Antiarrhythmic ionic mechanism of Guanfu base A—Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs
The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp te...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
JIN, Si-Si [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2015transfer abstract |
|---|
| Schlagwörter: |
|---|
| Umfang: |
7 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Generalized Galilean algebras and Newtonian gravity - González, N. ELSEVIER, 2016transfer abstract, [S.l.] |
|---|---|
| Übergeordnetes Werk: |
volume:13 ; year:2015 ; number:5 ; pages:361-367 ; extent:7 |
| Links: |
|---|
| DOI / URN: |
10.1016/S1875-5364(15)30027-3 |
|---|
| Katalog-ID: |
ELV028965337 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | ELV028965337 | ||
| 003 | DE-627 | ||
| 005 | 20230625164643.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180603s2015 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/S1875-5364(15)30027-3 |2 doi | |
| 028 | 5 | 2 | |a GBVA2015011000009.pica |
| 035 | |a (DE-627)ELV028965337 | ||
| 035 | |a (ELSEVIER)S1875-5364(15)30027-3 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | |a 610 | |
| 082 | 0 | 4 | |a 610 |q DE-600 |
| 082 | 0 | 4 | |a 530 |q VZ |
| 082 | 0 | 4 | |a 610 |q VZ |
| 084 | |a 77.50 |2 bkl | ||
| 100 | 1 | |a JIN, Si-Si |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Antiarrhythmic ionic mechanism of Guanfu base A—Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs |
| 264 | 1 | |c 2015transfer abstract | |
| 300 | |a 7 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders. | ||
| 520 | |a The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders. | ||
| 650 | 7 | |a Guanfu base A |2 Elsevier | |
| 650 | 7 | |a Arrhythmia |2 Elsevier | |
| 650 | 7 | |a Transient sodium current |2 Elsevier | |
| 650 | 7 | |a Late sodium current |2 Elsevier | |
| 650 | 7 | |a Kv1.5 current |2 Elsevier | |
| 700 | 1 | |a GUO, Qiao |4 oth | |
| 700 | 1 | |a XU, Jing |4 oth | |
| 700 | 1 | |a YU, Peng |4 oth | |
| 700 | 1 | |a LIU, Jing-Han |4 oth | |
| 700 | 1 | |a TANG, Yi-Qun |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier |a González, N. ELSEVIER |t Generalized Galilean algebras and Newtonian gravity |d 2016transfer abstract |g [S.l.] |w (DE-627)ELV014077353 |
| 773 | 1 | 8 | |g volume:13 |g year:2015 |g number:5 |g pages:361-367 |g extent:7 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/S1875-5364(15)30027-3 |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a GBV_ELV | ||
| 912 | |a SYSFLAG_U | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a GBV_ILN_11 | ||
| 912 | |a GBV_ILN_22 | ||
| 912 | |a GBV_ILN_40 | ||
| 936 | b | k | |a 77.50 |j Psychophysiologie |q VZ |
| 951 | |a AR | ||
| 952 | |d 13 |j 2015 |e 5 |h 361-367 |g 7 | ||
| 953 | |2 045F |a 610 | ||
| author_variant |
s s j ssj |
|---|---|
| matchkey_str |
jinsisiguoqiaoxujingyupengliujinghantang:2015----:nirhtmcoimcaimfunuaeslcieniiinfaeoimurniioaev |
| hierarchy_sort_str |
2015transfer abstract |
| bklnumber |
77.50 |
| publishDate |
2015 |
| allfields |
10.1016/S1875-5364(15)30027-3 doi GBVA2015011000009.pica (DE-627)ELV028965337 (ELSEVIER)S1875-5364(15)30027-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 610 VZ 77.50 bkl JIN, Si-Si verfasserin aut Antiarrhythmic ionic mechanism of Guanfu base A—Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs 2015transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders. The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders. Guanfu base A Elsevier Arrhythmia Elsevier Transient sodium current Elsevier Late sodium current Elsevier Kv1.5 current Elsevier GUO, Qiao oth XU, Jing oth YU, Peng oth LIU, Jing-Han oth TANG, Yi-Qun oth Enthalten in Elsevier González, N. ELSEVIER Generalized Galilean algebras and Newtonian gravity 2016transfer abstract [S.l.] (DE-627)ELV014077353 volume:13 year:2015 number:5 pages:361-367 extent:7 https://doi.org/10.1016/S1875-5364(15)30027-3 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_11 GBV_ILN_22 GBV_ILN_40 77.50 Psychophysiologie VZ AR 13 2015 5 361-367 7 045F 610 |
| spelling |
10.1016/S1875-5364(15)30027-3 doi GBVA2015011000009.pica (DE-627)ELV028965337 (ELSEVIER)S1875-5364(15)30027-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 610 VZ 77.50 bkl JIN, Si-Si verfasserin aut Antiarrhythmic ionic mechanism of Guanfu base A—Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs 2015transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders. The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders. Guanfu base A Elsevier Arrhythmia Elsevier Transient sodium current Elsevier Late sodium current Elsevier Kv1.5 current Elsevier GUO, Qiao oth XU, Jing oth YU, Peng oth LIU, Jing-Han oth TANG, Yi-Qun oth Enthalten in Elsevier González, N. ELSEVIER Generalized Galilean algebras and Newtonian gravity 2016transfer abstract [S.l.] (DE-627)ELV014077353 volume:13 year:2015 number:5 pages:361-367 extent:7 https://doi.org/10.1016/S1875-5364(15)30027-3 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_11 GBV_ILN_22 GBV_ILN_40 77.50 Psychophysiologie VZ AR 13 2015 5 361-367 7 045F 610 |
| allfields_unstemmed |
10.1016/S1875-5364(15)30027-3 doi GBVA2015011000009.pica (DE-627)ELV028965337 (ELSEVIER)S1875-5364(15)30027-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 610 VZ 77.50 bkl JIN, Si-Si verfasserin aut Antiarrhythmic ionic mechanism of Guanfu base A—Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs 2015transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders. The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders. Guanfu base A Elsevier Arrhythmia Elsevier Transient sodium current Elsevier Late sodium current Elsevier Kv1.5 current Elsevier GUO, Qiao oth XU, Jing oth YU, Peng oth LIU, Jing-Han oth TANG, Yi-Qun oth Enthalten in Elsevier González, N. ELSEVIER Generalized Galilean algebras and Newtonian gravity 2016transfer abstract [S.l.] (DE-627)ELV014077353 volume:13 year:2015 number:5 pages:361-367 extent:7 https://doi.org/10.1016/S1875-5364(15)30027-3 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_11 GBV_ILN_22 GBV_ILN_40 77.50 Psychophysiologie VZ AR 13 2015 5 361-367 7 045F 610 |
| allfieldsGer |
10.1016/S1875-5364(15)30027-3 doi GBVA2015011000009.pica (DE-627)ELV028965337 (ELSEVIER)S1875-5364(15)30027-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 610 VZ 77.50 bkl JIN, Si-Si verfasserin aut Antiarrhythmic ionic mechanism of Guanfu base A—Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs 2015transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders. The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders. Guanfu base A Elsevier Arrhythmia Elsevier Transient sodium current Elsevier Late sodium current Elsevier Kv1.5 current Elsevier GUO, Qiao oth XU, Jing oth YU, Peng oth LIU, Jing-Han oth TANG, Yi-Qun oth Enthalten in Elsevier González, N. ELSEVIER Generalized Galilean algebras and Newtonian gravity 2016transfer abstract [S.l.] (DE-627)ELV014077353 volume:13 year:2015 number:5 pages:361-367 extent:7 https://doi.org/10.1016/S1875-5364(15)30027-3 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_11 GBV_ILN_22 GBV_ILN_40 77.50 Psychophysiologie VZ AR 13 2015 5 361-367 7 045F 610 |
| allfieldsSound |
10.1016/S1875-5364(15)30027-3 doi GBVA2015011000009.pica (DE-627)ELV028965337 (ELSEVIER)S1875-5364(15)30027-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 610 VZ 77.50 bkl JIN, Si-Si verfasserin aut Antiarrhythmic ionic mechanism of Guanfu base A—Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs 2015transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders. The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders. Guanfu base A Elsevier Arrhythmia Elsevier Transient sodium current Elsevier Late sodium current Elsevier Kv1.5 current Elsevier GUO, Qiao oth XU, Jing oth YU, Peng oth LIU, Jing-Han oth TANG, Yi-Qun oth Enthalten in Elsevier González, N. ELSEVIER Generalized Galilean algebras and Newtonian gravity 2016transfer abstract [S.l.] (DE-627)ELV014077353 volume:13 year:2015 number:5 pages:361-367 extent:7 https://doi.org/10.1016/S1875-5364(15)30027-3 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_11 GBV_ILN_22 GBV_ILN_40 77.50 Psychophysiologie VZ AR 13 2015 5 361-367 7 045F 610 |
| language |
English |
| source |
Enthalten in Generalized Galilean algebras and Newtonian gravity [S.l.] volume:13 year:2015 number:5 pages:361-367 extent:7 |
| sourceStr |
Enthalten in Generalized Galilean algebras and Newtonian gravity [S.l.] volume:13 year:2015 number:5 pages:361-367 extent:7 |
| format_phy_str_mv |
Article |
| bklname |
Psychophysiologie |
| institution |
findex.gbv.de |
| topic_facet |
Guanfu base A Arrhythmia Transient sodium current Late sodium current Kv1.5 current |
| dewey-raw |
610 |
| isfreeaccess_bool |
false |
| container_title |
Generalized Galilean algebras and Newtonian gravity |
| authorswithroles_txt_mv |
JIN, Si-Si @@aut@@ GUO, Qiao @@oth@@ XU, Jing @@oth@@ YU, Peng @@oth@@ LIU, Jing-Han @@oth@@ TANG, Yi-Qun @@oth@@ |
| publishDateDaySort_date |
2015-01-01T00:00:00Z |
| hierarchy_top_id |
ELV014077353 |
| dewey-sort |
3610 |
| id |
ELV028965337 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV028965337</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625164643.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2015 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/S1875-5364(15)30027-3</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2015011000009.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV028965337</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1875-5364(15)30027-3</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">610</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">530</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">77.50</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">JIN, Si-Si</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Antiarrhythmic ionic mechanism of Guanfu base A—Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">7</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Guanfu base A</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Arrhythmia</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Transient sodium current</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Late sodium current</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Kv1.5 current</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">GUO, Qiao</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">XU, Jing</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">YU, Peng</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">LIU, Jing-Han</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">TANG, Yi-Qun</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier</subfield><subfield code="a">González, N. ELSEVIER</subfield><subfield code="t">Generalized Galilean algebras and Newtonian gravity</subfield><subfield code="d">2016transfer abstract</subfield><subfield code="g">[S.l.]</subfield><subfield code="w">(DE-627)ELV014077353</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:13</subfield><subfield code="g">year:2015</subfield><subfield code="g">number:5</subfield><subfield code="g">pages:361-367</subfield><subfield code="g">extent:7</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/S1875-5364(15)30027-3</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">77.50</subfield><subfield code="j">Psychophysiologie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">13</subfield><subfield code="j">2015</subfield><subfield code="e">5</subfield><subfield code="h">361-367</subfield><subfield code="g">7</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">610</subfield></datafield></record></collection>
|
| author |
JIN, Si-Si |
| spellingShingle |
JIN, Si-Si ddc 610 ddc 530 bkl 77.50 Elsevier Guanfu base A Elsevier Arrhythmia Elsevier Transient sodium current Elsevier Late sodium current Elsevier Kv1.5 current Antiarrhythmic ionic mechanism of Guanfu base A—Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs |
| authorStr |
JIN, Si-Si |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)ELV014077353 |
| format |
electronic Article |
| dewey-ones |
610 - Medicine & health 530 - Physics |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
elsevier |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
610 610 DE-600 530 VZ 610 VZ 77.50 bkl Antiarrhythmic ionic mechanism of Guanfu base A—Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs Guanfu base A Elsevier Arrhythmia Elsevier Transient sodium current Elsevier Late sodium current Elsevier Kv1.5 current Elsevier |
| topic |
ddc 610 ddc 530 bkl 77.50 Elsevier Guanfu base A Elsevier Arrhythmia Elsevier Transient sodium current Elsevier Late sodium current Elsevier Kv1.5 current |
| topic_unstemmed |
ddc 610 ddc 530 bkl 77.50 Elsevier Guanfu base A Elsevier Arrhythmia Elsevier Transient sodium current Elsevier Late sodium current Elsevier Kv1.5 current |
| topic_browse |
ddc 610 ddc 530 bkl 77.50 Elsevier Guanfu base A Elsevier Arrhythmia Elsevier Transient sodium current Elsevier Late sodium current Elsevier Kv1.5 current |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
q g qg j x jx p y py j h l jhl y q t yqt |
| hierarchy_parent_title |
Generalized Galilean algebras and Newtonian gravity |
| hierarchy_parent_id |
ELV014077353 |
| dewey-tens |
610 - Medicine & health 530 - Physics |
| hierarchy_top_title |
Generalized Galilean algebras and Newtonian gravity |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)ELV014077353 |
| title |
Antiarrhythmic ionic mechanism of Guanfu base A—Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs |
| ctrlnum |
(DE-627)ELV028965337 (ELSEVIER)S1875-5364(15)30027-3 |
| title_full |
Antiarrhythmic ionic mechanism of Guanfu base A—Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs |
| author_sort |
JIN, Si-Si |
| journal |
Generalized Galilean algebras and Newtonian gravity |
| journalStr |
Generalized Galilean algebras and Newtonian gravity |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
600 - Technology 500 - Science |
| recordtype |
marc |
| publishDateSort |
2015 |
| contenttype_str_mv |
zzz |
| container_start_page |
361 |
| author_browse |
JIN, Si-Si |
| container_volume |
13 |
| physical |
7 |
| class |
610 610 DE-600 530 VZ 610 VZ 77.50 bkl |
| format_se |
Elektronische Aufsätze |
| author-letter |
JIN, Si-Si |
| doi_str_mv |
10.1016/S1875-5364(15)30027-3 |
| dewey-full |
610 530 |
| title_sort |
antiarrhythmic ionic mechanism of guanfu base a—selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs |
| title_auth |
Antiarrhythmic ionic mechanism of Guanfu base A—Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs |
| abstract |
The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders. |
| abstractGer |
The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders. |
| abstract_unstemmed |
The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_11 GBV_ILN_22 GBV_ILN_40 |
| container_issue |
5 |
| title_short |
Antiarrhythmic ionic mechanism of Guanfu base A—Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs |
| url |
https://doi.org/10.1016/S1875-5364(15)30027-3 |
| remote_bool |
true |
| author2 |
GUO, Qiao XU, Jing YU, Peng LIU, Jing-Han TANG, Yi-Qun |
| author2Str |
GUO, Qiao XU, Jing YU, Peng LIU, Jing-Han TANG, Yi-Qun |
| ppnlink |
ELV014077353 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth |
| doi_str |
10.1016/S1875-5364(15)30027-3 |
| up_date |
2024-07-06T20:11:44.952Z |
| _version_ |
1803861837691748352 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV028965337</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625164643.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2015 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/S1875-5364(15)30027-3</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2015011000009.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV028965337</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1875-5364(15)30027-3</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">610</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">530</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">77.50</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">JIN, Si-Si</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Antiarrhythmic ionic mechanism of Guanfu base A—Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">7</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (I Na.L), transient sodium current (I Na.T), HERG current (I HERG), and Kv1.5 current (I Kv1.5). The values of I Na.L, I Na.T, IHERG and I Kv1.5 were recorded using the whole-cell patch clamp technique. Compared with other channels, GFA showed selective blocking activity in late sodium channel. It inhibited I Na.L in a concentration-dependent manner with an IC50 of (1.57 ± 0.14) μmol·L−1, which was significantly lower than its IC50 values of (21.17 ± 4.51) μmol·L−1 for the I Na.T. The inhibitory effect of GFA on I Na,L was not affected by 200 μmol·L−1 H2O2. It inhibited I HERG with an IC50 of (273 ± 34) μmol·L−1 and has slight blocking effect on I Kv1.5, decreasing I Kv1.5 by only 20.6% at 200 μmol·L−1. In summary, GFA inhibited I Na.L selectively and remained similar inhibition in presence of reactive oxygen species. These findings may suggest a novel molecular mechanism for the potential clinical application of GFA in the treatment of cardiovascular disorders.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Guanfu base A</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Arrhythmia</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Transient sodium current</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Late sodium current</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Kv1.5 current</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">GUO, Qiao</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">XU, Jing</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">YU, Peng</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">LIU, Jing-Han</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">TANG, Yi-Qun</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier</subfield><subfield code="a">González, N. ELSEVIER</subfield><subfield code="t">Generalized Galilean algebras and Newtonian gravity</subfield><subfield code="d">2016transfer abstract</subfield><subfield code="g">[S.l.]</subfield><subfield code="w">(DE-627)ELV014077353</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:13</subfield><subfield code="g">year:2015</subfield><subfield code="g">number:5</subfield><subfield code="g">pages:361-367</subfield><subfield code="g">extent:7</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/S1875-5364(15)30027-3</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">77.50</subfield><subfield code="j">Psychophysiologie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">13</subfield><subfield code="j">2015</subfield><subfield code="e">5</subfield><subfield code="h">361-367</subfield><subfield code="g">7</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">610</subfield></datafield></record></collection>
|
| score |
7.4001036 |