Screening of inhibitors of glycogen synthase kinase-3β from traditional Chinese medicines using enzyme-immobilized magnetic beads combined with high-performance liquid chromatography
• A screening method using GSK-3β-immobilized MBs coupled with HPLC-UV was developed. • This method was used to screen the inhibitory activity of extracts of 15 TCMs. • A new inhibitor of GSK-3β, fukugetin, was found from Garcinia xanthochymus. • Fukugetin was a non-ATP competitive inhibitor and its...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Li, Yunfang [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Umfang: |
9 |
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| Übergeordnetes Werk: |
Enthalten in: Defense development: The role of co-creation in filling the gap between policy-makers and technology development - Liwång, Hans ELSEVIER, 2022, including electrophoresis, mass spectrometry and other separation and detection methods, New York, NY [u.a.] |
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| Übergeordnetes Werk: |
volume:1425 ; year:2015 ; day:18 ; month:12 ; pages:8-16 ; extent:9 |
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| DOI / URN: |
10.1016/j.chroma.2015.10.062 |
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Screening of inhibitors of glycogen synthase kinase-3β from traditional Chinese medicines using enzyme-immobilized magnetic beads combined with high-performance liquid chromatography |
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• A screening method using GSK-3β-immobilized MBs coupled with HPLC-UV was developed. • This method was used to screen the inhibitory activity of extracts of 15 TCMs. • A new inhibitor of GSK-3β, fukugetin, was found from Garcinia xanthochymus. • Fukugetin was a non-ATP competitive inhibitor and its IC50 was 3.18±0.07μM. |
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• A screening method using GSK-3β-immobilized MBs coupled with HPLC-UV was developed. • This method was used to screen the inhibitory activity of extracts of 15 TCMs. • A new inhibitor of GSK-3β, fukugetin, was found from Garcinia xanthochymus. • Fukugetin was a non-ATP competitive inhibitor and its IC50 was 3.18±0.07μM. |
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• A screening method using GSK-3β-immobilized MBs coupled with HPLC-UV was developed. • This method was used to screen the inhibitory activity of extracts of 15 TCMs. • A new inhibitor of GSK-3β, fukugetin, was found from Garcinia xanthochymus. • Fukugetin was a non-ATP competitive inhibitor and its IC50 was 3.18±0.07μM. |
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Screening of inhibitors of glycogen synthase kinase-3β from traditional Chinese medicines using enzyme-immobilized magnetic beads combined with high-performance liquid chromatography |
| url |
https://doi.org/10.1016/j.chroma.2015.10.062 |
| remote_bool |
true |
| author2 |
Xu, Jia Chen, Yu Mei, Zhinan Xiao, Yuxiu |
| author2Str |
Xu, Jia Chen, Yu Mei, Zhinan Xiao, Yuxiu |
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oth oth oth oth |
| doi_str |
10.1016/j.chroma.2015.10.062 |
| up_date |
2024-07-06T21:11:06.789Z |
| _version_ |
1803865572550639616 |
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