Neoadjuvant dasatinib for muscle-invasive bladder cancer with tissue analysis of biologic activity

Preclinical urothelial carcinoma models suggest activity of dasatinib, an oral SRC-family kinase (SFK) inhibitor. We sought to determine the feasibility and biologic activity of neoadjuvant dasatinib (Neo-D) in patients with muscle-invasive urothelial carcinoma of the bladder (miUCB) preceding radic...
Ausführliche Beschreibung

Gespeichert in:
Autor*in:

Hahn, Noah M. [verfasserIn]

Knudsen, Beatrice S.

Daneshmand, Siamak

Koch, Michael O.

Bihrle, Richard

Foster, Richard S.

Gardner, Thomas A.

Cheng, Liang

Liu, Ziyue

Breen, Timothy

Fleming, Mark T.

Lance, Raymond

Corless, Christopher L.

Alva, Ajjai S.

Shen, Steven S.

Huang, Fangjin

Gertych, Arkadiusz

Gallick, Gary E.

Mallick, Jayati

Ryan, Christopher

Galsky, Matthew D.

Lerner, Seth P.

Posadas, Edwin M.

Sonpavde, Guru

Format:

E-Artikel

Sprache:

Englisch

Erschienen:

2016

Schlagwörter:

Src-family kinases

Neoadjuvant therapy

Dasatinib

Translational medical research

Bladder

Urothelial carcinoma

Protein kinase inhibitors

Umfang:

7

Übergeordnetes Werk:

Enthalten in: BOLD matches neuronal activity at the mm scale: A combined 7T fMRI and ECoG study in human sensorimotor cortex - Siero, Jeroen C.W. ELSEVIER, 2014transfer abstract, Amsterdam [u.a.]

Übergeordnetes Werk:

volume:34 ; year:2016 ; number:1 ; pages:411-417 ; extent:7

Links:

Volltext

DOI / URN:

10.1016/j.urolonc.2015.08.005

Katalog-ID:

ELV02997285X

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