Impaired context processing as a potential marker of psychosis risk state
While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCP...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Niendam, Tara A. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014transfer abstract |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: No title available - 221(2014), 1 vom: 30., Seite 13-20 |
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| Übergeordnetes Werk: |
volume:221 ; year:2014 ; number:1 ; day:30 ; month:01 ; pages:13-20 ; extent:8 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.pscychresns.2013.09.001 |
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| 520 | |a While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCPT) was administered to demographically matched clinical-high-risk (CHR; n=25), first-episode schizophrenia (FE; n=35), and healthy control (HC; n=35) participants during functional magnetic resonance imaging (fMRI) to investigate these relationships. CHR and FE individuals demonstrated impaired context processing and reduced DLPFC activation relative to HC individuals during increased cognitive control demands. FE and CHR individuals' ability to increase DLPFC activity in response to cognitive control demands was associated with better task performance. Task performance was also associated with severity of disorganization and poverty symptoms in FE participants. These findings support more extensive studies using fMRI to examine the clinical significance of prefrontal cortical functioning in the earliest stages of psychosis. | ||
| 520 | |a While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCPT) was administered to demographically matched clinical-high-risk (CHR; n=25), first-episode schizophrenia (FE; n=35), and healthy control (HC; n=35) participants during functional magnetic resonance imaging (fMRI) to investigate these relationships. CHR and FE individuals demonstrated impaired context processing and reduced DLPFC activation relative to HC individuals during increased cognitive control demands. FE and CHR individuals' ability to increase DLPFC activity in response to cognitive control demands was associated with better task performance. Task performance was also associated with severity of disorganization and poverty symptoms in FE participants. These findings support more extensive studies using fMRI to examine the clinical significance of prefrontal cortical functioning in the earliest stages of psychosis. | ||
| 650 | 7 | |a Psychosis |2 Elsevier | |
| 650 | 7 | |a fMRI |2 Elsevier | |
| 650 | 7 | |a Clinical high risk |2 Elsevier | |
| 650 | 7 | |a Cognition |2 Elsevier | |
| 650 | 7 | |a Prefrontal cortex |2 Elsevier | |
| 650 | 7 | |a Ultra high risk |2 Elsevier | |
| 700 | 1 | |a Lesh, Tyler A. |4 oth | |
| 700 | 1 | |a Yoon, Jong |4 oth | |
| 700 | 1 | |a Westphal, Andrew J. |4 oth | |
| 700 | 1 | |a Hutchison, Natalie |4 oth | |
| 700 | 1 | |a Daniel Ragland, J. |4 oth | |
| 700 | 1 | |a Solomon, Marjorie |4 oth | |
| 700 | 1 | |a Minzenberg, Michael |4 oth | |
| 700 | 1 | |a Carter, Cameron S. |4 oth | |
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10.1016/j.pscychresns.2013.09.001 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2014014000026.pica (DE-627)ELV028246675 (ELSEVIER)S0925-4927(13)00257-6 DE-627 ger DE-627 rakwb eng Niendam, Tara A. verfasserin aut Impaired context processing as a potential marker of psychosis risk state 2014transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCPT) was administered to demographically matched clinical-high-risk (CHR; n=25), first-episode schizophrenia (FE; n=35), and healthy control (HC; n=35) participants during functional magnetic resonance imaging (fMRI) to investigate these relationships. CHR and FE individuals demonstrated impaired context processing and reduced DLPFC activation relative to HC individuals during increased cognitive control demands. FE and CHR individuals' ability to increase DLPFC activity in response to cognitive control demands was associated with better task performance. Task performance was also associated with severity of disorganization and poverty symptoms in FE participants. These findings support more extensive studies using fMRI to examine the clinical significance of prefrontal cortical functioning in the earliest stages of psychosis. While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCPT) was administered to demographically matched clinical-high-risk (CHR; n=25), first-episode schizophrenia (FE; n=35), and healthy control (HC; n=35) participants during functional magnetic resonance imaging (fMRI) to investigate these relationships. CHR and FE individuals demonstrated impaired context processing and reduced DLPFC activation relative to HC individuals during increased cognitive control demands. FE and CHR individuals' ability to increase DLPFC activity in response to cognitive control demands was associated with better task performance. Task performance was also associated with severity of disorganization and poverty symptoms in FE participants. These findings support more extensive studies using fMRI to examine the clinical significance of prefrontal cortical functioning in the earliest stages of psychosis. Psychosis Elsevier fMRI Elsevier Clinical high risk Elsevier Cognition Elsevier Prefrontal cortex Elsevier Ultra high risk Elsevier Lesh, Tyler A. oth Yoon, Jong oth Westphal, Andrew J. oth Hutchison, Natalie oth Daniel Ragland, J. oth Solomon, Marjorie oth Minzenberg, Michael oth Carter, Cameron S. oth Enthalten in No title available 221(2014), 1 vom: 30., Seite 13-20 (DE-627)ELV025401890 (DE-600)5-4927 nnns volume:221 year:2014 number:1 day:30 month:01 pages:13-20 extent:8 https://doi.org/10.1016/j.pscychresns.2013.09.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 GBV_ILN_65 GBV_ILN_130 AR 221 2014 1 30 0130 13-20 8 |
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10.1016/j.pscychresns.2013.09.001 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2014014000026.pica (DE-627)ELV028246675 (ELSEVIER)S0925-4927(13)00257-6 DE-627 ger DE-627 rakwb eng Niendam, Tara A. verfasserin aut Impaired context processing as a potential marker of psychosis risk state 2014transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCPT) was administered to demographically matched clinical-high-risk (CHR; n=25), first-episode schizophrenia (FE; n=35), and healthy control (HC; n=35) participants during functional magnetic resonance imaging (fMRI) to investigate these relationships. CHR and FE individuals demonstrated impaired context processing and reduced DLPFC activation relative to HC individuals during increased cognitive control demands. FE and CHR individuals' ability to increase DLPFC activity in response to cognitive control demands was associated with better task performance. Task performance was also associated with severity of disorganization and poverty symptoms in FE participants. These findings support more extensive studies using fMRI to examine the clinical significance of prefrontal cortical functioning in the earliest stages of psychosis. While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCPT) was administered to demographically matched clinical-high-risk (CHR; n=25), first-episode schizophrenia (FE; n=35), and healthy control (HC; n=35) participants during functional magnetic resonance imaging (fMRI) to investigate these relationships. CHR and FE individuals demonstrated impaired context processing and reduced DLPFC activation relative to HC individuals during increased cognitive control demands. FE and CHR individuals' ability to increase DLPFC activity in response to cognitive control demands was associated with better task performance. Task performance was also associated with severity of disorganization and poverty symptoms in FE participants. These findings support more extensive studies using fMRI to examine the clinical significance of prefrontal cortical functioning in the earliest stages of psychosis. Psychosis Elsevier fMRI Elsevier Clinical high risk Elsevier Cognition Elsevier Prefrontal cortex Elsevier Ultra high risk Elsevier Lesh, Tyler A. oth Yoon, Jong oth Westphal, Andrew J. oth Hutchison, Natalie oth Daniel Ragland, J. oth Solomon, Marjorie oth Minzenberg, Michael oth Carter, Cameron S. oth Enthalten in No title available 221(2014), 1 vom: 30., Seite 13-20 (DE-627)ELV025401890 (DE-600)5-4927 nnns volume:221 year:2014 number:1 day:30 month:01 pages:13-20 extent:8 https://doi.org/10.1016/j.pscychresns.2013.09.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 GBV_ILN_65 GBV_ILN_130 AR 221 2014 1 30 0130 13-20 8 |
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10.1016/j.pscychresns.2013.09.001 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2014014000026.pica (DE-627)ELV028246675 (ELSEVIER)S0925-4927(13)00257-6 DE-627 ger DE-627 rakwb eng Niendam, Tara A. verfasserin aut Impaired context processing as a potential marker of psychosis risk state 2014transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCPT) was administered to demographically matched clinical-high-risk (CHR; n=25), first-episode schizophrenia (FE; n=35), and healthy control (HC; n=35) participants during functional magnetic resonance imaging (fMRI) to investigate these relationships. CHR and FE individuals demonstrated impaired context processing and reduced DLPFC activation relative to HC individuals during increased cognitive control demands. FE and CHR individuals' ability to increase DLPFC activity in response to cognitive control demands was associated with better task performance. Task performance was also associated with severity of disorganization and poverty symptoms in FE participants. These findings support more extensive studies using fMRI to examine the clinical significance of prefrontal cortical functioning in the earliest stages of psychosis. While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCPT) was administered to demographically matched clinical-high-risk (CHR; n=25), first-episode schizophrenia (FE; n=35), and healthy control (HC; n=35) participants during functional magnetic resonance imaging (fMRI) to investigate these relationships. CHR and FE individuals demonstrated impaired context processing and reduced DLPFC activation relative to HC individuals during increased cognitive control demands. FE and CHR individuals' ability to increase DLPFC activity in response to cognitive control demands was associated with better task performance. Task performance was also associated with severity of disorganization and poverty symptoms in FE participants. These findings support more extensive studies using fMRI to examine the clinical significance of prefrontal cortical functioning in the earliest stages of psychosis. Psychosis Elsevier fMRI Elsevier Clinical high risk Elsevier Cognition Elsevier Prefrontal cortex Elsevier Ultra high risk Elsevier Lesh, Tyler A. oth Yoon, Jong oth Westphal, Andrew J. oth Hutchison, Natalie oth Daniel Ragland, J. oth Solomon, Marjorie oth Minzenberg, Michael oth Carter, Cameron S. oth Enthalten in No title available 221(2014), 1 vom: 30., Seite 13-20 (DE-627)ELV025401890 (DE-600)5-4927 nnns volume:221 year:2014 number:1 day:30 month:01 pages:13-20 extent:8 https://doi.org/10.1016/j.pscychresns.2013.09.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 GBV_ILN_65 GBV_ILN_130 AR 221 2014 1 30 0130 13-20 8 |
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10.1016/j.pscychresns.2013.09.001 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2014014000026.pica (DE-627)ELV028246675 (ELSEVIER)S0925-4927(13)00257-6 DE-627 ger DE-627 rakwb eng Niendam, Tara A. verfasserin aut Impaired context processing as a potential marker of psychosis risk state 2014transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCPT) was administered to demographically matched clinical-high-risk (CHR; n=25), first-episode schizophrenia (FE; n=35), and healthy control (HC; n=35) participants during functional magnetic resonance imaging (fMRI) to investigate these relationships. CHR and FE individuals demonstrated impaired context processing and reduced DLPFC activation relative to HC individuals during increased cognitive control demands. FE and CHR individuals' ability to increase DLPFC activity in response to cognitive control demands was associated with better task performance. Task performance was also associated with severity of disorganization and poverty symptoms in FE participants. These findings support more extensive studies using fMRI to examine the clinical significance of prefrontal cortical functioning in the earliest stages of psychosis. While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCPT) was administered to demographically matched clinical-high-risk (CHR; n=25), first-episode schizophrenia (FE; n=35), and healthy control (HC; n=35) participants during functional magnetic resonance imaging (fMRI) to investigate these relationships. CHR and FE individuals demonstrated impaired context processing and reduced DLPFC activation relative to HC individuals during increased cognitive control demands. FE and CHR individuals' ability to increase DLPFC activity in response to cognitive control demands was associated with better task performance. Task performance was also associated with severity of disorganization and poverty symptoms in FE participants. These findings support more extensive studies using fMRI to examine the clinical significance of prefrontal cortical functioning in the earliest stages of psychosis. Psychosis Elsevier fMRI Elsevier Clinical high risk Elsevier Cognition Elsevier Prefrontal cortex Elsevier Ultra high risk Elsevier Lesh, Tyler A. oth Yoon, Jong oth Westphal, Andrew J. oth Hutchison, Natalie oth Daniel Ragland, J. oth Solomon, Marjorie oth Minzenberg, Michael oth Carter, Cameron S. oth Enthalten in No title available 221(2014), 1 vom: 30., Seite 13-20 (DE-627)ELV025401890 (DE-600)5-4927 nnns volume:221 year:2014 number:1 day:30 month:01 pages:13-20 extent:8 https://doi.org/10.1016/j.pscychresns.2013.09.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 GBV_ILN_65 GBV_ILN_130 AR 221 2014 1 30 0130 13-20 8 |
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10.1016/j.pscychresns.2013.09.001 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2014014000026.pica (DE-627)ELV028246675 (ELSEVIER)S0925-4927(13)00257-6 DE-627 ger DE-627 rakwb eng Niendam, Tara A. verfasserin aut Impaired context processing as a potential marker of psychosis risk state 2014transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCPT) was administered to demographically matched clinical-high-risk (CHR; n=25), first-episode schizophrenia (FE; n=35), and healthy control (HC; n=35) participants during functional magnetic resonance imaging (fMRI) to investigate these relationships. CHR and FE individuals demonstrated impaired context processing and reduced DLPFC activation relative to HC individuals during increased cognitive control demands. FE and CHR individuals' ability to increase DLPFC activity in response to cognitive control demands was associated with better task performance. Task performance was also associated with severity of disorganization and poverty symptoms in FE participants. These findings support more extensive studies using fMRI to examine the clinical significance of prefrontal cortical functioning in the earliest stages of psychosis. While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCPT) was administered to demographically matched clinical-high-risk (CHR; n=25), first-episode schizophrenia (FE; n=35), and healthy control (HC; n=35) participants during functional magnetic resonance imaging (fMRI) to investigate these relationships. CHR and FE individuals demonstrated impaired context processing and reduced DLPFC activation relative to HC individuals during increased cognitive control demands. FE and CHR individuals' ability to increase DLPFC activity in response to cognitive control demands was associated with better task performance. Task performance was also associated with severity of disorganization and poverty symptoms in FE participants. These findings support more extensive studies using fMRI to examine the clinical significance of prefrontal cortical functioning in the earliest stages of psychosis. Psychosis Elsevier fMRI Elsevier Clinical high risk Elsevier Cognition Elsevier Prefrontal cortex Elsevier Ultra high risk Elsevier Lesh, Tyler A. oth Yoon, Jong oth Westphal, Andrew J. oth Hutchison, Natalie oth Daniel Ragland, J. oth Solomon, Marjorie oth Minzenberg, Michael oth Carter, Cameron S. oth Enthalten in No title available 221(2014), 1 vom: 30., Seite 13-20 (DE-627)ELV025401890 (DE-600)5-4927 nnns volume:221 year:2014 number:1 day:30 month:01 pages:13-20 extent:8 https://doi.org/10.1016/j.pscychresns.2013.09.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 GBV_ILN_65 GBV_ILN_130 AR 221 2014 1 30 0130 13-20 8 |
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Impaired context processing as a potential marker of psychosis risk state |
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While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCPT) was administered to demographically matched clinical-high-risk (CHR; n=25), first-episode schizophrenia (FE; n=35), and healthy control (HC; n=35) participants during functional magnetic resonance imaging (fMRI) to investigate these relationships. CHR and FE individuals demonstrated impaired context processing and reduced DLPFC activation relative to HC individuals during increased cognitive control demands. FE and CHR individuals' ability to increase DLPFC activity in response to cognitive control demands was associated with better task performance. Task performance was also associated with severity of disorganization and poverty symptoms in FE participants. These findings support more extensive studies using fMRI to examine the clinical significance of prefrontal cortical functioning in the earliest stages of psychosis. |
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While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCPT) was administered to demographically matched clinical-high-risk (CHR; n=25), first-episode schizophrenia (FE; n=35), and healthy control (HC; n=35) participants during functional magnetic resonance imaging (fMRI) to investigate these relationships. CHR and FE individuals demonstrated impaired context processing and reduced DLPFC activation relative to HC individuals during increased cognitive control demands. FE and CHR individuals' ability to increase DLPFC activity in response to cognitive control demands was associated with better task performance. Task performance was also associated with severity of disorganization and poverty symptoms in FE participants. These findings support more extensive studies using fMRI to examine the clinical significance of prefrontal cortical functioning in the earliest stages of psychosis. |
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While structural abnormalities of the dorsolateral prefrontal cortex (DLPFC) may pre-date and predict psychosis onset, the relationships between functional deficits, cognitive and psychosocial impairments has yet to be explored in the at-risk period. An established measure of cognitive control (AXCPT) was administered to demographically matched clinical-high-risk (CHR; n=25), first-episode schizophrenia (FE; n=35), and healthy control (HC; n=35) participants during functional magnetic resonance imaging (fMRI) to investigate these relationships. CHR and FE individuals demonstrated impaired context processing and reduced DLPFC activation relative to HC individuals during increased cognitive control demands. FE and CHR individuals' ability to increase DLPFC activity in response to cognitive control demands was associated with better task performance. Task performance was also associated with severity of disorganization and poverty symptoms in FE participants. These findings support more extensive studies using fMRI to examine the clinical significance of prefrontal cortical functioning in the earliest stages of psychosis. |
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