Design, synthesis and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors
The optimization and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones were performed in this manuscript. Most of the compounds showed higher PPI inhibitory activities and antiproliferative activities. ▪
Gespeichert in:
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Zhou, Wei-Huang [verfasserIn] |
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2017 |
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4 |
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Enthalten in: Enhanced upconversion emission and magnetization in Yb3+-Er3+/Ho3+ codoped Gd2O3 nanocrystals by introducing Zn2+ ions - Li, Daguang ELSEVIER, 2016, Beijing |
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volume:28 ; year:2017 ; number:2 ; pages:422-425 ; extent:4 |
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10.1016/j.cclet.2016.09.001 |
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10.1016/j.cclet.2016.09.001 doi GBVA2017016000006.pica (DE-627)ELV030645808 (ELSEVIER)S1001-8417(16)30288-1 DE-627 ger DE-627 rakwb eng 540 540 DE-600 670 VZ 540 VZ 630 VZ Zhou, Wei-Huang verfasserin aut Design, synthesis and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors 2017 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The optimization and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones were performed in this manuscript. Most of the compounds showed higher PPI inhibitory activities and antiproliferative activities. ▪ Antiproliferative Elsevier Inhibitors Elsevier p53-MDM2 Elsevier Drug design Elsevier Structure–activity relationships Elsevier Protein–protein interaction Elsevier Xu, Xi-Guo oth Li, Jin oth Min, Xiao oth Yao, Jian-Zhong oth Dong, Guo-Qiang oth Zhuang, Chun-Lin oth Miao, Zhen-Yuan oth Zhang, Wan-Nian oth Enthalten in Institute of Materia Medica Li, Daguang ELSEVIER Enhanced upconversion emission and magnetization in Yb3+-Er3+/Ho3+ codoped Gd2O3 nanocrystals by introducing Zn2+ ions 2016 Beijing (DE-627)ELV014303019 volume:28 year:2017 number:2 pages:422-425 extent:4 https://doi.org/10.1016/j.cclet.2016.09.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_40 GBV_ILN_69 AR 28 2017 2 422-425 4 045F 540 |
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10.1016/j.cclet.2016.09.001 doi GBVA2017016000006.pica (DE-627)ELV030645808 (ELSEVIER)S1001-8417(16)30288-1 DE-627 ger DE-627 rakwb eng 540 540 DE-600 670 VZ 540 VZ 630 VZ Zhou, Wei-Huang verfasserin aut Design, synthesis and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors 2017 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The optimization and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones were performed in this manuscript. Most of the compounds showed higher PPI inhibitory activities and antiproliferative activities. ▪ Antiproliferative Elsevier Inhibitors Elsevier p53-MDM2 Elsevier Drug design Elsevier Structure–activity relationships Elsevier Protein–protein interaction Elsevier Xu, Xi-Guo oth Li, Jin oth Min, Xiao oth Yao, Jian-Zhong oth Dong, Guo-Qiang oth Zhuang, Chun-Lin oth Miao, Zhen-Yuan oth Zhang, Wan-Nian oth Enthalten in Institute of Materia Medica Li, Daguang ELSEVIER Enhanced upconversion emission and magnetization in Yb3+-Er3+/Ho3+ codoped Gd2O3 nanocrystals by introducing Zn2+ ions 2016 Beijing (DE-627)ELV014303019 volume:28 year:2017 number:2 pages:422-425 extent:4 https://doi.org/10.1016/j.cclet.2016.09.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_40 GBV_ILN_69 AR 28 2017 2 422-425 4 045F 540 |
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10.1016/j.cclet.2016.09.001 doi GBVA2017016000006.pica (DE-627)ELV030645808 (ELSEVIER)S1001-8417(16)30288-1 DE-627 ger DE-627 rakwb eng 540 540 DE-600 670 VZ 540 VZ 630 VZ Zhou, Wei-Huang verfasserin aut Design, synthesis and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors 2017 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The optimization and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones were performed in this manuscript. Most of the compounds showed higher PPI inhibitory activities and antiproliferative activities. ▪ Antiproliferative Elsevier Inhibitors Elsevier p53-MDM2 Elsevier Drug design Elsevier Structure–activity relationships Elsevier Protein–protein interaction Elsevier Xu, Xi-Guo oth Li, Jin oth Min, Xiao oth Yao, Jian-Zhong oth Dong, Guo-Qiang oth Zhuang, Chun-Lin oth Miao, Zhen-Yuan oth Zhang, Wan-Nian oth Enthalten in Institute of Materia Medica Li, Daguang ELSEVIER Enhanced upconversion emission and magnetization in Yb3+-Er3+/Ho3+ codoped Gd2O3 nanocrystals by introducing Zn2+ ions 2016 Beijing (DE-627)ELV014303019 volume:28 year:2017 number:2 pages:422-425 extent:4 https://doi.org/10.1016/j.cclet.2016.09.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_40 GBV_ILN_69 AR 28 2017 2 422-425 4 045F 540 |
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10.1016/j.cclet.2016.09.001 doi GBVA2017016000006.pica (DE-627)ELV030645808 (ELSEVIER)S1001-8417(16)30288-1 DE-627 ger DE-627 rakwb eng 540 540 DE-600 670 VZ 540 VZ 630 VZ Zhou, Wei-Huang verfasserin aut Design, synthesis and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors 2017 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The optimization and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones were performed in this manuscript. Most of the compounds showed higher PPI inhibitory activities and antiproliferative activities. ▪ Antiproliferative Elsevier Inhibitors Elsevier p53-MDM2 Elsevier Drug design Elsevier Structure–activity relationships Elsevier Protein–protein interaction Elsevier Xu, Xi-Guo oth Li, Jin oth Min, Xiao oth Yao, Jian-Zhong oth Dong, Guo-Qiang oth Zhuang, Chun-Lin oth Miao, Zhen-Yuan oth Zhang, Wan-Nian oth Enthalten in Institute of Materia Medica Li, Daguang ELSEVIER Enhanced upconversion emission and magnetization in Yb3+-Er3+/Ho3+ codoped Gd2O3 nanocrystals by introducing Zn2+ ions 2016 Beijing (DE-627)ELV014303019 volume:28 year:2017 number:2 pages:422-425 extent:4 https://doi.org/10.1016/j.cclet.2016.09.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_40 GBV_ILN_69 AR 28 2017 2 422-425 4 045F 540 |
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10.1016/j.cclet.2016.09.001 doi GBVA2017016000006.pica (DE-627)ELV030645808 (ELSEVIER)S1001-8417(16)30288-1 DE-627 ger DE-627 rakwb eng 540 540 DE-600 670 VZ 540 VZ 630 VZ Zhou, Wei-Huang verfasserin aut Design, synthesis and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors 2017 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The optimization and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones were performed in this manuscript. Most of the compounds showed higher PPI inhibitory activities and antiproliferative activities. ▪ Antiproliferative Elsevier Inhibitors Elsevier p53-MDM2 Elsevier Drug design Elsevier Structure–activity relationships Elsevier Protein–protein interaction Elsevier Xu, Xi-Guo oth Li, Jin oth Min, Xiao oth Yao, Jian-Zhong oth Dong, Guo-Qiang oth Zhuang, Chun-Lin oth Miao, Zhen-Yuan oth Zhang, Wan-Nian oth Enthalten in Institute of Materia Medica Li, Daguang ELSEVIER Enhanced upconversion emission and magnetization in Yb3+-Er3+/Ho3+ codoped Gd2O3 nanocrystals by introducing Zn2+ ions 2016 Beijing (DE-627)ELV014303019 volume:28 year:2017 number:2 pages:422-425 extent:4 https://doi.org/10.1016/j.cclet.2016.09.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_40 GBV_ILN_69 AR 28 2017 2 422-425 4 045F 540 |
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Zhou, Wei-Huang |
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10.1016/j.cclet.2016.09.001 |
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540 670 630 |
| title_sort |
design, synthesis and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1h)-ones as potent p53-mdm2 inhibitors |
| title_auth |
Design, synthesis and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors |
| abstract |
The optimization and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones were performed in this manuscript. Most of the compounds showed higher PPI inhibitory activities and antiproliferative activities. ▪ |
| abstractGer |
The optimization and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones were performed in this manuscript. Most of the compounds showed higher PPI inhibitory activities and antiproliferative activities. ▪ |
| abstract_unstemmed |
The optimization and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones were performed in this manuscript. Most of the compounds showed higher PPI inhibitory activities and antiproliferative activities. ▪ |
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| title_short |
Design, synthesis and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors |
| url |
https://doi.org/10.1016/j.cclet.2016.09.001 |
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Xu, Xi-Guo Li, Jin Min, Xiao Yao, Jian-Zhong Dong, Guo-Qiang Zhuang, Chun-Lin Miao, Zhen-Yuan Zhang, Wan-Nian |
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Xu, Xi-Guo Li, Jin Min, Xiao Yao, Jian-Zhong Dong, Guo-Qiang Zhuang, Chun-Lin Miao, Zhen-Yuan Zhang, Wan-Nian |
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