The NF-κB signalling pathway in osteoarthritis
• Osteoarthritis (OA) is a degenerative disease affecting all compartments of the joint. • NF-κB signalling pathway is a major catabolic pathway in OA joints. • NF-κB triggers the expression of various genes which are implicated in cartilage destruction, synovial membrane inflammation and increased...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Rigoglou, Stella [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013 |
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| Schlagwörter: |
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| Umfang: |
5 |
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| Übergeordnetes Werk: |
Enthalten in: Urological Diseases of the Byzantine Emperors (330-1453) - 2011, Amsterdam |
|---|---|
| Übergeordnetes Werk: |
volume:45 ; year:2013 ; number:11 ; pages:2580-2584 ; extent:5 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.biocel.2013.08.018 |
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| 520 | |a • Osteoarthritis (OA) is a degenerative disease affecting all compartments of the joint. • NF-κB signalling pathway is a major catabolic pathway in OA joints. • NF-κB triggers the expression of various genes which are implicated in cartilage destruction, synovial membrane inflammation and increased subchondral bone resorption. • Targeting of the NF-κB signalling cascade is a promising therapeutic strategy for OA treatment. | ||
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• Osteoarthritis (OA) is a degenerative disease affecting all compartments of the joint. • NF-κB signalling pathway is a major catabolic pathway in OA joints. • NF-κB triggers the expression of various genes which are implicated in cartilage destruction, synovial membrane inflammation and increased subchondral bone resorption. • Targeting of the NF-κB signalling cascade is a promising therapeutic strategy for OA treatment. |
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• Osteoarthritis (OA) is a degenerative disease affecting all compartments of the joint. • NF-κB signalling pathway is a major catabolic pathway in OA joints. • NF-κB triggers the expression of various genes which are implicated in cartilage destruction, synovial membrane inflammation and increased subchondral bone resorption. • Targeting of the NF-κB signalling cascade is a promising therapeutic strategy for OA treatment. |
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• Osteoarthritis (OA) is a degenerative disease affecting all compartments of the joint. • NF-κB signalling pathway is a major catabolic pathway in OA joints. • NF-κB triggers the expression of various genes which are implicated in cartilage destruction, synovial membrane inflammation and increased subchondral bone resorption. • Targeting of the NF-κB signalling cascade is a promising therapeutic strategy for OA treatment. |
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