Vascular and Metabolic Implications of Novel Targeted Cancer Therapies
Novel targeted cancer therapies, especially kinase inhibitors, have revolutionized the treatment of many cancers and have dramatically improved the survival of several types of malignancies. Because kinases not only are important in cancer development and progression, but also play a critical role i...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Li, Weijuan [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015transfer abstract |
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| Schlagwörter: |
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| Umfang: |
19 |
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| Übergeordnetes Werk: |
Enthalten in: Bimetallic diffusion modeling and temperature regulation during ball milling - Aureli, Matteo ELSEVIER, 2018, JACC, New York, NY |
|---|---|
| Übergeordnetes Werk: |
volume:66 ; year:2015 ; number:10 ; day:8 ; month:09 ; pages:1160-1178 ; extent:19 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.jacc.2015.07.025 |
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ELV029030250 |
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| 520 | |a Novel targeted cancer therapies, especially kinase inhibitors, have revolutionized the treatment of many cancers and have dramatically improved the survival of several types of malignancies. Because kinases not only are important in cancer development and progression, but also play a critical role in the cardiovascular (CV) system and metabolic homeostasis, important CV and metabolic sequelae have been associated with several types of kinase inhibitors. This paper reviews the incidences and highlights potential mechanisms of vascular and metabolic perturbations associated with 3 classes of commonly used kinase inhibitors that target the vascular endothelial growth factor signaling pathway, the ABL kinase, and the phosphoinositide 3-kinase/AKT/mammalian target of rapamycin signaling pathway. We propose preventive, screening, monitoring, and management strategies for CV care of patients treated with these novel agents. | ||
| 520 | |a Novel targeted cancer therapies, especially kinase inhibitors, have revolutionized the treatment of many cancers and have dramatically improved the survival of several types of malignancies. Because kinases not only are important in cancer development and progression, but also play a critical role in the cardiovascular (CV) system and metabolic homeostasis, important CV and metabolic sequelae have been associated with several types of kinase inhibitors. This paper reviews the incidences and highlights potential mechanisms of vascular and metabolic perturbations associated with 3 classes of commonly used kinase inhibitors that target the vascular endothelial growth factor signaling pathway, the ABL kinase, and the phosphoinositide 3-kinase/AKT/mammalian target of rapamycin signaling pathway. We propose preventive, screening, monitoring, and management strategies for CV care of patients treated with these novel agents. | ||
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10.1016/j.jacc.2015.07.025 doi GBVA2015013000010.pica (DE-627)ELV029030250 (ELSEVIER)S0735-1097(15)04515-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 600 690 VZ 51.00 bkl 51.32 bkl Li, Weijuan verfasserin aut Vascular and Metabolic Implications of Novel Targeted Cancer Therapies 2015transfer abstract 19 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Novel targeted cancer therapies, especially kinase inhibitors, have revolutionized the treatment of many cancers and have dramatically improved the survival of several types of malignancies. Because kinases not only are important in cancer development and progression, but also play a critical role in the cardiovascular (CV) system and metabolic homeostasis, important CV and metabolic sequelae have been associated with several types of kinase inhibitors. This paper reviews the incidences and highlights potential mechanisms of vascular and metabolic perturbations associated with 3 classes of commonly used kinase inhibitors that target the vascular endothelial growth factor signaling pathway, the ABL kinase, and the phosphoinositide 3-kinase/AKT/mammalian target of rapamycin signaling pathway. We propose preventive, screening, monitoring, and management strategies for CV care of patients treated with these novel agents. Novel targeted cancer therapies, especially kinase inhibitors, have revolutionized the treatment of many cancers and have dramatically improved the survival of several types of malignancies. Because kinases not only are important in cancer development and progression, but also play a critical role in the cardiovascular (CV) system and metabolic homeostasis, important CV and metabolic sequelae have been associated with several types of kinase inhibitors. This paper reviews the incidences and highlights potential mechanisms of vascular and metabolic perturbations associated with 3 classes of commonly used kinase inhibitors that target the vascular endothelial growth factor signaling pathway, the ABL kinase, and the phosphoinositide 3-kinase/AKT/mammalian target of rapamycin signaling pathway. We propose preventive, screening, monitoring, and management strategies for CV care of patients treated with these novel agents. cardiotoxicity Elsevier metabolic toxicity Elsevier vascular toxicity Elsevier cardio-oncology Elsevier Croce, Kevin oth Steensma, David P. oth McDermott, David F. oth Ben-Yehuda, Ori oth Moslehi, Javid oth Enthalten in Elsevier Aureli, Matteo ELSEVIER Bimetallic diffusion modeling and temperature regulation during ball milling 2018 JACC New York, NY (DE-627)ELV000161896 volume:66 year:2015 number:10 day:8 month:09 pages:1160-1178 extent:19 https://doi.org/10.1016/j.jacc.2015.07.025 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 66 2015 10 8 0908 1160-1178 19 045F 610 |
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10.1016/j.jacc.2015.07.025 doi GBVA2015013000010.pica (DE-627)ELV029030250 (ELSEVIER)S0735-1097(15)04515-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 600 690 VZ 51.00 bkl 51.32 bkl Li, Weijuan verfasserin aut Vascular and Metabolic Implications of Novel Targeted Cancer Therapies 2015transfer abstract 19 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Novel targeted cancer therapies, especially kinase inhibitors, have revolutionized the treatment of many cancers and have dramatically improved the survival of several types of malignancies. Because kinases not only are important in cancer development and progression, but also play a critical role in the cardiovascular (CV) system and metabolic homeostasis, important CV and metabolic sequelae have been associated with several types of kinase inhibitors. This paper reviews the incidences and highlights potential mechanisms of vascular and metabolic perturbations associated with 3 classes of commonly used kinase inhibitors that target the vascular endothelial growth factor signaling pathway, the ABL kinase, and the phosphoinositide 3-kinase/AKT/mammalian target of rapamycin signaling pathway. We propose preventive, screening, monitoring, and management strategies for CV care of patients treated with these novel agents. Novel targeted cancer therapies, especially kinase inhibitors, have revolutionized the treatment of many cancers and have dramatically improved the survival of several types of malignancies. Because kinases not only are important in cancer development and progression, but also play a critical role in the cardiovascular (CV) system and metabolic homeostasis, important CV and metabolic sequelae have been associated with several types of kinase inhibitors. This paper reviews the incidences and highlights potential mechanisms of vascular and metabolic perturbations associated with 3 classes of commonly used kinase inhibitors that target the vascular endothelial growth factor signaling pathway, the ABL kinase, and the phosphoinositide 3-kinase/AKT/mammalian target of rapamycin signaling pathway. We propose preventive, screening, monitoring, and management strategies for CV care of patients treated with these novel agents. cardiotoxicity Elsevier metabolic toxicity Elsevier vascular toxicity Elsevier cardio-oncology Elsevier Croce, Kevin oth Steensma, David P. oth McDermott, David F. oth Ben-Yehuda, Ori oth Moslehi, Javid oth Enthalten in Elsevier Aureli, Matteo ELSEVIER Bimetallic diffusion modeling and temperature regulation during ball milling 2018 JACC New York, NY (DE-627)ELV000161896 volume:66 year:2015 number:10 day:8 month:09 pages:1160-1178 extent:19 https://doi.org/10.1016/j.jacc.2015.07.025 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 66 2015 10 8 0908 1160-1178 19 045F 610 |
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10.1016/j.jacc.2015.07.025 doi GBVA2015013000010.pica (DE-627)ELV029030250 (ELSEVIER)S0735-1097(15)04515-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 600 690 VZ 51.00 bkl 51.32 bkl Li, Weijuan verfasserin aut Vascular and Metabolic Implications of Novel Targeted Cancer Therapies 2015transfer abstract 19 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Novel targeted cancer therapies, especially kinase inhibitors, have revolutionized the treatment of many cancers and have dramatically improved the survival of several types of malignancies. Because kinases not only are important in cancer development and progression, but also play a critical role in the cardiovascular (CV) system and metabolic homeostasis, important CV and metabolic sequelae have been associated with several types of kinase inhibitors. This paper reviews the incidences and highlights potential mechanisms of vascular and metabolic perturbations associated with 3 classes of commonly used kinase inhibitors that target the vascular endothelial growth factor signaling pathway, the ABL kinase, and the phosphoinositide 3-kinase/AKT/mammalian target of rapamycin signaling pathway. We propose preventive, screening, monitoring, and management strategies for CV care of patients treated with these novel agents. Novel targeted cancer therapies, especially kinase inhibitors, have revolutionized the treatment of many cancers and have dramatically improved the survival of several types of malignancies. Because kinases not only are important in cancer development and progression, but also play a critical role in the cardiovascular (CV) system and metabolic homeostasis, important CV and metabolic sequelae have been associated with several types of kinase inhibitors. This paper reviews the incidences and highlights potential mechanisms of vascular and metabolic perturbations associated with 3 classes of commonly used kinase inhibitors that target the vascular endothelial growth factor signaling pathway, the ABL kinase, and the phosphoinositide 3-kinase/AKT/mammalian target of rapamycin signaling pathway. We propose preventive, screening, monitoring, and management strategies for CV care of patients treated with these novel agents. cardiotoxicity Elsevier metabolic toxicity Elsevier vascular toxicity Elsevier cardio-oncology Elsevier Croce, Kevin oth Steensma, David P. oth McDermott, David F. oth Ben-Yehuda, Ori oth Moslehi, Javid oth Enthalten in Elsevier Aureli, Matteo ELSEVIER Bimetallic diffusion modeling and temperature regulation during ball milling 2018 JACC New York, NY (DE-627)ELV000161896 volume:66 year:2015 number:10 day:8 month:09 pages:1160-1178 extent:19 https://doi.org/10.1016/j.jacc.2015.07.025 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 66 2015 10 8 0908 1160-1178 19 045F 610 |
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vascular and metabolic implications of novel targeted cancer therapies |
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Vascular and Metabolic Implications of Novel Targeted Cancer Therapies |
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Novel targeted cancer therapies, especially kinase inhibitors, have revolutionized the treatment of many cancers and have dramatically improved the survival of several types of malignancies. Because kinases not only are important in cancer development and progression, but also play a critical role in the cardiovascular (CV) system and metabolic homeostasis, important CV and metabolic sequelae have been associated with several types of kinase inhibitors. This paper reviews the incidences and highlights potential mechanisms of vascular and metabolic perturbations associated with 3 classes of commonly used kinase inhibitors that target the vascular endothelial growth factor signaling pathway, the ABL kinase, and the phosphoinositide 3-kinase/AKT/mammalian target of rapamycin signaling pathway. We propose preventive, screening, monitoring, and management strategies for CV care of patients treated with these novel agents. |
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Novel targeted cancer therapies, especially kinase inhibitors, have revolutionized the treatment of many cancers and have dramatically improved the survival of several types of malignancies. Because kinases not only are important in cancer development and progression, but also play a critical role in the cardiovascular (CV) system and metabolic homeostasis, important CV and metabolic sequelae have been associated with several types of kinase inhibitors. This paper reviews the incidences and highlights potential mechanisms of vascular and metabolic perturbations associated with 3 classes of commonly used kinase inhibitors that target the vascular endothelial growth factor signaling pathway, the ABL kinase, and the phosphoinositide 3-kinase/AKT/mammalian target of rapamycin signaling pathway. We propose preventive, screening, monitoring, and management strategies for CV care of patients treated with these novel agents. |
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Novel targeted cancer therapies, especially kinase inhibitors, have revolutionized the treatment of many cancers and have dramatically improved the survival of several types of malignancies. Because kinases not only are important in cancer development and progression, but also play a critical role in the cardiovascular (CV) system and metabolic homeostasis, important CV and metabolic sequelae have been associated with several types of kinase inhibitors. This paper reviews the incidences and highlights potential mechanisms of vascular and metabolic perturbations associated with 3 classes of commonly used kinase inhibitors that target the vascular endothelial growth factor signaling pathway, the ABL kinase, and the phosphoinositide 3-kinase/AKT/mammalian target of rapamycin signaling pathway. We propose preventive, screening, monitoring, and management strategies for CV care of patients treated with these novel agents. |
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Croce, Kevin Steensma, David P. McDermott, David F. Ben-Yehuda, Ori Moslehi, Javid |
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