Disialoganglioside GD3-synthase over expression inhibits survival and angiogenesis of pancreatic cancer cells through cell cycle arrest at S-phase and disruption of integrin-β1-mediated anchorage
• The regulation of pancreatic cancer progression by sialic acid modulatory enzymes. • The intracellular mechanism of GD3-induced apoptosis in PDAC cells. • GD3-synthase transfected MIAPaCa2 cells showed apoptosis by arresting in S-phase. • Co-localisation of GD3 with Integrin-β1 inhibit its downstr...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mandal, Chandan [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
|---|
| Umfang: |
12 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Urological Diseases of the Byzantine Emperors (330-1453) - 2011, Amsterdam |
|---|---|
| Übergeordnetes Werk: |
volume:53 ; year:2014 ; pages:162-173 ; extent:12 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.biocel.2014.05.015 |
|---|
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ELV028381726 |
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Disialoganglioside GD3-synthase over expression inhibits survival and angiogenesis of pancreatic cancer cells through cell cycle arrest at S-phase and disruption of integrin-β1-mediated anchorage |
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• The regulation of pancreatic cancer progression by sialic acid modulatory enzymes. • The intracellular mechanism of GD3-induced apoptosis in PDAC cells. • GD3-synthase transfected MIAPaCa2 cells showed apoptosis by arresting in S-phase. • Co-localisation of GD3 with Integrin-β1 inhibit its downstream signalling. • It inhibits the cell adhesion with extra-cellular matrix and angiogenic pathway. |
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• The regulation of pancreatic cancer progression by sialic acid modulatory enzymes. • The intracellular mechanism of GD3-induced apoptosis in PDAC cells. • GD3-synthase transfected MIAPaCa2 cells showed apoptosis by arresting in S-phase. • Co-localisation of GD3 with Integrin-β1 inhibit its downstream signalling. • It inhibits the cell adhesion with extra-cellular matrix and angiogenic pathway. |
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• The regulation of pancreatic cancer progression by sialic acid modulatory enzymes. • The intracellular mechanism of GD3-induced apoptosis in PDAC cells. • GD3-synthase transfected MIAPaCa2 cells showed apoptosis by arresting in S-phase. • Co-localisation of GD3 with Integrin-β1 inhibit its downstream signalling. • It inhibits the cell adhesion with extra-cellular matrix and angiogenic pathway. |
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