The companion dog as a unique translational model for aging
The dog is a unique species due to its wide variation among breeds in terms of size, morphology, behaviour and lifespan, coupled with a genetic structure that facilitates the dissection of the genetic architecture that controls these traits. Dogs and humans co-evolved and share recent evolutionary s...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mazzatenta, Andrea [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017transfer abstract |
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| Schlagwörter: |
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| Umfang: |
13 |
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| Übergeordnetes Werk: |
Enthalten in: Spin-polarized bandgap of graphene induced by alternative chemisorption with MgO (111) substrate - Cho, Sung Beom ELSEVIER, 2014transfer abstract, London |
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| Übergeordnetes Werk: |
volume:70 ; year:2017 ; pages:141-153 ; extent:13 |
| Links: |
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| DOI / URN: |
10.1016/j.semcdb.2017.08.024 |
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| 520 | |a The dog is a unique species due to its wide variation among breeds in terms of size, morphology, behaviour and lifespan, coupled with a genetic structure that facilitates the dissection of the genetic architecture that controls these traits. Dogs and humans co-evolved and share recent evolutionary selection processes, such as adaptation to digest starch-rich diets. Many diseases of the dog have a human counterpart, and notably Alzheimer’s disease, which is otherwise difficult to model in other organisms. Unlike laboratory animals, companion dogs share the human environment and lifestyle, are exposed to the same pollutants, and are faced with pathogens and infections. Dogs represented a very useful model to understand the relationship between size, insulin-like growth factor-1 genetic variation and lifespan, and have been used to test the effects of dietary restriction and immunotherapy for Alzheimer’s disease. Very recently, rapamycin was tested in companion dogs outside the laboratory, and this approach where citizens are involved in research aimed at the benefit of dog welfare might become a game changer in geroscience. | ||
| 520 | |a The dog is a unique species due to its wide variation among breeds in terms of size, morphology, behaviour and lifespan, coupled with a genetic structure that facilitates the dissection of the genetic architecture that controls these traits. Dogs and humans co-evolved and share recent evolutionary selection processes, such as adaptation to digest starch-rich diets. Many diseases of the dog have a human counterpart, and notably Alzheimer’s disease, which is otherwise difficult to model in other organisms. Unlike laboratory animals, companion dogs share the human environment and lifestyle, are exposed to the same pollutants, and are faced with pathogens and infections. Dogs represented a very useful model to understand the relationship between size, insulin-like growth factor-1 genetic variation and lifespan, and have been used to test the effects of dietary restriction and immunotherapy for Alzheimer’s disease. Very recently, rapamycin was tested in companion dogs outside the laboratory, and this approach where citizens are involved in research aimed at the benefit of dog welfare might become a game changer in geroscience. | ||
| 650 | 7 | |a Aging dog |2 Elsevier | |
| 650 | 7 | |a Dog genetics |2 Elsevier | |
| 650 | 7 | |a Alzheimer’s disease |2 Elsevier | |
| 650 | 7 | |a Dog breeding |2 Elsevier | |
| 650 | 7 | |a Dog interventions |2 Elsevier | |
| 650 | 7 | |a Evolutionary theory of aging |2 Elsevier | |
| 650 | 7 | |a Calorie restriction |2 Elsevier | |
| 650 | 7 | |a Dog pathology |2 Elsevier | |
| 650 | 7 | |a IGF-1 |2 Elsevier | |
| 650 | 7 | |a Rapamycin |2 Elsevier | |
| 700 | 1 | |a Carluccio, Augusto |4 oth | |
| 700 | 1 | |a Robbe, Domenico |4 oth | |
| 700 | 1 | |a Giulio, Camillo Di |4 oth | |
| 700 | 1 | |a Cellerino, Alessandro |4 oth | |
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10.1016/j.semcdb.2017.08.024 doi GBVA2017018000004.pica (DE-627)ELV030685281 (ELSEVIER)S1084-9521(16)30443-8 DE-627 ger DE-627 rakwb eng 570 570 DE-600 540 VZ 500 VZ 33.25 bkl 31.00 bkl Mazzatenta, Andrea verfasserin aut The companion dog as a unique translational model for aging 2017transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The dog is a unique species due to its wide variation among breeds in terms of size, morphology, behaviour and lifespan, coupled with a genetic structure that facilitates the dissection of the genetic architecture that controls these traits. Dogs and humans co-evolved and share recent evolutionary selection processes, such as adaptation to digest starch-rich diets. Many diseases of the dog have a human counterpart, and notably Alzheimer’s disease, which is otherwise difficult to model in other organisms. Unlike laboratory animals, companion dogs share the human environment and lifestyle, are exposed to the same pollutants, and are faced with pathogens and infections. Dogs represented a very useful model to understand the relationship between size, insulin-like growth factor-1 genetic variation and lifespan, and have been used to test the effects of dietary restriction and immunotherapy for Alzheimer’s disease. Very recently, rapamycin was tested in companion dogs outside the laboratory, and this approach where citizens are involved in research aimed at the benefit of dog welfare might become a game changer in geroscience. The dog is a unique species due to its wide variation among breeds in terms of size, morphology, behaviour and lifespan, coupled with a genetic structure that facilitates the dissection of the genetic architecture that controls these traits. Dogs and humans co-evolved and share recent evolutionary selection processes, such as adaptation to digest starch-rich diets. Many diseases of the dog have a human counterpart, and notably Alzheimer’s disease, which is otherwise difficult to model in other organisms. Unlike laboratory animals, companion dogs share the human environment and lifestyle, are exposed to the same pollutants, and are faced with pathogens and infections. Dogs represented a very useful model to understand the relationship between size, insulin-like growth factor-1 genetic variation and lifespan, and have been used to test the effects of dietary restriction and immunotherapy for Alzheimer’s disease. Very recently, rapamycin was tested in companion dogs outside the laboratory, and this approach where citizens are involved in research aimed at the benefit of dog welfare might become a game changer in geroscience. Aging dog Elsevier Dog genetics Elsevier Alzheimer’s disease Elsevier Dog breeding Elsevier Dog interventions Elsevier Evolutionary theory of aging Elsevier Calorie restriction Elsevier Dog pathology Elsevier IGF-1 Elsevier Rapamycin Elsevier Carluccio, Augusto oth Robbe, Domenico oth Giulio, Camillo Di oth Cellerino, Alessandro oth Enthalten in Academic Press Cho, Sung Beom ELSEVIER Spin-polarized bandgap of graphene induced by alternative chemisorption with MgO (111) substrate 2014transfer abstract London (DE-627)ELV017968445 volume:70 year:2017 pages:141-153 extent:13 https://doi.org/10.1016/j.semcdb.2017.08.024 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT GBV_ILN_70 33.25 Thermodynamik statistische Physik VZ 31.00 Mathematik: Allgemeines VZ AR 70 2017 141-153 13 045F 570 |
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10.1016/j.semcdb.2017.08.024 doi GBVA2017018000004.pica (DE-627)ELV030685281 (ELSEVIER)S1084-9521(16)30443-8 DE-627 ger DE-627 rakwb eng 570 570 DE-600 540 VZ 500 VZ 33.25 bkl 31.00 bkl Mazzatenta, Andrea verfasserin aut The companion dog as a unique translational model for aging 2017transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The dog is a unique species due to its wide variation among breeds in terms of size, morphology, behaviour and lifespan, coupled with a genetic structure that facilitates the dissection of the genetic architecture that controls these traits. Dogs and humans co-evolved and share recent evolutionary selection processes, such as adaptation to digest starch-rich diets. Many diseases of the dog have a human counterpart, and notably Alzheimer’s disease, which is otherwise difficult to model in other organisms. Unlike laboratory animals, companion dogs share the human environment and lifestyle, are exposed to the same pollutants, and are faced with pathogens and infections. Dogs represented a very useful model to understand the relationship between size, insulin-like growth factor-1 genetic variation and lifespan, and have been used to test the effects of dietary restriction and immunotherapy for Alzheimer’s disease. Very recently, rapamycin was tested in companion dogs outside the laboratory, and this approach where citizens are involved in research aimed at the benefit of dog welfare might become a game changer in geroscience. The dog is a unique species due to its wide variation among breeds in terms of size, morphology, behaviour and lifespan, coupled with a genetic structure that facilitates the dissection of the genetic architecture that controls these traits. Dogs and humans co-evolved and share recent evolutionary selection processes, such as adaptation to digest starch-rich diets. Many diseases of the dog have a human counterpart, and notably Alzheimer’s disease, which is otherwise difficult to model in other organisms. Unlike laboratory animals, companion dogs share the human environment and lifestyle, are exposed to the same pollutants, and are faced with pathogens and infections. Dogs represented a very useful model to understand the relationship between size, insulin-like growth factor-1 genetic variation and lifespan, and have been used to test the effects of dietary restriction and immunotherapy for Alzheimer’s disease. Very recently, rapamycin was tested in companion dogs outside the laboratory, and this approach where citizens are involved in research aimed at the benefit of dog welfare might become a game changer in geroscience. Aging dog Elsevier Dog genetics Elsevier Alzheimer’s disease Elsevier Dog breeding Elsevier Dog interventions Elsevier Evolutionary theory of aging Elsevier Calorie restriction Elsevier Dog pathology Elsevier IGF-1 Elsevier Rapamycin Elsevier Carluccio, Augusto oth Robbe, Domenico oth Giulio, Camillo Di oth Cellerino, Alessandro oth Enthalten in Academic Press Cho, Sung Beom ELSEVIER Spin-polarized bandgap of graphene induced by alternative chemisorption with MgO (111) substrate 2014transfer abstract London (DE-627)ELV017968445 volume:70 year:2017 pages:141-153 extent:13 https://doi.org/10.1016/j.semcdb.2017.08.024 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT GBV_ILN_70 33.25 Thermodynamik statistische Physik VZ 31.00 Mathematik: Allgemeines VZ AR 70 2017 141-153 13 045F 570 |
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10.1016/j.semcdb.2017.08.024 doi GBVA2017018000004.pica (DE-627)ELV030685281 (ELSEVIER)S1084-9521(16)30443-8 DE-627 ger DE-627 rakwb eng 570 570 DE-600 540 VZ 500 VZ 33.25 bkl 31.00 bkl Mazzatenta, Andrea verfasserin aut The companion dog as a unique translational model for aging 2017transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The dog is a unique species due to its wide variation among breeds in terms of size, morphology, behaviour and lifespan, coupled with a genetic structure that facilitates the dissection of the genetic architecture that controls these traits. Dogs and humans co-evolved and share recent evolutionary selection processes, such as adaptation to digest starch-rich diets. Many diseases of the dog have a human counterpart, and notably Alzheimer’s disease, which is otherwise difficult to model in other organisms. Unlike laboratory animals, companion dogs share the human environment and lifestyle, are exposed to the same pollutants, and are faced with pathogens and infections. Dogs represented a very useful model to understand the relationship between size, insulin-like growth factor-1 genetic variation and lifespan, and have been used to test the effects of dietary restriction and immunotherapy for Alzheimer’s disease. Very recently, rapamycin was tested in companion dogs outside the laboratory, and this approach where citizens are involved in research aimed at the benefit of dog welfare might become a game changer in geroscience. The dog is a unique species due to its wide variation among breeds in terms of size, morphology, behaviour and lifespan, coupled with a genetic structure that facilitates the dissection of the genetic architecture that controls these traits. Dogs and humans co-evolved and share recent evolutionary selection processes, such as adaptation to digest starch-rich diets. Many diseases of the dog have a human counterpart, and notably Alzheimer’s disease, which is otherwise difficult to model in other organisms. Unlike laboratory animals, companion dogs share the human environment and lifestyle, are exposed to the same pollutants, and are faced with pathogens and infections. Dogs represented a very useful model to understand the relationship between size, insulin-like growth factor-1 genetic variation and lifespan, and have been used to test the effects of dietary restriction and immunotherapy for Alzheimer’s disease. Very recently, rapamycin was tested in companion dogs outside the laboratory, and this approach where citizens are involved in research aimed at the benefit of dog welfare might become a game changer in geroscience. Aging dog Elsevier Dog genetics Elsevier Alzheimer’s disease Elsevier Dog breeding Elsevier Dog interventions Elsevier Evolutionary theory of aging Elsevier Calorie restriction Elsevier Dog pathology Elsevier IGF-1 Elsevier Rapamycin Elsevier Carluccio, Augusto oth Robbe, Domenico oth Giulio, Camillo Di oth Cellerino, Alessandro oth Enthalten in Academic Press Cho, Sung Beom ELSEVIER Spin-polarized bandgap of graphene induced by alternative chemisorption with MgO (111) substrate 2014transfer abstract London (DE-627)ELV017968445 volume:70 year:2017 pages:141-153 extent:13 https://doi.org/10.1016/j.semcdb.2017.08.024 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT GBV_ILN_70 33.25 Thermodynamik statistische Physik VZ 31.00 Mathematik: Allgemeines VZ AR 70 2017 141-153 13 045F 570 |
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10.1016/j.semcdb.2017.08.024 doi GBVA2017018000004.pica (DE-627)ELV030685281 (ELSEVIER)S1084-9521(16)30443-8 DE-627 ger DE-627 rakwb eng 570 570 DE-600 540 VZ 500 VZ 33.25 bkl 31.00 bkl Mazzatenta, Andrea verfasserin aut The companion dog as a unique translational model for aging 2017transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The dog is a unique species due to its wide variation among breeds in terms of size, morphology, behaviour and lifespan, coupled with a genetic structure that facilitates the dissection of the genetic architecture that controls these traits. Dogs and humans co-evolved and share recent evolutionary selection processes, such as adaptation to digest starch-rich diets. Many diseases of the dog have a human counterpart, and notably Alzheimer’s disease, which is otherwise difficult to model in other organisms. Unlike laboratory animals, companion dogs share the human environment and lifestyle, are exposed to the same pollutants, and are faced with pathogens and infections. Dogs represented a very useful model to understand the relationship between size, insulin-like growth factor-1 genetic variation and lifespan, and have been used to test the effects of dietary restriction and immunotherapy for Alzheimer’s disease. Very recently, rapamycin was tested in companion dogs outside the laboratory, and this approach where citizens are involved in research aimed at the benefit of dog welfare might become a game changer in geroscience. The dog is a unique species due to its wide variation among breeds in terms of size, morphology, behaviour and lifespan, coupled with a genetic structure that facilitates the dissection of the genetic architecture that controls these traits. Dogs and humans co-evolved and share recent evolutionary selection processes, such as adaptation to digest starch-rich diets. Many diseases of the dog have a human counterpart, and notably Alzheimer’s disease, which is otherwise difficult to model in other organisms. Unlike laboratory animals, companion dogs share the human environment and lifestyle, are exposed to the same pollutants, and are faced with pathogens and infections. Dogs represented a very useful model to understand the relationship between size, insulin-like growth factor-1 genetic variation and lifespan, and have been used to test the effects of dietary restriction and immunotherapy for Alzheimer’s disease. Very recently, rapamycin was tested in companion dogs outside the laboratory, and this approach where citizens are involved in research aimed at the benefit of dog welfare might become a game changer in geroscience. Aging dog Elsevier Dog genetics Elsevier Alzheimer’s disease Elsevier Dog breeding Elsevier Dog interventions Elsevier Evolutionary theory of aging Elsevier Calorie restriction Elsevier Dog pathology Elsevier IGF-1 Elsevier Rapamycin Elsevier Carluccio, Augusto oth Robbe, Domenico oth Giulio, Camillo Di oth Cellerino, Alessandro oth Enthalten in Academic Press Cho, Sung Beom ELSEVIER Spin-polarized bandgap of graphene induced by alternative chemisorption with MgO (111) substrate 2014transfer abstract London (DE-627)ELV017968445 volume:70 year:2017 pages:141-153 extent:13 https://doi.org/10.1016/j.semcdb.2017.08.024 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT GBV_ILN_70 33.25 Thermodynamik statistische Physik VZ 31.00 Mathematik: Allgemeines VZ AR 70 2017 141-153 13 045F 570 |
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10.1016/j.semcdb.2017.08.024 doi GBVA2017018000004.pica (DE-627)ELV030685281 (ELSEVIER)S1084-9521(16)30443-8 DE-627 ger DE-627 rakwb eng 570 570 DE-600 540 VZ 500 VZ 33.25 bkl 31.00 bkl Mazzatenta, Andrea verfasserin aut The companion dog as a unique translational model for aging 2017transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The dog is a unique species due to its wide variation among breeds in terms of size, morphology, behaviour and lifespan, coupled with a genetic structure that facilitates the dissection of the genetic architecture that controls these traits. Dogs and humans co-evolved and share recent evolutionary selection processes, such as adaptation to digest starch-rich diets. Many diseases of the dog have a human counterpart, and notably Alzheimer’s disease, which is otherwise difficult to model in other organisms. Unlike laboratory animals, companion dogs share the human environment and lifestyle, are exposed to the same pollutants, and are faced with pathogens and infections. Dogs represented a very useful model to understand the relationship between size, insulin-like growth factor-1 genetic variation and lifespan, and have been used to test the effects of dietary restriction and immunotherapy for Alzheimer’s disease. Very recently, rapamycin was tested in companion dogs outside the laboratory, and this approach where citizens are involved in research aimed at the benefit of dog welfare might become a game changer in geroscience. The dog is a unique species due to its wide variation among breeds in terms of size, morphology, behaviour and lifespan, coupled with a genetic structure that facilitates the dissection of the genetic architecture that controls these traits. Dogs and humans co-evolved and share recent evolutionary selection processes, such as adaptation to digest starch-rich diets. Many diseases of the dog have a human counterpart, and notably Alzheimer’s disease, which is otherwise difficult to model in other organisms. Unlike laboratory animals, companion dogs share the human environment and lifestyle, are exposed to the same pollutants, and are faced with pathogens and infections. Dogs represented a very useful model to understand the relationship between size, insulin-like growth factor-1 genetic variation and lifespan, and have been used to test the effects of dietary restriction and immunotherapy for Alzheimer’s disease. Very recently, rapamycin was tested in companion dogs outside the laboratory, and this approach where citizens are involved in research aimed at the benefit of dog welfare might become a game changer in geroscience. Aging dog Elsevier Dog genetics Elsevier Alzheimer’s disease Elsevier Dog breeding Elsevier Dog interventions Elsevier Evolutionary theory of aging Elsevier Calorie restriction Elsevier Dog pathology Elsevier IGF-1 Elsevier Rapamycin Elsevier Carluccio, Augusto oth Robbe, Domenico oth Giulio, Camillo Di oth Cellerino, Alessandro oth Enthalten in Academic Press Cho, Sung Beom ELSEVIER Spin-polarized bandgap of graphene induced by alternative chemisorption with MgO (111) substrate 2014transfer abstract London (DE-627)ELV017968445 volume:70 year:2017 pages:141-153 extent:13 https://doi.org/10.1016/j.semcdb.2017.08.024 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-MAT GBV_ILN_70 33.25 Thermodynamik statistische Physik VZ 31.00 Mathematik: Allgemeines VZ AR 70 2017 141-153 13 045F 570 |
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Enthalten in Spin-polarized bandgap of graphene induced by alternative chemisorption with MgO (111) substrate London volume:70 year:2017 pages:141-153 extent:13 |
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The companion dog as a unique translational model for aging |
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The dog is a unique species due to its wide variation among breeds in terms of size, morphology, behaviour and lifespan, coupled with a genetic structure that facilitates the dissection of the genetic architecture that controls these traits. Dogs and humans co-evolved and share recent evolutionary selection processes, such as adaptation to digest starch-rich diets. Many diseases of the dog have a human counterpart, and notably Alzheimer’s disease, which is otherwise difficult to model in other organisms. Unlike laboratory animals, companion dogs share the human environment and lifestyle, are exposed to the same pollutants, and are faced with pathogens and infections. Dogs represented a very useful model to understand the relationship between size, insulin-like growth factor-1 genetic variation and lifespan, and have been used to test the effects of dietary restriction and immunotherapy for Alzheimer’s disease. Very recently, rapamycin was tested in companion dogs outside the laboratory, and this approach where citizens are involved in research aimed at the benefit of dog welfare might become a game changer in geroscience. |
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The dog is a unique species due to its wide variation among breeds in terms of size, morphology, behaviour and lifespan, coupled with a genetic structure that facilitates the dissection of the genetic architecture that controls these traits. Dogs and humans co-evolved and share recent evolutionary selection processes, such as adaptation to digest starch-rich diets. Many diseases of the dog have a human counterpart, and notably Alzheimer’s disease, which is otherwise difficult to model in other organisms. Unlike laboratory animals, companion dogs share the human environment and lifestyle, are exposed to the same pollutants, and are faced with pathogens and infections. Dogs represented a very useful model to understand the relationship between size, insulin-like growth factor-1 genetic variation and lifespan, and have been used to test the effects of dietary restriction and immunotherapy for Alzheimer’s disease. Very recently, rapamycin was tested in companion dogs outside the laboratory, and this approach where citizens are involved in research aimed at the benefit of dog welfare might become a game changer in geroscience. |
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The dog is a unique species due to its wide variation among breeds in terms of size, morphology, behaviour and lifespan, coupled with a genetic structure that facilitates the dissection of the genetic architecture that controls these traits. Dogs and humans co-evolved and share recent evolutionary selection processes, such as adaptation to digest starch-rich diets. Many diseases of the dog have a human counterpart, and notably Alzheimer’s disease, which is otherwise difficult to model in other organisms. Unlike laboratory animals, companion dogs share the human environment and lifestyle, are exposed to the same pollutants, and are faced with pathogens and infections. Dogs represented a very useful model to understand the relationship between size, insulin-like growth factor-1 genetic variation and lifespan, and have been used to test the effects of dietary restriction and immunotherapy for Alzheimer’s disease. Very recently, rapamycin was tested in companion dogs outside the laboratory, and this approach where citizens are involved in research aimed at the benefit of dog welfare might become a game changer in geroscience. |
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