Revealing the role of SGK1 in the dynamics of medulloblastoma using a mathematical model
Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine no...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kawka, Joanna [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014transfer abstract |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: Dissolution versus cementation and its role in determining tight sandstone quality: A case study from the Upper Paleozoic in northeastern Ordos Basin, China - Li, Yong ELSEVIER, 2020, Amsterdam |
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| Übergeordnetes Werk: |
volume:354 ; year:2014 ; day:7 ; month:08 ; pages:105-112 ; extent:8 |
| Links: |
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| DOI / URN: |
10.1016/j.jtbi.2014.03.028 |
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| 520 | |a Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We focus on the interplay between MYC and SGK1 (serum and glucocorticoid-inducible kinase 1), which are the products of Wnt/β-catenin signaling pathway, and GSK3β (glycogen synthase kinase). Numerical simulations of the model solutions yield a better understanding of the process and indicate the importance of the SGK1 gene in the development of medulloblastoma, which has been confirmed in our recent experiments. The model is calibrated based on the gene expression microarray data for two types of medulloblastoma, characterized by monosomy and trisomy of chromosome 6q to highlight the difference between diagnoses. | ||
| 520 | |a Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We focus on the interplay between MYC and SGK1 (serum and glucocorticoid-inducible kinase 1), which are the products of Wnt/β-catenin signaling pathway, and GSK3β (glycogen synthase kinase). Numerical simulations of the model solutions yield a better understanding of the process and indicate the importance of the SGK1 gene in the development of medulloblastoma, which has been confirmed in our recent experiments. The model is calibrated based on the gene expression microarray data for two types of medulloblastoma, characterized by monosomy and trisomy of chromosome 6q to highlight the difference between diagnoses. | ||
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10.1016/j.jtbi.2014.03.028 doi GBVA2014021000012.pica (DE-627)ELV028474090 (ELSEVIER)S0022-5193(14)00167-2 DE-627 ger DE-627 rakwb eng 570 570 DE-600 660 VZ Kawka, Joanna verfasserin aut Revealing the role of SGK1 in the dynamics of medulloblastoma using a mathematical model 2014transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We focus on the interplay between MYC and SGK1 (serum and glucocorticoid-inducible kinase 1), which are the products of Wnt/β-catenin signaling pathway, and GSK3β (glycogen synthase kinase). Numerical simulations of the model solutions yield a better understanding of the process and indicate the importance of the SGK1 gene in the development of medulloblastoma, which has been confirmed in our recent experiments. The model is calibrated based on the gene expression microarray data for two types of medulloblastoma, characterized by monosomy and trisomy of chromosome 6q to highlight the difference between diagnoses. Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We focus on the interplay between MYC and SGK1 (serum and glucocorticoid-inducible kinase 1), which are the products of Wnt/β-catenin signaling pathway, and GSK3β (glycogen synthase kinase). Numerical simulations of the model solutions yield a better understanding of the process and indicate the importance of the SGK1 gene in the development of medulloblastoma, which has been confirmed in our recent experiments. The model is calibrated based on the gene expression microarray data for two types of medulloblastoma, characterized by monosomy and trisomy of chromosome 6q to highlight the difference between diagnoses. Wnt signaling pathway Elsevier GSK3β Elsevier Differential equations Elsevier MYC Elsevier Sturm, Dominik oth Pleier, Sabrina oth Pfister, Stefan oth Marciniak-Czochra, Anna oth Enthalten in Elsevier Ltd Li, Yong ELSEVIER Dissolution versus cementation and its role in determining tight sandstone quality: A case study from the Upper Paleozoic in northeastern Ordos Basin, China 2020 Amsterdam (DE-627)ELV004081676 volume:354 year:2014 day:7 month:08 pages:105-112 extent:8 https://doi.org/10.1016/j.jtbi.2014.03.028 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA AR 354 2014 7 0807 105-112 8 045F 570 |
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10.1016/j.jtbi.2014.03.028 doi GBVA2014021000012.pica (DE-627)ELV028474090 (ELSEVIER)S0022-5193(14)00167-2 DE-627 ger DE-627 rakwb eng 570 570 DE-600 660 VZ Kawka, Joanna verfasserin aut Revealing the role of SGK1 in the dynamics of medulloblastoma using a mathematical model 2014transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We focus on the interplay between MYC and SGK1 (serum and glucocorticoid-inducible kinase 1), which are the products of Wnt/β-catenin signaling pathway, and GSK3β (glycogen synthase kinase). Numerical simulations of the model solutions yield a better understanding of the process and indicate the importance of the SGK1 gene in the development of medulloblastoma, which has been confirmed in our recent experiments. The model is calibrated based on the gene expression microarray data for two types of medulloblastoma, characterized by monosomy and trisomy of chromosome 6q to highlight the difference between diagnoses. Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We focus on the interplay between MYC and SGK1 (serum and glucocorticoid-inducible kinase 1), which are the products of Wnt/β-catenin signaling pathway, and GSK3β (glycogen synthase kinase). Numerical simulations of the model solutions yield a better understanding of the process and indicate the importance of the SGK1 gene in the development of medulloblastoma, which has been confirmed in our recent experiments. The model is calibrated based on the gene expression microarray data for two types of medulloblastoma, characterized by monosomy and trisomy of chromosome 6q to highlight the difference between diagnoses. Wnt signaling pathway Elsevier GSK3β Elsevier Differential equations Elsevier MYC Elsevier Sturm, Dominik oth Pleier, Sabrina oth Pfister, Stefan oth Marciniak-Czochra, Anna oth Enthalten in Elsevier Ltd Li, Yong ELSEVIER Dissolution versus cementation and its role in determining tight sandstone quality: A case study from the Upper Paleozoic in northeastern Ordos Basin, China 2020 Amsterdam (DE-627)ELV004081676 volume:354 year:2014 day:7 month:08 pages:105-112 extent:8 https://doi.org/10.1016/j.jtbi.2014.03.028 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA AR 354 2014 7 0807 105-112 8 045F 570 |
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10.1016/j.jtbi.2014.03.028 doi GBVA2014021000012.pica (DE-627)ELV028474090 (ELSEVIER)S0022-5193(14)00167-2 DE-627 ger DE-627 rakwb eng 570 570 DE-600 660 VZ Kawka, Joanna verfasserin aut Revealing the role of SGK1 in the dynamics of medulloblastoma using a mathematical model 2014transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We focus on the interplay between MYC and SGK1 (serum and glucocorticoid-inducible kinase 1), which are the products of Wnt/β-catenin signaling pathway, and GSK3β (glycogen synthase kinase). Numerical simulations of the model solutions yield a better understanding of the process and indicate the importance of the SGK1 gene in the development of medulloblastoma, which has been confirmed in our recent experiments. The model is calibrated based on the gene expression microarray data for two types of medulloblastoma, characterized by monosomy and trisomy of chromosome 6q to highlight the difference between diagnoses. Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We focus on the interplay between MYC and SGK1 (serum and glucocorticoid-inducible kinase 1), which are the products of Wnt/β-catenin signaling pathway, and GSK3β (glycogen synthase kinase). Numerical simulations of the model solutions yield a better understanding of the process and indicate the importance of the SGK1 gene in the development of medulloblastoma, which has been confirmed in our recent experiments. The model is calibrated based on the gene expression microarray data for two types of medulloblastoma, characterized by monosomy and trisomy of chromosome 6q to highlight the difference between diagnoses. Wnt signaling pathway Elsevier GSK3β Elsevier Differential equations Elsevier MYC Elsevier Sturm, Dominik oth Pleier, Sabrina oth Pfister, Stefan oth Marciniak-Czochra, Anna oth Enthalten in Elsevier Ltd Li, Yong ELSEVIER Dissolution versus cementation and its role in determining tight sandstone quality: A case study from the Upper Paleozoic in northeastern Ordos Basin, China 2020 Amsterdam (DE-627)ELV004081676 volume:354 year:2014 day:7 month:08 pages:105-112 extent:8 https://doi.org/10.1016/j.jtbi.2014.03.028 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA AR 354 2014 7 0807 105-112 8 045F 570 |
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10.1016/j.jtbi.2014.03.028 doi GBVA2014021000012.pica (DE-627)ELV028474090 (ELSEVIER)S0022-5193(14)00167-2 DE-627 ger DE-627 rakwb eng 570 570 DE-600 660 VZ Kawka, Joanna verfasserin aut Revealing the role of SGK1 in the dynamics of medulloblastoma using a mathematical model 2014transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We focus on the interplay between MYC and SGK1 (serum and glucocorticoid-inducible kinase 1), which are the products of Wnt/β-catenin signaling pathway, and GSK3β (glycogen synthase kinase). Numerical simulations of the model solutions yield a better understanding of the process and indicate the importance of the SGK1 gene in the development of medulloblastoma, which has been confirmed in our recent experiments. The model is calibrated based on the gene expression microarray data for two types of medulloblastoma, characterized by monosomy and trisomy of chromosome 6q to highlight the difference between diagnoses. Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We focus on the interplay between MYC and SGK1 (serum and glucocorticoid-inducible kinase 1), which are the products of Wnt/β-catenin signaling pathway, and GSK3β (glycogen synthase kinase). Numerical simulations of the model solutions yield a better understanding of the process and indicate the importance of the SGK1 gene in the development of medulloblastoma, which has been confirmed in our recent experiments. The model is calibrated based on the gene expression microarray data for two types of medulloblastoma, characterized by monosomy and trisomy of chromosome 6q to highlight the difference between diagnoses. Wnt signaling pathway Elsevier GSK3β Elsevier Differential equations Elsevier MYC Elsevier Sturm, Dominik oth Pleier, Sabrina oth Pfister, Stefan oth Marciniak-Czochra, Anna oth Enthalten in Elsevier Ltd Li, Yong ELSEVIER Dissolution versus cementation and its role in determining tight sandstone quality: A case study from the Upper Paleozoic in northeastern Ordos Basin, China 2020 Amsterdam (DE-627)ELV004081676 volume:354 year:2014 day:7 month:08 pages:105-112 extent:8 https://doi.org/10.1016/j.jtbi.2014.03.028 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA AR 354 2014 7 0807 105-112 8 045F 570 |
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10.1016/j.jtbi.2014.03.028 doi GBVA2014021000012.pica (DE-627)ELV028474090 (ELSEVIER)S0022-5193(14)00167-2 DE-627 ger DE-627 rakwb eng 570 570 DE-600 660 VZ Kawka, Joanna verfasserin aut Revealing the role of SGK1 in the dynamics of medulloblastoma using a mathematical model 2014transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We focus on the interplay between MYC and SGK1 (serum and glucocorticoid-inducible kinase 1), which are the products of Wnt/β-catenin signaling pathway, and GSK3β (glycogen synthase kinase). Numerical simulations of the model solutions yield a better understanding of the process and indicate the importance of the SGK1 gene in the development of medulloblastoma, which has been confirmed in our recent experiments. The model is calibrated based on the gene expression microarray data for two types of medulloblastoma, characterized by monosomy and trisomy of chromosome 6q to highlight the difference between diagnoses. Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We focus on the interplay between MYC and SGK1 (serum and glucocorticoid-inducible kinase 1), which are the products of Wnt/β-catenin signaling pathway, and GSK3β (glycogen synthase kinase). Numerical simulations of the model solutions yield a better understanding of the process and indicate the importance of the SGK1 gene in the development of medulloblastoma, which has been confirmed in our recent experiments. The model is calibrated based on the gene expression microarray data for two types of medulloblastoma, characterized by monosomy and trisomy of chromosome 6q to highlight the difference between diagnoses. Wnt signaling pathway Elsevier GSK3β Elsevier Differential equations Elsevier MYC Elsevier Sturm, Dominik oth Pleier, Sabrina oth Pfister, Stefan oth Marciniak-Czochra, Anna oth Enthalten in Elsevier Ltd Li, Yong ELSEVIER Dissolution versus cementation and its role in determining tight sandstone quality: A case study from the Upper Paleozoic in northeastern Ordos Basin, China 2020 Amsterdam (DE-627)ELV004081676 volume:354 year:2014 day:7 month:08 pages:105-112 extent:8 https://doi.org/10.1016/j.jtbi.2014.03.028 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA AR 354 2014 7 0807 105-112 8 045F 570 |
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Enthalten in Dissolution versus cementation and its role in determining tight sandstone quality: A case study from the Upper Paleozoic in northeastern Ordos Basin, China Amsterdam volume:354 year:2014 day:7 month:08 pages:105-112 extent:8 |
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Enthalten in Dissolution versus cementation and its role in determining tight sandstone quality: A case study from the Upper Paleozoic in northeastern Ordos Basin, China Amsterdam volume:354 year:2014 day:7 month:08 pages:105-112 extent:8 |
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Dissolution versus cementation and its role in determining tight sandstone quality: A case study from the Upper Paleozoic in northeastern Ordos Basin, China |
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Revealing the role of SGK1 in the dynamics of medulloblastoma using a mathematical model |
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Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We focus on the interplay between MYC and SGK1 (serum and glucocorticoid-inducible kinase 1), which are the products of Wnt/β-catenin signaling pathway, and GSK3β (glycogen synthase kinase). Numerical simulations of the model solutions yield a better understanding of the process and indicate the importance of the SGK1 gene in the development of medulloblastoma, which has been confirmed in our recent experiments. The model is calibrated based on the gene expression microarray data for two types of medulloblastoma, characterized by monosomy and trisomy of chromosome 6q to highlight the difference between diagnoses. |
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Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We focus on the interplay between MYC and SGK1 (serum and glucocorticoid-inducible kinase 1), which are the products of Wnt/β-catenin signaling pathway, and GSK3β (glycogen synthase kinase). Numerical simulations of the model solutions yield a better understanding of the process and indicate the importance of the SGK1 gene in the development of medulloblastoma, which has been confirmed in our recent experiments. The model is calibrated based on the gene expression microarray data for two types of medulloblastoma, characterized by monosomy and trisomy of chromosome 6q to highlight the difference between diagnoses. |
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Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We focus on the interplay between MYC and SGK1 (serum and glucocorticoid-inducible kinase 1), which are the products of Wnt/β-catenin signaling pathway, and GSK3β (glycogen synthase kinase). Numerical simulations of the model solutions yield a better understanding of the process and indicate the importance of the SGK1 gene in the development of medulloblastoma, which has been confirmed in our recent experiments. The model is calibrated based on the gene expression microarray data for two types of medulloblastoma, characterized by monosomy and trisomy of chromosome 6q to highlight the difference between diagnoses. |
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