To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion
The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Bindi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Patterson, Nicholas J. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2013transfer abstract |
|---|
| Schlagwörter: |
|---|
| Umfang: |
8 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Mo1377 Safety and Effectiveness of Colorectal Endoscopic Submucosal Dissection in Elderly Patients: Clinical Outcomes Including Long-Term Follow-up - 2012, an international journal dealing with the study of veterinary immunology and immunopathology as applied to domestic animals, laboratory animals and other species that are useful to man, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:155 ; year:2013 ; number:3 ; day:15 ; month:09 ; pages:147-154 ; extent:8 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.vetimm.2013.06.017 |
|---|
| Katalog-ID: |
ELV032834284 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | ELV032834284 | ||
| 003 | DE-627 | ||
| 005 | 20230625192312.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180603s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.vetimm.2013.06.017 |2 doi | |
| 028 | 5 | 2 | |a GBVA2013004000008.pica |
| 035 | |a (DE-627)ELV032834284 | ||
| 035 | |a (ELSEVIER)S0165-2427(13)00199-2 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | |a 630 | |
| 082 | 0 | 4 | |a 630 |q DE-600 |
| 082 | 0 | 4 | |a 610 |q VZ |
| 082 | 0 | 4 | |a 600 |a 670 |q VZ |
| 084 | |a 51.00 |2 bkl | ||
| 100 | 1 | |a Patterson, Nicholas J. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion |
| 264 | 1 | |c 2013transfer abstract | |
| 300 | |a 8 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp. | ||
| 520 | |a The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp. | ||
| 650 | 7 | |a Tcp |2 Elsevier | |
| 650 | 7 | |a TIR-domain containing protein |2 Elsevier | |
| 650 | 7 | |a TLR signalling pathway |2 Elsevier | |
| 650 | 7 | |a Innate Immunity |2 Elsevier | |
| 650 | 7 | |a TIR domain |2 Elsevier | |
| 700 | 1 | |a Werling, Dirk |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |t Mo1377 Safety and Effectiveness of Colorectal Endoscopic Submucosal Dissection in Elderly Patients: Clinical Outcomes Including Long-Term Follow-up |d 2012 |d an international journal dealing with the study of veterinary immunology and immunopathology as applied to domestic animals, laboratory animals and other species that are useful to man |g Amsterdam [u.a.] |w (DE-627)ELV011273445 |
| 773 | 1 | 8 | |g volume:155 |g year:2013 |g number:3 |g day:15 |g month:09 |g pages:147-154 |g extent:8 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.vetimm.2013.06.017 |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a GBV_ELV | ||
| 912 | |a SYSFLAG_U | ||
| 912 | |a GBV_ILN_21 | ||
| 912 | |a GBV_ILN_70 | ||
| 936 | b | k | |a 51.00 |j Werkstoffkunde: Allgemeines |q VZ |
| 951 | |a AR | ||
| 952 | |d 155 |j 2013 |e 3 |b 15 |c 0915 |h 147-154 |g 8 | ||
| 953 | |2 045F |a 630 | ||
| author_variant |
n j p nj njp |
|---|---|
| matchkey_str |
pattersonnicholasjwerlingdirk:2013----:oopoetotroanotiigrtiscad |
| hierarchy_sort_str |
2013transfer abstract |
| bklnumber |
51.00 |
| publishDate |
2013 |
| allfields |
10.1016/j.vetimm.2013.06.017 doi GBVA2013004000008.pica (DE-627)ELV032834284 (ELSEVIER)S0165-2427(13)00199-2 DE-627 ger DE-627 rakwb eng 630 630 DE-600 610 VZ 600 670 VZ 51.00 bkl Patterson, Nicholas J. verfasserin aut To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion 2013transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp. The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp. Tcp Elsevier TIR-domain containing protein Elsevier TLR signalling pathway Elsevier Innate Immunity Elsevier TIR domain Elsevier Werling, Dirk oth Enthalten in Elsevier Science Mo1377 Safety and Effectiveness of Colorectal Endoscopic Submucosal Dissection in Elderly Patients: Clinical Outcomes Including Long-Term Follow-up 2012 an international journal dealing with the study of veterinary immunology and immunopathology as applied to domestic animals, laboratory animals and other species that are useful to man Amsterdam [u.a.] (DE-627)ELV011273445 volume:155 year:2013 number:3 day:15 month:09 pages:147-154 extent:8 https://doi.org/10.1016/j.vetimm.2013.06.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_21 GBV_ILN_70 51.00 Werkstoffkunde: Allgemeines VZ AR 155 2013 3 15 0915 147-154 8 045F 630 |
| spelling |
10.1016/j.vetimm.2013.06.017 doi GBVA2013004000008.pica (DE-627)ELV032834284 (ELSEVIER)S0165-2427(13)00199-2 DE-627 ger DE-627 rakwb eng 630 630 DE-600 610 VZ 600 670 VZ 51.00 bkl Patterson, Nicholas J. verfasserin aut To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion 2013transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp. The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp. Tcp Elsevier TIR-domain containing protein Elsevier TLR signalling pathway Elsevier Innate Immunity Elsevier TIR domain Elsevier Werling, Dirk oth Enthalten in Elsevier Science Mo1377 Safety and Effectiveness of Colorectal Endoscopic Submucosal Dissection in Elderly Patients: Clinical Outcomes Including Long-Term Follow-up 2012 an international journal dealing with the study of veterinary immunology and immunopathology as applied to domestic animals, laboratory animals and other species that are useful to man Amsterdam [u.a.] (DE-627)ELV011273445 volume:155 year:2013 number:3 day:15 month:09 pages:147-154 extent:8 https://doi.org/10.1016/j.vetimm.2013.06.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_21 GBV_ILN_70 51.00 Werkstoffkunde: Allgemeines VZ AR 155 2013 3 15 0915 147-154 8 045F 630 |
| allfields_unstemmed |
10.1016/j.vetimm.2013.06.017 doi GBVA2013004000008.pica (DE-627)ELV032834284 (ELSEVIER)S0165-2427(13)00199-2 DE-627 ger DE-627 rakwb eng 630 630 DE-600 610 VZ 600 670 VZ 51.00 bkl Patterson, Nicholas J. verfasserin aut To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion 2013transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp. The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp. Tcp Elsevier TIR-domain containing protein Elsevier TLR signalling pathway Elsevier Innate Immunity Elsevier TIR domain Elsevier Werling, Dirk oth Enthalten in Elsevier Science Mo1377 Safety and Effectiveness of Colorectal Endoscopic Submucosal Dissection in Elderly Patients: Clinical Outcomes Including Long-Term Follow-up 2012 an international journal dealing with the study of veterinary immunology and immunopathology as applied to domestic animals, laboratory animals and other species that are useful to man Amsterdam [u.a.] (DE-627)ELV011273445 volume:155 year:2013 number:3 day:15 month:09 pages:147-154 extent:8 https://doi.org/10.1016/j.vetimm.2013.06.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_21 GBV_ILN_70 51.00 Werkstoffkunde: Allgemeines VZ AR 155 2013 3 15 0915 147-154 8 045F 630 |
| allfieldsGer |
10.1016/j.vetimm.2013.06.017 doi GBVA2013004000008.pica (DE-627)ELV032834284 (ELSEVIER)S0165-2427(13)00199-2 DE-627 ger DE-627 rakwb eng 630 630 DE-600 610 VZ 600 670 VZ 51.00 bkl Patterson, Nicholas J. verfasserin aut To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion 2013transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp. The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp. Tcp Elsevier TIR-domain containing protein Elsevier TLR signalling pathway Elsevier Innate Immunity Elsevier TIR domain Elsevier Werling, Dirk oth Enthalten in Elsevier Science Mo1377 Safety and Effectiveness of Colorectal Endoscopic Submucosal Dissection in Elderly Patients: Clinical Outcomes Including Long-Term Follow-up 2012 an international journal dealing with the study of veterinary immunology and immunopathology as applied to domestic animals, laboratory animals and other species that are useful to man Amsterdam [u.a.] (DE-627)ELV011273445 volume:155 year:2013 number:3 day:15 month:09 pages:147-154 extent:8 https://doi.org/10.1016/j.vetimm.2013.06.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_21 GBV_ILN_70 51.00 Werkstoffkunde: Allgemeines VZ AR 155 2013 3 15 0915 147-154 8 045F 630 |
| allfieldsSound |
10.1016/j.vetimm.2013.06.017 doi GBVA2013004000008.pica (DE-627)ELV032834284 (ELSEVIER)S0165-2427(13)00199-2 DE-627 ger DE-627 rakwb eng 630 630 DE-600 610 VZ 600 670 VZ 51.00 bkl Patterson, Nicholas J. verfasserin aut To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion 2013transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp. The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp. Tcp Elsevier TIR-domain containing protein Elsevier TLR signalling pathway Elsevier Innate Immunity Elsevier TIR domain Elsevier Werling, Dirk oth Enthalten in Elsevier Science Mo1377 Safety and Effectiveness of Colorectal Endoscopic Submucosal Dissection in Elderly Patients: Clinical Outcomes Including Long-Term Follow-up 2012 an international journal dealing with the study of veterinary immunology and immunopathology as applied to domestic animals, laboratory animals and other species that are useful to man Amsterdam [u.a.] (DE-627)ELV011273445 volume:155 year:2013 number:3 day:15 month:09 pages:147-154 extent:8 https://doi.org/10.1016/j.vetimm.2013.06.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_21 GBV_ILN_70 51.00 Werkstoffkunde: Allgemeines VZ AR 155 2013 3 15 0915 147-154 8 045F 630 |
| language |
English |
| source |
Enthalten in Mo1377 Safety and Effectiveness of Colorectal Endoscopic Submucosal Dissection in Elderly Patients: Clinical Outcomes Including Long-Term Follow-up Amsterdam [u.a.] volume:155 year:2013 number:3 day:15 month:09 pages:147-154 extent:8 |
| sourceStr |
Enthalten in Mo1377 Safety and Effectiveness of Colorectal Endoscopic Submucosal Dissection in Elderly Patients: Clinical Outcomes Including Long-Term Follow-up Amsterdam [u.a.] volume:155 year:2013 number:3 day:15 month:09 pages:147-154 extent:8 |
| format_phy_str_mv |
Article |
| bklname |
Werkstoffkunde: Allgemeines |
| institution |
findex.gbv.de |
| topic_facet |
Tcp TIR-domain containing protein TLR signalling pathway Innate Immunity TIR domain |
| dewey-raw |
630 |
| isfreeaccess_bool |
false |
| container_title |
Mo1377 Safety and Effectiveness of Colorectal Endoscopic Submucosal Dissection in Elderly Patients: Clinical Outcomes Including Long-Term Follow-up |
| authorswithroles_txt_mv |
Patterson, Nicholas J. @@aut@@ Werling, Dirk @@oth@@ |
| publishDateDaySort_date |
2013-01-15T00:00:00Z |
| hierarchy_top_id |
ELV011273445 |
| dewey-sort |
3630 |
| id |
ELV032834284 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV032834284</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625192312.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2013 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.vetimm.2013.06.017</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2013004000008.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV032834284</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0165-2427(13)00199-2</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">630</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">630</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">600</subfield><subfield code="a">670</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">51.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Patterson, Nicholas J.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2013transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Tcp</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">TIR-domain containing protein</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">TLR signalling pathway</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Innate Immunity</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">TIR domain</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Werling, Dirk</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="t">Mo1377 Safety and Effectiveness of Colorectal Endoscopic Submucosal Dissection in Elderly Patients: Clinical Outcomes Including Long-Term Follow-up</subfield><subfield code="d">2012</subfield><subfield code="d">an international journal dealing with the study of veterinary immunology and immunopathology as applied to domestic animals, laboratory animals and other species that are useful to man</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV011273445</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:155</subfield><subfield code="g">year:2013</subfield><subfield code="g">number:3</subfield><subfield code="g">day:15</subfield><subfield code="g">month:09</subfield><subfield code="g">pages:147-154</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.vetimm.2013.06.017</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_21</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">51.00</subfield><subfield code="j">Werkstoffkunde: Allgemeines</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">155</subfield><subfield code="j">2013</subfield><subfield code="e">3</subfield><subfield code="b">15</subfield><subfield code="c">0915</subfield><subfield code="h">147-154</subfield><subfield code="g">8</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">630</subfield></datafield></record></collection>
|
| author |
Patterson, Nicholas J. |
| spellingShingle |
Patterson, Nicholas J. ddc 630 ddc 610 ddc 600 bkl 51.00 Elsevier Tcp Elsevier TIR-domain containing protein Elsevier TLR signalling pathway Elsevier Innate Immunity Elsevier TIR domain To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion |
| authorStr |
Patterson, Nicholas J. |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)ELV011273445 |
| format |
electronic Article |
| dewey-ones |
630 - Agriculture & related technologies 610 - Medicine & health 600 - Technology 670 - Manufacturing |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
elsevier |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
630 630 DE-600 610 VZ 600 670 VZ 51.00 bkl To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion Tcp Elsevier TIR-domain containing protein Elsevier TLR signalling pathway Elsevier Innate Immunity Elsevier TIR domain Elsevier |
| topic |
ddc 630 ddc 610 ddc 600 bkl 51.00 Elsevier Tcp Elsevier TIR-domain containing protein Elsevier TLR signalling pathway Elsevier Innate Immunity Elsevier TIR domain |
| topic_unstemmed |
ddc 630 ddc 610 ddc 600 bkl 51.00 Elsevier Tcp Elsevier TIR-domain containing protein Elsevier TLR signalling pathway Elsevier Innate Immunity Elsevier TIR domain |
| topic_browse |
ddc 630 ddc 610 ddc 600 bkl 51.00 Elsevier Tcp Elsevier TIR-domain containing protein Elsevier TLR signalling pathway Elsevier Innate Immunity Elsevier TIR domain |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
d w dw |
| hierarchy_parent_title |
Mo1377 Safety and Effectiveness of Colorectal Endoscopic Submucosal Dissection in Elderly Patients: Clinical Outcomes Including Long-Term Follow-up |
| hierarchy_parent_id |
ELV011273445 |
| dewey-tens |
630 - Agriculture 610 - Medicine & health 600 - Technology 670 - Manufacturing |
| hierarchy_top_title |
Mo1377 Safety and Effectiveness of Colorectal Endoscopic Submucosal Dissection in Elderly Patients: Clinical Outcomes Including Long-Term Follow-up |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)ELV011273445 |
| title |
To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion |
| ctrlnum |
(DE-627)ELV032834284 (ELSEVIER)S0165-2427(13)00199-2 |
| title_full |
To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion |
| author_sort |
Patterson, Nicholas J. |
| journal |
Mo1377 Safety and Effectiveness of Colorectal Endoscopic Submucosal Dissection in Elderly Patients: Clinical Outcomes Including Long-Term Follow-up |
| journalStr |
Mo1377 Safety and Effectiveness of Colorectal Endoscopic Submucosal Dissection in Elderly Patients: Clinical Outcomes Including Long-Term Follow-up |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
600 - Technology |
| recordtype |
marc |
| publishDateSort |
2013 |
| contenttype_str_mv |
zzz |
| container_start_page |
147 |
| author_browse |
Patterson, Nicholas J. |
| container_volume |
155 |
| physical |
8 |
| class |
630 630 DE-600 610 VZ 600 670 VZ 51.00 bkl |
| format_se |
Elektronische Aufsätze |
| author-letter |
Patterson, Nicholas J. |
| doi_str_mv |
10.1016/j.vetimm.2013.06.017 |
| dewey-full |
630 610 600 670 |
| title_sort |
to con protection: tir-domain containing proteins (tcp) and innate immune evasion |
| title_auth |
To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion |
| abstract |
The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp. |
| abstractGer |
The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp. |
| abstract_unstemmed |
The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_21 GBV_ILN_70 |
| container_issue |
3 |
| title_short |
To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion |
| url |
https://doi.org/10.1016/j.vetimm.2013.06.017 |
| remote_bool |
true |
| author2 |
Werling, Dirk |
| author2Str |
Werling, Dirk |
| ppnlink |
ELV011273445 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth |
| doi_str |
10.1016/j.vetimm.2013.06.017 |
| up_date |
2024-07-06T17:10:46.203Z |
| _version_ |
1803850451471302656 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV032834284</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625192312.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2013 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.vetimm.2013.06.017</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2013004000008.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV032834284</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0165-2427(13)00199-2</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">630</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">630</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">600</subfield><subfield code="a">670</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">51.00</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Patterson, Nicholas J.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">To con protection: TIR-domain containing proteins (Tcp) and innate immune evasion</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2013transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The innate immune system provides the host's first line of defence against invading pathogens. Key to the stimulation of the innate immune response is pattern-recognition receptors (PRRs), such as Toll-like receptors (TLRs), which recognize microbial-associated molecular patterns (MAMPs). Binding of MAMPs to TLRs triggers a signalling cascade resulting in the production of pro-inflammatory mediators. Central to this TLR signalling pathway are heterotypic protein–protein interactions mediated through Toll/interleukin-1 receptor (TIR) domains found in both the cytoplasmic regions of TLRs and several key adaptor proteins. Interestingly, TIR-domain containing proteins (Tcps) do not seem to be unique to the mammalian TLR system, but occurs in abundance in many biological forms. Recent evidence suggests that pathogenic bacteria have developed a range of ingenuous strategies to evade the host immune mechanisms involving Tcps. There is increasing evidence to suggest that these pathogen-encoded Tcps interfere directly with the TLR signalling pathway and thus inhibit the activation of NF-κB, with different modes of action and roles in virulence. Here, we review the current state of knowledge on the possible roles and mechanisms of action of bacterial encoded Tcp.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Tcp</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">TIR-domain containing protein</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">TLR signalling pathway</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Innate Immunity</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">TIR domain</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Werling, Dirk</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="t">Mo1377 Safety and Effectiveness of Colorectal Endoscopic Submucosal Dissection in Elderly Patients: Clinical Outcomes Including Long-Term Follow-up</subfield><subfield code="d">2012</subfield><subfield code="d">an international journal dealing with the study of veterinary immunology and immunopathology as applied to domestic animals, laboratory animals and other species that are useful to man</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV011273445</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:155</subfield><subfield code="g">year:2013</subfield><subfield code="g">number:3</subfield><subfield code="g">day:15</subfield><subfield code="g">month:09</subfield><subfield code="g">pages:147-154</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.vetimm.2013.06.017</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_21</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_70</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">51.00</subfield><subfield code="j">Werkstoffkunde: Allgemeines</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">155</subfield><subfield code="j">2013</subfield><subfield code="e">3</subfield><subfield code="b">15</subfield><subfield code="c">0915</subfield><subfield code="h">147-154</subfield><subfield code="g">8</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">630</subfield></datafield></record></collection>
|
| score |
7.3995934 |