Comparison of multiple adjuvants on the stability and immunogenicity of a clade C HIV-1 gp140 trimer
• We compare the stability and immunogenicity of a clade C HIV-1 Env trimer in 12 different adjuvants in guinea pigs. • We find that oil-in-water emulsions resulted in partial aggregation and loss of structural integrity of the gp140 trimer. • We find that multiple classes of adjuvants similarly aug...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Nkolola, Joseph P. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: Quantifying contributions of leaf area and longevity to leaf area duration under increased planting density and nitrogen input regimens during maize yield improvement - Li, Yaoyao ELSEVIER, 2022, Amsterdam |
|---|---|
| Übergeordnetes Werk: |
volume:32 ; year:2014 ; number:18 ; day:11 ; month:04 ; pages:2109-2116 ; extent:8 |
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| DOI / URN: |
10.1016/j.vaccine.2014.02.001 |
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Comparison of multiple adjuvants on the stability and immunogenicity of a clade C HIV-1 gp140 trimer |
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• We compare the stability and immunogenicity of a clade C HIV-1 Env trimer in 12 different adjuvants in guinea pigs. • We find that oil-in-water emulsions resulted in partial aggregation and loss of structural integrity of the gp140 trimer. • We find that multiple classes of adjuvants similarly augmented Env-specific binding and neutralizing antibody responses. |
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• We compare the stability and immunogenicity of a clade C HIV-1 Env trimer in 12 different adjuvants in guinea pigs. • We find that oil-in-water emulsions resulted in partial aggregation and loss of structural integrity of the gp140 trimer. • We find that multiple classes of adjuvants similarly augmented Env-specific binding and neutralizing antibody responses. |
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• We compare the stability and immunogenicity of a clade C HIV-1 Env trimer in 12 different adjuvants in guinea pigs. • We find that oil-in-water emulsions resulted in partial aggregation and loss of structural integrity of the gp140 trimer. • We find that multiple classes of adjuvants similarly augmented Env-specific binding and neutralizing antibody responses. |
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Comparison of multiple adjuvants on the stability and immunogenicity of a clade C HIV-1 gp140 trimer |
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https://doi.org/10.1016/j.vaccine.2014.02.001 |
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Cheung, Ann Perry, James R. Carter, Darrick Reed, Steve Schuitemaker, Hanneke Pau, Maria Grazia Seaman, Michael S. Chen, Bing Barouch, Dan H. |
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Cheung, Ann Perry, James R. Carter, Darrick Reed, Steve Schuitemaker, Hanneke Pau, Maria Grazia Seaman, Michael S. Chen, Bing Barouch, Dan H. |
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10.1016/j.vaccine.2014.02.001 |
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2024-07-06T17:40:11.014Z |
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