Automated electrophilic radiosynthesis of [18F]FBPA using a modified nucleophilic GE TRACERlab FXFDG
We modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-phenylalanine with [18F]F2 gas. [18F...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mairinger, Severin [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015transfer abstract |
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| Schlagwörter: |
Electrophilic [18F]fluorination |
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| Umfang: |
4 |
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| Übergeordnetes Werk: |
Enthalten in: Time-dependent shape factors for fractured reservoir simulation: Effect of stress sensitivity in matrix system - Wang, Lu ELSEVIER, 2018, a journal of nuclear and radiation techniques and their applications in the physical, chemical, biological, medical, earth, planetary, environmental and engineering science, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:104 ; year:2015 ; pages:124-127 ; extent:4 |
| Links: |
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| DOI / URN: |
10.1016/j.apradiso.2015.06.034 |
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| Katalog-ID: |
ELV029152860 |
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| 245 | 1 | 0 | |a Automated electrophilic radiosynthesis of [18F]FBPA using a modified nucleophilic GE TRACERlab FXFDG |
| 264 | 1 | |c 2015transfer abstract | |
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| 520 | |a We modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-phenylalanine with [18F]F2 gas. [18F]FBPA was obtained with a RCY of 8.5±2.0% and a radiochemical purity of 98±1% in a total synthesis time of 72±7min (n=22). The modified synthesis module might also be useful for the synthesis of other [18F]radiopharmaceuticals via electrophilic substitution reactions while still being suitable for nucleophilic substitution reactions. | ||
| 520 | |a We modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-phenylalanine with [18F]F2 gas. [18F]FBPA was obtained with a RCY of 8.5±2.0% and a radiochemical purity of 98±1% in a total synthesis time of 72±7min (n=22). The modified synthesis module might also be useful for the synthesis of other [18F]radiopharmaceuticals via electrophilic substitution reactions while still being suitable for nucleophilic substitution reactions. | ||
| 650 | 7 | |a Electrophilic [18F]fluorination |2 Elsevier | |
| 650 | 7 | |a 2-[18F]fluoro-4-borono-l-phenylalanine |2 Elsevier | |
| 650 | 7 | |a TRACERlab™ FXFDG |2 Elsevier | |
| 650 | 7 | |a Boron neutron capture therapy |2 Elsevier | |
| 650 | 7 | |a Automated synthesis |2 Elsevier | |
| 700 | 1 | |a Stanek, Johann |4 oth | |
| 700 | 1 | |a Wanek, Thomas |4 oth | |
| 700 | 1 | |a Langer, Oliver |4 oth | |
| 700 | 1 | |a Kuntner, Claudia |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Wang, Lu ELSEVIER |t Time-dependent shape factors for fractured reservoir simulation: Effect of stress sensitivity in matrix system |d 2018 |d a journal of nuclear and radiation techniques and their applications in the physical, chemical, biological, medical, earth, planetary, environmental and engineering science |g Amsterdam [u.a.] |w (DE-627)ELV001919369 |
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10.1016/j.apradiso.2015.06.034 doi GBVA2015017000010.pica (DE-627)ELV029152860 (ELSEVIER)S0969-8043(15)30080-4 DE-627 ger DE-627 rakwb eng 530 610 540 530 DE-600 610 DE-600 540 DE-600 660 VZ 38.51 bkl 57.36 bkl Mairinger, Severin verfasserin aut Automated electrophilic radiosynthesis of [18F]FBPA using a modified nucleophilic GE TRACERlab FXFDG 2015transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-phenylalanine with [18F]F2 gas. [18F]FBPA was obtained with a RCY of 8.5±2.0% and a radiochemical purity of 98±1% in a total synthesis time of 72±7min (n=22). The modified synthesis module might also be useful for the synthesis of other [18F]radiopharmaceuticals via electrophilic substitution reactions while still being suitable for nucleophilic substitution reactions. We modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-phenylalanine with [18F]F2 gas. [18F]FBPA was obtained with a RCY of 8.5±2.0% and a radiochemical purity of 98±1% in a total synthesis time of 72±7min (n=22). The modified synthesis module might also be useful for the synthesis of other [18F]radiopharmaceuticals via electrophilic substitution reactions while still being suitable for nucleophilic substitution reactions. Electrophilic [18F]fluorination Elsevier 2-[18F]fluoro-4-borono-l-phenylalanine Elsevier TRACERlab™ FXFDG Elsevier Boron neutron capture therapy Elsevier Automated synthesis Elsevier Stanek, Johann oth Wanek, Thomas oth Langer, Oliver oth Kuntner, Claudia oth Enthalten in Elsevier Science Wang, Lu ELSEVIER Time-dependent shape factors for fractured reservoir simulation: Effect of stress sensitivity in matrix system 2018 a journal of nuclear and radiation techniques and their applications in the physical, chemical, biological, medical, earth, planetary, environmental and engineering science Amsterdam [u.a.] (DE-627)ELV001919369 volume:104 year:2015 pages:124-127 extent:4 https://doi.org/10.1016/j.apradiso.2015.06.034 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 38.51 Geologie fossiler Brennstoffe VZ 57.36 Erdölgewinnung Erdgasgewinnung VZ AR 104 2015 124-127 4 045F 530 |
| spelling |
10.1016/j.apradiso.2015.06.034 doi GBVA2015017000010.pica (DE-627)ELV029152860 (ELSEVIER)S0969-8043(15)30080-4 DE-627 ger DE-627 rakwb eng 530 610 540 530 DE-600 610 DE-600 540 DE-600 660 VZ 38.51 bkl 57.36 bkl Mairinger, Severin verfasserin aut Automated electrophilic radiosynthesis of [18F]FBPA using a modified nucleophilic GE TRACERlab FXFDG 2015transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-phenylalanine with [18F]F2 gas. [18F]FBPA was obtained with a RCY of 8.5±2.0% and a radiochemical purity of 98±1% in a total synthesis time of 72±7min (n=22). The modified synthesis module might also be useful for the synthesis of other [18F]radiopharmaceuticals via electrophilic substitution reactions while still being suitable for nucleophilic substitution reactions. We modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-phenylalanine with [18F]F2 gas. [18F]FBPA was obtained with a RCY of 8.5±2.0% and a radiochemical purity of 98±1% in a total synthesis time of 72±7min (n=22). The modified synthesis module might also be useful for the synthesis of other [18F]radiopharmaceuticals via electrophilic substitution reactions while still being suitable for nucleophilic substitution reactions. Electrophilic [18F]fluorination Elsevier 2-[18F]fluoro-4-borono-l-phenylalanine Elsevier TRACERlab™ FXFDG Elsevier Boron neutron capture therapy Elsevier Automated synthesis Elsevier Stanek, Johann oth Wanek, Thomas oth Langer, Oliver oth Kuntner, Claudia oth Enthalten in Elsevier Science Wang, Lu ELSEVIER Time-dependent shape factors for fractured reservoir simulation: Effect of stress sensitivity in matrix system 2018 a journal of nuclear and radiation techniques and their applications in the physical, chemical, biological, medical, earth, planetary, environmental and engineering science Amsterdam [u.a.] (DE-627)ELV001919369 volume:104 year:2015 pages:124-127 extent:4 https://doi.org/10.1016/j.apradiso.2015.06.034 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 38.51 Geologie fossiler Brennstoffe VZ 57.36 Erdölgewinnung Erdgasgewinnung VZ AR 104 2015 124-127 4 045F 530 |
| allfields_unstemmed |
10.1016/j.apradiso.2015.06.034 doi GBVA2015017000010.pica (DE-627)ELV029152860 (ELSEVIER)S0969-8043(15)30080-4 DE-627 ger DE-627 rakwb eng 530 610 540 530 DE-600 610 DE-600 540 DE-600 660 VZ 38.51 bkl 57.36 bkl Mairinger, Severin verfasserin aut Automated electrophilic radiosynthesis of [18F]FBPA using a modified nucleophilic GE TRACERlab FXFDG 2015transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-phenylalanine with [18F]F2 gas. [18F]FBPA was obtained with a RCY of 8.5±2.0% and a radiochemical purity of 98±1% in a total synthesis time of 72±7min (n=22). The modified synthesis module might also be useful for the synthesis of other [18F]radiopharmaceuticals via electrophilic substitution reactions while still being suitable for nucleophilic substitution reactions. We modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-phenylalanine with [18F]F2 gas. [18F]FBPA was obtained with a RCY of 8.5±2.0% and a radiochemical purity of 98±1% in a total synthesis time of 72±7min (n=22). The modified synthesis module might also be useful for the synthesis of other [18F]radiopharmaceuticals via electrophilic substitution reactions while still being suitable for nucleophilic substitution reactions. Electrophilic [18F]fluorination Elsevier 2-[18F]fluoro-4-borono-l-phenylalanine Elsevier TRACERlab™ FXFDG Elsevier Boron neutron capture therapy Elsevier Automated synthesis Elsevier Stanek, Johann oth Wanek, Thomas oth Langer, Oliver oth Kuntner, Claudia oth Enthalten in Elsevier Science Wang, Lu ELSEVIER Time-dependent shape factors for fractured reservoir simulation: Effect of stress sensitivity in matrix system 2018 a journal of nuclear and radiation techniques and their applications in the physical, chemical, biological, medical, earth, planetary, environmental and engineering science Amsterdam [u.a.] (DE-627)ELV001919369 volume:104 year:2015 pages:124-127 extent:4 https://doi.org/10.1016/j.apradiso.2015.06.034 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 38.51 Geologie fossiler Brennstoffe VZ 57.36 Erdölgewinnung Erdgasgewinnung VZ AR 104 2015 124-127 4 045F 530 |
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10.1016/j.apradiso.2015.06.034 doi GBVA2015017000010.pica (DE-627)ELV029152860 (ELSEVIER)S0969-8043(15)30080-4 DE-627 ger DE-627 rakwb eng 530 610 540 530 DE-600 610 DE-600 540 DE-600 660 VZ 38.51 bkl 57.36 bkl Mairinger, Severin verfasserin aut Automated electrophilic radiosynthesis of [18F]FBPA using a modified nucleophilic GE TRACERlab FXFDG 2015transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-phenylalanine with [18F]F2 gas. [18F]FBPA was obtained with a RCY of 8.5±2.0% and a radiochemical purity of 98±1% in a total synthesis time of 72±7min (n=22). The modified synthesis module might also be useful for the synthesis of other [18F]radiopharmaceuticals via electrophilic substitution reactions while still being suitable for nucleophilic substitution reactions. We modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-phenylalanine with [18F]F2 gas. [18F]FBPA was obtained with a RCY of 8.5±2.0% and a radiochemical purity of 98±1% in a total synthesis time of 72±7min (n=22). The modified synthesis module might also be useful for the synthesis of other [18F]radiopharmaceuticals via electrophilic substitution reactions while still being suitable for nucleophilic substitution reactions. Electrophilic [18F]fluorination Elsevier 2-[18F]fluoro-4-borono-l-phenylalanine Elsevier TRACERlab™ FXFDG Elsevier Boron neutron capture therapy Elsevier Automated synthesis Elsevier Stanek, Johann oth Wanek, Thomas oth Langer, Oliver oth Kuntner, Claudia oth Enthalten in Elsevier Science Wang, Lu ELSEVIER Time-dependent shape factors for fractured reservoir simulation: Effect of stress sensitivity in matrix system 2018 a journal of nuclear and radiation techniques and their applications in the physical, chemical, biological, medical, earth, planetary, environmental and engineering science Amsterdam [u.a.] (DE-627)ELV001919369 volume:104 year:2015 pages:124-127 extent:4 https://doi.org/10.1016/j.apradiso.2015.06.034 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 38.51 Geologie fossiler Brennstoffe VZ 57.36 Erdölgewinnung Erdgasgewinnung VZ AR 104 2015 124-127 4 045F 530 |
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10.1016/j.apradiso.2015.06.034 doi GBVA2015017000010.pica (DE-627)ELV029152860 (ELSEVIER)S0969-8043(15)30080-4 DE-627 ger DE-627 rakwb eng 530 610 540 530 DE-600 610 DE-600 540 DE-600 660 VZ 38.51 bkl 57.36 bkl Mairinger, Severin verfasserin aut Automated electrophilic radiosynthesis of [18F]FBPA using a modified nucleophilic GE TRACERlab FXFDG 2015transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-phenylalanine with [18F]F2 gas. [18F]FBPA was obtained with a RCY of 8.5±2.0% and a radiochemical purity of 98±1% in a total synthesis time of 72±7min (n=22). The modified synthesis module might also be useful for the synthesis of other [18F]radiopharmaceuticals via electrophilic substitution reactions while still being suitable for nucleophilic substitution reactions. We modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-phenylalanine with [18F]F2 gas. [18F]FBPA was obtained with a RCY of 8.5±2.0% and a radiochemical purity of 98±1% in a total synthesis time of 72±7min (n=22). The modified synthesis module might also be useful for the synthesis of other [18F]radiopharmaceuticals via electrophilic substitution reactions while still being suitable for nucleophilic substitution reactions. Electrophilic [18F]fluorination Elsevier 2-[18F]fluoro-4-borono-l-phenylalanine Elsevier TRACERlab™ FXFDG Elsevier Boron neutron capture therapy Elsevier Automated synthesis Elsevier Stanek, Johann oth Wanek, Thomas oth Langer, Oliver oth Kuntner, Claudia oth Enthalten in Elsevier Science Wang, Lu ELSEVIER Time-dependent shape factors for fractured reservoir simulation: Effect of stress sensitivity in matrix system 2018 a journal of nuclear and radiation techniques and their applications in the physical, chemical, biological, medical, earth, planetary, environmental and engineering science Amsterdam [u.a.] (DE-627)ELV001919369 volume:104 year:2015 pages:124-127 extent:4 https://doi.org/10.1016/j.apradiso.2015.06.034 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-GGO 38.51 Geologie fossiler Brennstoffe VZ 57.36 Erdölgewinnung Erdgasgewinnung VZ AR 104 2015 124-127 4 045F 530 |
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Enthalten in Time-dependent shape factors for fractured reservoir simulation: Effect of stress sensitivity in matrix system Amsterdam [u.a.] volume:104 year:2015 pages:124-127 extent:4 |
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Enthalten in Time-dependent shape factors for fractured reservoir simulation: Effect of stress sensitivity in matrix system Amsterdam [u.a.] volume:104 year:2015 pages:124-127 extent:4 |
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Electrophilic [18F]fluorination 2-[18F]fluoro-4-borono-l-phenylalanine TRACERlab™ FXFDG Boron neutron capture therapy Automated synthesis |
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Time-dependent shape factors for fractured reservoir simulation: Effect of stress sensitivity in matrix system |
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Mairinger, Severin @@aut@@ Stanek, Johann @@oth@@ Wanek, Thomas @@oth@@ Langer, Oliver @@oth@@ Kuntner, Claudia @@oth@@ |
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automated electrophilic radiosynthesis of [18f]fbpa using a modified nucleophilic ge tracerlab fxfdg |
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Automated electrophilic radiosynthesis of [18F]FBPA using a modified nucleophilic GE TRACERlab FXFDG |
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We modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-phenylalanine with [18F]F2 gas. [18F]FBPA was obtained with a RCY of 8.5±2.0% and a radiochemical purity of 98±1% in a total synthesis time of 72±7min (n=22). The modified synthesis module might also be useful for the synthesis of other [18F]radiopharmaceuticals via electrophilic substitution reactions while still being suitable for nucleophilic substitution reactions. |
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We modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-phenylalanine with [18F]F2 gas. [18F]FBPA was obtained with a RCY of 8.5±2.0% and a radiochemical purity of 98±1% in a total synthesis time of 72±7min (n=22). The modified synthesis module might also be useful for the synthesis of other [18F]radiopharmaceuticals via electrophilic substitution reactions while still being suitable for nucleophilic substitution reactions. |
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We modified a commercially available synthesis module for nucleophilic [18F]fluorinations (TRACERlabTM FXFDG, GE Healthcare) to enable the reliable synthesis of 2-[18F]fluoro-4-borono-l-phenylalanine ([18F]FBPA) via direct electrophilic substitution of 4-borono-l-phenylalanine with [18F]F2 gas. [18F]FBPA was obtained with a RCY of 8.5±2.0% and a radiochemical purity of 98±1% in a total synthesis time of 72±7min (n=22). The modified synthesis module might also be useful for the synthesis of other [18F]radiopharmaceuticals via electrophilic substitution reactions while still being suitable for nucleophilic substitution reactions. |
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Automated electrophilic radiosynthesis of [18F]FBPA using a modified nucleophilic GE TRACERlab FXFDG |
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