Predictors for symptom re-exacerbation after targeted stepwise drug discontinuation in first-episode schizophrenia
After a first episode in schizophrenia guidelines recommend antipsychotic maintenance treatment (MT) for at least 1year. Recent RCTs on subsequent targeted intermittent treatment (IT) after stepwise drug discontinuation yielded noticeably higher relapse rates than during MT also in first-episode pat...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Gaebel, Wolfgang [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Umfang: |
9 |
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| Übergeordnetes Werk: |
Enthalten in: Idiopathic Environmental Intolerance: A Treatment Model - Van den Bergh, Omer ELSEVIER, 2021, an international multidisciplinary journal, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:170 ; year:2016 ; number:1 ; pages:168-176 ; extent:9 |
| Links: |
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| DOI / URN: |
10.1016/j.schres.2015.10.024 |
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| 520 | |a After a first episode in schizophrenia guidelines recommend antipsychotic maintenance treatment (MT) for at least 1year. Recent RCTs on subsequent targeted intermittent treatment (IT) after stepwise drug discontinuation yielded noticeably higher relapse rates than during MT also in first-episode patients. Nevertheless, about 50% of patients remain stable under IT. Given the potential adverse effects of antipsychotics and the preference of many patients to discontinue drugs, valid predictors for the feasibility of IT are urgently needed to support decision making. | ||
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10.1016/j.schres.2015.10.024 doi GBVA2016015000028.pica (DE-627)ELV029887526 (ELSEVIER)S0920-9964(15)30024-4 DE-627 ger DE-627 rakwb eng 610 610 DE-600 150 VZ Gaebel, Wolfgang verfasserin aut Predictors for symptom re-exacerbation after targeted stepwise drug discontinuation in first-episode schizophrenia 2016 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier After a first episode in schizophrenia guidelines recommend antipsychotic maintenance treatment (MT) for at least 1year. Recent RCTs on subsequent targeted intermittent treatment (IT) after stepwise drug discontinuation yielded noticeably higher relapse rates than during MT also in first-episode patients. Nevertheless, about 50% of patients remain stable under IT. Given the potential adverse effects of antipsychotics and the preference of many patients to discontinue drugs, valid predictors for the feasibility of IT are urgently needed to support decision making. Riesbeck, Mathias oth Wölwer, Wolfgang oth Klimke, Ansgar oth Eickhoff, Matthias oth von Wilmsdorff, Martina oth de Millas, Walter oth Maier, Wolfgang oth Ruhrmann, Stephan oth Falkai, Peter oth Sauer, Heinrich oth Schmitt, Andrea oth Riedel, Michael oth Klingberg, Stefan oth Möller, Hans-Jürgen oth Enthalten in Elsevier Science Van den Bergh, Omer ELSEVIER Idiopathic Environmental Intolerance: A Treatment Model 2021 an international multidisciplinary journal Amsterdam [u.a.] (DE-627)ELV005829860 volume:170 year:2016 number:1 pages:168-176 extent:9 https://doi.org/10.1016/j.schres.2015.10.024 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 170 2016 1 168-176 9 045F 610 |
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Predictors for symptom re-exacerbation after targeted stepwise drug discontinuation in first-episode schizophrenia |
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After a first episode in schizophrenia guidelines recommend antipsychotic maintenance treatment (MT) for at least 1year. Recent RCTs on subsequent targeted intermittent treatment (IT) after stepwise drug discontinuation yielded noticeably higher relapse rates than during MT also in first-episode patients. Nevertheless, about 50% of patients remain stable under IT. Given the potential adverse effects of antipsychotics and the preference of many patients to discontinue drugs, valid predictors for the feasibility of IT are urgently needed to support decision making. |
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After a first episode in schizophrenia guidelines recommend antipsychotic maintenance treatment (MT) for at least 1year. Recent RCTs on subsequent targeted intermittent treatment (IT) after stepwise drug discontinuation yielded noticeably higher relapse rates than during MT also in first-episode patients. Nevertheless, about 50% of patients remain stable under IT. Given the potential adverse effects of antipsychotics and the preference of many patients to discontinue drugs, valid predictors for the feasibility of IT are urgently needed to support decision making. |
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After a first episode in schizophrenia guidelines recommend antipsychotic maintenance treatment (MT) for at least 1year. Recent RCTs on subsequent targeted intermittent treatment (IT) after stepwise drug discontinuation yielded noticeably higher relapse rates than during MT also in first-episode patients. Nevertheless, about 50% of patients remain stable under IT. Given the potential adverse effects of antipsychotics and the preference of many patients to discontinue drugs, valid predictors for the feasibility of IT are urgently needed to support decision making. |
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