Microparticles of Aloe vera/vitamin E/chitosan: Microscopic, a nuclear imaging and an in vivo test analysis for burn treatment
Abstract The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In orde...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Pereira, Gabriela Garrastazu [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014transfer abstract |
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| Schlagwörter: |
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| Umfang: |
9 |
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| Übergeordnetes Werk: |
Enthalten in: Combat periarticular tibia injury outcome study (CAPTIOUS): risk factors for reoperation and amputation after open periarticular tibia fractures - Fleming, Mark E. ELSEVIER, 2015, EJPB : official journal of the International Association for Pharmaceutical Technology, New York, NY [u.a.] |
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| Übergeordnetes Werk: |
volume:86 ; year:2014 ; number:2 ; pages:292-300 ; extent:9 |
| Links: |
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| DOI / URN: |
10.1016/j.ejpb.2013.10.011 |
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| 245 | 1 | 0 | |a Microparticles of Aloe vera/vitamin E/chitosan: Microscopic, a nuclear imaging and an in vivo test analysis for burn treatment |
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| 520 | |a Abstract The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In order to observe the morphological properties, Raman and atomic force microscopy evaluation were performed. The biodistribution studies were analyzed by using a nuclear methodology, labeling the microparticles with Technetium-99m and in vivo test was procedure to analyzed the cicatrization process. The results of AFM analysis show the formation and the adherence property of the microparticles. Raman analyses show the distribution of each component in the microparticle. The nuclear method used shows that the biodistribution of the microparticles remained in the skin. The in vivo cicatrization test showed that the poloxamer gel containing the microparticles make a better cicatrization in relation to the other formulations tested. | ||
| 520 | |a Abstract The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In order to observe the morphological properties, Raman and atomic force microscopy evaluation were performed. The biodistribution studies were analyzed by using a nuclear methodology, labeling the microparticles with Technetium-99m and in vivo test was procedure to analyzed the cicatrization process. The results of AFM analysis show the formation and the adherence property of the microparticles. Raman analyses show the distribution of each component in the microparticle. The nuclear method used shows that the biodistribution of the microparticles remained in the skin. The in vivo cicatrization test showed that the poloxamer gel containing the microparticles make a better cicatrization in relation to the other formulations tested. | ||
| 650 | 7 | |a Burn |2 Elsevier | |
| 650 | 7 | |a Atomic force microscopy |2 Elsevier | |
| 650 | 7 | |a Skin |2 Elsevier | |
| 650 | 7 | |a Technetium-99m |2 Elsevier | |
| 650 | 7 | |a In vivo cicatrization |2 Elsevier | |
| 700 | 1 | |a Santos-Oliveira, Ralph |4 oth | |
| 700 | 1 | |a Albernaz, Martha S. |4 oth | |
| 700 | 1 | |a Canema, Daniel |4 oth | |
| 700 | 1 | |a Weismüller, Gilberto |4 oth | |
| 700 | 1 | |a Barros, Eduardo Bede |4 oth | |
| 700 | 1 | |a Magalhães, Luciana |4 oth | |
| 700 | 1 | |a Lima-Ribeiro, Maria Helena Madruga |4 oth | |
| 700 | 1 | |a Pohlmann, Adriana Raffin |4 oth | |
| 700 | 1 | |a Guterres, Silvia S. |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier |a Fleming, Mark E. ELSEVIER |t Combat periarticular tibia injury outcome study (CAPTIOUS): risk factors for reoperation and amputation after open periarticular tibia fractures |d 2015 |d EJPB : official journal of the International Association for Pharmaceutical Technology |g New York, NY [u.a.] |w (DE-627)ELV013352458 |
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10.1016/j.ejpb.2013.10.011 doi GBVA2014014000015.pica (DE-627)ELV028229282 (ELSEVIER)S0939-6411(13)00337-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 540 530 VZ ASIEN DE-1a fid 6,25 ssgn 35.90 bkl 33.61 bkl 51.00 bkl Pereira, Gabriela Garrastazu verfasserin aut Microparticles of Aloe vera/vitamin E/chitosan: Microscopic, a nuclear imaging and an in vivo test analysis for burn treatment 2014transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In order to observe the morphological properties, Raman and atomic force microscopy evaluation were performed. The biodistribution studies were analyzed by using a nuclear methodology, labeling the microparticles with Technetium-99m and in vivo test was procedure to analyzed the cicatrization process. The results of AFM analysis show the formation and the adherence property of the microparticles. Raman analyses show the distribution of each component in the microparticle. The nuclear method used shows that the biodistribution of the microparticles remained in the skin. The in vivo cicatrization test showed that the poloxamer gel containing the microparticles make a better cicatrization in relation to the other formulations tested. Abstract The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In order to observe the morphological properties, Raman and atomic force microscopy evaluation were performed. The biodistribution studies were analyzed by using a nuclear methodology, labeling the microparticles with Technetium-99m and in vivo test was procedure to analyzed the cicatrization process. The results of AFM analysis show the formation and the adherence property of the microparticles. Raman analyses show the distribution of each component in the microparticle. The nuclear method used shows that the biodistribution of the microparticles remained in the skin. The in vivo cicatrization test showed that the poloxamer gel containing the microparticles make a better cicatrization in relation to the other formulations tested. Burn Elsevier Atomic force microscopy Elsevier Skin Elsevier Technetium-99m Elsevier In vivo cicatrization Elsevier Santos-Oliveira, Ralph oth Albernaz, Martha S. oth Canema, Daniel oth Weismüller, Gilberto oth Barros, Eduardo Bede oth Magalhães, Luciana oth Lima-Ribeiro, Maria Helena Madruga oth Pohlmann, Adriana Raffin oth Guterres, Silvia S. oth Enthalten in Elsevier Fleming, Mark E. ELSEVIER Combat periarticular tibia injury outcome study (CAPTIOUS): risk factors for reoperation and amputation after open periarticular tibia fractures 2015 EJPB : official journal of the International Association for Pharmaceutical Technology New York, NY [u.a.] (DE-627)ELV013352458 volume:86 year:2014 number:2 pages:292-300 extent:9 https://doi.org/10.1016/j.ejpb.2013.10.011 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-ASIEN SSG-OLC-PHA GBV_ILN_40 35.90 Festkörperchemie VZ 33.61 Festkörperphysik VZ 51.00 Werkstoffkunde: Allgemeines VZ AR 86 2014 2 292-300 9 045F 610 |
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10.1016/j.ejpb.2013.10.011 doi GBVA2014014000015.pica (DE-627)ELV028229282 (ELSEVIER)S0939-6411(13)00337-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 540 530 VZ ASIEN DE-1a fid 6,25 ssgn 35.90 bkl 33.61 bkl 51.00 bkl Pereira, Gabriela Garrastazu verfasserin aut Microparticles of Aloe vera/vitamin E/chitosan: Microscopic, a nuclear imaging and an in vivo test analysis for burn treatment 2014transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In order to observe the morphological properties, Raman and atomic force microscopy evaluation were performed. The biodistribution studies were analyzed by using a nuclear methodology, labeling the microparticles with Technetium-99m and in vivo test was procedure to analyzed the cicatrization process. The results of AFM analysis show the formation and the adherence property of the microparticles. Raman analyses show the distribution of each component in the microparticle. The nuclear method used shows that the biodistribution of the microparticles remained in the skin. The in vivo cicatrization test showed that the poloxamer gel containing the microparticles make a better cicatrization in relation to the other formulations tested. Abstract The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In order to observe the morphological properties, Raman and atomic force microscopy evaluation were performed. The biodistribution studies were analyzed by using a nuclear methodology, labeling the microparticles with Technetium-99m and in vivo test was procedure to analyzed the cicatrization process. The results of AFM analysis show the formation and the adherence property of the microparticles. Raman analyses show the distribution of each component in the microparticle. The nuclear method used shows that the biodistribution of the microparticles remained in the skin. The in vivo cicatrization test showed that the poloxamer gel containing the microparticles make a better cicatrization in relation to the other formulations tested. Burn Elsevier Atomic force microscopy Elsevier Skin Elsevier Technetium-99m Elsevier In vivo cicatrization Elsevier Santos-Oliveira, Ralph oth Albernaz, Martha S. oth Canema, Daniel oth Weismüller, Gilberto oth Barros, Eduardo Bede oth Magalhães, Luciana oth Lima-Ribeiro, Maria Helena Madruga oth Pohlmann, Adriana Raffin oth Guterres, Silvia S. oth Enthalten in Elsevier Fleming, Mark E. ELSEVIER Combat periarticular tibia injury outcome study (CAPTIOUS): risk factors for reoperation and amputation after open periarticular tibia fractures 2015 EJPB : official journal of the International Association for Pharmaceutical Technology New York, NY [u.a.] (DE-627)ELV013352458 volume:86 year:2014 number:2 pages:292-300 extent:9 https://doi.org/10.1016/j.ejpb.2013.10.011 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-ASIEN SSG-OLC-PHA GBV_ILN_40 35.90 Festkörperchemie VZ 33.61 Festkörperphysik VZ 51.00 Werkstoffkunde: Allgemeines VZ AR 86 2014 2 292-300 9 045F 610 |
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10.1016/j.ejpb.2013.10.011 doi GBVA2014014000015.pica (DE-627)ELV028229282 (ELSEVIER)S0939-6411(13)00337-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 540 530 VZ ASIEN DE-1a fid 6,25 ssgn 35.90 bkl 33.61 bkl 51.00 bkl Pereira, Gabriela Garrastazu verfasserin aut Microparticles of Aloe vera/vitamin E/chitosan: Microscopic, a nuclear imaging and an in vivo test analysis for burn treatment 2014transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In order to observe the morphological properties, Raman and atomic force microscopy evaluation were performed. The biodistribution studies were analyzed by using a nuclear methodology, labeling the microparticles with Technetium-99m and in vivo test was procedure to analyzed the cicatrization process. The results of AFM analysis show the formation and the adherence property of the microparticles. Raman analyses show the distribution of each component in the microparticle. The nuclear method used shows that the biodistribution of the microparticles remained in the skin. The in vivo cicatrization test showed that the poloxamer gel containing the microparticles make a better cicatrization in relation to the other formulations tested. Abstract The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In order to observe the morphological properties, Raman and atomic force microscopy evaluation were performed. The biodistribution studies were analyzed by using a nuclear methodology, labeling the microparticles with Technetium-99m and in vivo test was procedure to analyzed the cicatrization process. The results of AFM analysis show the formation and the adherence property of the microparticles. Raman analyses show the distribution of each component in the microparticle. The nuclear method used shows that the biodistribution of the microparticles remained in the skin. The in vivo cicatrization test showed that the poloxamer gel containing the microparticles make a better cicatrization in relation to the other formulations tested. Burn Elsevier Atomic force microscopy Elsevier Skin Elsevier Technetium-99m Elsevier In vivo cicatrization Elsevier Santos-Oliveira, Ralph oth Albernaz, Martha S. oth Canema, Daniel oth Weismüller, Gilberto oth Barros, Eduardo Bede oth Magalhães, Luciana oth Lima-Ribeiro, Maria Helena Madruga oth Pohlmann, Adriana Raffin oth Guterres, Silvia S. oth Enthalten in Elsevier Fleming, Mark E. ELSEVIER Combat periarticular tibia injury outcome study (CAPTIOUS): risk factors for reoperation and amputation after open periarticular tibia fractures 2015 EJPB : official journal of the International Association for Pharmaceutical Technology New York, NY [u.a.] (DE-627)ELV013352458 volume:86 year:2014 number:2 pages:292-300 extent:9 https://doi.org/10.1016/j.ejpb.2013.10.011 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-ASIEN SSG-OLC-PHA GBV_ILN_40 35.90 Festkörperchemie VZ 33.61 Festkörperphysik VZ 51.00 Werkstoffkunde: Allgemeines VZ AR 86 2014 2 292-300 9 045F 610 |
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10.1016/j.ejpb.2013.10.011 doi GBVA2014014000015.pica (DE-627)ELV028229282 (ELSEVIER)S0939-6411(13)00337-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 540 530 VZ ASIEN DE-1a fid 6,25 ssgn 35.90 bkl 33.61 bkl 51.00 bkl Pereira, Gabriela Garrastazu verfasserin aut Microparticles of Aloe vera/vitamin E/chitosan: Microscopic, a nuclear imaging and an in vivo test analysis for burn treatment 2014transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In order to observe the morphological properties, Raman and atomic force microscopy evaluation were performed. The biodistribution studies were analyzed by using a nuclear methodology, labeling the microparticles with Technetium-99m and in vivo test was procedure to analyzed the cicatrization process. The results of AFM analysis show the formation and the adherence property of the microparticles. Raman analyses show the distribution of each component in the microparticle. The nuclear method used shows that the biodistribution of the microparticles remained in the skin. The in vivo cicatrization test showed that the poloxamer gel containing the microparticles make a better cicatrization in relation to the other formulations tested. Abstract The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In order to observe the morphological properties, Raman and atomic force microscopy evaluation were performed. The biodistribution studies were analyzed by using a nuclear methodology, labeling the microparticles with Technetium-99m and in vivo test was procedure to analyzed the cicatrization process. The results of AFM analysis show the formation and the adherence property of the microparticles. Raman analyses show the distribution of each component in the microparticle. The nuclear method used shows that the biodistribution of the microparticles remained in the skin. The in vivo cicatrization test showed that the poloxamer gel containing the microparticles make a better cicatrization in relation to the other formulations tested. Burn Elsevier Atomic force microscopy Elsevier Skin Elsevier Technetium-99m Elsevier In vivo cicatrization Elsevier Santos-Oliveira, Ralph oth Albernaz, Martha S. oth Canema, Daniel oth Weismüller, Gilberto oth Barros, Eduardo Bede oth Magalhães, Luciana oth Lima-Ribeiro, Maria Helena Madruga oth Pohlmann, Adriana Raffin oth Guterres, Silvia S. oth Enthalten in Elsevier Fleming, Mark E. ELSEVIER Combat periarticular tibia injury outcome study (CAPTIOUS): risk factors for reoperation and amputation after open periarticular tibia fractures 2015 EJPB : official journal of the International Association for Pharmaceutical Technology New York, NY [u.a.] (DE-627)ELV013352458 volume:86 year:2014 number:2 pages:292-300 extent:9 https://doi.org/10.1016/j.ejpb.2013.10.011 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-ASIEN SSG-OLC-PHA GBV_ILN_40 35.90 Festkörperchemie VZ 33.61 Festkörperphysik VZ 51.00 Werkstoffkunde: Allgemeines VZ AR 86 2014 2 292-300 9 045F 610 |
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10.1016/j.ejpb.2013.10.011 doi GBVA2014014000015.pica (DE-627)ELV028229282 (ELSEVIER)S0939-6411(13)00337-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 540 530 VZ ASIEN DE-1a fid 6,25 ssgn 35.90 bkl 33.61 bkl 51.00 bkl Pereira, Gabriela Garrastazu verfasserin aut Microparticles of Aloe vera/vitamin E/chitosan: Microscopic, a nuclear imaging and an in vivo test analysis for burn treatment 2014transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In order to observe the morphological properties, Raman and atomic force microscopy evaluation were performed. The biodistribution studies were analyzed by using a nuclear methodology, labeling the microparticles with Technetium-99m and in vivo test was procedure to analyzed the cicatrization process. The results of AFM analysis show the formation and the adherence property of the microparticles. Raman analyses show the distribution of each component in the microparticle. The nuclear method used shows that the biodistribution of the microparticles remained in the skin. The in vivo cicatrization test showed that the poloxamer gel containing the microparticles make a better cicatrization in relation to the other formulations tested. Abstract The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In order to observe the morphological properties, Raman and atomic force microscopy evaluation were performed. The biodistribution studies were analyzed by using a nuclear methodology, labeling the microparticles with Technetium-99m and in vivo test was procedure to analyzed the cicatrization process. The results of AFM analysis show the formation and the adherence property of the microparticles. Raman analyses show the distribution of each component in the microparticle. The nuclear method used shows that the biodistribution of the microparticles remained in the skin. The in vivo cicatrization test showed that the poloxamer gel containing the microparticles make a better cicatrization in relation to the other formulations tested. Burn Elsevier Atomic force microscopy Elsevier Skin Elsevier Technetium-99m Elsevier In vivo cicatrization Elsevier Santos-Oliveira, Ralph oth Albernaz, Martha S. oth Canema, Daniel oth Weismüller, Gilberto oth Barros, Eduardo Bede oth Magalhães, Luciana oth Lima-Ribeiro, Maria Helena Madruga oth Pohlmann, Adriana Raffin oth Guterres, Silvia S. oth Enthalten in Elsevier Fleming, Mark E. ELSEVIER Combat periarticular tibia injury outcome study (CAPTIOUS): risk factors for reoperation and amputation after open periarticular tibia fractures 2015 EJPB : official journal of the International Association for Pharmaceutical Technology New York, NY [u.a.] (DE-627)ELV013352458 volume:86 year:2014 number:2 pages:292-300 extent:9 https://doi.org/10.1016/j.ejpb.2013.10.011 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-ASIEN SSG-OLC-PHA GBV_ILN_40 35.90 Festkörperchemie VZ 33.61 Festkörperphysik VZ 51.00 Werkstoffkunde: Allgemeines VZ AR 86 2014 2 292-300 9 045F 610 |
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English |
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Enthalten in Combat periarticular tibia injury outcome study (CAPTIOUS): risk factors for reoperation and amputation after open periarticular tibia fractures New York, NY [u.a.] volume:86 year:2014 number:2 pages:292-300 extent:9 |
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Enthalten in Combat periarticular tibia injury outcome study (CAPTIOUS): risk factors for reoperation and amputation after open periarticular tibia fractures New York, NY [u.a.] volume:86 year:2014 number:2 pages:292-300 extent:9 |
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Combat periarticular tibia injury outcome study (CAPTIOUS): risk factors for reoperation and amputation after open periarticular tibia fractures |
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Pereira, Gabriela Garrastazu @@aut@@ Santos-Oliveira, Ralph @@oth@@ Albernaz, Martha S. @@oth@@ Canema, Daniel @@oth@@ Weismüller, Gilberto @@oth@@ Barros, Eduardo Bede @@oth@@ Magalhães, Luciana @@oth@@ Lima-Ribeiro, Maria Helena Madruga @@oth@@ Pohlmann, Adriana Raffin @@oth@@ Guterres, Silvia S. @@oth@@ |
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Microparticles of Aloe vera/vitamin E/chitosan: Microscopic, a nuclear imaging and an in vivo test analysis for burn treatment |
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Abstract The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In order to observe the morphological properties, Raman and atomic force microscopy evaluation were performed. The biodistribution studies were analyzed by using a nuclear methodology, labeling the microparticles with Technetium-99m and in vivo test was procedure to analyzed the cicatrization process. The results of AFM analysis show the formation and the adherence property of the microparticles. Raman analyses show the distribution of each component in the microparticle. The nuclear method used shows that the biodistribution of the microparticles remained in the skin. The in vivo cicatrization test showed that the poloxamer gel containing the microparticles make a better cicatrization in relation to the other formulations tested. |
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Abstract The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In order to observe the morphological properties, Raman and atomic force microscopy evaluation were performed. The biodistribution studies were analyzed by using a nuclear methodology, labeling the microparticles with Technetium-99m and in vivo test was procedure to analyzed the cicatrization process. The results of AFM analysis show the formation and the adherence property of the microparticles. Raman analyses show the distribution of each component in the microparticle. The nuclear method used shows that the biodistribution of the microparticles remained in the skin. The in vivo cicatrization test showed that the poloxamer gel containing the microparticles make a better cicatrization in relation to the other formulations tested. |
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Abstract The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In order to observe the morphological properties, Raman and atomic force microscopy evaluation were performed. The biodistribution studies were analyzed by using a nuclear methodology, labeling the microparticles with Technetium-99m and in vivo test was procedure to analyzed the cicatrization process. The results of AFM analysis show the formation and the adherence property of the microparticles. Raman analyses show the distribution of each component in the microparticle. The nuclear method used shows that the biodistribution of the microparticles remained in the skin. The in vivo cicatrization test showed that the poloxamer gel containing the microparticles make a better cicatrization in relation to the other formulations tested. |
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