Increased epicardial adipose tissue is associated with coronary artery disease and major adverse cardiovascular events
Background: Increased-epicardial-adipose tissue (EAT) is associated with the presence and severity of subclinical-atherosclerosis. This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Hajsadeghi, Fereshteh [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014transfer abstract |
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| Schlagwörter: |
Computed tomography angiography (CTA) |
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| Umfang: |
4 |
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| Übergeordnetes Werk: |
Enthalten in: No title available - 237(2014), 2, Seite 486-489 |
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| Übergeordnetes Werk: |
volume:237 ; year:2014 ; number:2 ; pages:486-489 ; extent:4 |
| Links: |
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| DOI / URN: |
10.1016/j.atherosclerosis.2014.09.037 |
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ELV028481194 |
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| 100 | 1 | |a Hajsadeghi, Fereshteh |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Increased epicardial adipose tissue is associated with coronary artery disease and major adverse cardiovascular events |
| 264 | 1 | |c 2014transfer abstract | |
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| 520 | |a Background: Increased-epicardial-adipose tissue (EAT) is associated with the presence and severity of subclinical-atherosclerosis. This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). Conclusion: Increased EAT is directly associated with CAD and predicts MACE independent of the age, gender and conventional-risk-factors. | ||
| 520 | |a Background: Increased-epicardial-adipose tissue (EAT) is associated with the presence and severity of subclinical-atherosclerosis. This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). Conclusion: Increased EAT is directly associated with CAD and predicts MACE independent of the age, gender and conventional-risk-factors. | ||
| 650 | 7 | |a Coronary artery disease (CAD) |2 Elsevier | |
| 650 | 7 | |a Computed tomography angiography (CTA) |2 Elsevier | |
| 650 | 7 | |a Epicardial adipose tissue (EAT) |2 Elsevier | |
| 650 | 7 | |a Major adverse cardiac event (MACE) |2 Elsevier | |
| 700 | 1 | |a Nabavi, Vahid |4 oth | |
| 700 | 1 | |a Bhandari, Ajay |4 oth | |
| 700 | 1 | |a Choi, Andrew |4 oth | |
| 700 | 1 | |a Vincent, Hunter |4 oth | |
| 700 | 1 | |a Flores, Ferdinand |4 oth | |
| 700 | 1 | |a Budoff, Matthew |4 oth | |
| 700 | 1 | |a Ahmadi, Naser |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |t No title available |g 237(2014), 2, Seite 486-489 |w (DE-627)ELV012595616 |w (DE-600)1-9150 |7 nnns |
| 773 | 1 | 8 | |g volume:237 |g year:2014 |g number:2 |g pages:486-489 |g extent:4 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.atherosclerosis.2014.09.037 |3 Volltext |
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2014transfer abstract |
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2014 |
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10.1016/j.atherosclerosis.2014.09.037 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2014021000017.pica (DE-627)ELV028481194 (ELSEVIER)S0021-9150(14)01461-0 DE-627 ger DE-627 rakwb eng Hajsadeghi, Fereshteh verfasserin aut Increased epicardial adipose tissue is associated with coronary artery disease and major adverse cardiovascular events 2014transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: Increased-epicardial-adipose tissue (EAT) is associated with the presence and severity of subclinical-atherosclerosis. This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). Conclusion: Increased EAT is directly associated with CAD and predicts MACE independent of the age, gender and conventional-risk-factors. Background: Increased-epicardial-adipose tissue (EAT) is associated with the presence and severity of subclinical-atherosclerosis. This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). Conclusion: Increased EAT is directly associated with CAD and predicts MACE independent of the age, gender and conventional-risk-factors. Coronary artery disease (CAD) Elsevier Computed tomography angiography (CTA) Elsevier Epicardial adipose tissue (EAT) Elsevier Major adverse cardiac event (MACE) Elsevier Nabavi, Vahid oth Bhandari, Ajay oth Choi, Andrew oth Vincent, Hunter oth Flores, Ferdinand oth Budoff, Matthew oth Ahmadi, Naser oth Enthalten in No title available 237(2014), 2, Seite 486-489 (DE-627)ELV012595616 (DE-600)1-9150 nnns volume:237 year:2014 number:2 pages:486-489 extent:4 https://doi.org/10.1016/j.atherosclerosis.2014.09.037 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_40 GBV_ILN_105 AR 237 2014 2 486-489 4 |
| spelling |
10.1016/j.atherosclerosis.2014.09.037 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2014021000017.pica (DE-627)ELV028481194 (ELSEVIER)S0021-9150(14)01461-0 DE-627 ger DE-627 rakwb eng Hajsadeghi, Fereshteh verfasserin aut Increased epicardial adipose tissue is associated with coronary artery disease and major adverse cardiovascular events 2014transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: Increased-epicardial-adipose tissue (EAT) is associated with the presence and severity of subclinical-atherosclerosis. This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). Conclusion: Increased EAT is directly associated with CAD and predicts MACE independent of the age, gender and conventional-risk-factors. Background: Increased-epicardial-adipose tissue (EAT) is associated with the presence and severity of subclinical-atherosclerosis. This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). Conclusion: Increased EAT is directly associated with CAD and predicts MACE independent of the age, gender and conventional-risk-factors. Coronary artery disease (CAD) Elsevier Computed tomography angiography (CTA) Elsevier Epicardial adipose tissue (EAT) Elsevier Major adverse cardiac event (MACE) Elsevier Nabavi, Vahid oth Bhandari, Ajay oth Choi, Andrew oth Vincent, Hunter oth Flores, Ferdinand oth Budoff, Matthew oth Ahmadi, Naser oth Enthalten in No title available 237(2014), 2, Seite 486-489 (DE-627)ELV012595616 (DE-600)1-9150 nnns volume:237 year:2014 number:2 pages:486-489 extent:4 https://doi.org/10.1016/j.atherosclerosis.2014.09.037 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_40 GBV_ILN_105 AR 237 2014 2 486-489 4 |
| allfields_unstemmed |
10.1016/j.atherosclerosis.2014.09.037 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2014021000017.pica (DE-627)ELV028481194 (ELSEVIER)S0021-9150(14)01461-0 DE-627 ger DE-627 rakwb eng Hajsadeghi, Fereshteh verfasserin aut Increased epicardial adipose tissue is associated with coronary artery disease and major adverse cardiovascular events 2014transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: Increased-epicardial-adipose tissue (EAT) is associated with the presence and severity of subclinical-atherosclerosis. This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). Conclusion: Increased EAT is directly associated with CAD and predicts MACE independent of the age, gender and conventional-risk-factors. Background: Increased-epicardial-adipose tissue (EAT) is associated with the presence and severity of subclinical-atherosclerosis. This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). Conclusion: Increased EAT is directly associated with CAD and predicts MACE independent of the age, gender and conventional-risk-factors. Coronary artery disease (CAD) Elsevier Computed tomography angiography (CTA) Elsevier Epicardial adipose tissue (EAT) Elsevier Major adverse cardiac event (MACE) Elsevier Nabavi, Vahid oth Bhandari, Ajay oth Choi, Andrew oth Vincent, Hunter oth Flores, Ferdinand oth Budoff, Matthew oth Ahmadi, Naser oth Enthalten in No title available 237(2014), 2, Seite 486-489 (DE-627)ELV012595616 (DE-600)1-9150 nnns volume:237 year:2014 number:2 pages:486-489 extent:4 https://doi.org/10.1016/j.atherosclerosis.2014.09.037 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_40 GBV_ILN_105 AR 237 2014 2 486-489 4 |
| allfieldsGer |
10.1016/j.atherosclerosis.2014.09.037 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2014021000017.pica (DE-627)ELV028481194 (ELSEVIER)S0021-9150(14)01461-0 DE-627 ger DE-627 rakwb eng Hajsadeghi, Fereshteh verfasserin aut Increased epicardial adipose tissue is associated with coronary artery disease and major adverse cardiovascular events 2014transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: Increased-epicardial-adipose tissue (EAT) is associated with the presence and severity of subclinical-atherosclerosis. This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). Conclusion: Increased EAT is directly associated with CAD and predicts MACE independent of the age, gender and conventional-risk-factors. Background: Increased-epicardial-adipose tissue (EAT) is associated with the presence and severity of subclinical-atherosclerosis. This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). Conclusion: Increased EAT is directly associated with CAD and predicts MACE independent of the age, gender and conventional-risk-factors. Coronary artery disease (CAD) Elsevier Computed tomography angiography (CTA) Elsevier Epicardial adipose tissue (EAT) Elsevier Major adverse cardiac event (MACE) Elsevier Nabavi, Vahid oth Bhandari, Ajay oth Choi, Andrew oth Vincent, Hunter oth Flores, Ferdinand oth Budoff, Matthew oth Ahmadi, Naser oth Enthalten in No title available 237(2014), 2, Seite 486-489 (DE-627)ELV012595616 (DE-600)1-9150 nnns volume:237 year:2014 number:2 pages:486-489 extent:4 https://doi.org/10.1016/j.atherosclerosis.2014.09.037 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_40 GBV_ILN_105 AR 237 2014 2 486-489 4 |
| allfieldsSound |
10.1016/j.atherosclerosis.2014.09.037 doi /export/home/cbs_olc/import_discovery/elsevier/convert/GBV-Archive_01_06_pica_neu/GBVA2014021000017.pica (DE-627)ELV028481194 (ELSEVIER)S0021-9150(14)01461-0 DE-627 ger DE-627 rakwb eng Hajsadeghi, Fereshteh verfasserin aut Increased epicardial adipose tissue is associated with coronary artery disease and major adverse cardiovascular events 2014transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: Increased-epicardial-adipose tissue (EAT) is associated with the presence and severity of subclinical-atherosclerosis. This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). Conclusion: Increased EAT is directly associated with CAD and predicts MACE independent of the age, gender and conventional-risk-factors. Background: Increased-epicardial-adipose tissue (EAT) is associated with the presence and severity of subclinical-atherosclerosis. This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). Conclusion: Increased EAT is directly associated with CAD and predicts MACE independent of the age, gender and conventional-risk-factors. Coronary artery disease (CAD) Elsevier Computed tomography angiography (CTA) Elsevier Epicardial adipose tissue (EAT) Elsevier Major adverse cardiac event (MACE) Elsevier Nabavi, Vahid oth Bhandari, Ajay oth Choi, Andrew oth Vincent, Hunter oth Flores, Ferdinand oth Budoff, Matthew oth Ahmadi, Naser oth Enthalten in No title available 237(2014), 2, Seite 486-489 (DE-627)ELV012595616 (DE-600)1-9150 nnns volume:237 year:2014 number:2 pages:486-489 extent:4 https://doi.org/10.1016/j.atherosclerosis.2014.09.037 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_20 GBV_ILN_40 GBV_ILN_105 AR 237 2014 2 486-489 4 |
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Coronary artery disease (CAD) Computed tomography angiography (CTA) Epicardial adipose tissue (EAT) Major adverse cardiac event (MACE) |
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Hajsadeghi, Fereshteh @@aut@@ Nabavi, Vahid @@oth@@ Bhandari, Ajay @@oth@@ Choi, Andrew @@oth@@ Vincent, Hunter @@oth@@ Flores, Ferdinand @@oth@@ Budoff, Matthew @@oth@@ Ahmadi, Naser @@oth@@ |
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This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). Conclusion: Increased EAT is directly associated with CAD and predicts MACE independent of the age, gender and conventional-risk-factors.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: Increased-epicardial-adipose tissue (EAT) is associated with the presence and severity of subclinical-atherosclerosis. This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). 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increased epicardial adipose tissue is associated with coronary artery disease and major adverse cardiovascular events |
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Increased epicardial adipose tissue is associated with coronary artery disease and major adverse cardiovascular events |
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Background: Increased-epicardial-adipose tissue (EAT) is associated with the presence and severity of subclinical-atherosclerosis. This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). Conclusion: Increased EAT is directly associated with CAD and predicts MACE independent of the age, gender and conventional-risk-factors. |
| abstractGer |
Background: Increased-epicardial-adipose tissue (EAT) is associated with the presence and severity of subclinical-atherosclerosis. This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). Conclusion: Increased EAT is directly associated with CAD and predicts MACE independent of the age, gender and conventional-risk-factors. |
| abstract_unstemmed |
Background: Increased-epicardial-adipose tissue (EAT) is associated with the presence and severity of subclinical-atherosclerosis. This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). Conclusion: Increased EAT is directly associated with CAD and predicts MACE independent of the age, gender and conventional-risk-factors. |
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Increased epicardial adipose tissue is associated with coronary artery disease and major adverse cardiovascular events |
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Nabavi, Vahid Bhandari, Ajay Choi, Andrew Vincent, Hunter Flores, Ferdinand Budoff, Matthew Ahmadi, Naser |
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This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). Conclusion: Increased EAT is directly associated with CAD and predicts MACE independent of the age, gender and conventional-risk-factors.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: Increased-epicardial-adipose tissue (EAT) is associated with the presence and severity of subclinical-atherosclerosis. This study investigates the long-term clinical-outcome of subjects with and without increased-EAT. Methods: Two hundred and forty-five subjects, aged 61 ± 9 years and 34% women underwent clinically-indicated computed-tomography-angiography (CTA), and body-surface-area adjusted EAT was measured and were followed prospectively. CTA-diagnosed coronary-artery-disease (CAD) was defined as obstructive (luminal-stenosis ≥50%), non-obstructive (luminal-stenosis: 1–49%) and zero-obstruction. Major-adverse-cardiac-event (MACE) was defined as myocardial-infarction or cardiovascular-death. Results: EAT increased significantly from subjects with zero-obstruction-coronaries (93 ± 37 cm3/m2) to non-obstructive-CAD (132 ± 25 cm3/m2) to obstructive-CAD (145 ± 35 cm3/m2) (P = 0.01). During the 48-month follow-up, the event-rate was 8.6% (21). The event free survival-rate decreased significantly from 99% in the lowest-quartile to 86.6% in the highest-quartile of EAT. After adjustment for risk-factors, the hazard ratio of MACE was 1.4, 3.1 and 5.7 in lower mid-, upper mid- and highest-quartiles of EAT as compared to lowest-quartile of EAT (P < 0.05). Conclusion: Increased EAT is directly associated with CAD and predicts MACE independent of the age, gender and conventional-risk-factors.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Coronary artery disease (CAD)</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Computed tomography angiography (CTA)</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Epicardial adipose tissue (EAT)</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Major adverse cardiac event (MACE)</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nabavi, Vahid</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bhandari, Ajay</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Choi, Andrew</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Vincent, Hunter</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Flores, Ferdinand</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Budoff, Matthew</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ahmadi, Naser</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">No title available</subfield><subfield code="g">237(2014), 2, Seite 486-489</subfield><subfield code="w">(DE-627)ELV012595616</subfield><subfield code="w">(DE-600)1-9150</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:237</subfield><subfield code="g">year:2014</subfield><subfield code="g">number:2</subfield><subfield code="g">pages:486-489</subfield><subfield code="g">extent:4</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.atherosclerosis.2014.09.037</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">237</subfield><subfield code="j">2014</subfield><subfield code="e">2</subfield><subfield code="h">486-489</subfield><subfield code="g">4</subfield></datafield></record></collection>
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