Metabolite characterization of a novel sedative drug, remimazolam in human plasma and urine using ultra high-performance liquid chromatography coupled with synapt high-definition mass spectrometry
• An UPLC-Q-TOF/HDMS/MSE method combined with multiple data processing techniques was developed. • The method was applied for profile metabolites of remimazolam in human. • A total of 5 metabolites were observed and 2 of them were confirmed. • The metabolic pathways and the fragmentation patterns of...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zhou, Ying [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Umfang: |
6 |
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| Übergeordnetes Werk: |
Enthalten in: Monitoring the changes in physicochemical, sensory properties and microbiota of village-type homemade yoghurts along three consecutive back-slopping procedures - Gölbaşι, Gülcan ELSEVIER, 2023, the official analytical journal of the American Association of Pharmaceutical Scientists, New York, NY [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:137 ; year:2017 ; day:15 ; month:04 ; pages:78-83 ; extent:6 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.jpba.2017.01.016 |
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Metabolite characterization of a novel sedative drug, remimazolam in human plasma and urine using ultra high-performance liquid chromatography coupled with synapt high-definition mass spectrometry |
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• An UPLC-Q-TOF/HDMS/MSE method combined with multiple data processing techniques was developed. • The method was applied for profile metabolites of remimazolam in human. • A total of 5 metabolites were observed and 2 of them were confirmed. • The metabolic pathways and the fragmentation patterns of metabolites were summarized. • This is the first report of the human metabolic profile of remimazolam. |
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• An UPLC-Q-TOF/HDMS/MSE method combined with multiple data processing techniques was developed. • The method was applied for profile metabolites of remimazolam in human. • A total of 5 metabolites were observed and 2 of them were confirmed. • The metabolic pathways and the fragmentation patterns of metabolites were summarized. • This is the first report of the human metabolic profile of remimazolam. |
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• An UPLC-Q-TOF/HDMS/MSE method combined with multiple data processing techniques was developed. • The method was applied for profile metabolites of remimazolam in human. • A total of 5 metabolites were observed and 2 of them were confirmed. • The metabolic pathways and the fragmentation patterns of metabolites were summarized. • This is the first report of the human metabolic profile of remimazolam. |
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Metabolite characterization of a novel sedative drug, remimazolam in human plasma and urine using ultra high-performance liquid chromatography coupled with synapt high-definition mass spectrometry |
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https://doi.org/10.1016/j.jpba.2017.01.016 |
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Hu, Pei Jiang, Ji |
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Hu, Pei Jiang, Ji |
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10.1016/j.jpba.2017.01.016 |
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2024-07-06T17:48:12.992Z |
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