Ascorbic acid derivatives as a new class of antiproliferative molecules
• We synthesized a small chemical library of analogues of ascorbic acid. • We tested the activity of our analogs in vitro and in vivo in comparison to the known ascorbic acid activities. • We showed that some of our analogs have antiproliferative activity in vitro. • We showed that one of them (K873...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Bordignon, Benoit [verfasserIn] |
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| Format: |
E-Artikel |
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Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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11 |
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| Übergeordnetes Werk: |
Enthalten in: GW26-e0273 Relationship between thrombelastography test and routine platelet parameters in patients with acute coronary syndrome - Hao, Lijun ELSEVIER, 2015, an international journal providing a forum for original and pertinent contributions in cancer research, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:338 ; year:2013 ; number:2 ; day:28 ; month:09 ; pages:317-327 ; extent:11 |
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| DOI / URN: |
10.1016/j.canlet.2013.06.015 |
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10.1016/j.canlet.2013.06.015 doi GBVA2013010000010.pica (DE-627)ELV033074453 (ELSEVIER)S0304-3835(13)00465-5 DE-627 ger DE-627 rakwb eng 570 570 DE-600 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Bordignon, Benoit verfasserin aut Ascorbic acid derivatives as a new class of antiproliferative molecules 2013 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • We synthesized a small chemical library of analogues of ascorbic acid. • We tested the activity of our analogs in vitro and in vivo in comparison to the known ascorbic acid activities. • We showed that some of our analogs have antiproliferative activity in vitro. • We showed that one of them (K873) had antiproliferative activity in vivo in mouse xenograft models. • K873 does not enter the cell by the transporter of ascorbic acid, SVCT2. Antiproliferative drugs Elsevier Xenograft models Elsevier Ascorbic acid Elsevier Derivative of ascorbic acid Elsevier Chiron, Julien oth Fontés, Michel oth Enthalten in Elsevier Science Hao, Lijun ELSEVIER GW26-e0273 Relationship between thrombelastography test and routine platelet parameters in patients with acute coronary syndrome 2015 an international journal providing a forum for original and pertinent contributions in cancer research Amsterdam [u.a.] (DE-627)ELV013094742 volume:338 year:2013 number:2 day:28 month:09 pages:317-327 extent:11 https://doi.org/10.1016/j.canlet.2013.06.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_11 GBV_ILN_40 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 338 2013 2 28 0928 317-327 11 045F 570 |
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• We synthesized a small chemical library of analogues of ascorbic acid. • We tested the activity of our analogs in vitro and in vivo in comparison to the known ascorbic acid activities. • We showed that some of our analogs have antiproliferative activity in vitro. • We showed that one of them (K873) had antiproliferative activity in vivo in mouse xenograft models. • K873 does not enter the cell by the transporter of ascorbic acid, SVCT2. |
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• We synthesized a small chemical library of analogues of ascorbic acid. • We tested the activity of our analogs in vitro and in vivo in comparison to the known ascorbic acid activities. • We showed that some of our analogs have antiproliferative activity in vitro. • We showed that one of them (K873) had antiproliferative activity in vivo in mouse xenograft models. • K873 does not enter the cell by the transporter of ascorbic acid, SVCT2. |
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• We synthesized a small chemical library of analogues of ascorbic acid. • We tested the activity of our analogs in vitro and in vivo in comparison to the known ascorbic acid activities. • We showed that some of our analogs have antiproliferative activity in vitro. • We showed that one of them (K873) had antiproliferative activity in vivo in mouse xenograft models. • K873 does not enter the cell by the transporter of ascorbic acid, SVCT2. |
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Ascorbic acid derivatives as a new class of antiproliferative molecules |
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Chiron, Julien Fontés, Michel |
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