High-throughput screening and radioligand binding studies reveal monoamine oxidase-B as the primary binding target for d-deprenyl
d-deprenyl is a useful positron emission tomography tracer for visualization of inflammatory processes. Studies with [11C]-d-deprenyl showed robust uptake in peripheral painful sites of patients with rheumatoid arthritis or chronic whiplash injury. The mechanism of preferential d-deprenyl uptake is...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Lesniak, Anna [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2016 |
|---|
| Umfang: |
7 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Transition of convective heat transfer to subcooled flow boiling due to crystallization fouling - Abd-Elhady, M.S. ELSEVIER, 2016, including pharmacology letters, New York, NY [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:152 ; year:2016 ; day:1 ; month:05 ; pages:231-237 ; extent:7 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.lfs.2016.03.058 |
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d-deprenyl is a useful positron emission tomography tracer for visualization of inflammatory processes. Studies with [11C]-d-deprenyl showed robust uptake in peripheral painful sites of patients with rheumatoid arthritis or chronic whiplash injury. The mechanism of preferential d-deprenyl uptake is not yet known, but the existence of a specific binding site was proposed. Thus, in the present study, we sought to identify the binding site for d-deprenyl and verify the hypothesis about the possibility of monoamine oxidase enzymes as major targets for this molecule. |
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d-deprenyl is a useful positron emission tomography tracer for visualization of inflammatory processes. Studies with [11C]-d-deprenyl showed robust uptake in peripheral painful sites of patients with rheumatoid arthritis or chronic whiplash injury. The mechanism of preferential d-deprenyl uptake is not yet known, but the existence of a specific binding site was proposed. Thus, in the present study, we sought to identify the binding site for d-deprenyl and verify the hypothesis about the possibility of monoamine oxidase enzymes as major targets for this molecule. |
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d-deprenyl is a useful positron emission tomography tracer for visualization of inflammatory processes. Studies with [11C]-d-deprenyl showed robust uptake in peripheral painful sites of patients with rheumatoid arthritis or chronic whiplash injury. The mechanism of preferential d-deprenyl uptake is not yet known, but the existence of a specific binding site was proposed. Thus, in the present study, we sought to identify the binding site for d-deprenyl and verify the hypothesis about the possibility of monoamine oxidase enzymes as major targets for this molecule. |
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