1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors
Abstract A novel series of 1,2-benzisothiazol-3-one derivatives was synthesized and their biological activities were evaluated for inhibiting caspase-3 and -7 activities, in which some of them showed low nanomolar potency against caspase-3 in vitro and significant protection against apoptosis in a c...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wu, Lixin [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Umfang: |
11 |
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| Übergeordnetes Werk: |
Enthalten in: A theoretical model of cyberchondria development: Antecedents and intermediate processes - Zheng, Han ELSEVIER, 2021, a Tetrahedron publication for the rapid dissemination of full original research papers and critical reviews on bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:22 ; year:2014 ; number:8 ; day:15 ; month:04 ; pages:2416-2426 ; extent:11 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.bmc.2014.03.002 |
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ELV028295161 |
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| 520 | |a Abstract A novel series of 1,2-benzisothiazol-3-one derivatives was synthesized and their biological activities were evaluated for inhibiting caspase-3 and -7 activities, in which some of them showed low nanomolar potency against caspase-3 in vitro and significant protection against apoptosis in a camptothecin-induced Jurkat T cells system. Among the tested compounds, compound 5i exhibited the most potent caspase-3 inhibitory activity (IC50 =1.15nM). The molecular docking predicted the interactions and binding modes of the synthesized inhibitor in the caspase-3 active site. | ||
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| 700 | 1 | |a Yan, Zhihui |4 oth | |
| 700 | 1 | |a Tang, Xiaobin |4 oth | |
| 700 | 1 | |a Sun, Bo |4 oth | |
| 700 | 1 | |a Liu, Wei |4 oth | |
| 700 | 1 | |a Zhou, Honggang |4 oth | |
| 700 | 1 | |a Yang, Cheng |4 oth | |
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10.1016/j.bmc.2014.03.002 doi GBVA2014016000014.pica (DE-627)ELV028295161 (ELSEVIER)S0968-0896(14)00175-8 DE-627 ger DE-627 rakwb eng 540 610 540 DE-600 610 DE-600 004 VZ 53.70 bkl 05.42 bkl 53.76 bkl 54.00 bkl Wu, Lixin verfasserin aut 1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors 2014 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract A novel series of 1,2-benzisothiazol-3-one derivatives was synthesized and their biological activities were evaluated for inhibiting caspase-3 and -7 activities, in which some of them showed low nanomolar potency against caspase-3 in vitro and significant protection against apoptosis in a camptothecin-induced Jurkat T cells system. Among the tested compounds, compound 5i exhibited the most potent caspase-3 inhibitory activity (IC50 =1.15nM). The molecular docking predicted the interactions and binding modes of the synthesized inhibitor in the caspase-3 active site. Inhibitors Elsevier 1,2-Benzisothiazol-3-one Elsevier Caspase-3 Elsevier Apoptosis Elsevier Lu, Meiqi oth Yan, Zhihui oth Tang, Xiaobin oth Sun, Bo oth Liu, Wei oth Zhou, Honggang oth Yang, Cheng oth Enthalten in Elsevier Zheng, Han ELSEVIER A theoretical model of cyberchondria development: Antecedents and intermediate processes 2021 a Tetrahedron publication for the rapid dissemination of full original research papers and critical reviews on bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines Amsterdam [u.a.] (DE-627)ELV006510728 volume:22 year:2014 number:8 day:15 month:04 pages:2416-2426 extent:11 https://doi.org/10.1016/j.bmc.2014.03.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 53.70 Nachrichtentechnik Kommunikationstechnik: Allgemeines VZ 05.42 Telekommunikation VZ 53.76 Kommunikationsdienste Fernmeldetechnik VZ 54.00 Informatik: Allgemeines VZ AR 22 2014 8 15 0415 2416-2426 11 045F 540 |
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10.1016/j.bmc.2014.03.002 doi GBVA2014016000014.pica (DE-627)ELV028295161 (ELSEVIER)S0968-0896(14)00175-8 DE-627 ger DE-627 rakwb eng 540 610 540 DE-600 610 DE-600 004 VZ 53.70 bkl 05.42 bkl 53.76 bkl 54.00 bkl Wu, Lixin verfasserin aut 1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors 2014 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract A novel series of 1,2-benzisothiazol-3-one derivatives was synthesized and their biological activities were evaluated for inhibiting caspase-3 and -7 activities, in which some of them showed low nanomolar potency against caspase-3 in vitro and significant protection against apoptosis in a camptothecin-induced Jurkat T cells system. Among the tested compounds, compound 5i exhibited the most potent caspase-3 inhibitory activity (IC50 =1.15nM). The molecular docking predicted the interactions and binding modes of the synthesized inhibitor in the caspase-3 active site. Inhibitors Elsevier 1,2-Benzisothiazol-3-one Elsevier Caspase-3 Elsevier Apoptosis Elsevier Lu, Meiqi oth Yan, Zhihui oth Tang, Xiaobin oth Sun, Bo oth Liu, Wei oth Zhou, Honggang oth Yang, Cheng oth Enthalten in Elsevier Zheng, Han ELSEVIER A theoretical model of cyberchondria development: Antecedents and intermediate processes 2021 a Tetrahedron publication for the rapid dissemination of full original research papers and critical reviews on bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines Amsterdam [u.a.] (DE-627)ELV006510728 volume:22 year:2014 number:8 day:15 month:04 pages:2416-2426 extent:11 https://doi.org/10.1016/j.bmc.2014.03.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 53.70 Nachrichtentechnik Kommunikationstechnik: Allgemeines VZ 05.42 Telekommunikation VZ 53.76 Kommunikationsdienste Fernmeldetechnik VZ 54.00 Informatik: Allgemeines VZ AR 22 2014 8 15 0415 2416-2426 11 045F 540 |
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10.1016/j.bmc.2014.03.002 doi GBVA2014016000014.pica (DE-627)ELV028295161 (ELSEVIER)S0968-0896(14)00175-8 DE-627 ger DE-627 rakwb eng 540 610 540 DE-600 610 DE-600 004 VZ 53.70 bkl 05.42 bkl 53.76 bkl 54.00 bkl Wu, Lixin verfasserin aut 1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors 2014 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract A novel series of 1,2-benzisothiazol-3-one derivatives was synthesized and their biological activities were evaluated for inhibiting caspase-3 and -7 activities, in which some of them showed low nanomolar potency against caspase-3 in vitro and significant protection against apoptosis in a camptothecin-induced Jurkat T cells system. Among the tested compounds, compound 5i exhibited the most potent caspase-3 inhibitory activity (IC50 =1.15nM). The molecular docking predicted the interactions and binding modes of the synthesized inhibitor in the caspase-3 active site. Inhibitors Elsevier 1,2-Benzisothiazol-3-one Elsevier Caspase-3 Elsevier Apoptosis Elsevier Lu, Meiqi oth Yan, Zhihui oth Tang, Xiaobin oth Sun, Bo oth Liu, Wei oth Zhou, Honggang oth Yang, Cheng oth Enthalten in Elsevier Zheng, Han ELSEVIER A theoretical model of cyberchondria development: Antecedents and intermediate processes 2021 a Tetrahedron publication for the rapid dissemination of full original research papers and critical reviews on bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines Amsterdam [u.a.] (DE-627)ELV006510728 volume:22 year:2014 number:8 day:15 month:04 pages:2416-2426 extent:11 https://doi.org/10.1016/j.bmc.2014.03.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 53.70 Nachrichtentechnik Kommunikationstechnik: Allgemeines VZ 05.42 Telekommunikation VZ 53.76 Kommunikationsdienste Fernmeldetechnik VZ 54.00 Informatik: Allgemeines VZ AR 22 2014 8 15 0415 2416-2426 11 045F 540 |
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10.1016/j.bmc.2014.03.002 doi GBVA2014016000014.pica (DE-627)ELV028295161 (ELSEVIER)S0968-0896(14)00175-8 DE-627 ger DE-627 rakwb eng 540 610 540 DE-600 610 DE-600 004 VZ 53.70 bkl 05.42 bkl 53.76 bkl 54.00 bkl Wu, Lixin verfasserin aut 1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors 2014 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract A novel series of 1,2-benzisothiazol-3-one derivatives was synthesized and their biological activities were evaluated for inhibiting caspase-3 and -7 activities, in which some of them showed low nanomolar potency against caspase-3 in vitro and significant protection against apoptosis in a camptothecin-induced Jurkat T cells system. Among the tested compounds, compound 5i exhibited the most potent caspase-3 inhibitory activity (IC50 =1.15nM). The molecular docking predicted the interactions and binding modes of the synthesized inhibitor in the caspase-3 active site. Inhibitors Elsevier 1,2-Benzisothiazol-3-one Elsevier Caspase-3 Elsevier Apoptosis Elsevier Lu, Meiqi oth Yan, Zhihui oth Tang, Xiaobin oth Sun, Bo oth Liu, Wei oth Zhou, Honggang oth Yang, Cheng oth Enthalten in Elsevier Zheng, Han ELSEVIER A theoretical model of cyberchondria development: Antecedents and intermediate processes 2021 a Tetrahedron publication for the rapid dissemination of full original research papers and critical reviews on bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines Amsterdam [u.a.] (DE-627)ELV006510728 volume:22 year:2014 number:8 day:15 month:04 pages:2416-2426 extent:11 https://doi.org/10.1016/j.bmc.2014.03.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 53.70 Nachrichtentechnik Kommunikationstechnik: Allgemeines VZ 05.42 Telekommunikation VZ 53.76 Kommunikationsdienste Fernmeldetechnik VZ 54.00 Informatik: Allgemeines VZ AR 22 2014 8 15 0415 2416-2426 11 045F 540 |
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10.1016/j.bmc.2014.03.002 doi GBVA2014016000014.pica (DE-627)ELV028295161 (ELSEVIER)S0968-0896(14)00175-8 DE-627 ger DE-627 rakwb eng 540 610 540 DE-600 610 DE-600 004 VZ 53.70 bkl 05.42 bkl 53.76 bkl 54.00 bkl Wu, Lixin verfasserin aut 1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors 2014 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract A novel series of 1,2-benzisothiazol-3-one derivatives was synthesized and their biological activities were evaluated for inhibiting caspase-3 and -7 activities, in which some of them showed low nanomolar potency against caspase-3 in vitro and significant protection against apoptosis in a camptothecin-induced Jurkat T cells system. Among the tested compounds, compound 5i exhibited the most potent caspase-3 inhibitory activity (IC50 =1.15nM). The molecular docking predicted the interactions and binding modes of the synthesized inhibitor in the caspase-3 active site. Inhibitors Elsevier 1,2-Benzisothiazol-3-one Elsevier Caspase-3 Elsevier Apoptosis Elsevier Lu, Meiqi oth Yan, Zhihui oth Tang, Xiaobin oth Sun, Bo oth Liu, Wei oth Zhou, Honggang oth Yang, Cheng oth Enthalten in Elsevier Zheng, Han ELSEVIER A theoretical model of cyberchondria development: Antecedents and intermediate processes 2021 a Tetrahedron publication for the rapid dissemination of full original research papers and critical reviews on bioorganic chemistry, medicinal chemistry, bioinorganic chemistry and related disciplines Amsterdam [u.a.] (DE-627)ELV006510728 volume:22 year:2014 number:8 day:15 month:04 pages:2416-2426 extent:11 https://doi.org/10.1016/j.bmc.2014.03.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 53.70 Nachrichtentechnik Kommunikationstechnik: Allgemeines VZ 05.42 Telekommunikation VZ 53.76 Kommunikationsdienste Fernmeldetechnik VZ 54.00 Informatik: Allgemeines VZ AR 22 2014 8 15 0415 2416-2426 11 045F 540 |
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A theoretical model of cyberchondria development: Antecedents and intermediate processes |
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A theoretical model of cyberchondria development: Antecedents and intermediate processes |
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1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors |
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1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors |
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Wu, Lixin |
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A theoretical model of cyberchondria development: Antecedents and intermediate processes |
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10.1016/j.bmc.2014.03.002 |
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1,2-benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors |
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1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors |
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Abstract A novel series of 1,2-benzisothiazol-3-one derivatives was synthesized and their biological activities were evaluated for inhibiting caspase-3 and -7 activities, in which some of them showed low nanomolar potency against caspase-3 in vitro and significant protection against apoptosis in a camptothecin-induced Jurkat T cells system. Among the tested compounds, compound 5i exhibited the most potent caspase-3 inhibitory activity (IC50 =1.15nM). The molecular docking predicted the interactions and binding modes of the synthesized inhibitor in the caspase-3 active site. |
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Abstract A novel series of 1,2-benzisothiazol-3-one derivatives was synthesized and their biological activities were evaluated for inhibiting caspase-3 and -7 activities, in which some of them showed low nanomolar potency against caspase-3 in vitro and significant protection against apoptosis in a camptothecin-induced Jurkat T cells system. Among the tested compounds, compound 5i exhibited the most potent caspase-3 inhibitory activity (IC50 =1.15nM). The molecular docking predicted the interactions and binding modes of the synthesized inhibitor in the caspase-3 active site. |
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Abstract A novel series of 1,2-benzisothiazol-3-one derivatives was synthesized and their biological activities were evaluated for inhibiting caspase-3 and -7 activities, in which some of them showed low nanomolar potency against caspase-3 in vitro and significant protection against apoptosis in a camptothecin-induced Jurkat T cells system. Among the tested compounds, compound 5i exhibited the most potent caspase-3 inhibitory activity (IC50 =1.15nM). The molecular docking predicted the interactions and binding modes of the synthesized inhibitor in the caspase-3 active site. |
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1,2-Benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors |
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Lu, Meiqi Yan, Zhihui Tang, Xiaobin Sun, Bo Liu, Wei Zhou, Honggang Yang, Cheng |
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