterdam [u.a.] volume:75 year:2014 number:6 pages:524-530 extent:7 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Multiple sclerosis IgG Human herpesvirus 6 p41 HLA-A∗02 |
| dewey-raw |
610 |
| isfreeaccess_bool |
false |
| container_title |
Towards a Dynamic Understanding of Cadherin-Based Mechanobiology |
| authorswithroles_txt_mv |
Engdahl, Elin @@aut@@ Gustafsson, Rasmus @@oth@@ Ramanujam, Ryan @@oth@@ Sundqvist, Emilie @@oth@@ Olsson, Tomas @@oth@@ Hillert, Jan @@oth@@ Alfredsson, Lars @@oth@@ Kockum, Ingrid @@oth@@ Fogdell-Hahn, Anna @@oth@@ |
| publishDateDaySort_date |
2014-01-01T00:00:00Z |
| hierarchy_top_id |
ELV000456578 |
| dewey-sort |
3610 |
| id |
ELV027985954 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV027985954</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625152747.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2014 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.humimm.2014.03.001</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2014007000028.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV027985954</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0198-8859(14)00109-8</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">610</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">570</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIODIV</subfield><subfield code="q">DE-30</subfield><subfield code="2">fid</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Engdahl, Elin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">HLA-A∗02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2014transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">7</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Multiple sclerosis</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">IgG</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Human herpesvirus 6</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">p41</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">HLA-A∗02</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gustafsson, Rasmus</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ramanujam, Ryan</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sundqvist, Emilie</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Olsson, Tomas</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hillert, Jan</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Alfredsson, Lars</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kockum, Ingrid</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fogdell-Hahn, Anna</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Hoffman, Brenton D. ELSEVIER</subfield><subfield code="t">Towards a Dynamic Understanding of Cadherin-Based Mechanobiology</subfield><subfield code="d">2015</subfield><subfield code="d">official journal of the American Society for Histocompatibility and Immunogenetics (ASHI)</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV000456578</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:75</subfield><subfield code="g">year:2014</subfield><subfield code="g">number:6</subfield><subfield code="g">pages:524-530</subfield><subfield code="g">extent:7</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.humimm.2014.03.001</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">FID-BIODIV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">75</subfield><subfield code="j">2014</subfield><subfield code="e">6</subfield><subfield code="h">524-530</subfield><subfield code="g">7</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">610</subfield></datafield></record></collection>
|
| author |
Engdahl, Elin |
| spellingShingle |
Engdahl, Elin ddc 610 ddc 570 fid BIODIV Elsevier Multiple sclerosis Elsevier IgG Elsevier Human herpesvirus 6 Elsevier p41 Elsevier HLA-A∗02 HLA-A∗02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6 |
| authorStr |
Engdahl, Elin |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)ELV000456578 |
| format |
electronic Article |
| dewey-ones |
610 - Medicine & health 570 - Life sciences; biology |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
elsevier |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
610 610 DE-600 570 VZ BIODIV DE-30 fid HLA-A∗02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6 Multiple sclerosis Elsevier IgG Elsevier Human herpesvirus 6 Elsevier p41 Elsevier HLA-A∗02 Elsevier |
| topic |
ddc 610 ddc 570 fid BIODIV Elsevier Multiple sclerosis Elsevier IgG Elsevier Human herpesvirus 6 Elsevier p41 Elsevier HLA-A∗02 |
| topic_unstemmed |
ddc 610 ddc 570 fid BIODIV Elsevier Multiple sclerosis Elsevier IgG Elsevier Human herpesvirus 6 Elsevier p41 Elsevier HLA-A∗02 |
| topic_browse |
ddc 610 ddc 570 fid BIODIV Elsevier Multiple sclerosis Elsevier IgG Elsevier Human herpesvirus 6 Elsevier p41 Elsevier HLA-A∗02 |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
r g rg r r rr e s es t o to j h jh l a la i k ik a f h afh |
| hierarchy_parent_title |
Towards a Dynamic Understanding of Cadherin-Based Mechanobiology |
| hierarchy_parent_id |
ELV000456578 |
| dewey-tens |
610 - Medicine & health 570 - Life sciences; biology |
| hierarchy_top_title |
Towards a Dynamic Understanding of Cadherin-Based Mechanobiology |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)ELV000456578 |
| title |
HLA-A∗02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6 |
| ctrlnum |
(DE-627)ELV027985954 (ELSEVIER)S0198-8859(14)00109-8 |
| title_full |
HLA-A∗02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6 |
| author_sort |
Engdahl, Elin |
| journal |
Towards a Dynamic Understanding of Cadherin-Based Mechanobiology |
| journalStr |
Towards a Dynamic Understanding of Cadherin-Based Mechanobiology |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
600 - Technology 500 - Science |
| recordtype |
marc |
| publishDateSort |
2014 |
| contenttype_str_mv |
zzz |
| container_start_page |
524 |
| author_browse |
Engdahl, Elin |
| container_volume |
75 |
| physical |
7 |
| class |
610 610 DE-600 570 VZ BIODIV DE-30 fid |
| format_se |
Elektronische Aufsätze |
| author-letter |
Engdahl, Elin |
| doi_str_mv |
10.1016/j.humimm.2014.03.001 |
| dewey-full |
610 570 |
| title_sort |
hla-a∗02, gender and tobacco smoking, but not multiple sclerosis, affects the igg antibody response against human herpesvirus 6 |
| title_auth |
HLA-A∗02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6 |
| abstract |
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections. |
| abstractGer |
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections. |
| abstract_unstemmed |
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA |
| container_issue |
6 |
| title_short |
HLA-A∗02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6 |
| url |
https://doi.org/10.1016/j.humimm.2014.03.001 |
| remote_bool |
true |
| author2 |
Gustafsson, Rasmus Ramanujam, Ryan Sundqvist, Emilie Olsson, Tomas Hillert, Jan Alfredsson, Lars Kockum, Ingrid Fogdell-Hahn, Anna |
| author2Str |
Gustafsson, Rasmus Ramanujam, Ryan Sundqvist, Emilie Olsson, Tomas Hillert, Jan Alfredsson, Lars Kockum, Ingrid Fogdell-Hahn, Anna |
| ppnlink |
ELV000456578 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth oth oth oth |
| doi_str |
10.1016/j.humimm.2014.03.001 |
| up_date |
2024-07-06T17:38:40.345Z |
| _version_ |
1803852206935375872 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV027985954</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625152747.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2014 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.humimm.2014.03.001</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2014007000028.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV027985954</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0198-8859(14)00109-8</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">610</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">570</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIODIV</subfield><subfield code="q">DE-30</subfield><subfield code="2">fid</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Engdahl, Elin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">HLA-A∗02, gender and tobacco smoking, but not multiple sclerosis, affects the IgG antibody response against human herpesvirus 6</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2014transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">7</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Both genetic and environmental factors contribute to disease susceptibility and two viruses associated with MS are human herpesvirus (HHV)-6A and HHV-6B, together referred to as HHV-6. This study characterized the plasma IgG antibody response against HHV-6 in MS patients (n =446) and healthy controls (n =487), and the relationship between MS susceptibility factors and the anti-HHV-6 response was investigated. In addition, 134 samples were further investigated for IgG against the early HHV-6 antigen p41. Antibody levels were measured with ELISA. The overall seroprevalence against HHV-6 was 90%, with no significant difference in positivity or levels between MS patients and controls. Interestingly, carriership of HLA-A∗02 and tobacco smoking was associated with lower anti-HHV-6 IgG levels (p =0.0017 and p =0.026 respectively), whereas females sex was associated with higher levels (p =0.0090). No difference in IgG titers against p41 was observed between MS patients and controls. In conclusion, the IgG response against HHV-6 was associated with several factors that have previously been associated with MS susceptibility, possibly reflecting a relation between autoimmunity and how the immune system handles viral infections.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Multiple sclerosis</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">IgG</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Human herpesvirus 6</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">p41</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">HLA-A∗02</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gustafsson, Rasmus</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ramanujam, Ryan</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sundqvist, Emilie</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Olsson, Tomas</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hillert, Jan</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Alfredsson, Lars</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kockum, Ingrid</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fogdell-Hahn, Anna</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Hoffman, Brenton D. ELSEVIER</subfield><subfield code="t">Towards a Dynamic Understanding of Cadherin-Based Mechanobiology</subfield><subfield code="d">2015</subfield><subfield code="d">official journal of the American Society for Histocompatibility and Immunogenetics (ASHI)</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV000456578</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:75</subfield><subfield code="g">year:2014</subfield><subfield code="g">number:6</subfield><subfield code="g">pages:524-530</subfield><subfield code="g">extent:7</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.humimm.2014.03.001</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">FID-BIODIV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">75</subfield><subfield code="j">2014</subfield><subfield code="e">6</subfield><subfield code="h">524-530</subfield><subfield code="g">7</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">610</subfield></datafield></record></collection>
|
| score |
7.4017324 |