Effect of ionic strength on ligand exchange kinetics between a mononuclear ferric citrate complex and siderophore desferrioxamine B
The effect of ionic strength (I) on the ligand exchange reaction between a mononuclear ferric citrate complex and the siderophore, desferrioxamine B (DFB), was examined in the NaCl concentration range of 0.01–0.5M, particularly focusing on the kinetics and mechanism of ligand exchange under environm...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ito, Hiroaki [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015transfer abstract |
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| Umfang: |
17 |
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| Übergeordnetes Werk: |
Enthalten in: 109 Discovery of Novel DNA Methylation Markers for the Detection of Colorectal Neoplasia: Selection by Methylome-Wide Analysis - Taylor, William R. ELSEVIER, 2014, journal of the Geochemical Society and the Meteoritical Society, New York, NY [u.a.] |
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| Übergeordnetes Werk: |
volume:154 ; year:2015 ; day:1 ; month:04 ; pages:81-97 ; extent:17 |
| Links: |
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| DOI / URN: |
10.1016/j.gca.2015.01.020 |
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| Katalog-ID: |
ELV029309263 |
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| 100 | 1 | |a Ito, Hiroaki |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect of ionic strength on ligand exchange kinetics between a mononuclear ferric citrate complex and siderophore desferrioxamine B |
| 264 | 1 | |c 2015transfer abstract | |
| 300 | |a 17 | ||
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| 520 | |a The effect of ionic strength (I) on the ligand exchange reaction between a mononuclear ferric citrate complex and the siderophore, desferrioxamine B (DFB), was examined in the NaCl concentration range of 0.01–0.5M, particularly focusing on the kinetics and mechanism of ligand exchange under environmentally relevant conditions. Overall ligand exchange rate constants were determined by spectrophotometrically measuring the time course of ferrioxamine B formation at a water temperature of 25°C, pH 8.0, and citrate/Fe molar ratios of 500–5000. The overall ligand exchange rate decreased by 2–11-fold (depending on the citrate/Fe molar ratios) as I increased from approximately 0.01 to 0.5M. In particular, a relatively large decrease was observed at lower I (<0.1M). A ligand exchange model describing the effect of I on the ligand exchange rate via disjunctive and adjunctive pathways was developed by considering the pseudo-equilibration of ferric citrate complexes and subsequent ferrioxamine formation on the basis of the Eigen–Wilkins metal–ligand complexation theory. The model and experimental data consistently suggest that the adjunctive pathway (i.e., direct association of DFB with ferric mono- and di-citrate complexes following dissociation of citrate from the parent complexes) dominates in ferrioxamine formation under the experimental conditions used. The model also predicts that the higher rate of ligand exchange at lower I is associated with the decrease in the ferric dicitrate complex stability because of the relatively high electrical repulsion between ferric monocitrate and free citrate at lower I (note that the reactivity of ferric dicitrate with DFB is smaller than that for the monocitrate complex). Overall, the findings of this study contribute to the understanding of the potential effect of I on ligand exchange kinetics in natural waters and provide fundamental knowledge on iron transformation and bioavailability. | ||
| 520 | |a The effect of ionic strength (I) on the ligand exchange reaction between a mononuclear ferric citrate complex and the siderophore, desferrioxamine B (DFB), was examined in the NaCl concentration range of 0.01–0.5M, particularly focusing on the kinetics and mechanism of ligand exchange under environmentally relevant conditions. Overall ligand exchange rate constants were determined by spectrophotometrically measuring the time course of ferrioxamine B formation at a water temperature of 25°C, pH 8.0, and citrate/Fe molar ratios of 500–5000. The overall ligand exchange rate decreased by 2–11-fold (depending on the citrate/Fe molar ratios) as I increased from approximately 0.01 to 0.5M. In particular, a relatively large decrease was observed at lower I (<0.1M). A ligand exchange model describing the effect of I on the ligand exchange rate via disjunctive and adjunctive pathways was developed by considering the pseudo-equilibration of ferric citrate complexes and subsequent ferrioxamine formation on the basis of the Eigen–Wilkins metal–ligand complexation theory. The model and experimental data consistently suggest that the adjunctive pathway (i.e., direct association of DFB with ferric mono- and di-citrate complexes following dissociation of citrate from the parent complexes) dominates in ferrioxamine formation under the experimental conditions used. The model also predicts that the higher rate of ligand exchange at lower I is associated with the decrease in the ferric dicitrate complex stability because of the relatively high electrical repulsion between ferric monocitrate and free citrate at lower I (note that the reactivity of ferric dicitrate with DFB is smaller than that for the monocitrate complex). Overall, the findings of this study contribute to the understanding of the potential effect of I on ligand exchange kinetics in natural waters and provide fundamental knowledge on iron transformation and bioavailability. | ||
| 700 | 1 | |a Fujii, Manabu |4 oth | |
| 700 | 1 | |a Masago, Yoshifumi |4 oth | |
| 700 | 1 | |a Waite, T. David |4 oth | |
| 700 | 1 | |a Omura, Tatsuo |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier |a Taylor, William R. ELSEVIER |t 109 Discovery of Novel DNA Methylation Markers for the Detection of Colorectal Neoplasia: Selection by Methylome-Wide Analysis |d 2014 |d journal of the Geochemical Society and the Meteoritical Society |g New York, NY [u.a.] |w (DE-627)ELV012653268 |
| 773 | 1 | 8 | |g volume:154 |g year:2015 |g day:1 |g month:04 |g pages:81-97 |g extent:17 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.gca.2015.01.020 |3 Volltext |
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10.1016/j.gca.2015.01.020 doi GBVA2015021000018.pica (DE-627)ELV029309263 (ELSEVIER)S0016-7037(15)00031-9 DE-627 ger DE-627 rakwb eng 550 550 DE-600 610 VZ 570 VZ BIODIV DE-30 fid 35.70 bkl 42.12 bkl 42.15 bkl Ito, Hiroaki verfasserin aut Effect of ionic strength on ligand exchange kinetics between a mononuclear ferric citrate complex and siderophore desferrioxamine B 2015transfer abstract 17 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effect of ionic strength (I) on the ligand exchange reaction between a mononuclear ferric citrate complex and the siderophore, desferrioxamine B (DFB), was examined in the NaCl concentration range of 0.01–0.5M, particularly focusing on the kinetics and mechanism of ligand exchange under environmentally relevant conditions. Overall ligand exchange rate constants were determined by spectrophotometrically measuring the time course of ferrioxamine B formation at a water temperature of 25°C, pH 8.0, and citrate/Fe molar ratios of 500–5000. The overall ligand exchange rate decreased by 2–11-fold (depending on the citrate/Fe molar ratios) as I increased from approximately 0.01 to 0.5M. In particular, a relatively large decrease was observed at lower I (<0.1M). A ligand exchange model describing the effect of I on the ligand exchange rate via disjunctive and adjunctive pathways was developed by considering the pseudo-equilibration of ferric citrate complexes and subsequent ferrioxamine formation on the basis of the Eigen–Wilkins metal–ligand complexation theory. The model and experimental data consistently suggest that the adjunctive pathway (i.e., direct association of DFB with ferric mono- and di-citrate complexes following dissociation of citrate from the parent complexes) dominates in ferrioxamine formation under the experimental conditions used. The model also predicts that the higher rate of ligand exchange at lower I is associated with the decrease in the ferric dicitrate complex stability because of the relatively high electrical repulsion between ferric monocitrate and free citrate at lower I (note that the reactivity of ferric dicitrate with DFB is smaller than that for the monocitrate complex). Overall, the findings of this study contribute to the understanding of the potential effect of I on ligand exchange kinetics in natural waters and provide fundamental knowledge on iron transformation and bioavailability. The effect of ionic strength (I) on the ligand exchange reaction between a mononuclear ferric citrate complex and the siderophore, desferrioxamine B (DFB), was examined in the NaCl concentration range of 0.01–0.5M, particularly focusing on the kinetics and mechanism of ligand exchange under environmentally relevant conditions. Overall ligand exchange rate constants were determined by spectrophotometrically measuring the time course of ferrioxamine B formation at a water temperature of 25°C, pH 8.0, and citrate/Fe molar ratios of 500–5000. The overall ligand exchange rate decreased by 2–11-fold (depending on the citrate/Fe molar ratios) as I increased from approximately 0.01 to 0.5M. In particular, a relatively large decrease was observed at lower I (<0.1M). A ligand exchange model describing the effect of I on the ligand exchange rate via disjunctive and adjunctive pathways was developed by considering the pseudo-equilibration of ferric citrate complexes and subsequent ferrioxamine formation on the basis of the Eigen–Wilkins metal–ligand complexation theory. The model and experimental data consistently suggest that the adjunctive pathway (i.e., direct association of DFB with ferric mono- and di-citrate complexes following dissociation of citrate from the parent complexes) dominates in ferrioxamine formation under the experimental conditions used. The model also predicts that the higher rate of ligand exchange at lower I is associated with the decrease in the ferric dicitrate complex stability because of the relatively high electrical repulsion between ferric monocitrate and free citrate at lower I (note that the reactivity of ferric dicitrate with DFB is smaller than that for the monocitrate complex). Overall, the findings of this study contribute to the understanding of the potential effect of I on ligand exchange kinetics in natural waters and provide fundamental knowledge on iron transformation and bioavailability. Fujii, Manabu oth Masago, Yoshifumi oth Waite, T. David oth Omura, Tatsuo oth Enthalten in Elsevier Taylor, William R. ELSEVIER 109 Discovery of Novel DNA Methylation Markers for the Detection of Colorectal Neoplasia: Selection by Methylome-Wide Analysis 2014 journal of the Geochemical Society and the Meteoritical Society New York, NY [u.a.] (DE-627)ELV012653268 volume:154 year:2015 day:1 month:04 pages:81-97 extent:17 https://doi.org/10.1016/j.gca.2015.01.020 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 35.70 Biochemie: Allgemeines VZ 42.12 Biophysik VZ 42.15 Zellbiologie VZ AR 154 2015 1 0401 81-97 17 045F 550 |
| spelling |
10.1016/j.gca.2015.01.020 doi GBVA2015021000018.pica (DE-627)ELV029309263 (ELSEVIER)S0016-7037(15)00031-9 DE-627 ger DE-627 rakwb eng 550 550 DE-600 610 VZ 570 VZ BIODIV DE-30 fid 35.70 bkl 42.12 bkl 42.15 bkl Ito, Hiroaki verfasserin aut Effect of ionic strength on ligand exchange kinetics between a mononuclear ferric citrate complex and siderophore desferrioxamine B 2015transfer abstract 17 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effect of ionic strength (I) on the ligand exchange reaction between a mononuclear ferric citrate complex and the siderophore, desferrioxamine B (DFB), was examined in the NaCl concentration range of 0.01–0.5M, particularly focusing on the kinetics and mechanism of ligand exchange under environmentally relevant conditions. Overall ligand exchange rate constants were determined by spectrophotometrically measuring the time course of ferrioxamine B formation at a water temperature of 25°C, pH 8.0, and citrate/Fe molar ratios of 500–5000. The overall ligand exchange rate decreased by 2–11-fold (depending on the citrate/Fe molar ratios) as I increased from approximately 0.01 to 0.5M. In particular, a relatively large decrease was observed at lower I (<0.1M). A ligand exchange model describing the effect of I on the ligand exchange rate via disjunctive and adjunctive pathways was developed by considering the pseudo-equilibration of ferric citrate complexes and subsequent ferrioxamine formation on the basis of the Eigen–Wilkins metal–ligand complexation theory. The model and experimental data consistently suggest that the adjunctive pathway (i.e., direct association of DFB with ferric mono- and di-citrate complexes following dissociation of citrate from the parent complexes) dominates in ferrioxamine formation under the experimental conditions used. The model also predicts that the higher rate of ligand exchange at lower I is associated with the decrease in the ferric dicitrate complex stability because of the relatively high electrical repulsion between ferric monocitrate and free citrate at lower I (note that the reactivity of ferric dicitrate with DFB is smaller than that for the monocitrate complex). Overall, the findings of this study contribute to the understanding of the potential effect of I on ligand exchange kinetics in natural waters and provide fundamental knowledge on iron transformation and bioavailability. The effect of ionic strength (I) on the ligand exchange reaction between a mononuclear ferric citrate complex and the siderophore, desferrioxamine B (DFB), was examined in the NaCl concentration range of 0.01–0.5M, particularly focusing on the kinetics and mechanism of ligand exchange under environmentally relevant conditions. Overall ligand exchange rate constants were determined by spectrophotometrically measuring the time course of ferrioxamine B formation at a water temperature of 25°C, pH 8.0, and citrate/Fe molar ratios of 500–5000. The overall ligand exchange rate decreased by 2–11-fold (depending on the citrate/Fe molar ratios) as I increased from approximately 0.01 to 0.5M. In particular, a relatively large decrease was observed at lower I (<0.1M). A ligand exchange model describing the effect of I on the ligand exchange rate via disjunctive and adjunctive pathways was developed by considering the pseudo-equilibration of ferric citrate complexes and subsequent ferrioxamine formation on the basis of the Eigen–Wilkins metal–ligand complexation theory. The model and experimental data consistently suggest that the adjunctive pathway (i.e., direct association of DFB with ferric mono- and di-citrate complexes following dissociation of citrate from the parent complexes) dominates in ferrioxamine formation under the experimental conditions used. The model also predicts that the higher rate of ligand exchange at lower I is associated with the decrease in the ferric dicitrate complex stability because of the relatively high electrical repulsion between ferric monocitrate and free citrate at lower I (note that the reactivity of ferric dicitrate with DFB is smaller than that for the monocitrate complex). Overall, the findings of this study contribute to the understanding of the potential effect of I on ligand exchange kinetics in natural waters and provide fundamental knowledge on iron transformation and bioavailability. Fujii, Manabu oth Masago, Yoshifumi oth Waite, T. David oth Omura, Tatsuo oth Enthalten in Elsevier Taylor, William R. ELSEVIER 109 Discovery of Novel DNA Methylation Markers for the Detection of Colorectal Neoplasia: Selection by Methylome-Wide Analysis 2014 journal of the Geochemical Society and the Meteoritical Society New York, NY [u.a.] (DE-627)ELV012653268 volume:154 year:2015 day:1 month:04 pages:81-97 extent:17 https://doi.org/10.1016/j.gca.2015.01.020 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 35.70 Biochemie: Allgemeines VZ 42.12 Biophysik VZ 42.15 Zellbiologie VZ AR 154 2015 1 0401 81-97 17 045F 550 |
| allfields_unstemmed |
10.1016/j.gca.2015.01.020 doi GBVA2015021000018.pica (DE-627)ELV029309263 (ELSEVIER)S0016-7037(15)00031-9 DE-627 ger DE-627 rakwb eng 550 550 DE-600 610 VZ 570 VZ BIODIV DE-30 fid 35.70 bkl 42.12 bkl 42.15 bkl Ito, Hiroaki verfasserin aut Effect of ionic strength on ligand exchange kinetics between a mononuclear ferric citrate complex and siderophore desferrioxamine B 2015transfer abstract 17 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effect of ionic strength (I) on the ligand exchange reaction between a mononuclear ferric citrate complex and the siderophore, desferrioxamine B (DFB), was examined in the NaCl concentration range of 0.01–0.5M, particularly focusing on the kinetics and mechanism of ligand exchange under environmentally relevant conditions. Overall ligand exchange rate constants were determined by spectrophotometrically measuring the time course of ferrioxamine B formation at a water temperature of 25°C, pH 8.0, and citrate/Fe molar ratios of 500–5000. The overall ligand exchange rate decreased by 2–11-fold (depending on the citrate/Fe molar ratios) as I increased from approximately 0.01 to 0.5M. In particular, a relatively large decrease was observed at lower I (<0.1M). A ligand exchange model describing the effect of I on the ligand exchange rate via disjunctive and adjunctive pathways was developed by considering the pseudo-equilibration of ferric citrate complexes and subsequent ferrioxamine formation on the basis of the Eigen–Wilkins metal–ligand complexation theory. The model and experimental data consistently suggest that the adjunctive pathway (i.e., direct association of DFB with ferric mono- and di-citrate complexes following dissociation of citrate from the parent complexes) dominates in ferrioxamine formation under the experimental conditions used. The model also predicts that the higher rate of ligand exchange at lower I is associated with the decrease in the ferric dicitrate complex stability because of the relatively high electrical repulsion between ferric monocitrate and free citrate at lower I (note that the reactivity of ferric dicitrate with DFB is smaller than that for the monocitrate complex). Overall, the findings of this study contribute to the understanding of the potential effect of I on ligand exchange kinetics in natural waters and provide fundamental knowledge on iron transformation and bioavailability. The effect of ionic strength (I) on the ligand exchange reaction between a mononuclear ferric citrate complex and the siderophore, desferrioxamine B (DFB), was examined in the NaCl concentration range of 0.01–0.5M, particularly focusing on the kinetics and mechanism of ligand exchange under environmentally relevant conditions. Overall ligand exchange rate constants were determined by spectrophotometrically measuring the time course of ferrioxamine B formation at a water temperature of 25°C, pH 8.0, and citrate/Fe molar ratios of 500–5000. The overall ligand exchange rate decreased by 2–11-fold (depending on the citrate/Fe molar ratios) as I increased from approximately 0.01 to 0.5M. In particular, a relatively large decrease was observed at lower I (<0.1M). A ligand exchange model describing the effect of I on the ligand exchange rate via disjunctive and adjunctive pathways was developed by considering the pseudo-equilibration of ferric citrate complexes and subsequent ferrioxamine formation on the basis of the Eigen–Wilkins metal–ligand complexation theory. The model and experimental data consistently suggest that the adjunctive pathway (i.e., direct association of DFB with ferric mono- and di-citrate complexes following dissociation of citrate from the parent complexes) dominates in ferrioxamine formation under the experimental conditions used. The model also predicts that the higher rate of ligand exchange at lower I is associated with the decrease in the ferric dicitrate complex stability because of the relatively high electrical repulsion between ferric monocitrate and free citrate at lower I (note that the reactivity of ferric dicitrate with DFB is smaller than that for the monocitrate complex). Overall, the findings of this study contribute to the understanding of the potential effect of I on ligand exchange kinetics in natural waters and provide fundamental knowledge on iron transformation and bioavailability. Fujii, Manabu oth Masago, Yoshifumi oth Waite, T. David oth Omura, Tatsuo oth Enthalten in Elsevier Taylor, William R. ELSEVIER 109 Discovery of Novel DNA Methylation Markers for the Detection of Colorectal Neoplasia: Selection by Methylome-Wide Analysis 2014 journal of the Geochemical Society and the Meteoritical Society New York, NY [u.a.] (DE-627)ELV012653268 volume:154 year:2015 day:1 month:04 pages:81-97 extent:17 https://doi.org/10.1016/j.gca.2015.01.020 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 35.70 Biochemie: Allgemeines VZ 42.12 Biophysik VZ 42.15 Zellbiologie VZ AR 154 2015 1 0401 81-97 17 045F 550 |
| allfieldsGer |
10.1016/j.gca.2015.01.020 doi GBVA2015021000018.pica (DE-627)ELV029309263 (ELSEVIER)S0016-7037(15)00031-9 DE-627 ger DE-627 rakwb eng 550 550 DE-600 610 VZ 570 VZ BIODIV DE-30 fid 35.70 bkl 42.12 bkl 42.15 bkl Ito, Hiroaki verfasserin aut Effect of ionic strength on ligand exchange kinetics between a mononuclear ferric citrate complex and siderophore desferrioxamine B 2015transfer abstract 17 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effect of ionic strength (I) on the ligand exchange reaction between a mononuclear ferric citrate complex and the siderophore, desferrioxamine B (DFB), was examined in the NaCl concentration range of 0.01–0.5M, particularly focusing on the kinetics and mechanism of ligand exchange under environmentally relevant conditions. Overall ligand exchange rate constants were determined by spectrophotometrically measuring the time course of ferrioxamine B formation at a water temperature of 25°C, pH 8.0, and citrate/Fe molar ratios of 500–5000. The overall ligand exchange rate decreased by 2–11-fold (depending on the citrate/Fe molar ratios) as I increased from approximately 0.01 to 0.5M. In particular, a relatively large decrease was observed at lower I (<0.1M). A ligand exchange model describing the effect of I on the ligand exchange rate via disjunctive and adjunctive pathways was developed by considering the pseudo-equilibration of ferric citrate complexes and subsequent ferrioxamine formation on the basis of the Eigen–Wilkins metal–ligand complexation theory. The model and experimental data consistently suggest that the adjunctive pathway (i.e., direct association of DFB with ferric mono- and di-citrate complexes following dissociation of citrate from the parent complexes) dominates in ferrioxamine formation under the experimental conditions used. The model also predicts that the higher rate of ligand exchange at lower I is associated with the decrease in the ferric dicitrate complex stability because of the relatively high electrical repulsion between ferric monocitrate and free citrate at lower I (note that the reactivity of ferric dicitrate with DFB is smaller than that for the monocitrate complex). Overall, the findings of this study contribute to the understanding of the potential effect of I on ligand exchange kinetics in natural waters and provide fundamental knowledge on iron transformation and bioavailability. The effect of ionic strength (I) on the ligand exchange reaction between a mononuclear ferric citrate complex and the siderophore, desferrioxamine B (DFB), was examined in the NaCl concentration range of 0.01–0.5M, particularly focusing on the kinetics and mechanism of ligand exchange under environmentally relevant conditions. Overall ligand exchange rate constants were determined by spectrophotometrically measuring the time course of ferrioxamine B formation at a water temperature of 25°C, pH 8.0, and citrate/Fe molar ratios of 500–5000. The overall ligand exchange rate decreased by 2–11-fold (depending on the citrate/Fe molar ratios) as I increased from approximately 0.01 to 0.5M. In particular, a relatively large decrease was observed at lower I (<0.1M). A ligand exchange model describing the effect of I on the ligand exchange rate via disjunctive and adjunctive pathways was developed by considering the pseudo-equilibration of ferric citrate complexes and subsequent ferrioxamine formation on the basis of the Eigen–Wilkins metal–ligand complexation theory. The model and experimental data consistently suggest that the adjunctive pathway (i.e., direct association of DFB with ferric mono- and di-citrate complexes following dissociation of citrate from the parent complexes) dominates in ferrioxamine formation under the experimental conditions used. The model also predicts that the higher rate of ligand exchange at lower I is associated with the decrease in the ferric dicitrate complex stability because of the relatively high electrical repulsion between ferric monocitrate and free citrate at lower I (note that the reactivity of ferric dicitrate with DFB is smaller than that for the monocitrate complex). Overall, the findings of this study contribute to the understanding of the potential effect of I on ligand exchange kinetics in natural waters and provide fundamental knowledge on iron transformation and bioavailability. Fujii, Manabu oth Masago, Yoshifumi oth Waite, T. David oth Omura, Tatsuo oth Enthalten in Elsevier Taylor, William R. ELSEVIER 109 Discovery of Novel DNA Methylation Markers for the Detection of Colorectal Neoplasia: Selection by Methylome-Wide Analysis 2014 journal of the Geochemical Society and the Meteoritical Society New York, NY [u.a.] (DE-627)ELV012653268 volume:154 year:2015 day:1 month:04 pages:81-97 extent:17 https://doi.org/10.1016/j.gca.2015.01.020 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 35.70 Biochemie: Allgemeines VZ 42.12 Biophysik VZ 42.15 Zellbiologie VZ AR 154 2015 1 0401 81-97 17 045F 550 |
| allfieldsSound |
10.1016/j.gca.2015.01.020 doi GBVA2015021000018.pica (DE-627)ELV029309263 (ELSEVIER)S0016-7037(15)00031-9 DE-627 ger DE-627 rakwb eng 550 550 DE-600 610 VZ 570 VZ BIODIV DE-30 fid 35.70 bkl 42.12 bkl 42.15 bkl Ito, Hiroaki verfasserin aut Effect of ionic strength on ligand exchange kinetics between a mononuclear ferric citrate complex and siderophore desferrioxamine B 2015transfer abstract 17 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effect of ionic strength (I) on the ligand exchange reaction between a mononuclear ferric citrate complex and the siderophore, desferrioxamine B (DFB), was examined in the NaCl concentration range of 0.01–0.5M, particularly focusing on the kinetics and mechanism of ligand exchange under environmentally relevant conditions. Overall ligand exchange rate constants were determined by spectrophotometrically measuring the time course of ferrioxamine B formation at a water temperature of 25°C, pH 8.0, and citrate/Fe molar ratios of 500–5000. The overall ligand exchange rate decreased by 2–11-fold (depending on the citrate/Fe molar ratios) as I increased from approximately 0.01 to 0.5M. In particular, a relatively large decrease was observed at lower I (<0.1M). A ligand exchange model describing the effect of I on the ligand exchange rate via disjunctive and adjunctive pathways was developed by considering the pseudo-equilibration of ferric citrate complexes and subsequent ferrioxamine formation on the basis of the Eigen–Wilkins metal–ligand complexation theory. The model and experimental data consistently suggest that the adjunctive pathway (i.e., direct association of DFB with ferric mono- and di-citrate complexes following dissociation of citrate from the parent complexes) dominates in ferrioxamine formation under the experimental conditions used. The model also predicts that the higher rate of ligand exchange at lower I is associated with the decrease in the ferric dicitrate complex stability because of the relatively high electrical repulsion between ferric monocitrate and free citrate at lower I (note that the reactivity of ferric dicitrate with DFB is smaller than that for the monocitrate complex). Overall, the findings of this study contribute to the understanding of the potential effect of I on ligand exchange kinetics in natural waters and provide fundamental knowledge on iron transformation and bioavailability. The effect of ionic strength (I) on the ligand exchange reaction between a mononuclear ferric citrate complex and the siderophore, desferrioxamine B (DFB), was examined in the NaCl concentration range of 0.01–0.5M, particularly focusing on the kinetics and mechanism of ligand exchange under environmentally relevant conditions. Overall ligand exchange rate constants were determined by spectrophotometrically measuring the time course of ferrioxamine B formation at a water temperature of 25°C, pH 8.0, and citrate/Fe molar ratios of 500–5000. The overall ligand exchange rate decreased by 2–11-fold (depending on the citrate/Fe molar ratios) as I increased from approximately 0.01 to 0.5M. In particular, a relatively large decrease was observed at lower I (<0.1M). A ligand exchange model describing the effect of I on the ligand exchange rate via disjunctive and adjunctive pathways was developed by considering the pseudo-equilibration of ferric citrate complexes and subsequent ferrioxamine formation on the basis of the Eigen–Wilkins metal–ligand complexation theory. The model and experimental data consistently suggest that the adjunctive pathway (i.e., direct association of DFB with ferric mono- and di-citrate complexes following dissociation of citrate from the parent complexes) dominates in ferrioxamine formation under the experimental conditions used. The model also predicts that the higher rate of ligand exchange at lower I is associated with the decrease in the ferric dicitrate complex stability because of the relatively high electrical repulsion between ferric monocitrate and free citrate at lower I (note that the reactivity of ferric dicitrate with DFB is smaller than that for the monocitrate complex). Overall, the findings of this study contribute to the understanding of the potential effect of I on ligand exchange kinetics in natural waters and provide fundamental knowledge on iron transformation and bioavailability. Fujii, Manabu oth Masago, Yoshifumi oth Waite, T. David oth Omura, Tatsuo oth Enthalten in Elsevier Taylor, William R. ELSEVIER 109 Discovery of Novel DNA Methylation Markers for the Detection of Colorectal Neoplasia: Selection by Methylome-Wide Analysis 2014 journal of the Geochemical Society and the Meteoritical Society New York, NY [u.a.] (DE-627)ELV012653268 volume:154 year:2015 day:1 month:04 pages:81-97 extent:17 https://doi.org/10.1016/j.gca.2015.01.020 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 35.70 Biochemie: Allgemeines VZ 42.12 Biophysik VZ 42.15 Zellbiologie VZ AR 154 2015 1 0401 81-97 17 045F 550 |
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Effect of ionic strength on ligand exchange kinetics between a mononuclear ferric citrate complex and siderophore desferrioxamine B |
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The effect of ionic strength (I) on the ligand exchange reaction between a mononuclear ferric citrate complex and the siderophore, desferrioxamine B (DFB), was examined in the NaCl concentration range of 0.01–0.5M, particularly focusing on the kinetics and mechanism of ligand exchange under environmentally relevant conditions. Overall ligand exchange rate constants were determined by spectrophotometrically measuring the time course of ferrioxamine B formation at a water temperature of 25°C, pH 8.0, and citrate/Fe molar ratios of 500–5000. The overall ligand exchange rate decreased by 2–11-fold (depending on the citrate/Fe molar ratios) as I increased from approximately 0.01 to 0.5M. In particular, a relatively large decrease was observed at lower I (<0.1M). A ligand exchange model describing the effect of I on the ligand exchange rate via disjunctive and adjunctive pathways was developed by considering the pseudo-equilibration of ferric citrate complexes and subsequent ferrioxamine formation on the basis of the Eigen–Wilkins metal–ligand complexation theory. The model and experimental data consistently suggest that the adjunctive pathway (i.e., direct association of DFB with ferric mono- and di-citrate complexes following dissociation of citrate from the parent complexes) dominates in ferrioxamine formation under the experimental conditions used. The model also predicts that the higher rate of ligand exchange at lower I is associated with the decrease in the ferric dicitrate complex stability because of the relatively high electrical repulsion between ferric monocitrate and free citrate at lower I (note that the reactivity of ferric dicitrate with DFB is smaller than that for the monocitrate complex). Overall, the findings of this study contribute to the understanding of the potential effect of I on ligand exchange kinetics in natural waters and provide fundamental knowledge on iron transformation and bioavailability. |
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The effect of ionic strength (I) on the ligand exchange reaction between a mononuclear ferric citrate complex and the siderophore, desferrioxamine B (DFB), was examined in the NaCl concentration range of 0.01–0.5M, particularly focusing on the kinetics and mechanism of ligand exchange under environmentally relevant conditions. Overall ligand exchange rate constants were determined by spectrophotometrically measuring the time course of ferrioxamine B formation at a water temperature of 25°C, pH 8.0, and citrate/Fe molar ratios of 500–5000. The overall ligand exchange rate decreased by 2–11-fold (depending on the citrate/Fe molar ratios) as I increased from approximately 0.01 to 0.5M. In particular, a relatively large decrease was observed at lower I (<0.1M). A ligand exchange model describing the effect of I on the ligand exchange rate via disjunctive and adjunctive pathways was developed by considering the pseudo-equilibration of ferric citrate complexes and subsequent ferrioxamine formation on the basis of the Eigen–Wilkins metal–ligand complexation theory. The model and experimental data consistently suggest that the adjunctive pathway (i.e., direct association of DFB with ferric mono- and di-citrate complexes following dissociation of citrate from the parent complexes) dominates in ferrioxamine formation under the experimental conditions used. The model also predicts that the higher rate of ligand exchange at lower I is associated with the decrease in the ferric dicitrate complex stability because of the relatively high electrical repulsion between ferric monocitrate and free citrate at lower I (note that the reactivity of ferric dicitrate with DFB is smaller than that for the monocitrate complex). Overall, the findings of this study contribute to the understanding of the potential effect of I on ligand exchange kinetics in natural waters and provide fundamental knowledge on iron transformation and bioavailability. |
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The effect of ionic strength (I) on the ligand exchange reaction between a mononuclear ferric citrate complex and the siderophore, desferrioxamine B (DFB), was examined in the NaCl concentration range of 0.01–0.5M, particularly focusing on the kinetics and mechanism of ligand exchange under environmentally relevant conditions. Overall ligand exchange rate constants were determined by spectrophotometrically measuring the time course of ferrioxamine B formation at a water temperature of 25°C, pH 8.0, and citrate/Fe molar ratios of 500–5000. The overall ligand exchange rate decreased by 2–11-fold (depending on the citrate/Fe molar ratios) as I increased from approximately 0.01 to 0.5M. In particular, a relatively large decrease was observed at lower I (<0.1M). A ligand exchange model describing the effect of I on the ligand exchange rate via disjunctive and adjunctive pathways was developed by considering the pseudo-equilibration of ferric citrate complexes and subsequent ferrioxamine formation on the basis of the Eigen–Wilkins metal–ligand complexation theory. The model and experimental data consistently suggest that the adjunctive pathway (i.e., direct association of DFB with ferric mono- and di-citrate complexes following dissociation of citrate from the parent complexes) dominates in ferrioxamine formation under the experimental conditions used. The model also predicts that the higher rate of ligand exchange at lower I is associated with the decrease in the ferric dicitrate complex stability because of the relatively high electrical repulsion between ferric monocitrate and free citrate at lower I (note that the reactivity of ferric dicitrate with DFB is smaller than that for the monocitrate complex). Overall, the findings of this study contribute to the understanding of the potential effect of I on ligand exchange kinetics in natural waters and provide fundamental knowledge on iron transformation and bioavailability. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV029309263</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625172112.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2015 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.gca.2015.01.020</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2015021000018.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV029309263</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0016-7037(15)00031-9</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">550</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">550</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">570</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIODIV</subfield><subfield code="q">DE-30</subfield><subfield code="2">fid</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">35.70</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">42.12</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">42.15</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Ito, Hiroaki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Effect of ionic strength on ligand exchange kinetics between a mononuclear ferric citrate complex and siderophore desferrioxamine B</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2015transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">17</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The effect of ionic strength (I) on the ligand exchange reaction between a mononuclear ferric citrate complex and the siderophore, desferrioxamine B (DFB), was examined in the NaCl concentration range of 0.01–0.5M, particularly focusing on the kinetics and mechanism of ligand exchange under environmentally relevant conditions. Overall ligand exchange rate constants were determined by spectrophotometrically measuring the time course of ferrioxamine B formation at a water temperature of 25°C, pH 8.0, and citrate/Fe molar ratios of 500–5000. The overall ligand exchange rate decreased by 2–11-fold (depending on the citrate/Fe molar ratios) as I increased from approximately 0.01 to 0.5M. In particular, a relatively large decrease was observed at lower I (<0.1M). A ligand exchange model describing the effect of I on the ligand exchange rate via disjunctive and adjunctive pathways was developed by considering the pseudo-equilibration of ferric citrate complexes and subsequent ferrioxamine formation on the basis of the Eigen–Wilkins metal–ligand complexation theory. The model and experimental data consistently suggest that the adjunctive pathway (i.e., direct association of DFB with ferric mono- and di-citrate complexes following dissociation of citrate from the parent complexes) dominates in ferrioxamine formation under the experimental conditions used. The model also predicts that the higher rate of ligand exchange at lower I is associated with the decrease in the ferric dicitrate complex stability because of the relatively high electrical repulsion between ferric monocitrate and free citrate at lower I (note that the reactivity of ferric dicitrate with DFB is smaller than that for the monocitrate complex). Overall, the findings of this study contribute to the understanding of the potential effect of I on ligand exchange kinetics in natural waters and provide fundamental knowledge on iron transformation and bioavailability.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The effect of ionic strength (I) on the ligand exchange reaction between a mononuclear ferric citrate complex and the siderophore, desferrioxamine B (DFB), was examined in the NaCl concentration range of 0.01–0.5M, particularly focusing on the kinetics and mechanism of ligand exchange under environmentally relevant conditions. Overall ligand exchange rate constants were determined by spectrophotometrically measuring the time course of ferrioxamine B formation at a water temperature of 25°C, pH 8.0, and citrate/Fe molar ratios of 500–5000. The overall ligand exchange rate decreased by 2–11-fold (depending on the citrate/Fe molar ratios) as I increased from approximately 0.01 to 0.5M. In particular, a relatively large decrease was observed at lower I (<0.1M). A ligand exchange model describing the effect of I on the ligand exchange rate via disjunctive and adjunctive pathways was developed by considering the pseudo-equilibration of ferric citrate complexes and subsequent ferrioxamine formation on the basis of the Eigen–Wilkins metal–ligand complexation theory. The model and experimental data consistently suggest that the adjunctive pathway (i.e., direct association of DFB with ferric mono- and di-citrate complexes following dissociation of citrate from the parent complexes) dominates in ferrioxamine formation under the experimental conditions used. The model also predicts that the higher rate of ligand exchange at lower I is associated with the decrease in the ferric dicitrate complex stability because of the relatively high electrical repulsion between ferric monocitrate and free citrate at lower I (note that the reactivity of ferric dicitrate with DFB is smaller than that for the monocitrate complex). Overall, the findings of this study contribute to the understanding of the potential effect of I on ligand exchange kinetics in natural waters and provide fundamental knowledge on iron transformation and bioavailability.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fujii, Manabu</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Masago, Yoshifumi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Waite, T. David</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Omura, Tatsuo</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier</subfield><subfield code="a">Taylor, William R. ELSEVIER</subfield><subfield code="t">109 Discovery of Novel DNA Methylation Markers for the Detection of Colorectal Neoplasia: Selection by Methylome-Wide Analysis</subfield><subfield code="d">2014</subfield><subfield code="d">journal of the Geochemical Society and the Meteoritical Society</subfield><subfield code="g">New York, NY [u.a.]</subfield><subfield code="w">(DE-627)ELV012653268</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:154</subfield><subfield code="g">year:2015</subfield><subfield code="g">day:1</subfield><subfield code="g">month:04</subfield><subfield code="g">pages:81-97</subfield><subfield code="g">extent:17</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.gca.2015.01.020</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">FID-BIODIV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">35.70</subfield><subfield code="j">Biochemie: Allgemeines</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">42.12</subfield><subfield code="j">Biophysik</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">42.15</subfield><subfield code="j">Zellbiologie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">154</subfield><subfield code="j">2015</subfield><subfield code="b">1</subfield><subfield code="c">0401</subfield><subfield code="h">81-97</subfield><subfield code="g">17</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">550</subfield></datafield></record></collection>
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