High resolution myelin water imaging incorporating local tissue susceptibility analysis
Quantitative myelin water imaging (MWI) from signal T 2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wu, Zhe [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017transfer abstract |
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| Umfang: |
7 |
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| Übergeordnetes Werk: |
Enthalten in: Synthesis, characterization and catalytic performance of MgO-coated Ni/SBA-15 catalysts for methane dry reforming to syngas and hydrogen - Wang, Ning ELSEVIER, 2013transfer abstract, an international journal of basic research and clinical applications, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:42 ; year:2017 ; pages:107-113 ; extent:7 |
| Links: |
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| DOI / URN: |
10.1016/j.mri.2017.06.005 |
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ELV030521890 |
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| 520 | |a Quantitative myelin water imaging (MWI) from signal T 2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool WM model with frequency shift terms could produce more stable parameter estimation for myelin water fraction mapping. MWI maps of higher spatial resolution resulting in more detailed tissue structures and reduced partial volume effects around white matter/gray matter (WM/GM) interface, however, is more desirable. Furthermore, as signal-to-noise ratio (SNR) of original images decreases due to reduced voxel size, the direct complex fitting procedure of myelin water imaging becomes more prone to systematic errors which severely compromised stability and reliability of the result. Instead of using the original part of T 2* decay, this work presents a new method based on the WM-induced phase from tissue susceptibility calculated with the same mGRE dataset, in a three-pool WM model (water of myelin, axonal and extracellular water), to improve high resolution MWI. Compared with direct complex fitting for the higher spatial resolution case, the proposed method is shown to provide a more stable and accurate estimation of MWI parameters, and finer details near WM/GM boundaries with greatly reduced partial volume effects. | ||
| 520 | |a Quantitative myelin water imaging (MWI) from signal T 2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool WM model with frequency shift terms could produce more stable parameter estimation for myelin water fraction mapping. MWI maps of higher spatial resolution resulting in more detailed tissue structures and reduced partial volume effects around white matter/gray matter (WM/GM) interface, however, is more desirable. Furthermore, as signal-to-noise ratio (SNR) of original images decreases due to reduced voxel size, the direct complex fitting procedure of myelin water imaging becomes more prone to systematic errors which severely compromised stability and reliability of the result. Instead of using the original part of T 2* decay, this work presents a new method based on the WM-induced phase from tissue susceptibility calculated with the same mGRE dataset, in a three-pool WM model (water of myelin, axonal and extracellular water), to improve high resolution MWI. Compared with direct complex fitting for the higher spatial resolution case, the proposed method is shown to provide a more stable and accurate estimation of MWI parameters, and finer details near WM/GM boundaries with greatly reduced partial volume effects. | ||
| 700 | 1 | |a He, Hongjian |4 oth | |
| 700 | 1 | |a Sun, Yi |4 oth | |
| 700 | 1 | |a Du, Yiping |4 oth | |
| 700 | 1 | |a Zhong, Jianhui |4 oth | |
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10.1016/j.mri.2017.06.005 doi GBVA2017012000019.pica (DE-627)ELV030521890 (ELSEVIER)S0730-725X(17)30107-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 660 VZ 620 VZ 610 VZ 44.94 bkl Wu, Zhe verfasserin aut High resolution myelin water imaging incorporating local tissue susceptibility analysis 2017transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Quantitative myelin water imaging (MWI) from signal T 2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool WM model with frequency shift terms could produce more stable parameter estimation for myelin water fraction mapping. MWI maps of higher spatial resolution resulting in more detailed tissue structures and reduced partial volume effects around white matter/gray matter (WM/GM) interface, however, is more desirable. Furthermore, as signal-to-noise ratio (SNR) of original images decreases due to reduced voxel size, the direct complex fitting procedure of myelin water imaging becomes more prone to systematic errors which severely compromised stability and reliability of the result. Instead of using the original part of T 2* decay, this work presents a new method based on the WM-induced phase from tissue susceptibility calculated with the same mGRE dataset, in a three-pool WM model (water of myelin, axonal and extracellular water), to improve high resolution MWI. Compared with direct complex fitting for the higher spatial resolution case, the proposed method is shown to provide a more stable and accurate estimation of MWI parameters, and finer details near WM/GM boundaries with greatly reduced partial volume effects. Quantitative myelin water imaging (MWI) from signal T 2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool WM model with frequency shift terms could produce more stable parameter estimation for myelin water fraction mapping. MWI maps of higher spatial resolution resulting in more detailed tissue structures and reduced partial volume effects around white matter/gray matter (WM/GM) interface, however, is more desirable. Furthermore, as signal-to-noise ratio (SNR) of original images decreases due to reduced voxel size, the direct complex fitting procedure of myelin water imaging becomes more prone to systematic errors which severely compromised stability and reliability of the result. Instead of using the original part of T 2* decay, this work presents a new method based on the WM-induced phase from tissue susceptibility calculated with the same mGRE dataset, in a three-pool WM model (water of myelin, axonal and extracellular water), to improve high resolution MWI. Compared with direct complex fitting for the higher spatial resolution case, the proposed method is shown to provide a more stable and accurate estimation of MWI parameters, and finer details near WM/GM boundaries with greatly reduced partial volume effects. He, Hongjian oth Sun, Yi oth Du, Yiping oth Zhong, Jianhui oth Enthalten in Elsevier Science Wang, Ning ELSEVIER Synthesis, characterization and catalytic performance of MgO-coated Ni/SBA-15 catalysts for methane dry reforming to syngas and hydrogen 2013transfer abstract an international journal of basic research and clinical applications Amsterdam [u.a.] (DE-627)ELV011546964 volume:42 year:2017 pages:107-113 extent:7 https://doi.org/10.1016/j.mri.2017.06.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.94 Hals-Nasen-Ohrenheilkunde VZ AR 42 2017 107-113 7 045F 610 |
| spelling |
10.1016/j.mri.2017.06.005 doi GBVA2017012000019.pica (DE-627)ELV030521890 (ELSEVIER)S0730-725X(17)30107-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 660 VZ 620 VZ 610 VZ 44.94 bkl Wu, Zhe verfasserin aut High resolution myelin water imaging incorporating local tissue susceptibility analysis 2017transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Quantitative myelin water imaging (MWI) from signal T 2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool WM model with frequency shift terms could produce more stable parameter estimation for myelin water fraction mapping. MWI maps of higher spatial resolution resulting in more detailed tissue structures and reduced partial volume effects around white matter/gray matter (WM/GM) interface, however, is more desirable. Furthermore, as signal-to-noise ratio (SNR) of original images decreases due to reduced voxel size, the direct complex fitting procedure of myelin water imaging becomes more prone to systematic errors which severely compromised stability and reliability of the result. Instead of using the original part of T 2* decay, this work presents a new method based on the WM-induced phase from tissue susceptibility calculated with the same mGRE dataset, in a three-pool WM model (water of myelin, axonal and extracellular water), to improve high resolution MWI. Compared with direct complex fitting for the higher spatial resolution case, the proposed method is shown to provide a more stable and accurate estimation of MWI parameters, and finer details near WM/GM boundaries with greatly reduced partial volume effects. Quantitative myelin water imaging (MWI) from signal T 2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool WM model with frequency shift terms could produce more stable parameter estimation for myelin water fraction mapping. MWI maps of higher spatial resolution resulting in more detailed tissue structures and reduced partial volume effects around white matter/gray matter (WM/GM) interface, however, is more desirable. Furthermore, as signal-to-noise ratio (SNR) of original images decreases due to reduced voxel size, the direct complex fitting procedure of myelin water imaging becomes more prone to systematic errors which severely compromised stability and reliability of the result. Instead of using the original part of T 2* decay, this work presents a new method based on the WM-induced phase from tissue susceptibility calculated with the same mGRE dataset, in a three-pool WM model (water of myelin, axonal and extracellular water), to improve high resolution MWI. Compared with direct complex fitting for the higher spatial resolution case, the proposed method is shown to provide a more stable and accurate estimation of MWI parameters, and finer details near WM/GM boundaries with greatly reduced partial volume effects. He, Hongjian oth Sun, Yi oth Du, Yiping oth Zhong, Jianhui oth Enthalten in Elsevier Science Wang, Ning ELSEVIER Synthesis, characterization and catalytic performance of MgO-coated Ni/SBA-15 catalysts for methane dry reforming to syngas and hydrogen 2013transfer abstract an international journal of basic research and clinical applications Amsterdam [u.a.] (DE-627)ELV011546964 volume:42 year:2017 pages:107-113 extent:7 https://doi.org/10.1016/j.mri.2017.06.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.94 Hals-Nasen-Ohrenheilkunde VZ AR 42 2017 107-113 7 045F 610 |
| allfields_unstemmed |
10.1016/j.mri.2017.06.005 doi GBVA2017012000019.pica (DE-627)ELV030521890 (ELSEVIER)S0730-725X(17)30107-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 660 VZ 620 VZ 610 VZ 44.94 bkl Wu, Zhe verfasserin aut High resolution myelin water imaging incorporating local tissue susceptibility analysis 2017transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Quantitative myelin water imaging (MWI) from signal T 2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool WM model with frequency shift terms could produce more stable parameter estimation for myelin water fraction mapping. MWI maps of higher spatial resolution resulting in more detailed tissue structures and reduced partial volume effects around white matter/gray matter (WM/GM) interface, however, is more desirable. Furthermore, as signal-to-noise ratio (SNR) of original images decreases due to reduced voxel size, the direct complex fitting procedure of myelin water imaging becomes more prone to systematic errors which severely compromised stability and reliability of the result. Instead of using the original part of T 2* decay, this work presents a new method based on the WM-induced phase from tissue susceptibility calculated with the same mGRE dataset, in a three-pool WM model (water of myelin, axonal and extracellular water), to improve high resolution MWI. Compared with direct complex fitting for the higher spatial resolution case, the proposed method is shown to provide a more stable and accurate estimation of MWI parameters, and finer details near WM/GM boundaries with greatly reduced partial volume effects. Quantitative myelin water imaging (MWI) from signal T 2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool WM model with frequency shift terms could produce more stable parameter estimation for myelin water fraction mapping. MWI maps of higher spatial resolution resulting in more detailed tissue structures and reduced partial volume effects around white matter/gray matter (WM/GM) interface, however, is more desirable. Furthermore, as signal-to-noise ratio (SNR) of original images decreases due to reduced voxel size, the direct complex fitting procedure of myelin water imaging becomes more prone to systematic errors which severely compromised stability and reliability of the result. Instead of using the original part of T 2* decay, this work presents a new method based on the WM-induced phase from tissue susceptibility calculated with the same mGRE dataset, in a three-pool WM model (water of myelin, axonal and extracellular water), to improve high resolution MWI. Compared with direct complex fitting for the higher spatial resolution case, the proposed method is shown to provide a more stable and accurate estimation of MWI parameters, and finer details near WM/GM boundaries with greatly reduced partial volume effects. He, Hongjian oth Sun, Yi oth Du, Yiping oth Zhong, Jianhui oth Enthalten in Elsevier Science Wang, Ning ELSEVIER Synthesis, characterization and catalytic performance of MgO-coated Ni/SBA-15 catalysts for methane dry reforming to syngas and hydrogen 2013transfer abstract an international journal of basic research and clinical applications Amsterdam [u.a.] (DE-627)ELV011546964 volume:42 year:2017 pages:107-113 extent:7 https://doi.org/10.1016/j.mri.2017.06.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.94 Hals-Nasen-Ohrenheilkunde VZ AR 42 2017 107-113 7 045F 610 |
| allfieldsGer |
10.1016/j.mri.2017.06.005 doi GBVA2017012000019.pica (DE-627)ELV030521890 (ELSEVIER)S0730-725X(17)30107-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 660 VZ 620 VZ 610 VZ 44.94 bkl Wu, Zhe verfasserin aut High resolution myelin water imaging incorporating local tissue susceptibility analysis 2017transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Quantitative myelin water imaging (MWI) from signal T 2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool WM model with frequency shift terms could produce more stable parameter estimation for myelin water fraction mapping. MWI maps of higher spatial resolution resulting in more detailed tissue structures and reduced partial volume effects around white matter/gray matter (WM/GM) interface, however, is more desirable. Furthermore, as signal-to-noise ratio (SNR) of original images decreases due to reduced voxel size, the direct complex fitting procedure of myelin water imaging becomes more prone to systematic errors which severely compromised stability and reliability of the result. Instead of using the original part of T 2* decay, this work presents a new method based on the WM-induced phase from tissue susceptibility calculated with the same mGRE dataset, in a three-pool WM model (water of myelin, axonal and extracellular water), to improve high resolution MWI. Compared with direct complex fitting for the higher spatial resolution case, the proposed method is shown to provide a more stable and accurate estimation of MWI parameters, and finer details near WM/GM boundaries with greatly reduced partial volume effects. Quantitative myelin water imaging (MWI) from signal T 2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool WM model with frequency shift terms could produce more stable parameter estimation for myelin water fraction mapping. MWI maps of higher spatial resolution resulting in more detailed tissue structures and reduced partial volume effects around white matter/gray matter (WM/GM) interface, however, is more desirable. Furthermore, as signal-to-noise ratio (SNR) of original images decreases due to reduced voxel size, the direct complex fitting procedure of myelin water imaging becomes more prone to systematic errors which severely compromised stability and reliability of the result. Instead of using the original part of T 2* decay, this work presents a new method based on the WM-induced phase from tissue susceptibility calculated with the same mGRE dataset, in a three-pool WM model (water of myelin, axonal and extracellular water), to improve high resolution MWI. Compared with direct complex fitting for the higher spatial resolution case, the proposed method is shown to provide a more stable and accurate estimation of MWI parameters, and finer details near WM/GM boundaries with greatly reduced partial volume effects. He, Hongjian oth Sun, Yi oth Du, Yiping oth Zhong, Jianhui oth Enthalten in Elsevier Science Wang, Ning ELSEVIER Synthesis, characterization and catalytic performance of MgO-coated Ni/SBA-15 catalysts for methane dry reforming to syngas and hydrogen 2013transfer abstract an international journal of basic research and clinical applications Amsterdam [u.a.] (DE-627)ELV011546964 volume:42 year:2017 pages:107-113 extent:7 https://doi.org/10.1016/j.mri.2017.06.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.94 Hals-Nasen-Ohrenheilkunde VZ AR 42 2017 107-113 7 045F 610 |
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10.1016/j.mri.2017.06.005 doi GBVA2017012000019.pica (DE-627)ELV030521890 (ELSEVIER)S0730-725X(17)30107-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 660 VZ 620 VZ 610 VZ 44.94 bkl Wu, Zhe verfasserin aut High resolution myelin water imaging incorporating local tissue susceptibility analysis 2017transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Quantitative myelin water imaging (MWI) from signal T 2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool WM model with frequency shift terms could produce more stable parameter estimation for myelin water fraction mapping. MWI maps of higher spatial resolution resulting in more detailed tissue structures and reduced partial volume effects around white matter/gray matter (WM/GM) interface, however, is more desirable. Furthermore, as signal-to-noise ratio (SNR) of original images decreases due to reduced voxel size, the direct complex fitting procedure of myelin water imaging becomes more prone to systematic errors which severely compromised stability and reliability of the result. Instead of using the original part of T 2* decay, this work presents a new method based on the WM-induced phase from tissue susceptibility calculated with the same mGRE dataset, in a three-pool WM model (water of myelin, axonal and extracellular water), to improve high resolution MWI. Compared with direct complex fitting for the higher spatial resolution case, the proposed method is shown to provide a more stable and accurate estimation of MWI parameters, and finer details near WM/GM boundaries with greatly reduced partial volume effects. Quantitative myelin water imaging (MWI) from signal T 2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool WM model with frequency shift terms could produce more stable parameter estimation for myelin water fraction mapping. MWI maps of higher spatial resolution resulting in more detailed tissue structures and reduced partial volume effects around white matter/gray matter (WM/GM) interface, however, is more desirable. Furthermore, as signal-to-noise ratio (SNR) of original images decreases due to reduced voxel size, the direct complex fitting procedure of myelin water imaging becomes more prone to systematic errors which severely compromised stability and reliability of the result. Instead of using the original part of T 2* decay, this work presents a new method based on the WM-induced phase from tissue susceptibility calculated with the same mGRE dataset, in a three-pool WM model (water of myelin, axonal and extracellular water), to improve high resolution MWI. Compared with direct complex fitting for the higher spatial resolution case, the proposed method is shown to provide a more stable and accurate estimation of MWI parameters, and finer details near WM/GM boundaries with greatly reduced partial volume effects. He, Hongjian oth Sun, Yi oth Du, Yiping oth Zhong, Jianhui oth Enthalten in Elsevier Science Wang, Ning ELSEVIER Synthesis, characterization and catalytic performance of MgO-coated Ni/SBA-15 catalysts for methane dry reforming to syngas and hydrogen 2013transfer abstract an international journal of basic research and clinical applications Amsterdam [u.a.] (DE-627)ELV011546964 volume:42 year:2017 pages:107-113 extent:7 https://doi.org/10.1016/j.mri.2017.06.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.94 Hals-Nasen-Ohrenheilkunde VZ AR 42 2017 107-113 7 045F 610 |
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English |
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Enthalten in Synthesis, characterization and catalytic performance of MgO-coated Ni/SBA-15 catalysts for methane dry reforming to syngas and hydrogen Amsterdam [u.a.] volume:42 year:2017 pages:107-113 extent:7 |
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Enthalten in Synthesis, characterization and catalytic performance of MgO-coated Ni/SBA-15 catalysts for methane dry reforming to syngas and hydrogen Amsterdam [u.a.] volume:42 year:2017 pages:107-113 extent:7 |
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Synthesis, characterization and catalytic performance of MgO-coated Ni/SBA-15 catalysts for methane dry reforming to syngas and hydrogen |
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Wu, Zhe @@aut@@ He, Hongjian @@oth@@ Sun, Yi @@oth@@ Du, Yiping @@oth@@ Zhong, Jianhui @@oth@@ |
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Synthesis, characterization and catalytic performance of MgO-coated Ni/SBA-15 catalysts for methane dry reforming to syngas and hydrogen |
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high resolution myelin water imaging incorporating local tissue susceptibility analysis |
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High resolution myelin water imaging incorporating local tissue susceptibility analysis |
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Quantitative myelin water imaging (MWI) from signal T 2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool WM model with frequency shift terms could produce more stable parameter estimation for myelin water fraction mapping. MWI maps of higher spatial resolution resulting in more detailed tissue structures and reduced partial volume effects around white matter/gray matter (WM/GM) interface, however, is more desirable. Furthermore, as signal-to-noise ratio (SNR) of original images decreases due to reduced voxel size, the direct complex fitting procedure of myelin water imaging becomes more prone to systematic errors which severely compromised stability and reliability of the result. Instead of using the original part of T 2* decay, this work presents a new method based on the WM-induced phase from tissue susceptibility calculated with the same mGRE dataset, in a three-pool WM model (water of myelin, axonal and extracellular water), to improve high resolution MWI. Compared with direct complex fitting for the higher spatial resolution case, the proposed method is shown to provide a more stable and accurate estimation of MWI parameters, and finer details near WM/GM boundaries with greatly reduced partial volume effects. |
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Quantitative myelin water imaging (MWI) from signal T 2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool WM model with frequency shift terms could produce more stable parameter estimation for myelin water fraction mapping. MWI maps of higher spatial resolution resulting in more detailed tissue structures and reduced partial volume effects around white matter/gray matter (WM/GM) interface, however, is more desirable. Furthermore, as signal-to-noise ratio (SNR) of original images decreases due to reduced voxel size, the direct complex fitting procedure of myelin water imaging becomes more prone to systematic errors which severely compromised stability and reliability of the result. Instead of using the original part of T 2* decay, this work presents a new method based on the WM-induced phase from tissue susceptibility calculated with the same mGRE dataset, in a three-pool WM model (water of myelin, axonal and extracellular water), to improve high resolution MWI. Compared with direct complex fitting for the higher spatial resolution case, the proposed method is shown to provide a more stable and accurate estimation of MWI parameters, and finer details near WM/GM boundaries with greatly reduced partial volume effects. |
| abstract_unstemmed |
Quantitative myelin water imaging (MWI) from signal T 2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool WM model with frequency shift terms could produce more stable parameter estimation for myelin water fraction mapping. MWI maps of higher spatial resolution resulting in more detailed tissue structures and reduced partial volume effects around white matter/gray matter (WM/GM) interface, however, is more desirable. Furthermore, as signal-to-noise ratio (SNR) of original images decreases due to reduced voxel size, the direct complex fitting procedure of myelin water imaging becomes more prone to systematic errors which severely compromised stability and reliability of the result. Instead of using the original part of T 2* decay, this work presents a new method based on the WM-induced phase from tissue susceptibility calculated with the same mGRE dataset, in a three-pool WM model (water of myelin, axonal and extracellular water), to improve high resolution MWI. Compared with direct complex fitting for the higher spatial resolution case, the proposed method is shown to provide a more stable and accurate estimation of MWI parameters, and finer details near WM/GM boundaries with greatly reduced partial volume effects. |
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High resolution myelin water imaging incorporating local tissue susceptibility analysis |
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