Comparative study of interleukin-17C (IL-17C) and IL-17D in large yellow croaker <ce:italic>Larimichthys crocea</ce:italic> reveals their similar but differential functional activity
Interleukin 17 (IL-17) family members are key players in regulating the immune response in mammals. Here, we identified the IL-17C and IL-17D homologs from large yellow croaker (Larimichthys crocea), named LcIL-17C and LcIL-17D, respectively. The deduced LcIL-17C and LcIL-17D proteins possessed the...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ding, Yang [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017transfer abstract |
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| Schlagwörter: |
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| Umfang: |
11 |
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| Übergeordnetes Werk: |
Enthalten in: GABAergic mRNA expression is differentially expressed across the prelimbic and orbitofrontal cortices of rats sensitized to methamphetamine: Relevance to psychosis - Wearne, Travis A. ELSEVIER, 2016transfer abstract, ontogeny, phylogeny, aging : the official journal of the International Society of Developmental and Comparative Immunology, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:76 ; year:2017 ; pages:34-44 ; extent:11 |
| Links: |
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| DOI / URN: |
10.1016/j.dci.2017.05.014 |
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| Katalog-ID: |
ELV030269407 |
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| 245 | 1 | 0 | |a Comparative study of interleukin-17C (IL-17C) and IL-17D in large yellow croaker <ce:italic>Larimichthys crocea</ce:italic> reveals their similar but differential functional activity |
| 264 | 1 | |c 2017transfer abstract | |
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| 520 | |a Interleukin 17 (IL-17) family members are key players in regulating the immune response in mammals. Here, we identified the IL-17C and IL-17D homologs from large yellow croaker (Larimichthys crocea), named LcIL-17C and LcIL-17D, respectively. The deduced LcIL-17C and LcIL-17D proteins possessed the typical IL-17 domain and shared a conserved arrangement of eight cysteine residues. Both LcIL-17C and LcIL-17Dc genes were constitutively expressed in all tissues examined, although at different levels. After challenge with Aeromonas hydrophila, the expression of LcIL-17C and LcIL-17D was significantly increased in gills, head kidney, and spleen. In the peripheral blood leukocytes (PBLs), the recombinant LcIL-17C (rLcIL-17C) could strongly promote the expression of chemokines (CXCL8, CXCL12, and CXCL13), proinflammatory factors (TNF-α, IL-1β, IL-6, and IFNg), and antibacterial peptide hepcidin, whereas rLcIL-17D induced a weaker expression of these chemokines. Consistently, the culture supernatants from the PBLs treated by rLcIL-17C showed a stronger ability to induce the migration of PBLs than those treated by rLcIL-17D. Furthermore, both rLcIL-17C and rLcIL-17D could activate the NF-κB signalling in the epithelioma papulosum cyprini (EPC) cells. Taken together, these results indicated that LcIL-17C and LcIL-17D, although differing in their ability to mediate chemotaxis for PBLs, may promote the inflammatory response and host defence via activating NF-κB signalling. To our knowledge, this is the first report on functional identification of a IL-17C in teleost. | ||
| 520 | |a Interleukin 17 (IL-17) family members are key players in regulating the immune response in mammals. Here, we identified the IL-17C and IL-17D homologs from large yellow croaker (Larimichthys crocea), named LcIL-17C and LcIL-17D, respectively. The deduced LcIL-17C and LcIL-17D proteins possessed the typical IL-17 domain and shared a conserved arrangement of eight cysteine residues. Both LcIL-17C and LcIL-17Dc genes were constitutively expressed in all tissues examined, although at different levels. After challenge with Aeromonas hydrophila, the expression of LcIL-17C and LcIL-17D was significantly increased in gills, head kidney, and spleen. In the peripheral blood leukocytes (PBLs), the recombinant LcIL-17C (rLcIL-17C) could strongly promote the expression of chemokines (CXCL8, CXCL12, and CXCL13), proinflammatory factors (TNF-α, IL-1β, IL-6, and IFNg), and antibacterial peptide hepcidin, whereas rLcIL-17D induced a weaker expression of these chemokines. Consistently, the culture supernatants from the PBLs treated by rLcIL-17C showed a stronger ability to induce the migration of PBLs than those treated by rLcIL-17D. Furthermore, both rLcIL-17C and rLcIL-17D could activate the NF-κB signalling in the epithelioma papulosum cyprini (EPC) cells. Taken together, these results indicated that LcIL-17C and LcIL-17D, although differing in their ability to mediate chemotaxis for PBLs, may promote the inflammatory response and host defence via activating NF-κB signalling. To our knowledge, this is the first report on functional identification of a IL-17C in teleost. | ||
| 650 | 7 | |a Functional analysis |2 Elsevier | |
| 650 | 7 | |a Molecular characterization |2 Elsevier | |
| 650 | 7 | |a Large yellow croaker (<ce:italic>Larimichthys crocea</ce:italic>) |2 Elsevier | |
| 650 | 7 | |a Interleukin-17C and D |2 Elsevier | |
| 700 | 1 | |a Ao, Jingqun |4 oth | |
| 700 | 1 | |a Chen, Xinhua |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Wearne, Travis A. ELSEVIER |t GABAergic mRNA expression is differentially expressed across the prelimbic and orbitofrontal cortices of rats sensitized to methamphetamine: Relevance to psychosis |d 2016transfer abstract |d ontogeny, phylogeny, aging : the official journal of the International Society of Developmental and Comparative Immunology |g Amsterdam [u.a.] |w (DE-627)ELV019920881 |
| 773 | 1 | 8 | |g volume:76 |g year:2017 |g pages:34-44 |g extent:11 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.dci.2017.05.014 |3 Volltext |
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| 936 | b | k | |a 44.88 |j Urologie |j Nephrologie |q VZ |
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10.1016/j.dci.2017.05.014 doi GBV00000000000374.pica (DE-627)ELV030269407 (ELSEVIER)S0145-305X(17)30113-1 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.88 bkl Ding, Yang verfasserin aut Comparative study of interleukin-17C (IL-17C) and IL-17D in large yellow croaker <ce:italic>Larimichthys crocea</ce:italic> reveals their similar but differential functional activity 2017transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Interleukin 17 (IL-17) family members are key players in regulating the immune response in mammals. Here, we identified the IL-17C and IL-17D homologs from large yellow croaker (Larimichthys crocea), named LcIL-17C and LcIL-17D, respectively. The deduced LcIL-17C and LcIL-17D proteins possessed the typical IL-17 domain and shared a conserved arrangement of eight cysteine residues. Both LcIL-17C and LcIL-17Dc genes were constitutively expressed in all tissues examined, although at different levels. After challenge with Aeromonas hydrophila, the expression of LcIL-17C and LcIL-17D was significantly increased in gills, head kidney, and spleen. In the peripheral blood leukocytes (PBLs), the recombinant LcIL-17C (rLcIL-17C) could strongly promote the expression of chemokines (CXCL8, CXCL12, and CXCL13), proinflammatory factors (TNF-α, IL-1β, IL-6, and IFNg), and antibacterial peptide hepcidin, whereas rLcIL-17D induced a weaker expression of these chemokines. Consistently, the culture supernatants from the PBLs treated by rLcIL-17C showed a stronger ability to induce the migration of PBLs than those treated by rLcIL-17D. Furthermore, both rLcIL-17C and rLcIL-17D could activate the NF-κB signalling in the epithelioma papulosum cyprini (EPC) cells. Taken together, these results indicated that LcIL-17C and LcIL-17D, although differing in their ability to mediate chemotaxis for PBLs, may promote the inflammatory response and host defence via activating NF-κB signalling. To our knowledge, this is the first report on functional identification of a IL-17C in teleost. Interleukin 17 (IL-17) family members are key players in regulating the immune response in mammals. Here, we identified the IL-17C and IL-17D homologs from large yellow croaker (Larimichthys crocea), named LcIL-17C and LcIL-17D, respectively. The deduced LcIL-17C and LcIL-17D proteins possessed the typical IL-17 domain and shared a conserved arrangement of eight cysteine residues. Both LcIL-17C and LcIL-17Dc genes were constitutively expressed in all tissues examined, although at different levels. After challenge with Aeromonas hydrophila, the expression of LcIL-17C and LcIL-17D was significantly increased in gills, head kidney, and spleen. In the peripheral blood leukocytes (PBLs), the recombinant LcIL-17C (rLcIL-17C) could strongly promote the expression of chemokines (CXCL8, CXCL12, and CXCL13), proinflammatory factors (TNF-α, IL-1β, IL-6, and IFNg), and antibacterial peptide hepcidin, whereas rLcIL-17D induced a weaker expression of these chemokines. Consistently, the culture supernatants from the PBLs treated by rLcIL-17C showed a stronger ability to induce the migration of PBLs than those treated by rLcIL-17D. Furthermore, both rLcIL-17C and rLcIL-17D could activate the NF-κB signalling in the epithelioma papulosum cyprini (EPC) cells. Taken together, these results indicated that LcIL-17C and LcIL-17D, although differing in their ability to mediate chemotaxis for PBLs, may promote the inflammatory response and host defence via activating NF-κB signalling. To our knowledge, this is the first report on functional identification of a IL-17C in teleost. Functional analysis Elsevier Molecular characterization Elsevier Large yellow croaker (<ce:italic>Larimichthys crocea</ce:italic>) Elsevier Interleukin-17C and D Elsevier Ao, Jingqun oth Chen, Xinhua oth Enthalten in Elsevier Science Wearne, Travis A. ELSEVIER GABAergic mRNA expression is differentially expressed across the prelimbic and orbitofrontal cortices of rats sensitized to methamphetamine: Relevance to psychosis 2016transfer abstract ontogeny, phylogeny, aging : the official journal of the International Society of Developmental and Comparative Immunology Amsterdam [u.a.] (DE-627)ELV019920881 volume:76 year:2017 pages:34-44 extent:11 https://doi.org/10.1016/j.dci.2017.05.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_60 44.88 Urologie Nephrologie VZ AR 76 2017 34-44 11 |
| spelling |
10.1016/j.dci.2017.05.014 doi GBV00000000000374.pica (DE-627)ELV030269407 (ELSEVIER)S0145-305X(17)30113-1 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.88 bkl Ding, Yang verfasserin aut Comparative study of interleukin-17C (IL-17C) and IL-17D in large yellow croaker <ce:italic>Larimichthys crocea</ce:italic> reveals their similar but differential functional activity 2017transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Interleukin 17 (IL-17) family members are key players in regulating the immune response in mammals. Here, we identified the IL-17C and IL-17D homologs from large yellow croaker (Larimichthys crocea), named LcIL-17C and LcIL-17D, respectively. The deduced LcIL-17C and LcIL-17D proteins possessed the typical IL-17 domain and shared a conserved arrangement of eight cysteine residues. Both LcIL-17C and LcIL-17Dc genes were constitutively expressed in all tissues examined, although at different levels. After challenge with Aeromonas hydrophila, the expression of LcIL-17C and LcIL-17D was significantly increased in gills, head kidney, and spleen. In the peripheral blood leukocytes (PBLs), the recombinant LcIL-17C (rLcIL-17C) could strongly promote the expression of chemokines (CXCL8, CXCL12, and CXCL13), proinflammatory factors (TNF-α, IL-1β, IL-6, and IFNg), and antibacterial peptide hepcidin, whereas rLcIL-17D induced a weaker expression of these chemokines. Consistently, the culture supernatants from the PBLs treated by rLcIL-17C showed a stronger ability to induce the migration of PBLs than those treated by rLcIL-17D. Furthermore, both rLcIL-17C and rLcIL-17D could activate the NF-κB signalling in the epithelioma papulosum cyprini (EPC) cells. Taken together, these results indicated that LcIL-17C and LcIL-17D, although differing in their ability to mediate chemotaxis for PBLs, may promote the inflammatory response and host defence via activating NF-κB signalling. To our knowledge, this is the first report on functional identification of a IL-17C in teleost. Interleukin 17 (IL-17) family members are key players in regulating the immune response in mammals. Here, we identified the IL-17C and IL-17D homologs from large yellow croaker (Larimichthys crocea), named LcIL-17C and LcIL-17D, respectively. The deduced LcIL-17C and LcIL-17D proteins possessed the typical IL-17 domain and shared a conserved arrangement of eight cysteine residues. Both LcIL-17C and LcIL-17Dc genes were constitutively expressed in all tissues examined, although at different levels. After challenge with Aeromonas hydrophila, the expression of LcIL-17C and LcIL-17D was significantly increased in gills, head kidney, and spleen. In the peripheral blood leukocytes (PBLs), the recombinant LcIL-17C (rLcIL-17C) could strongly promote the expression of chemokines (CXCL8, CXCL12, and CXCL13), proinflammatory factors (TNF-α, IL-1β, IL-6, and IFNg), and antibacterial peptide hepcidin, whereas rLcIL-17D induced a weaker expression of these chemokines. Consistently, the culture supernatants from the PBLs treated by rLcIL-17C showed a stronger ability to induce the migration of PBLs than those treated by rLcIL-17D. Furthermore, both rLcIL-17C and rLcIL-17D could activate the NF-κB signalling in the epithelioma papulosum cyprini (EPC) cells. Taken together, these results indicated that LcIL-17C and LcIL-17D, although differing in their ability to mediate chemotaxis for PBLs, may promote the inflammatory response and host defence via activating NF-κB signalling. To our knowledge, this is the first report on functional identification of a IL-17C in teleost. Functional analysis Elsevier Molecular characterization Elsevier Large yellow croaker (<ce:italic>Larimichthys crocea</ce:italic>) Elsevier Interleukin-17C and D Elsevier Ao, Jingqun oth Chen, Xinhua oth Enthalten in Elsevier Science Wearne, Travis A. ELSEVIER GABAergic mRNA expression is differentially expressed across the prelimbic and orbitofrontal cortices of rats sensitized to methamphetamine: Relevance to psychosis 2016transfer abstract ontogeny, phylogeny, aging : the official journal of the International Society of Developmental and Comparative Immunology Amsterdam [u.a.] (DE-627)ELV019920881 volume:76 year:2017 pages:34-44 extent:11 https://doi.org/10.1016/j.dci.2017.05.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_60 44.88 Urologie Nephrologie VZ AR 76 2017 34-44 11 |
| allfields_unstemmed |
10.1016/j.dci.2017.05.014 doi GBV00000000000374.pica (DE-627)ELV030269407 (ELSEVIER)S0145-305X(17)30113-1 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.88 bkl Ding, Yang verfasserin aut Comparative study of interleukin-17C (IL-17C) and IL-17D in large yellow croaker <ce:italic>Larimichthys crocea</ce:italic> reveals their similar but differential functional activity 2017transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Interleukin 17 (IL-17) family members are key players in regulating the immune response in mammals. Here, we identified the IL-17C and IL-17D homologs from large yellow croaker (Larimichthys crocea), named LcIL-17C and LcIL-17D, respectively. The deduced LcIL-17C and LcIL-17D proteins possessed the typical IL-17 domain and shared a conserved arrangement of eight cysteine residues. Both LcIL-17C and LcIL-17Dc genes were constitutively expressed in all tissues examined, although at different levels. After challenge with Aeromonas hydrophila, the expression of LcIL-17C and LcIL-17D was significantly increased in gills, head kidney, and spleen. In the peripheral blood leukocytes (PBLs), the recombinant LcIL-17C (rLcIL-17C) could strongly promote the expression of chemokines (CXCL8, CXCL12, and CXCL13), proinflammatory factors (TNF-α, IL-1β, IL-6, and IFNg), and antibacterial peptide hepcidin, whereas rLcIL-17D induced a weaker expression of these chemokines. Consistently, the culture supernatants from the PBLs treated by rLcIL-17C showed a stronger ability to induce the migration of PBLs than those treated by rLcIL-17D. Furthermore, both rLcIL-17C and rLcIL-17D could activate the NF-κB signalling in the epithelioma papulosum cyprini (EPC) cells. Taken together, these results indicated that LcIL-17C and LcIL-17D, although differing in their ability to mediate chemotaxis for PBLs, may promote the inflammatory response and host defence via activating NF-κB signalling. To our knowledge, this is the first report on functional identification of a IL-17C in teleost. Interleukin 17 (IL-17) family members are key players in regulating the immune response in mammals. Here, we identified the IL-17C and IL-17D homologs from large yellow croaker (Larimichthys crocea), named LcIL-17C and LcIL-17D, respectively. The deduced LcIL-17C and LcIL-17D proteins possessed the typical IL-17 domain and shared a conserved arrangement of eight cysteine residues. Both LcIL-17C and LcIL-17Dc genes were constitutively expressed in all tissues examined, although at different levels. After challenge with Aeromonas hydrophila, the expression of LcIL-17C and LcIL-17D was significantly increased in gills, head kidney, and spleen. In the peripheral blood leukocytes (PBLs), the recombinant LcIL-17C (rLcIL-17C) could strongly promote the expression of chemokines (CXCL8, CXCL12, and CXCL13), proinflammatory factors (TNF-α, IL-1β, IL-6, and IFNg), and antibacterial peptide hepcidin, whereas rLcIL-17D induced a weaker expression of these chemokines. Consistently, the culture supernatants from the PBLs treated by rLcIL-17C showed a stronger ability to induce the migration of PBLs than those treated by rLcIL-17D. Furthermore, both rLcIL-17C and rLcIL-17D could activate the NF-κB signalling in the epithelioma papulosum cyprini (EPC) cells. Taken together, these results indicated that LcIL-17C and LcIL-17D, although differing in their ability to mediate chemotaxis for PBLs, may promote the inflammatory response and host defence via activating NF-κB signalling. To our knowledge, this is the first report on functional identification of a IL-17C in teleost. Functional analysis Elsevier Molecular characterization Elsevier Large yellow croaker (<ce:italic>Larimichthys crocea</ce:italic>) Elsevier Interleukin-17C and D Elsevier Ao, Jingqun oth Chen, Xinhua oth Enthalten in Elsevier Science Wearne, Travis A. ELSEVIER GABAergic mRNA expression is differentially expressed across the prelimbic and orbitofrontal cortices of rats sensitized to methamphetamine: Relevance to psychosis 2016transfer abstract ontogeny, phylogeny, aging : the official journal of the International Society of Developmental and Comparative Immunology Amsterdam [u.a.] (DE-627)ELV019920881 volume:76 year:2017 pages:34-44 extent:11 https://doi.org/10.1016/j.dci.2017.05.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_60 44.88 Urologie Nephrologie VZ AR 76 2017 34-44 11 |
| allfieldsGer |
10.1016/j.dci.2017.05.014 doi GBV00000000000374.pica (DE-627)ELV030269407 (ELSEVIER)S0145-305X(17)30113-1 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.88 bkl Ding, Yang verfasserin aut Comparative study of interleukin-17C (IL-17C) and IL-17D in large yellow croaker <ce:italic>Larimichthys crocea</ce:italic> reveals their similar but differential functional activity 2017transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Interleukin 17 (IL-17) family members are key players in regulating the immune response in mammals. Here, we identified the IL-17C and IL-17D homologs from large yellow croaker (Larimichthys crocea), named LcIL-17C and LcIL-17D, respectively. The deduced LcIL-17C and LcIL-17D proteins possessed the typical IL-17 domain and shared a conserved arrangement of eight cysteine residues. Both LcIL-17C and LcIL-17Dc genes were constitutively expressed in all tissues examined, although at different levels. After challenge with Aeromonas hydrophila, the expression of LcIL-17C and LcIL-17D was significantly increased in gills, head kidney, and spleen. In the peripheral blood leukocytes (PBLs), the recombinant LcIL-17C (rLcIL-17C) could strongly promote the expression of chemokines (CXCL8, CXCL12, and CXCL13), proinflammatory factors (TNF-α, IL-1β, IL-6, and IFNg), and antibacterial peptide hepcidin, whereas rLcIL-17D induced a weaker expression of these chemokines. Consistently, the culture supernatants from the PBLs treated by rLcIL-17C showed a stronger ability to induce the migration of PBLs than those treated by rLcIL-17D. Furthermore, both rLcIL-17C and rLcIL-17D could activate the NF-κB signalling in the epithelioma papulosum cyprini (EPC) cells. Taken together, these results indicated that LcIL-17C and LcIL-17D, although differing in their ability to mediate chemotaxis for PBLs, may promote the inflammatory response and host defence via activating NF-κB signalling. To our knowledge, this is the first report on functional identification of a IL-17C in teleost. Interleukin 17 (IL-17) family members are key players in regulating the immune response in mammals. Here, we identified the IL-17C and IL-17D homologs from large yellow croaker (Larimichthys crocea), named LcIL-17C and LcIL-17D, respectively. The deduced LcIL-17C and LcIL-17D proteins possessed the typical IL-17 domain and shared a conserved arrangement of eight cysteine residues. Both LcIL-17C and LcIL-17Dc genes were constitutively expressed in all tissues examined, although at different levels. After challenge with Aeromonas hydrophila, the expression of LcIL-17C and LcIL-17D was significantly increased in gills, head kidney, and spleen. In the peripheral blood leukocytes (PBLs), the recombinant LcIL-17C (rLcIL-17C) could strongly promote the expression of chemokines (CXCL8, CXCL12, and CXCL13), proinflammatory factors (TNF-α, IL-1β, IL-6, and IFNg), and antibacterial peptide hepcidin, whereas rLcIL-17D induced a weaker expression of these chemokines. Consistently, the culture supernatants from the PBLs treated by rLcIL-17C showed a stronger ability to induce the migration of PBLs than those treated by rLcIL-17D. Furthermore, both rLcIL-17C and rLcIL-17D could activate the NF-κB signalling in the epithelioma papulosum cyprini (EPC) cells. Taken together, these results indicated that LcIL-17C and LcIL-17D, although differing in their ability to mediate chemotaxis for PBLs, may promote the inflammatory response and host defence via activating NF-κB signalling. To our knowledge, this is the first report on functional identification of a IL-17C in teleost. Functional analysis Elsevier Molecular characterization Elsevier Large yellow croaker (<ce:italic>Larimichthys crocea</ce:italic>) Elsevier Interleukin-17C and D Elsevier Ao, Jingqun oth Chen, Xinhua oth Enthalten in Elsevier Science Wearne, Travis A. ELSEVIER GABAergic mRNA expression is differentially expressed across the prelimbic and orbitofrontal cortices of rats sensitized to methamphetamine: Relevance to psychosis 2016transfer abstract ontogeny, phylogeny, aging : the official journal of the International Society of Developmental and Comparative Immunology Amsterdam [u.a.] (DE-627)ELV019920881 volume:76 year:2017 pages:34-44 extent:11 https://doi.org/10.1016/j.dci.2017.05.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_60 44.88 Urologie Nephrologie VZ AR 76 2017 34-44 11 |
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10.1016/j.dci.2017.05.014 doi GBV00000000000374.pica (DE-627)ELV030269407 (ELSEVIER)S0145-305X(17)30113-1 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.88 bkl Ding, Yang verfasserin aut Comparative study of interleukin-17C (IL-17C) and IL-17D in large yellow croaker <ce:italic>Larimichthys crocea</ce:italic> reveals their similar but differential functional activity 2017transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Interleukin 17 (IL-17) family members are key players in regulating the immune response in mammals. Here, we identified the IL-17C and IL-17D homologs from large yellow croaker (Larimichthys crocea), named LcIL-17C and LcIL-17D, respectively. The deduced LcIL-17C and LcIL-17D proteins possessed the typical IL-17 domain and shared a conserved arrangement of eight cysteine residues. Both LcIL-17C and LcIL-17Dc genes were constitutively expressed in all tissues examined, although at different levels. After challenge with Aeromonas hydrophila, the expression of LcIL-17C and LcIL-17D was significantly increased in gills, head kidney, and spleen. In the peripheral blood leukocytes (PBLs), the recombinant LcIL-17C (rLcIL-17C) could strongly promote the expression of chemokines (CXCL8, CXCL12, and CXCL13), proinflammatory factors (TNF-α, IL-1β, IL-6, and IFNg), and antibacterial peptide hepcidin, whereas rLcIL-17D induced a weaker expression of these chemokines. Consistently, the culture supernatants from the PBLs treated by rLcIL-17C showed a stronger ability to induce the migration of PBLs than those treated by rLcIL-17D. Furthermore, both rLcIL-17C and rLcIL-17D could activate the NF-κB signalling in the epithelioma papulosum cyprini (EPC) cells. Taken together, these results indicated that LcIL-17C and LcIL-17D, although differing in their ability to mediate chemotaxis for PBLs, may promote the inflammatory response and host defence via activating NF-κB signalling. To our knowledge, this is the first report on functional identification of a IL-17C in teleost. Interleukin 17 (IL-17) family members are key players in regulating the immune response in mammals. Here, we identified the IL-17C and IL-17D homologs from large yellow croaker (Larimichthys crocea), named LcIL-17C and LcIL-17D, respectively. The deduced LcIL-17C and LcIL-17D proteins possessed the typical IL-17 domain and shared a conserved arrangement of eight cysteine residues. Both LcIL-17C and LcIL-17Dc genes were constitutively expressed in all tissues examined, although at different levels. After challenge with Aeromonas hydrophila, the expression of LcIL-17C and LcIL-17D was significantly increased in gills, head kidney, and spleen. In the peripheral blood leukocytes (PBLs), the recombinant LcIL-17C (rLcIL-17C) could strongly promote the expression of chemokines (CXCL8, CXCL12, and CXCL13), proinflammatory factors (TNF-α, IL-1β, IL-6, and IFNg), and antibacterial peptide hepcidin, whereas rLcIL-17D induced a weaker expression of these chemokines. Consistently, the culture supernatants from the PBLs treated by rLcIL-17C showed a stronger ability to induce the migration of PBLs than those treated by rLcIL-17D. Furthermore, both rLcIL-17C and rLcIL-17D could activate the NF-κB signalling in the epithelioma papulosum cyprini (EPC) cells. Taken together, these results indicated that LcIL-17C and LcIL-17D, although differing in their ability to mediate chemotaxis for PBLs, may promote the inflammatory response and host defence via activating NF-κB signalling. To our knowledge, this is the first report on functional identification of a IL-17C in teleost. Functional analysis Elsevier Molecular characterization Elsevier Large yellow croaker (<ce:italic>Larimichthys crocea</ce:italic>) Elsevier Interleukin-17C and D Elsevier Ao, Jingqun oth Chen, Xinhua oth Enthalten in Elsevier Science Wearne, Travis A. ELSEVIER GABAergic mRNA expression is differentially expressed across the prelimbic and orbitofrontal cortices of rats sensitized to methamphetamine: Relevance to psychosis 2016transfer abstract ontogeny, phylogeny, aging : the official journal of the International Society of Developmental and Comparative Immunology Amsterdam [u.a.] (DE-627)ELV019920881 volume:76 year:2017 pages:34-44 extent:11 https://doi.org/10.1016/j.dci.2017.05.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_60 44.88 Urologie Nephrologie VZ AR 76 2017 34-44 11 |
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comparative study of interleukin-17c (il-17c) and il-17d in large yellow croaker <ce:italic>larimichthys crocea</ce:italic> reveals their similar but differential functional activity |
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Comparative study of interleukin-17C (IL-17C) and IL-17D in large yellow croaker <ce:italic>Larimichthys crocea</ce:italic> reveals their similar but differential functional activity |
| abstract |
Interleukin 17 (IL-17) family members are key players in regulating the immune response in mammals. Here, we identified the IL-17C and IL-17D homologs from large yellow croaker (Larimichthys crocea), named LcIL-17C and LcIL-17D, respectively. The deduced LcIL-17C and LcIL-17D proteins possessed the typical IL-17 domain and shared a conserved arrangement of eight cysteine residues. Both LcIL-17C and LcIL-17Dc genes were constitutively expressed in all tissues examined, although at different levels. After challenge with Aeromonas hydrophila, the expression of LcIL-17C and LcIL-17D was significantly increased in gills, head kidney, and spleen. In the peripheral blood leukocytes (PBLs), the recombinant LcIL-17C (rLcIL-17C) could strongly promote the expression of chemokines (CXCL8, CXCL12, and CXCL13), proinflammatory factors (TNF-α, IL-1β, IL-6, and IFNg), and antibacterial peptide hepcidin, whereas rLcIL-17D induced a weaker expression of these chemokines. Consistently, the culture supernatants from the PBLs treated by rLcIL-17C showed a stronger ability to induce the migration of PBLs than those treated by rLcIL-17D. Furthermore, both rLcIL-17C and rLcIL-17D could activate the NF-κB signalling in the epithelioma papulosum cyprini (EPC) cells. Taken together, these results indicated that LcIL-17C and LcIL-17D, although differing in their ability to mediate chemotaxis for PBLs, may promote the inflammatory response and host defence via activating NF-κB signalling. To our knowledge, this is the first report on functional identification of a IL-17C in teleost. |
| abstractGer |
Interleukin 17 (IL-17) family members are key players in regulating the immune response in mammals. Here, we identified the IL-17C and IL-17D homologs from large yellow croaker (Larimichthys crocea), named LcIL-17C and LcIL-17D, respectively. The deduced LcIL-17C and LcIL-17D proteins possessed the typical IL-17 domain and shared a conserved arrangement of eight cysteine residues. Both LcIL-17C and LcIL-17Dc genes were constitutively expressed in all tissues examined, although at different levels. After challenge with Aeromonas hydrophila, the expression of LcIL-17C and LcIL-17D was significantly increased in gills, head kidney, and spleen. In the peripheral blood leukocytes (PBLs), the recombinant LcIL-17C (rLcIL-17C) could strongly promote the expression of chemokines (CXCL8, CXCL12, and CXCL13), proinflammatory factors (TNF-α, IL-1β, IL-6, and IFNg), and antibacterial peptide hepcidin, whereas rLcIL-17D induced a weaker expression of these chemokines. Consistently, the culture supernatants from the PBLs treated by rLcIL-17C showed a stronger ability to induce the migration of PBLs than those treated by rLcIL-17D. Furthermore, both rLcIL-17C and rLcIL-17D could activate the NF-κB signalling in the epithelioma papulosum cyprini (EPC) cells. Taken together, these results indicated that LcIL-17C and LcIL-17D, although differing in their ability to mediate chemotaxis for PBLs, may promote the inflammatory response and host defence via activating NF-κB signalling. To our knowledge, this is the first report on functional identification of a IL-17C in teleost. |
| abstract_unstemmed |
Interleukin 17 (IL-17) family members are key players in regulating the immune response in mammals. Here, we identified the IL-17C and IL-17D homologs from large yellow croaker (Larimichthys crocea), named LcIL-17C and LcIL-17D, respectively. The deduced LcIL-17C and LcIL-17D proteins possessed the typical IL-17 domain and shared a conserved arrangement of eight cysteine residues. Both LcIL-17C and LcIL-17Dc genes were constitutively expressed in all tissues examined, although at different levels. After challenge with Aeromonas hydrophila, the expression of LcIL-17C and LcIL-17D was significantly increased in gills, head kidney, and spleen. In the peripheral blood leukocytes (PBLs), the recombinant LcIL-17C (rLcIL-17C) could strongly promote the expression of chemokines (CXCL8, CXCL12, and CXCL13), proinflammatory factors (TNF-α, IL-1β, IL-6, and IFNg), and antibacterial peptide hepcidin, whereas rLcIL-17D induced a weaker expression of these chemokines. Consistently, the culture supernatants from the PBLs treated by rLcIL-17C showed a stronger ability to induce the migration of PBLs than those treated by rLcIL-17D. Furthermore, both rLcIL-17C and rLcIL-17D could activate the NF-κB signalling in the epithelioma papulosum cyprini (EPC) cells. Taken together, these results indicated that LcIL-17C and LcIL-17D, although differing in their ability to mediate chemotaxis for PBLs, may promote the inflammatory response and host defence via activating NF-κB signalling. To our knowledge, this is the first report on functional identification of a IL-17C in teleost. |
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| title_short |
Comparative study of interleukin-17C (IL-17C) and IL-17D in large yellow croaker <ce:italic>Larimichthys crocea</ce:italic> reveals their similar but differential functional activity |
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https://doi.org/10.1016/j.dci.2017.05.014 |
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Ao, Jingqun Chen, Xinhua |
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| doi_str |
10.1016/j.dci.2017.05.014 |
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2024-07-06T17:08:39.846Z |
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