Everolimus Alleviates Obstructive Hydrocephalus due to Subependymal Giant Cell Astrocytomas
Subependymal giant cell astrocytomas (SEGAs) are low-grade tumors affecting up to 20% of patients with tuberous sclerosis complex (TSC). Early neurosurgical resection has been the only standard treatment until few years ago when a better understanding of the molecular pathogenesis of TSC led to the...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Moavero, Romina [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017transfer abstract |
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| Schlagwörter: |
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| Umfang: |
5 |
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| Übergeordnetes Werk: |
Enthalten in: NOVEL INSIGHTS INTO THE PHYSIOLOGY OF CARDIAC-CORONARY INTERACTION: A FIRST-IN-HUMAN STUDY UTILISING INVASIVE REAL-TIME SIMULTANEOUS MEASURES OF CORONARY AND LEFT VENTRICULAR HEMODYNAMICS - Patterson, Tiffany ELSEVIER, 2016, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:68 ; year:2017 ; pages:59-63 ; extent:5 |
| Links: |
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| DOI / URN: |
10.1016/j.pediatrneurol.2016.11.003 |
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| Katalog-ID: |
ELV030586828 |
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| 520 | |a Subependymal giant cell astrocytomas (SEGAs) are low-grade tumors affecting up to 20% of patients with tuberous sclerosis complex (TSC). Early neurosurgical resection has been the only standard treatment until few years ago when a better understanding of the molecular pathogenesis of TSC led to the use of mammalian target of rapamycin (mTOR) inhibitors. Surgical resection of SEGAs is still considered as the first line treatment in individuals with symptomatic hydrocephalus and intratumoral hemorrhage. We describe four patients with symptomatic or asymptomatic hydrocephalus who were successfully treated with the mTOR inhibitor everolimus. | ||
| 520 | |a Subependymal giant cell astrocytomas (SEGAs) are low-grade tumors affecting up to 20% of patients with tuberous sclerosis complex (TSC). Early neurosurgical resection has been the only standard treatment until few years ago when a better understanding of the molecular pathogenesis of TSC led to the use of mammalian target of rapamycin (mTOR) inhibitors. Surgical resection of SEGAs is still considered as the first line treatment in individuals with symptomatic hydrocephalus and intratumoral hemorrhage. We describe four patients with symptomatic or asymptomatic hydrocephalus who were successfully treated with the mTOR inhibitor everolimus. | ||
| 650 | 7 | |a treatment |2 Elsevier | |
| 650 | 7 | |a everolimus |2 Elsevier | |
| 650 | 7 | |a tuberous sclerosis complex |2 Elsevier | |
| 650 | 7 | |a hydrocephalus |2 Elsevier | |
| 650 | 7 | |a mTOR inhibitors |2 Elsevier | |
| 650 | 7 | |a SEGA |2 Elsevier | |
| 700 | 1 | |a Carai, Andrea |4 oth | |
| 700 | 1 | |a Mastronuzzi, Angela |4 oth | |
| 700 | 1 | |a Marciano, Sara |4 oth | |
| 700 | 1 | |a Graziola, Federica |4 oth | |
| 700 | 1 | |a Vigevano, Federico |4 oth | |
| 700 | 1 | |a Curatolo, Paolo |4 oth | |
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10.1016/j.pediatrneurol.2016.11.003 doi GBVA2017014000014.pica (DE-627)ELV030586828 (ELSEVIER)S0887-8994(16)30569-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Moavero, Romina verfasserin aut Everolimus Alleviates Obstructive Hydrocephalus due to Subependymal Giant Cell Astrocytomas 2017transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Subependymal giant cell astrocytomas (SEGAs) are low-grade tumors affecting up to 20% of patients with tuberous sclerosis complex (TSC). Early neurosurgical resection has been the only standard treatment until few years ago when a better understanding of the molecular pathogenesis of TSC led to the use of mammalian target of rapamycin (mTOR) inhibitors. Surgical resection of SEGAs is still considered as the first line treatment in individuals with symptomatic hydrocephalus and intratumoral hemorrhage. We describe four patients with symptomatic or asymptomatic hydrocephalus who were successfully treated with the mTOR inhibitor everolimus. Subependymal giant cell astrocytomas (SEGAs) are low-grade tumors affecting up to 20% of patients with tuberous sclerosis complex (TSC). Early neurosurgical resection has been the only standard treatment until few years ago when a better understanding of the molecular pathogenesis of TSC led to the use of mammalian target of rapamycin (mTOR) inhibitors. Surgical resection of SEGAs is still considered as the first line treatment in individuals with symptomatic hydrocephalus and intratumoral hemorrhage. We describe four patients with symptomatic or asymptomatic hydrocephalus who were successfully treated with the mTOR inhibitor everolimus. treatment Elsevier everolimus Elsevier tuberous sclerosis complex Elsevier hydrocephalus Elsevier mTOR inhibitors Elsevier SEGA Elsevier Carai, Andrea oth Mastronuzzi, Angela oth Marciano, Sara oth Graziola, Federica oth Vigevano, Federico oth Curatolo, Paolo oth Enthalten in Elsevier Science Patterson, Tiffany ELSEVIER NOVEL INSIGHTS INTO THE PHYSIOLOGY OF CARDIAC-CORONARY INTERACTION: A FIRST-IN-HUMAN STUDY UTILISING INVASIVE REAL-TIME SIMULTANEOUS MEASURES OF CORONARY AND LEFT VENTRICULAR HEMODYNAMICS 2016 Amsterdam [u.a.] (DE-627)ELV01421802X volume:68 year:2017 pages:59-63 extent:5 https://doi.org/10.1016/j.pediatrneurol.2016.11.003 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 68 2017 59-63 5 045F 610 |
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10.1016/j.pediatrneurol.2016.11.003 doi GBVA2017014000014.pica (DE-627)ELV030586828 (ELSEVIER)S0887-8994(16)30569-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Moavero, Romina verfasserin aut Everolimus Alleviates Obstructive Hydrocephalus due to Subependymal Giant Cell Astrocytomas 2017transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Subependymal giant cell astrocytomas (SEGAs) are low-grade tumors affecting up to 20% of patients with tuberous sclerosis complex (TSC). Early neurosurgical resection has been the only standard treatment until few years ago when a better understanding of the molecular pathogenesis of TSC led to the use of mammalian target of rapamycin (mTOR) inhibitors. Surgical resection of SEGAs is still considered as the first line treatment in individuals with symptomatic hydrocephalus and intratumoral hemorrhage. We describe four patients with symptomatic or asymptomatic hydrocephalus who were successfully treated with the mTOR inhibitor everolimus. Subependymal giant cell astrocytomas (SEGAs) are low-grade tumors affecting up to 20% of patients with tuberous sclerosis complex (TSC). Early neurosurgical resection has been the only standard treatment until few years ago when a better understanding of the molecular pathogenesis of TSC led to the use of mammalian target of rapamycin (mTOR) inhibitors. Surgical resection of SEGAs is still considered as the first line treatment in individuals with symptomatic hydrocephalus and intratumoral hemorrhage. We describe four patients with symptomatic or asymptomatic hydrocephalus who were successfully treated with the mTOR inhibitor everolimus. treatment Elsevier everolimus Elsevier tuberous sclerosis complex Elsevier hydrocephalus Elsevier mTOR inhibitors Elsevier SEGA Elsevier Carai, Andrea oth Mastronuzzi, Angela oth Marciano, Sara oth Graziola, Federica oth Vigevano, Federico oth Curatolo, Paolo oth Enthalten in Elsevier Science Patterson, Tiffany ELSEVIER NOVEL INSIGHTS INTO THE PHYSIOLOGY OF CARDIAC-CORONARY INTERACTION: A FIRST-IN-HUMAN STUDY UTILISING INVASIVE REAL-TIME SIMULTANEOUS MEASURES OF CORONARY AND LEFT VENTRICULAR HEMODYNAMICS 2016 Amsterdam [u.a.] (DE-627)ELV01421802X volume:68 year:2017 pages:59-63 extent:5 https://doi.org/10.1016/j.pediatrneurol.2016.11.003 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 68 2017 59-63 5 045F 610 |
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10.1016/j.pediatrneurol.2016.11.003 doi GBVA2017014000014.pica (DE-627)ELV030586828 (ELSEVIER)S0887-8994(16)30569-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Moavero, Romina verfasserin aut Everolimus Alleviates Obstructive Hydrocephalus due to Subependymal Giant Cell Astrocytomas 2017transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Subependymal giant cell astrocytomas (SEGAs) are low-grade tumors affecting up to 20% of patients with tuberous sclerosis complex (TSC). Early neurosurgical resection has been the only standard treatment until few years ago when a better understanding of the molecular pathogenesis of TSC led to the use of mammalian target of rapamycin (mTOR) inhibitors. Surgical resection of SEGAs is still considered as the first line treatment in individuals with symptomatic hydrocephalus and intratumoral hemorrhage. We describe four patients with symptomatic or asymptomatic hydrocephalus who were successfully treated with the mTOR inhibitor everolimus. Subependymal giant cell astrocytomas (SEGAs) are low-grade tumors affecting up to 20% of patients with tuberous sclerosis complex (TSC). Early neurosurgical resection has been the only standard treatment until few years ago when a better understanding of the molecular pathogenesis of TSC led to the use of mammalian target of rapamycin (mTOR) inhibitors. Surgical resection of SEGAs is still considered as the first line treatment in individuals with symptomatic hydrocephalus and intratumoral hemorrhage. We describe four patients with symptomatic or asymptomatic hydrocephalus who were successfully treated with the mTOR inhibitor everolimus. treatment Elsevier everolimus Elsevier tuberous sclerosis complex Elsevier hydrocephalus Elsevier mTOR inhibitors Elsevier SEGA Elsevier Carai, Andrea oth Mastronuzzi, Angela oth Marciano, Sara oth Graziola, Federica oth Vigevano, Federico oth Curatolo, Paolo oth Enthalten in Elsevier Science Patterson, Tiffany ELSEVIER NOVEL INSIGHTS INTO THE PHYSIOLOGY OF CARDIAC-CORONARY INTERACTION: A FIRST-IN-HUMAN STUDY UTILISING INVASIVE REAL-TIME SIMULTANEOUS MEASURES OF CORONARY AND LEFT VENTRICULAR HEMODYNAMICS 2016 Amsterdam [u.a.] (DE-627)ELV01421802X volume:68 year:2017 pages:59-63 extent:5 https://doi.org/10.1016/j.pediatrneurol.2016.11.003 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 68 2017 59-63 5 045F 610 |
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10.1016/j.pediatrneurol.2016.11.003 doi GBVA2017014000014.pica (DE-627)ELV030586828 (ELSEVIER)S0887-8994(16)30569-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Moavero, Romina verfasserin aut Everolimus Alleviates Obstructive Hydrocephalus due to Subependymal Giant Cell Astrocytomas 2017transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Subependymal giant cell astrocytomas (SEGAs) are low-grade tumors affecting up to 20% of patients with tuberous sclerosis complex (TSC). Early neurosurgical resection has been the only standard treatment until few years ago when a better understanding of the molecular pathogenesis of TSC led to the use of mammalian target of rapamycin (mTOR) inhibitors. Surgical resection of SEGAs is still considered as the first line treatment in individuals with symptomatic hydrocephalus and intratumoral hemorrhage. We describe four patients with symptomatic or asymptomatic hydrocephalus who were successfully treated with the mTOR inhibitor everolimus. Subependymal giant cell astrocytomas (SEGAs) are low-grade tumors affecting up to 20% of patients with tuberous sclerosis complex (TSC). Early neurosurgical resection has been the only standard treatment until few years ago when a better understanding of the molecular pathogenesis of TSC led to the use of mammalian target of rapamycin (mTOR) inhibitors. Surgical resection of SEGAs is still considered as the first line treatment in individuals with symptomatic hydrocephalus and intratumoral hemorrhage. We describe four patients with symptomatic or asymptomatic hydrocephalus who were successfully treated with the mTOR inhibitor everolimus. treatment Elsevier everolimus Elsevier tuberous sclerosis complex Elsevier hydrocephalus Elsevier mTOR inhibitors Elsevier SEGA Elsevier Carai, Andrea oth Mastronuzzi, Angela oth Marciano, Sara oth Graziola, Federica oth Vigevano, Federico oth Curatolo, Paolo oth Enthalten in Elsevier Science Patterson, Tiffany ELSEVIER NOVEL INSIGHTS INTO THE PHYSIOLOGY OF CARDIAC-CORONARY INTERACTION: A FIRST-IN-HUMAN STUDY UTILISING INVASIVE REAL-TIME SIMULTANEOUS MEASURES OF CORONARY AND LEFT VENTRICULAR HEMODYNAMICS 2016 Amsterdam [u.a.] (DE-627)ELV01421802X volume:68 year:2017 pages:59-63 extent:5 https://doi.org/10.1016/j.pediatrneurol.2016.11.003 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 68 2017 59-63 5 045F 610 |
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10.1016/j.pediatrneurol.2016.11.003 doi GBVA2017014000014.pica (DE-627)ELV030586828 (ELSEVIER)S0887-8994(16)30569-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Moavero, Romina verfasserin aut Everolimus Alleviates Obstructive Hydrocephalus due to Subependymal Giant Cell Astrocytomas 2017transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Subependymal giant cell astrocytomas (SEGAs) are low-grade tumors affecting up to 20% of patients with tuberous sclerosis complex (TSC). Early neurosurgical resection has been the only standard treatment until few years ago when a better understanding of the molecular pathogenesis of TSC led to the use of mammalian target of rapamycin (mTOR) inhibitors. Surgical resection of SEGAs is still considered as the first line treatment in individuals with symptomatic hydrocephalus and intratumoral hemorrhage. We describe four patients with symptomatic or asymptomatic hydrocephalus who were successfully treated with the mTOR inhibitor everolimus. Subependymal giant cell astrocytomas (SEGAs) are low-grade tumors affecting up to 20% of patients with tuberous sclerosis complex (TSC). Early neurosurgical resection has been the only standard treatment until few years ago when a better understanding of the molecular pathogenesis of TSC led to the use of mammalian target of rapamycin (mTOR) inhibitors. Surgical resection of SEGAs is still considered as the first line treatment in individuals with symptomatic hydrocephalus and intratumoral hemorrhage. We describe four patients with symptomatic or asymptomatic hydrocephalus who were successfully treated with the mTOR inhibitor everolimus. treatment Elsevier everolimus Elsevier tuberous sclerosis complex Elsevier hydrocephalus Elsevier mTOR inhibitors Elsevier SEGA Elsevier Carai, Andrea oth Mastronuzzi, Angela oth Marciano, Sara oth Graziola, Federica oth Vigevano, Federico oth Curatolo, Paolo oth Enthalten in Elsevier Science Patterson, Tiffany ELSEVIER NOVEL INSIGHTS INTO THE PHYSIOLOGY OF CARDIAC-CORONARY INTERACTION: A FIRST-IN-HUMAN STUDY UTILISING INVASIVE REAL-TIME SIMULTANEOUS MEASURES OF CORONARY AND LEFT VENTRICULAR HEMODYNAMICS 2016 Amsterdam [u.a.] (DE-627)ELV01421802X volume:68 year:2017 pages:59-63 extent:5 https://doi.org/10.1016/j.pediatrneurol.2016.11.003 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 68 2017 59-63 5 045F 610 |
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Enthalten in NOVEL INSIGHTS INTO THE PHYSIOLOGY OF CARDIAC-CORONARY INTERACTION: A FIRST-IN-HUMAN STUDY UTILISING INVASIVE REAL-TIME SIMULTANEOUS MEASURES OF CORONARY AND LEFT VENTRICULAR HEMODYNAMICS Amsterdam [u.a.] volume:68 year:2017 pages:59-63 extent:5 |
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Enthalten in NOVEL INSIGHTS INTO THE PHYSIOLOGY OF CARDIAC-CORONARY INTERACTION: A FIRST-IN-HUMAN STUDY UTILISING INVASIVE REAL-TIME SIMULTANEOUS MEASURES OF CORONARY AND LEFT VENTRICULAR HEMODYNAMICS Amsterdam [u.a.] volume:68 year:2017 pages:59-63 extent:5 |
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NOVEL INSIGHTS INTO THE PHYSIOLOGY OF CARDIAC-CORONARY INTERACTION: A FIRST-IN-HUMAN STUDY UTILISING INVASIVE REAL-TIME SIMULTANEOUS MEASURES OF CORONARY AND LEFT VENTRICULAR HEMODYNAMICS |
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Everolimus Alleviates Obstructive Hydrocephalus due to Subependymal Giant Cell Astrocytomas |
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Subependymal giant cell astrocytomas (SEGAs) are low-grade tumors affecting up to 20% of patients with tuberous sclerosis complex (TSC). Early neurosurgical resection has been the only standard treatment until few years ago when a better understanding of the molecular pathogenesis of TSC led to the use of mammalian target of rapamycin (mTOR) inhibitors. Surgical resection of SEGAs is still considered as the first line treatment in individuals with symptomatic hydrocephalus and intratumoral hemorrhage. We describe four patients with symptomatic or asymptomatic hydrocephalus who were successfully treated with the mTOR inhibitor everolimus. |
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Subependymal giant cell astrocytomas (SEGAs) are low-grade tumors affecting up to 20% of patients with tuberous sclerosis complex (TSC). Early neurosurgical resection has been the only standard treatment until few years ago when a better understanding of the molecular pathogenesis of TSC led to the use of mammalian target of rapamycin (mTOR) inhibitors. Surgical resection of SEGAs is still considered as the first line treatment in individuals with symptomatic hydrocephalus and intratumoral hemorrhage. We describe four patients with symptomatic or asymptomatic hydrocephalus who were successfully treated with the mTOR inhibitor everolimus. |
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Subependymal giant cell astrocytomas (SEGAs) are low-grade tumors affecting up to 20% of patients with tuberous sclerosis complex (TSC). Early neurosurgical resection has been the only standard treatment until few years ago when a better understanding of the molecular pathogenesis of TSC led to the use of mammalian target of rapamycin (mTOR) inhibitors. Surgical resection of SEGAs is still considered as the first line treatment in individuals with symptomatic hydrocephalus and intratumoral hemorrhage. We describe four patients with symptomatic or asymptomatic hydrocephalus who were successfully treated with the mTOR inhibitor everolimus. |
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