Carboxymethyl flavonoids and a chromone with antimicrobial activity from Selaginella moellendorffii Hieron
Five new carboxymethyl flavonoids named 5-carboxymethyl-3′, 4′, 7-trihydroxyflavone (1), (2S)- 5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2a), (2R)-5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2b), (2S)-5-carboxymethyl-4′, 7-dihydroxyflavonone (3), 5- carbomethoxymethyl-4′, 7-dihydroxyflavone...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zou, ZhenXing [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016transfer abstract |
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| Umfang: |
6 |
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| Übergeordnetes Werk: |
Enthalten in: MASE-EGTI: An agent-based simulator for environmental land change - Coelho, Cássio Giorgio Couto ELSEVIER, 2021, the journal of the study of medicinal plants, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:111 ; year:2016 ; pages:124-129 ; extent:6 |
| Links: |
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| DOI / URN: |
10.1016/j.fitote.2016.04.022 |
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ELV02973696X |
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| 245 | 1 | 0 | |a Carboxymethyl flavonoids and a chromone with antimicrobial activity from Selaginella moellendorffii Hieron |
| 264 | 1 | |c 2016transfer abstract | |
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| 520 | |a Five new carboxymethyl flavonoids named 5-carboxymethyl-3′, 4′, 7-trihydroxyflavone (1), (2S)- 5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2a), (2R)-5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2b), (2S)-5-carboxymethyl-4′, 7-dihydroxyflavonone (3), 5- carbomethoxymethyl-4′, 7-dihydroxyflavone (4), and a new chromone named 5-carboxymethyl-7-hydroxychromone (5), together with two known compounds 5-carboxymethyl-4′-hydroxyflavone-7-O-β-d-glucopyranoside (6), 5-carboxymethyl-4′, 7-dihydroxyflavone (7) were isolated from Selaginella moellendorffii Hieron. Their structures including absolute configuration were elucidated by extensive spectroscopic methods and experimental electronic circular dichroism (ECD) spectra. What's worth mentioning is that a carboxymethyl substituent appeared at the C-5 position of all isolated compounds, only recently discovered in genus Selaginella. Compounds 2a and 2b were identified as a pair of chiral isomers; compound 5 was discovered as the first chromone comprising a carboxymethyl side chain. Furthermore, all compounds were evaluated for their antibacterial activities against various Gram-positives and Gram-negatives, and compared to the reference drugs amoxicillin and norfloxacin. As a result, compounds 3 and 4 exhibited as potent antimicrobial agents with a broad spectrum, and compound 5 appeared as the most promising one to combat Gram-positives. | ||
| 520 | |a Five new carboxymethyl flavonoids named 5-carboxymethyl-3′, 4′, 7-trihydroxyflavone (1), (2S)- 5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2a), (2R)-5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2b), (2S)-5-carboxymethyl-4′, 7-dihydroxyflavonone (3), 5- carbomethoxymethyl-4′, 7-dihydroxyflavone (4), and a new chromone named 5-carboxymethyl-7-hydroxychromone (5), together with two known compounds 5-carboxymethyl-4′-hydroxyflavone-7-O-β-d-glucopyranoside (6), 5-carboxymethyl-4′, 7-dihydroxyflavone (7) were isolated from Selaginella moellendorffii Hieron. Their structures including absolute configuration were elucidated by extensive spectroscopic methods and experimental electronic circular dichroism (ECD) spectra. What's worth mentioning is that a carboxymethyl substituent appeared at the C-5 position of all isolated compounds, only recently discovered in genus Selaginella. Compounds 2a and 2b were identified as a pair of chiral isomers; compound 5 was discovered as the first chromone comprising a carboxymethyl side chain. Furthermore, all compounds were evaluated for their antibacterial activities against various Gram-positives and Gram-negatives, and compared to the reference drugs amoxicillin and norfloxacin. As a result, compounds 3 and 4 exhibited as potent antimicrobial agents with a broad spectrum, and compound 5 appeared as the most promising one to combat Gram-positives. | ||
| 700 | 1 | |a Xu, PingSheng |4 oth | |
| 700 | 1 | |a Wu, CanRong |4 oth | |
| 700 | 1 | |a Zhu, WeiXing |4 oth | |
| 700 | 1 | |a Zhu, GangZhi |4 oth | |
| 700 | 1 | |a He, XiaoAi |4 oth | |
| 700 | 1 | |a Zhang, GuoGang |4 oth | |
| 700 | 1 | |a Hu, JianZhong |4 oth | |
| 700 | 1 | |a Liu, Shao |4 oth | |
| 700 | 1 | |a Zeng, Wei |4 oth | |
| 700 | 1 | |a Xu, KangPing |4 oth | |
| 700 | 1 | |a Tan, GuiShan |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Coelho, Cássio Giorgio Couto ELSEVIER |t MASE-EGTI: An agent-based simulator for environmental land change |d 2021 |d the journal of the study of medicinal plants |g Amsterdam [u.a.] |w (DE-627)ELV007030444 |
| 773 | 1 | 8 | |g volume:111 |g year:2016 |g pages:124-129 |g extent:6 |
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10.1016/j.fitote.2016.04.022 doi GBVA2016012000001.pica (DE-627)ELV02973696X (ELSEVIER)S0367-326X(16)30096-X DE-627 ger DE-627 rakwb eng 570 570 DE-600 690 004 VZ 43.03 bkl Zou, ZhenXing verfasserin aut Carboxymethyl flavonoids and a chromone with antimicrobial activity from Selaginella moellendorffii Hieron 2016transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Five new carboxymethyl flavonoids named 5-carboxymethyl-3′, 4′, 7-trihydroxyflavone (1), (2S)- 5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2a), (2R)-5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2b), (2S)-5-carboxymethyl-4′, 7-dihydroxyflavonone (3), 5- carbomethoxymethyl-4′, 7-dihydroxyflavone (4), and a new chromone named 5-carboxymethyl-7-hydroxychromone (5), together with two known compounds 5-carboxymethyl-4′-hydroxyflavone-7-O-β-d-glucopyranoside (6), 5-carboxymethyl-4′, 7-dihydroxyflavone (7) were isolated from Selaginella moellendorffii Hieron. Their structures including absolute configuration were elucidated by extensive spectroscopic methods and experimental electronic circular dichroism (ECD) spectra. What's worth mentioning is that a carboxymethyl substituent appeared at the C-5 position of all isolated compounds, only recently discovered in genus Selaginella. Compounds 2a and 2b were identified as a pair of chiral isomers; compound 5 was discovered as the first chromone comprising a carboxymethyl side chain. Furthermore, all compounds were evaluated for their antibacterial activities against various Gram-positives and Gram-negatives, and compared to the reference drugs amoxicillin and norfloxacin. As a result, compounds 3 and 4 exhibited as potent antimicrobial agents with a broad spectrum, and compound 5 appeared as the most promising one to combat Gram-positives. Five new carboxymethyl flavonoids named 5-carboxymethyl-3′, 4′, 7-trihydroxyflavone (1), (2S)- 5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2a), (2R)-5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2b), (2S)-5-carboxymethyl-4′, 7-dihydroxyflavonone (3), 5- carbomethoxymethyl-4′, 7-dihydroxyflavone (4), and a new chromone named 5-carboxymethyl-7-hydroxychromone (5), together with two known compounds 5-carboxymethyl-4′-hydroxyflavone-7-O-β-d-glucopyranoside (6), 5-carboxymethyl-4′, 7-dihydroxyflavone (7) were isolated from Selaginella moellendorffii Hieron. Their structures including absolute configuration were elucidated by extensive spectroscopic methods and experimental electronic circular dichroism (ECD) spectra. What's worth mentioning is that a carboxymethyl substituent appeared at the C-5 position of all isolated compounds, only recently discovered in genus Selaginella. Compounds 2a and 2b were identified as a pair of chiral isomers; compound 5 was discovered as the first chromone comprising a carboxymethyl side chain. Furthermore, all compounds were evaluated for their antibacterial activities against various Gram-positives and Gram-negatives, and compared to the reference drugs amoxicillin and norfloxacin. As a result, compounds 3 and 4 exhibited as potent antimicrobial agents with a broad spectrum, and compound 5 appeared as the most promising one to combat Gram-positives. Xu, PingSheng oth Wu, CanRong oth Zhu, WeiXing oth Zhu, GangZhi oth He, XiaoAi oth Zhang, GuoGang oth Hu, JianZhong oth Liu, Shao oth Zeng, Wei oth Xu, KangPing oth Tan, GuiShan oth Enthalten in Elsevier Science Coelho, Cássio Giorgio Couto ELSEVIER MASE-EGTI: An agent-based simulator for environmental land change 2021 the journal of the study of medicinal plants Amsterdam [u.a.] (DE-627)ELV007030444 volume:111 year:2016 pages:124-129 extent:6 https://doi.org/10.1016/j.fitote.2016.04.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-MAT SSG-OLC-FOR 43.03 Methoden der Umweltforschung und des Umweltschutzes VZ AR 111 2016 124-129 6 045F 570 |
| spelling |
10.1016/j.fitote.2016.04.022 doi GBVA2016012000001.pica (DE-627)ELV02973696X (ELSEVIER)S0367-326X(16)30096-X DE-627 ger DE-627 rakwb eng 570 570 DE-600 690 004 VZ 43.03 bkl Zou, ZhenXing verfasserin aut Carboxymethyl flavonoids and a chromone with antimicrobial activity from Selaginella moellendorffii Hieron 2016transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Five new carboxymethyl flavonoids named 5-carboxymethyl-3′, 4′, 7-trihydroxyflavone (1), (2S)- 5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2a), (2R)-5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2b), (2S)-5-carboxymethyl-4′, 7-dihydroxyflavonone (3), 5- carbomethoxymethyl-4′, 7-dihydroxyflavone (4), and a new chromone named 5-carboxymethyl-7-hydroxychromone (5), together with two known compounds 5-carboxymethyl-4′-hydroxyflavone-7-O-β-d-glucopyranoside (6), 5-carboxymethyl-4′, 7-dihydroxyflavone (7) were isolated from Selaginella moellendorffii Hieron. Their structures including absolute configuration were elucidated by extensive spectroscopic methods and experimental electronic circular dichroism (ECD) spectra. What's worth mentioning is that a carboxymethyl substituent appeared at the C-5 position of all isolated compounds, only recently discovered in genus Selaginella. Compounds 2a and 2b were identified as a pair of chiral isomers; compound 5 was discovered as the first chromone comprising a carboxymethyl side chain. Furthermore, all compounds were evaluated for their antibacterial activities against various Gram-positives and Gram-negatives, and compared to the reference drugs amoxicillin and norfloxacin. As a result, compounds 3 and 4 exhibited as potent antimicrobial agents with a broad spectrum, and compound 5 appeared as the most promising one to combat Gram-positives. Five new carboxymethyl flavonoids named 5-carboxymethyl-3′, 4′, 7-trihydroxyflavone (1), (2S)- 5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2a), (2R)-5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2b), (2S)-5-carboxymethyl-4′, 7-dihydroxyflavonone (3), 5- carbomethoxymethyl-4′, 7-dihydroxyflavone (4), and a new chromone named 5-carboxymethyl-7-hydroxychromone (5), together with two known compounds 5-carboxymethyl-4′-hydroxyflavone-7-O-β-d-glucopyranoside (6), 5-carboxymethyl-4′, 7-dihydroxyflavone (7) were isolated from Selaginella moellendorffii Hieron. Their structures including absolute configuration were elucidated by extensive spectroscopic methods and experimental electronic circular dichroism (ECD) spectra. What's worth mentioning is that a carboxymethyl substituent appeared at the C-5 position of all isolated compounds, only recently discovered in genus Selaginella. Compounds 2a and 2b were identified as a pair of chiral isomers; compound 5 was discovered as the first chromone comprising a carboxymethyl side chain. Furthermore, all compounds were evaluated for their antibacterial activities against various Gram-positives and Gram-negatives, and compared to the reference drugs amoxicillin and norfloxacin. As a result, compounds 3 and 4 exhibited as potent antimicrobial agents with a broad spectrum, and compound 5 appeared as the most promising one to combat Gram-positives. Xu, PingSheng oth Wu, CanRong oth Zhu, WeiXing oth Zhu, GangZhi oth He, XiaoAi oth Zhang, GuoGang oth Hu, JianZhong oth Liu, Shao oth Zeng, Wei oth Xu, KangPing oth Tan, GuiShan oth Enthalten in Elsevier Science Coelho, Cássio Giorgio Couto ELSEVIER MASE-EGTI: An agent-based simulator for environmental land change 2021 the journal of the study of medicinal plants Amsterdam [u.a.] (DE-627)ELV007030444 volume:111 year:2016 pages:124-129 extent:6 https://doi.org/10.1016/j.fitote.2016.04.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-MAT SSG-OLC-FOR 43.03 Methoden der Umweltforschung und des Umweltschutzes VZ AR 111 2016 124-129 6 045F 570 |
| allfields_unstemmed |
10.1016/j.fitote.2016.04.022 doi GBVA2016012000001.pica (DE-627)ELV02973696X (ELSEVIER)S0367-326X(16)30096-X DE-627 ger DE-627 rakwb eng 570 570 DE-600 690 004 VZ 43.03 bkl Zou, ZhenXing verfasserin aut Carboxymethyl flavonoids and a chromone with antimicrobial activity from Selaginella moellendorffii Hieron 2016transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Five new carboxymethyl flavonoids named 5-carboxymethyl-3′, 4′, 7-trihydroxyflavone (1), (2S)- 5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2a), (2R)-5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2b), (2S)-5-carboxymethyl-4′, 7-dihydroxyflavonone (3), 5- carbomethoxymethyl-4′, 7-dihydroxyflavone (4), and a new chromone named 5-carboxymethyl-7-hydroxychromone (5), together with two known compounds 5-carboxymethyl-4′-hydroxyflavone-7-O-β-d-glucopyranoside (6), 5-carboxymethyl-4′, 7-dihydroxyflavone (7) were isolated from Selaginella moellendorffii Hieron. Their structures including absolute configuration were elucidated by extensive spectroscopic methods and experimental electronic circular dichroism (ECD) spectra. What's worth mentioning is that a carboxymethyl substituent appeared at the C-5 position of all isolated compounds, only recently discovered in genus Selaginella. Compounds 2a and 2b were identified as a pair of chiral isomers; compound 5 was discovered as the first chromone comprising a carboxymethyl side chain. Furthermore, all compounds were evaluated for their antibacterial activities against various Gram-positives and Gram-negatives, and compared to the reference drugs amoxicillin and norfloxacin. As a result, compounds 3 and 4 exhibited as potent antimicrobial agents with a broad spectrum, and compound 5 appeared as the most promising one to combat Gram-positives. Five new carboxymethyl flavonoids named 5-carboxymethyl-3′, 4′, 7-trihydroxyflavone (1), (2S)- 5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2a), (2R)-5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2b), (2S)-5-carboxymethyl-4′, 7-dihydroxyflavonone (3), 5- carbomethoxymethyl-4′, 7-dihydroxyflavone (4), and a new chromone named 5-carboxymethyl-7-hydroxychromone (5), together with two known compounds 5-carboxymethyl-4′-hydroxyflavone-7-O-β-d-glucopyranoside (6), 5-carboxymethyl-4′, 7-dihydroxyflavone (7) were isolated from Selaginella moellendorffii Hieron. Their structures including absolute configuration were elucidated by extensive spectroscopic methods and experimental electronic circular dichroism (ECD) spectra. What's worth mentioning is that a carboxymethyl substituent appeared at the C-5 position of all isolated compounds, only recently discovered in genus Selaginella. Compounds 2a and 2b were identified as a pair of chiral isomers; compound 5 was discovered as the first chromone comprising a carboxymethyl side chain. Furthermore, all compounds were evaluated for their antibacterial activities against various Gram-positives and Gram-negatives, and compared to the reference drugs amoxicillin and norfloxacin. As a result, compounds 3 and 4 exhibited as potent antimicrobial agents with a broad spectrum, and compound 5 appeared as the most promising one to combat Gram-positives. Xu, PingSheng oth Wu, CanRong oth Zhu, WeiXing oth Zhu, GangZhi oth He, XiaoAi oth Zhang, GuoGang oth Hu, JianZhong oth Liu, Shao oth Zeng, Wei oth Xu, KangPing oth Tan, GuiShan oth Enthalten in Elsevier Science Coelho, Cássio Giorgio Couto ELSEVIER MASE-EGTI: An agent-based simulator for environmental land change 2021 the journal of the study of medicinal plants Amsterdam [u.a.] (DE-627)ELV007030444 volume:111 year:2016 pages:124-129 extent:6 https://doi.org/10.1016/j.fitote.2016.04.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-MAT SSG-OLC-FOR 43.03 Methoden der Umweltforschung und des Umweltschutzes VZ AR 111 2016 124-129 6 045F 570 |
| allfieldsGer |
10.1016/j.fitote.2016.04.022 doi GBVA2016012000001.pica (DE-627)ELV02973696X (ELSEVIER)S0367-326X(16)30096-X DE-627 ger DE-627 rakwb eng 570 570 DE-600 690 004 VZ 43.03 bkl Zou, ZhenXing verfasserin aut Carboxymethyl flavonoids and a chromone with antimicrobial activity from Selaginella moellendorffii Hieron 2016transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Five new carboxymethyl flavonoids named 5-carboxymethyl-3′, 4′, 7-trihydroxyflavone (1), (2S)- 5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2a), (2R)-5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2b), (2S)-5-carboxymethyl-4′, 7-dihydroxyflavonone (3), 5- carbomethoxymethyl-4′, 7-dihydroxyflavone (4), and a new chromone named 5-carboxymethyl-7-hydroxychromone (5), together with two known compounds 5-carboxymethyl-4′-hydroxyflavone-7-O-β-d-glucopyranoside (6), 5-carboxymethyl-4′, 7-dihydroxyflavone (7) were isolated from Selaginella moellendorffii Hieron. Their structures including absolute configuration were elucidated by extensive spectroscopic methods and experimental electronic circular dichroism (ECD) spectra. What's worth mentioning is that a carboxymethyl substituent appeared at the C-5 position of all isolated compounds, only recently discovered in genus Selaginella. Compounds 2a and 2b were identified as a pair of chiral isomers; compound 5 was discovered as the first chromone comprising a carboxymethyl side chain. Furthermore, all compounds were evaluated for their antibacterial activities against various Gram-positives and Gram-negatives, and compared to the reference drugs amoxicillin and norfloxacin. As a result, compounds 3 and 4 exhibited as potent antimicrobial agents with a broad spectrum, and compound 5 appeared as the most promising one to combat Gram-positives. Five new carboxymethyl flavonoids named 5-carboxymethyl-3′, 4′, 7-trihydroxyflavone (1), (2S)- 5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2a), (2R)-5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2b), (2S)-5-carboxymethyl-4′, 7-dihydroxyflavonone (3), 5- carbomethoxymethyl-4′, 7-dihydroxyflavone (4), and a new chromone named 5-carboxymethyl-7-hydroxychromone (5), together with two known compounds 5-carboxymethyl-4′-hydroxyflavone-7-O-β-d-glucopyranoside (6), 5-carboxymethyl-4′, 7-dihydroxyflavone (7) were isolated from Selaginella moellendorffii Hieron. Their structures including absolute configuration were elucidated by extensive spectroscopic methods and experimental electronic circular dichroism (ECD) spectra. What's worth mentioning is that a carboxymethyl substituent appeared at the C-5 position of all isolated compounds, only recently discovered in genus Selaginella. Compounds 2a and 2b were identified as a pair of chiral isomers; compound 5 was discovered as the first chromone comprising a carboxymethyl side chain. Furthermore, all compounds were evaluated for their antibacterial activities against various Gram-positives and Gram-negatives, and compared to the reference drugs amoxicillin and norfloxacin. As a result, compounds 3 and 4 exhibited as potent antimicrobial agents with a broad spectrum, and compound 5 appeared as the most promising one to combat Gram-positives. Xu, PingSheng oth Wu, CanRong oth Zhu, WeiXing oth Zhu, GangZhi oth He, XiaoAi oth Zhang, GuoGang oth Hu, JianZhong oth Liu, Shao oth Zeng, Wei oth Xu, KangPing oth Tan, GuiShan oth Enthalten in Elsevier Science Coelho, Cássio Giorgio Couto ELSEVIER MASE-EGTI: An agent-based simulator for environmental land change 2021 the journal of the study of medicinal plants Amsterdam [u.a.] (DE-627)ELV007030444 volume:111 year:2016 pages:124-129 extent:6 https://doi.org/10.1016/j.fitote.2016.04.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-UMW SSG-OLC-ARC SSG-OLC-TEC SSG-OLC-MAT SSG-OLC-FOR 43.03 Methoden der Umweltforschung und des Umweltschutzes VZ AR 111 2016 124-129 6 045F 570 |
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carboxymethyl flavonoids and a chromone with antimicrobial activity from selaginella moellendorffii hieron |
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Carboxymethyl flavonoids and a chromone with antimicrobial activity from Selaginella moellendorffii Hieron |
| abstract |
Five new carboxymethyl flavonoids named 5-carboxymethyl-3′, 4′, 7-trihydroxyflavone (1), (2S)- 5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2a), (2R)-5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2b), (2S)-5-carboxymethyl-4′, 7-dihydroxyflavonone (3), 5- carbomethoxymethyl-4′, 7-dihydroxyflavone (4), and a new chromone named 5-carboxymethyl-7-hydroxychromone (5), together with two known compounds 5-carboxymethyl-4′-hydroxyflavone-7-O-β-d-glucopyranoside (6), 5-carboxymethyl-4′, 7-dihydroxyflavone (7) were isolated from Selaginella moellendorffii Hieron. Their structures including absolute configuration were elucidated by extensive spectroscopic methods and experimental electronic circular dichroism (ECD) spectra. What's worth mentioning is that a carboxymethyl substituent appeared at the C-5 position of all isolated compounds, only recently discovered in genus Selaginella. Compounds 2a and 2b were identified as a pair of chiral isomers; compound 5 was discovered as the first chromone comprising a carboxymethyl side chain. Furthermore, all compounds were evaluated for their antibacterial activities against various Gram-positives and Gram-negatives, and compared to the reference drugs amoxicillin and norfloxacin. As a result, compounds 3 and 4 exhibited as potent antimicrobial agents with a broad spectrum, and compound 5 appeared as the most promising one to combat Gram-positives. |
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Five new carboxymethyl flavonoids named 5-carboxymethyl-3′, 4′, 7-trihydroxyflavone (1), (2S)- 5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2a), (2R)-5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2b), (2S)-5-carboxymethyl-4′, 7-dihydroxyflavonone (3), 5- carbomethoxymethyl-4′, 7-dihydroxyflavone (4), and a new chromone named 5-carboxymethyl-7-hydroxychromone (5), together with two known compounds 5-carboxymethyl-4′-hydroxyflavone-7-O-β-d-glucopyranoside (6), 5-carboxymethyl-4′, 7-dihydroxyflavone (7) were isolated from Selaginella moellendorffii Hieron. Their structures including absolute configuration were elucidated by extensive spectroscopic methods and experimental electronic circular dichroism (ECD) spectra. What's worth mentioning is that a carboxymethyl substituent appeared at the C-5 position of all isolated compounds, only recently discovered in genus Selaginella. Compounds 2a and 2b were identified as a pair of chiral isomers; compound 5 was discovered as the first chromone comprising a carboxymethyl side chain. Furthermore, all compounds were evaluated for their antibacterial activities against various Gram-positives and Gram-negatives, and compared to the reference drugs amoxicillin and norfloxacin. As a result, compounds 3 and 4 exhibited as potent antimicrobial agents with a broad spectrum, and compound 5 appeared as the most promising one to combat Gram-positives. |
| abstract_unstemmed |
Five new carboxymethyl flavonoids named 5-carboxymethyl-3′, 4′, 7-trihydroxyflavone (1), (2S)- 5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2a), (2R)-5-carboxymethyl-3′, 4′, 7-trihydroxyflavonone (2b), (2S)-5-carboxymethyl-4′, 7-dihydroxyflavonone (3), 5- carbomethoxymethyl-4′, 7-dihydroxyflavone (4), and a new chromone named 5-carboxymethyl-7-hydroxychromone (5), together with two known compounds 5-carboxymethyl-4′-hydroxyflavone-7-O-β-d-glucopyranoside (6), 5-carboxymethyl-4′, 7-dihydroxyflavone (7) were isolated from Selaginella moellendorffii Hieron. Their structures including absolute configuration were elucidated by extensive spectroscopic methods and experimental electronic circular dichroism (ECD) spectra. What's worth mentioning is that a carboxymethyl substituent appeared at the C-5 position of all isolated compounds, only recently discovered in genus Selaginella. Compounds 2a and 2b were identified as a pair of chiral isomers; compound 5 was discovered as the first chromone comprising a carboxymethyl side chain. Furthermore, all compounds were evaluated for their antibacterial activities against various Gram-positives and Gram-negatives, and compared to the reference drugs amoxicillin and norfloxacin. As a result, compounds 3 and 4 exhibited as potent antimicrobial agents with a broad spectrum, and compound 5 appeared as the most promising one to combat Gram-positives. |
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Xu, PingSheng Wu, CanRong Zhu, WeiXing Zhu, GangZhi He, XiaoAi Zhang, GuoGang Hu, JianZhong Liu, Shao Zeng, Wei Xu, KangPing Tan, GuiShan |
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Xu, PingSheng Wu, CanRong Zhu, WeiXing Zhu, GangZhi He, XiaoAi Zhang, GuoGang Hu, JianZhong Liu, Shao Zeng, Wei Xu, KangPing Tan, GuiShan |
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10.1016/j.fitote.2016.04.022 |
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2024-07-06T22:14:17.643Z |
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