Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus
Abstract Three structurally interesting new diterpenoids, phyllanflexoids A–C (1–3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computat...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zhao, Jian-Qiang [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013transfer abstract |
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| Umfang: |
5 |
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| Übergeordnetes Werk: |
Enthalten in: Continuing Medical Education Program - 2013, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:54 ; year:2013 ; number:35 ; day:28 ; month:08 ; pages:4670-4674 ; extent:5 |
| Links: |
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| DOI / URN: |
10.1016/j.tetlet.2013.06.082 |
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| 520 | |a Abstract Three structurally interesting new diterpenoids, phyllanflexoids A–C (1–3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1–3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5μM, respectively. | ||
| 520 | |a Abstract Three structurally interesting new diterpenoids, phyllanflexoids A–C (1–3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1–3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5μM, respectively. | ||
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| 650 | 7 | |a 18-Nor-diterpenoid glycoside |2 Elsevier | |
| 650 | 7 | |a Phyllanflexoids A–C |2 Elsevier | |
| 650 | 7 | |a Phenylacetylene |2 Elsevier | |
| 650 | 7 | |a Cytotoxic activity |2 Elsevier | |
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| 700 | 1 | |a Wang, Dong |4 oth | |
| 700 | 1 | |a Yang, Chong-Ren |4 oth | |
| 700 | 1 | |a Wang, Yi-Fei |4 oth | |
| 700 | 1 | |a Zhang, Ying-Jun |4 oth | |
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10.1016/j.tetlet.2013.06.082 doi GBVA2013001000010.pica (DE-627)ELV032713568 (ELSEVIER)S0040-4039(13)01058-7 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 540 VZ 35.00 bkl Zhao, Jian-Qiang verfasserin aut Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Three structurally interesting new diterpenoids, phyllanflexoids A–C (1–3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1–3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5μM, respectively. Abstract Three structurally interesting new diterpenoids, phyllanflexoids A–C (1–3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1–3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5μM, respectively. Phyllanthus flexuosus Elsevier 18-Nor-diterpenoid glycoside Elsevier Phyllanflexoids A–C Elsevier Phenylacetylene Elsevier Cytotoxic activity Elsevier Lv, Jun-Jiang oth Wang, Yan-Ming oth Xu, Min oth Zhu, Hong-Tao oth Wang, Dong oth Yang, Chong-Ren oth Wang, Yi-Fei oth Zhang, Ying-Jun oth Enthalten in Elsevier Science Continuing Medical Education Program 2013 Amsterdam [u.a.] (DE-627)ELV011942339 volume:54 year:2013 number:35 day:28 month:08 pages:4670-4674 extent:5 https://doi.org/10.1016/j.tetlet.2013.06.082 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 54 2013 35 28 0828 4670-4674 5 045F 540 |
| spelling |
10.1016/j.tetlet.2013.06.082 doi GBVA2013001000010.pica (DE-627)ELV032713568 (ELSEVIER)S0040-4039(13)01058-7 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 540 VZ 35.00 bkl Zhao, Jian-Qiang verfasserin aut Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Three structurally interesting new diterpenoids, phyllanflexoids A–C (1–3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1–3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5μM, respectively. Abstract Three structurally interesting new diterpenoids, phyllanflexoids A–C (1–3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1–3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5μM, respectively. Phyllanthus flexuosus Elsevier 18-Nor-diterpenoid glycoside Elsevier Phyllanflexoids A–C Elsevier Phenylacetylene Elsevier Cytotoxic activity Elsevier Lv, Jun-Jiang oth Wang, Yan-Ming oth Xu, Min oth Zhu, Hong-Tao oth Wang, Dong oth Yang, Chong-Ren oth Wang, Yi-Fei oth Zhang, Ying-Jun oth Enthalten in Elsevier Science Continuing Medical Education Program 2013 Amsterdam [u.a.] (DE-627)ELV011942339 volume:54 year:2013 number:35 day:28 month:08 pages:4670-4674 extent:5 https://doi.org/10.1016/j.tetlet.2013.06.082 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 54 2013 35 28 0828 4670-4674 5 045F 540 |
| allfields_unstemmed |
10.1016/j.tetlet.2013.06.082 doi GBVA2013001000010.pica (DE-627)ELV032713568 (ELSEVIER)S0040-4039(13)01058-7 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 540 VZ 35.00 bkl Zhao, Jian-Qiang verfasserin aut Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Three structurally interesting new diterpenoids, phyllanflexoids A–C (1–3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1–3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5μM, respectively. Abstract Three structurally interesting new diterpenoids, phyllanflexoids A–C (1–3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1–3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5μM, respectively. Phyllanthus flexuosus Elsevier 18-Nor-diterpenoid glycoside Elsevier Phyllanflexoids A–C Elsevier Phenylacetylene Elsevier Cytotoxic activity Elsevier Lv, Jun-Jiang oth Wang, Yan-Ming oth Xu, Min oth Zhu, Hong-Tao oth Wang, Dong oth Yang, Chong-Ren oth Wang, Yi-Fei oth Zhang, Ying-Jun oth Enthalten in Elsevier Science Continuing Medical Education Program 2013 Amsterdam [u.a.] (DE-627)ELV011942339 volume:54 year:2013 number:35 day:28 month:08 pages:4670-4674 extent:5 https://doi.org/10.1016/j.tetlet.2013.06.082 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 54 2013 35 28 0828 4670-4674 5 045F 540 |
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10.1016/j.tetlet.2013.06.082 doi GBVA2013001000010.pica (DE-627)ELV032713568 (ELSEVIER)S0040-4039(13)01058-7 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 540 VZ 35.00 bkl Zhao, Jian-Qiang verfasserin aut Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Three structurally interesting new diterpenoids, phyllanflexoids A–C (1–3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1–3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5μM, respectively. Abstract Three structurally interesting new diterpenoids, phyllanflexoids A–C (1–3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1–3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5μM, respectively. Phyllanthus flexuosus Elsevier 18-Nor-diterpenoid glycoside Elsevier Phyllanflexoids A–C Elsevier Phenylacetylene Elsevier Cytotoxic activity Elsevier Lv, Jun-Jiang oth Wang, Yan-Ming oth Xu, Min oth Zhu, Hong-Tao oth Wang, Dong oth Yang, Chong-Ren oth Wang, Yi-Fei oth Zhang, Ying-Jun oth Enthalten in Elsevier Science Continuing Medical Education Program 2013 Amsterdam [u.a.] (DE-627)ELV011942339 volume:54 year:2013 number:35 day:28 month:08 pages:4670-4674 extent:5 https://doi.org/10.1016/j.tetlet.2013.06.082 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 54 2013 35 28 0828 4670-4674 5 045F 540 |
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10.1016/j.tetlet.2013.06.082 doi GBVA2013001000010.pica (DE-627)ELV032713568 (ELSEVIER)S0040-4039(13)01058-7 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 540 VZ 35.00 bkl Zhao, Jian-Qiang verfasserin aut Phyllanflexoid C: first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside from the roots of Phyllanthus flexuosus 2013transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Three structurally interesting new diterpenoids, phyllanflexoids A–C (1–3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1–3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5μM, respectively. Abstract Three structurally interesting new diterpenoids, phyllanflexoids A–C (1–3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1–3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5μM, respectively. Phyllanthus flexuosus Elsevier 18-Nor-diterpenoid glycoside Elsevier Phyllanflexoids A–C Elsevier Phenylacetylene Elsevier Cytotoxic activity Elsevier Lv, Jun-Jiang oth Wang, Yan-Ming oth Xu, Min oth Zhu, Hong-Tao oth Wang, Dong oth Yang, Chong-Ren oth Wang, Yi-Fei oth Zhang, Ying-Jun oth Enthalten in Elsevier Science Continuing Medical Education Program 2013 Amsterdam [u.a.] (DE-627)ELV011942339 volume:54 year:2013 number:35 day:28 month:08 pages:4670-4674 extent:5 https://doi.org/10.1016/j.tetlet.2013.06.082 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 35.00 Chemie: Allgemeines VZ AR 54 2013 35 28 0828 4670-4674 5 045F 540 |
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Abstract Three structurally interesting new diterpenoids, phyllanflexoids A–C (1–3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1–3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5μM, respectively. |
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Abstract Three structurally interesting new diterpenoids, phyllanflexoids A–C (1–3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1–3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5μM, respectively. |
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Abstract Three structurally interesting new diterpenoids, phyllanflexoids A–C (1–3), together with cleistanthol (4) were isolated from the roots of Phyllanthus flexuosus. Their structures with the absolute stereochemistry were elucidated on the basis of comprehensive spectroscopic analysis, computational method, and acidic hydrolysis in the case of 3. Compounds 1–3 were phenylacetylene-bearing tricyclic diterpenes and 3 was the first example of phenylacetylene-bearing 18-nor-diterpenoid glycoside. Compounds 1, 2, and 4 exhibited weak cytotoxicity against human esophagus cancer cell ECA109 with IC50 of 42.7, 21.4, and 24.5μM, respectively. |
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